{"id":3129,"date":"2026-10-04T14:43:08","date_gmt":"2026-10-04T14:43:08","guid":{"rendered":"https:\/\/nhdbio.com\/?p=3129"},"modified":"2026-10-04T15:12:46","modified_gmt":"2026-10-04T15:12:46","slug":"mots-c-%d8%af%d8%b1%d8%a7%d8%b3%d8%a9-%d8%ae%d9%84%d9%8a%d8%a9-%d9%88%d8%a7%d8%ad%d8%af%d8%a9-%d9%84%d9%84%d8%a8%d9%84%d8%a7%d8%b9%d9%85-%d8%af%d9%84%d9%8a%d9%84-2026","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ar\/mots-c-macrophage-single-cell-study-evidence-2026\/","title":{"rendered":"MOTS-c \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629: \u0645\u0627 \u0648\u062c\u062f\u062a\u0647 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0648\u0627\u062d\u062f\u0629 \u0641\u0639\u0644\u064a\u064b\u0627"},"content":{"rendered":"<p>\u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u064a\u064f\u0646\u0627\u0642\u0634 MOTS-c \u0641\u064a\u0645\u0627 \u064a\u062a\u0639\u0644\u0642 \u0628\u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u0637\u0627\u0642\u0629. \u062a\u0633\u0623\u0644 \u062f\u0631\u0627\u0633\u0629 \u062d\u062f\u064a\u062b\u0629 \u0633\u0624\u0627\u0644\u064b\u0627 \u0645\u062e\u062a\u0644\u0641\u064b\u0627: \u0647\u0644 \u064a\u0645\u0643\u0646\u0647 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0639\u0644\u0649 \u0643\u064a\u0641\u064a\u0629 \u062a\u0637\u0648\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629\u061f \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0645\u062b\u064a\u0631\u0629 \u0644\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u0647\u064a \u062a\u063a\u064a\u0651\u0631 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0646\u0634\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u0627\u062a\u060c \u0648\u0644\u064a\u0633 \u0639\u0644\u0627\u062c\u064b\u0627 \u0645\u064f\u062b\u0628\u062a\u064b\u0627 \u0644\u0644\u0623\u0634\u062e\u0627\u0635.<\/p>\n<h2>\u0645\u0627 \u0627\u0644\u0630\u064a \u0642\u0627\u0631\u0646\u0647 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646\u061f<\/h2>\n<p>The 2026 eLife paper examined mouse bone-marrow cells from animals aged 4 and 20 months, including both sexes. Cells developed into macrophages over seven days. In treated cultures, MOTS-c was added at the start at 10 \u03bcM, with the medium replaced after three days. Each biological group combined cells from five animals into one sequencing library.<\/p>\n<h2>\u0645\u0627\u0630\u0627 \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a\u061f<\/h2>\n<p>After filtering likely cell doublets, the analysis used 15,060 single cells and identified eight clusters. Clusters 5 and 6 were more prominent in MOTS-c-treated cultures. Their gene patterns involved interferon signalling and antigen presentation\u2014processes that help cells respond to signals and present material to the immune system. These are reported cellular findings, not a percentage improvement in human immunity.<\/p>\n<h2>\u0644\u0645\u0627\u0630\u0627 \u064a\u0647\u0645 \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0639\u064a\u0646\u0629<\/h2>\n<p>\u0622\u0644\u0627\u0641 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u064f\u0633\u0644\u0633\u064e\u0644\u0629 \u0644\u064a\u0633\u062a \u0622\u0644\u0627\u0641 \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u064f\u0639\u0627\u0644\u064e\u062c\u0629 \u0628\u0634\u0643\u0644 \u0645\u0633\u062a\u0642\u0644. \u062a\u062c\u0645\u064a\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0641\u064a \u0645\u0643\u062a\u0628\u0629 \u0648\u0627\u062d\u062f\u0629 \u0644\u0643\u0644 \u0645\u062c\u0645\u0648\u0639\u0629 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u064a\u062d\u062f \u0645\u0646 \u0645\u062f\u0649 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u062a\u0628\u0627\u064a\u0646 \u0628\u064a\u0646 \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0645\u0628\u0627\u0634\u0631\u0629\u064b \u0645\u0646 \u062a\u0644\u0643 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a. \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u062a\u062f\u0639\u0645 \u0645\u0632\u064a\u062f\u064b\u0627 \u0645\u0646 \u0627\u0644\u0628\u062d\u062b\u061b \u0644\u0643\u0646\u0647\u0627 \u0644\u0627 \u062a\u064f\u062b\u0628\u062a \u0641\u0627\u0626\u062f\u0629 \u0639\u0644\u0627\u062c\u064a\u0629 \u0644\u0644\u0625\u0646\u0633\u0627\u0646\u060c \u0648\u0644\u0627 \u062c\u0631\u0639\u0629 \u0628\u0634\u0631\u064a\u0629 \u0641\u0639\u0651\u0627\u0644\u0629\u060c \u0648\u0644\u0627 \u062a\u0643\u0627\u0641\u0624\u064b\u0627 \u0645\u0639 \u0642\u0627\u0631\u0648\u0631\u0629 MOTS-c \u062a\u062c\u0627\u0631\u064a\u0629.<\/p>\n<h2>\u0643\u064a\u0641 \u062a\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0641\u064a \u062e\u0637\u0629 \u0628\u062d\u062b\u064a\u0629<\/h2>\n<p>\u0639\u0646\u062f \u0642\u0631\u0627\u0621\u0629 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0648\u0627\u062d\u062f\u0629\u060c \u0627\u0641\u0635\u0644 \u0628\u064a\u0646 \u062b\u0644\u0627\u062b\u0629 \u0623\u0633\u0626\u0644\u0629: \u0645\u0627 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062a\u064a \u0627\u062e\u062a\u064f\u0628\u0631\u062a\u060c \u0648\u0645\u0627 \u0627\u0644\u0646\u0645\u0648\u0630\u062c \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u060c \u0648\u0645\u0627 \u0627\u0644\u0630\u064a \u062a\u063a\u064a\u0651\u0631. \u0642\u062f \u064a\u0634\u064a\u0631 \u062a\u063a\u064a\u0651\u0631 \u0641\u064a \u0646\u0634\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0625\u0644\u0649 \u0622\u0644\u064a\u0629 \u062a\u0633\u062a\u062d\u0642 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u060c \u0644\u0643\u0646 \u0627\u0644\u0645\u062a\u0627\u0628\u0639\u0629 \u0627\u0644\u0645\u0641\u064a\u062f\u0629 \u062a\u062d\u062a\u0627\u062c \u0623\u064a\u0636\u064b\u0627 \u0625\u0644\u0649 \u0645\u0642\u064a\u0627\u0633 \u0648\u0638\u064a\u0641\u064a \u0648\u0636\u0648\u0627\u0628\u0637 \u0645\u0646\u0627\u0633\u0628\u0629. \u0633\u062c\u0651\u0644 \u0647\u0648\u064a\u0629 \u0627\u0644\u0628\u0628\u062a\u064a\u062f\u060c \u0648\u0627\u0644\u0648\u0633\u0637\u060c \u0648\u0627\u0644\u062a\u0648\u0642\u064a\u062a\u060c \u0648\u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u062d\u0627\u0645\u0644\u0629\u060c \u0648\u0627\u0644\u062a\u0648\u062b\u064a\u0642 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u064a \u0642\u0628\u0644 \u0645\u0642\u0627\u0631\u0646\u0629 \u062a\u062c\u0631\u0628\u062a\u0643 \u0628\u0627\u0644\u0648\u0631\u0642\u0629 \u0627\u0644\u0628\u062d\u062b\u064a\u0629. \u0644\u0627 \u062a\u0633\u062a\u0639\u0650\u0631 \u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0645\u0632\u0631\u0639\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 \u0641\u064a\u0647\u0627 \u0643\u062a\u0648\u0635\u064a\u0629 \u0644\u0646\u0638\u0627\u0645 \u0622\u062e\u0631.<\/p>\n<h2>\u0645\u0648\u0627\u062f \u0627\u0644\u0628\u062d\u062b \u0648\u0627\u0644\u062e\u0637\u0648\u0627\u062a \u0627\u0644\u062a\u0627\u0644\u064a\u0629<\/h2>\n<p>\u0627\u0644\u0640 <a href=\"https:\/\/nhdbio.com\/ar\/%d8%a7%d9%84%d9%85%d9%86%d8%aa%d8%ac%d8%a7%d8%aa\/%d9%83%d9%84%d9%85%d8%a7%d8%aa-c-human\/\">NHD \u0635\u0641\u062d\u0629 MOTS-c<\/a> \u0647\u064a \u0646\u0642\u0637\u0629 \u0628\u062f\u0627\u064a\u0629 \u0644\u062a\u062d\u062f\u064a\u062f \u062e\u064a\u0627\u0631\u0627\u062a \u0627\u0644\u0643\u062a\u0627\u0644\u0648\u062c. \u0648\u0647\u064a \u0644\u0627 \u062a\u062b\u0628\u062a \u0623\u0646 \u0645\u0627\u062f\u0629 NHD \u062a\u0637\u0627\u0628\u0642 \u0639\u064a\u0646\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629. <a href=\"https:\/\/nhdbio.com\/ar\/%d8%a7%d9%82%d8%aa%d8%a8%d8%a7%d8%b3\/\">\u0623\u0631\u0633\u0644 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0627\u0644\u0645\u0637\u0644\u0648\u0628 \u0648\u0627\u0644\u0643\u0645\u064a\u0629 \u0648\u0645\u062a\u0637\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0646\u062f\u0627\u062a<\/a> \u062d\u062a\u0649 \u064a\u0645\u0643\u0646 \u062a\u0623\u0643\u064a\u062f \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0648\u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0645\u0645\u0643\u0646 \u0648\u0646\u0637\u0627\u0642 \u0627\u0644\u062a\u0633\u0644\u064a\u0645.<\/p>\n<h2>\u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0623\u0635\u0644\u064a<\/h2>\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC13485304\/\">Rice et al.\u060c eLife (2026): MOTS-c \u0647\u0648 \u0628\u0628\u062a\u064a\u062f \u062f\u0641\u0627\u0639 \u0645\u0636\u064a\u0641 \u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0625\u0646\u062a\u0631\u0641\u064a\u0631\u0648\u0646 \u0648\u0645\u0634\u0641\u0651\u0631 \u0641\u064a \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627<\/a>. DOI: 10.7554\/eLife.87615.<\/p>\n<p>\u0627\u0644\u0631\u0633\u0648\u0645 \u0627\u0644\u062a\u0648\u0636\u064a\u062d\u064a\u0629 \u0645\u0641\u0627\u0647\u064a\u0645\u064a\u0629. \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0644\u064a\u0633\u062a \u0628\u064a\u0627\u0646\u0627\u062a \u062f\u0641\u0639\u0629 NHD. \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0628\u062d\u062b\u064a\u0629 \u0645\u062e\u0635\u0635\u0629 \u0644\u0644\u0628\u062d\u062b \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u064a \u0648\u0627\u0644\u062a\u0637\u0648\u064a\u0631 \u0648\u0627\u0644\u062a\u0635\u0646\u064a\u0639\u060c \u0648\u0644\u064a\u0633 \u0644\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0628\u0634\u0631\u064a \u0623\u0648 \u0627\u0644\u0628\u064a\u0637\u0631\u064a.<\/p>","protected":false},"excerpt":{"rendered":"<p>\u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u064a\u064f\u0646\u0627\u0642\u0634 MOTS-c \u0641\u064a\u0645\u0627 \u064a\u062a\u0639\u0644\u0642 \u0628\u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u0637\u0627\u0642\u0629. \u062a\u0633\u0623\u0644 \u062f\u0631\u0627\u0633\u0629 \u062d\u062f\u064a\u062b\u0629 \u0633\u0624\u0627\u0644\u064b\u0627 \u0645\u062e\u062a\u0644\u0641\u064b\u0627: \u0647\u0644 \u064a\u0645\u0643\u0646\u0647 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0639\u0644\u0649 \u0643\u064a\u0641\u064a\u0629 \u062a\u0637\u0648\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629\u061f \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0645\u062b\u064a\u0631\u0629 \u0644\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u0647\u064a \u062a\u063a\u064a\u0651\u0631 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0646\u0634\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u0627\u062a\u060c \u0648\u0644\u064a\u0633 \u0639\u0644\u0627\u062c\u064b\u0627 \u0645\u064f\u062b\u0628\u062a\u064b\u0627 \u0644\u0644\u0623\u0634\u062e\u0627\u0635.<\/p>","protected":false},"author":1,"featured_media":3131,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"352","pim_article_type":"Primary-literature evidence note","pim_evidence_level":"Cell and mouse evidence; not a clinical trial","pim_reviewer":"Codex AI editorial","pim_reviewed_date":"2026-10-04","pim_editorial_note":"The numerical findings apply to the cited study material and model, not NHD batches. Original full text was checked.","pim_review_status":"reviewed","pim_review_reason":"Original-record, numerical, model and readability checks; no independent human technical review recorded.","pim_creation_method":"AI-assisted original-source reading, editorial checks and conceptual illustration.","pim_sources":"[{\"title\":\"Rice et al., eLife (2026): MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide\",\"url\":\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC13485304\/\",\"note\":\"Original publication; reported findings apply to its study material and model. Checked 2026-10-04.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-3129","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>MOTS-c and immune cells: what a single-cell study actually found - NHD<\/title>\n<meta name=\"description\" content=\"Peptide Raw Materials and Custom Peptide Synthesis\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nhdbio.com\/ar\/mots-c-\u062f\u0631\u0627\u0633\u0629-\u062e\u0644\u064a\u0629-\u0648\u0627\u062d\u062f\u0629-\u0644\u0644\u0628\u0644\u0627\u0639\u0645-\u062f\u0644\u064a\u0644-2026\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MOTS-c and immune cells: what a single-cell study actually found\" \/>\n<meta property=\"og:description\" content=\"MOTS-c is often discussed in connection with energy metabolism. A recent study asks a different question: can it influence how immune cells develop? 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