{"id":4567,"date":"2026-10-13T16:14:30","date_gmt":"2026-10-13T16:14:30","guid":{"rendered":"https:\/\/nhdbio.com\/?p=4567"},"modified":"2026-10-13T16:14:30","modified_gmt":"2026-10-13T16:14:30","slug":"%d8%b4%d8%b1%d8%ad-%d8%a8%d9%86%d9%8a%d8%a9-%d9%85%d8%b3%d8%aa%d9%82%d8%a8%d9%84%d8%a7%d8%aa-%d8%b1%d9%8a%d8%aa%d8%a7%d8%aa%d8%b1%d9%88%d8%aa%d8%a7%d9%8a%d8%af-%d8%a7%d9%84%d8%ab%d9%84%d8%a7%d8%ab","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ar\/retatrutide-three-receptor-structure-explained\/","title":{"rendered":"\u0643\u064a\u0641 \u064a\u0645\u0643\u0646 \u0644\u0628\u0628\u062a\u064a\u062f \u0648\u0627\u062d\u062f \u0623\u0646 \u064a\u0631\u062a\u0628\u0637 \u0628\u062b\u0644\u0627\u062b\u0629 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a\u061f \u0634\u0631\u062d \u0631\u064a\u062a\u0627\u062a\u0631\u0648\u062a\u0627\u064a\u062f"},"content":{"rendered":"<section class=\"nhd-cp-topic\" id=\"nhd-cp-topic-knowledge-20261013-11\">\n<p class=\"nhd-cp-lead\">Retatrutide&#039;s &quot;three receptors&quot; means the same molecule can act on three types of receptors. It is not three peptides in one vial, and it is not three receptors each contributing a fixed one-third of the effect.<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/nhd-knowledge-20261013-11.webp\" alt=\"\u0631\u0633\u0645 \u062a\u0648\u0636\u064a\u062d\u064a \u0633\u0627\u062e\u0631 \u0644\u0644\u0645\u0648\u0636\u0648\u0639 \u0627\u0644\u0630\u064a \u064a\u062a\u0646\u0627\u0648\u0644\u0647 \u0647\u0630\u0627 \u0627\u0644\u062f\u0644\u064a\u0644\"><figcaption>\u0631\u0633\u0645 \u062a\u0648\u0636\u064a\u062d\u064a \u062a\u062d\u0631\u064a\u0631\u064a\u061b \u0644\u064a\u0633 \u0635\u0648\u0631\u0629 \u0641\u0648\u062a\u0648\u063a\u0631\u0627\u0641\u064a\u0629 \u062a\u062c\u0631\u064a\u0628\u064a\u0629.<\/figcaption><\/figure>\n<h3>\u0623\u0648\u0644\u0627\u064b\u060c \u0627\u0641\u0647\u0645 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a: \u0627\u0644\u0645\u0648\u0627\u0642\u0639 \u0627\u0644\u062a\u064a \u062a\u062a\u0648\u0627\u0635\u0644 \u0641\u064a\u0647\u0627 \u0627\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627<\/h3>\n<p>\u062a\u062e\u064a\u0644 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0643\u0645\u0648\u0642\u0639 \u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u062e\u0644\u064a\u0629. \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u064a\u0645\u0643\u0646 \u0644\u062c\u0632\u064a\u0621 \u0623\u0646 \u064a\u0631\u062a\u0628\u0637 \u0628\u0647\u060c \u0648\u0643\u064a\u0641 \u062a\u0633\u062a\u062c\u064a\u0628 \u0627\u0644\u062e\u0644\u064a\u0629 \u0628\u0639\u062f \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637\u060c \u064a\u062d\u062a\u0627\u062c\u0627\u0646 \u0625\u0644\u0649 \u0627\u0644\u062d\u0643\u0645 \u0639\u0644\u064a\u0647\u0645\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u062c\u0627\u0631\u0628 \u0645\u062e\u062a\u0644\u0641\u0629. \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0627\u0644\u062d\u0642\u064a\u0642\u064a \u064a\u062a\u0636\u0645\u0646 \u0627\u0644\u0634\u0643\u0644 \u0648\u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629\u060c \u0648\u0644\u0627 \u064a\u0645\u0643\u0646 \u062a\u0641\u0633\u064a\u0631\u0647 \u0628\u0627\u0644\u0643\u0627\u0645\u0644 \u0628\u0645\u062c\u0627\u0632 \u0627\u0644\u0645\u0641\u062a\u0627\u062d \u0648\u0627\u0644\u0642\u0641\u0644 \u0648\u062d\u062f\u0647.<\/p>\n<p>\u0627\u0644\u0623\u0633\u0645\u0627\u0621 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0647\u0646\u0627 \u0647\u064a GLP-1R\u060c \u0648GIPR\u060c \u0648GCGR\u060c \u0648\u0647\u064a \u062a\u0642\u0627\u0628\u0644 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0640 GLP-1\u060c \u0648GIP\u060c \u0648\u0627\u0644\u063a\u0644\u0648\u0643\u0627\u063a\u0648\u0646. \u0639\u0646\u062f\u0645\u0627 \u062a\u0631\u0649 \u0627\u0644\u062d\u0631\u0641 R \u0641\u064a \u0648\u0631\u0642\u0629 \u0628\u062d\u062b\u064a\u0629\u060c \u064a\u0645\u0643\u0646\u0643 \u0623\u0646 \u062a\u0641\u0647\u0645\u0647 \u0623\u0648\u0644\u0627\u064b \u0639\u0644\u0649 \u0623\u0646\u0647 \u0645\u0633\u062a\u0642\u0628\u0644.<\/p>\n<h3>How do structural studies see &quot;three kinds of binding&quot;?<\/h3>\n<p>\u062d\u0644\u0644\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0628\u0646\u064a\u0648\u064a\u0629 \u0627\u0644\u0623\u0635\u0644\u064a\u0629 \u0641\u064a 2024 \u0627\u0644\u0645\u0639\u0642\u062f\u0627\u062a \u0627\u0644\u062a\u064a \u064a\u0634\u0643\u0644\u0647\u0627 Retatrutide \u0645\u0639 \u0643\u0644 \u0645\u0646 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0639\u0644\u0649 \u062d\u062f\u0629. \u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646 \u062a\u062c\u0627\u0631\u0628 \u0628\u0646\u064a\u0648\u064a\u0629 \u0648\u0648\u0638\u064a\u0641\u064a\u0629 \u0644\u062f\u0631\u0627\u0633\u0629 \u0643\u064a\u0641\u064a\u0629 \u062a\u0639\u0631\u0641 \u0643\u0644 \u0645\u0633\u062a\u0642\u0628\u0644 \u0639\u0644\u0649 \u0647\u0630\u0627 \u0627\u0644\u0628\u0628\u062a\u064a\u062f\u060c \u0648\u0646\u0627\u0642\u0634\u0648\u0627 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0645\u0634\u062a\u0631\u0643\u0629 \u0648\u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a.<\/p>\n<p>&quot;Separately&quot; matters: it is not one molecule straddling three receptors at once in the figure. The structural figures show observations of different complexes, and colors are only there to distinguish the parts.<\/p>\n<h3>\u0639\u0646\u062f \u0627\u0644\u0646\u0638\u0631 \u0625\u0644\u0649 \u0634\u0643\u0644 \u0628\u0646\u064a\u0648\u064a\u060c \u0627\u0628\u062d\u062b \u0623\u0648\u0644\u0627\u064b \u0639\u0646 \u062b\u0644\u0627\u062b\u0629 \u0645\u0648\u0627\u0636\u0639<\/h3>\n<p>First find the peptide, then find the receptor&#039;s binding region, and finally see which contacts are similar across the different complexes and which change. This helps you understand that the same peptide can keep a shared recognition mode while adapting to the local structure of different receptors.<\/p>\n<p>The three cards in the teaching figure only represent three independent binding scenarios. They do not reproduce the original paper&#039;s atomic coordinates, nor do they show true molecular size. For the complete structure and specific residues, go back to the original paper&#039;s figures and supplementary materials.<\/p>\n<h3>\u0645\u0627 \u0627\u0644\u0630\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u062c\u064a\u0628 \u0639\u0646\u0647 \u0627\u0644\u0628\u0646\u064a\u0629\u060c \u0648\u0645\u0627 \u0627\u0644\u0630\u064a \u0644\u0627 \u064a\u0645\u0643\u0646\u0647\u0627 \u0627\u0644\u0625\u062c\u0627\u0628\u0629 \u0639\u0646\u0647 \u0645\u0628\u0627\u0634\u0631\u0629\u061f<\/h3>\n<p>\u062a\u0633\u0627\u0639\u062f \u0627\u0644\u0628\u0646\u064a\u0629 \u0641\u064a \u062a\u0641\u0633\u064a\u0631 \u0627\u0644\u062a\u0639\u0631\u0641 \u0648\u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637. \u0644\u0627 \u062a\u0632\u0627\u0644 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0628\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0642\u064a\u0627\u0633 \u0627\u0644\u0625\u0634\u0627\u0631\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0628\u0639\u062f \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637\u061b \u062b\u0645 \u062a\u062d\u062a\u0627\u062c \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0625\u0644\u0649 \u0645\u0644\u0627\u062d\u0638\u0629 \u0645\u0642\u0627\u064a\u064a\u0633 \u0645\u062d\u062f\u062f\u0629 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0629. \u0647\u0630\u0647 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0645\u062a\u0631\u0627\u0628\u0637\u0629\u060c \u0644\u0643\u0646\u0647\u0627 \u0644\u064a\u0633\u062a \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0646\u0641\u0633\u0647\u0627.<\/p>\n<p>So you cannot directly calculate how much weight a person will lose from the shape of a binding pocket; nor can you directly assert from &quot;three receptors&quot; that it must be more suitable for a given person than a &quot;dual receptor&quot; option.<\/p>\n<h3>\u0645\u0627 \u0641\u0627\u0626\u062f\u0629 \u0647\u0630\u0647 \u0627\u0644\u0648\u0631\u0642\u0629 \u0639\u0646\u062f \u0627\u062e\u062a\u064a\u0627\u0631 \u0645\u0648\u0627\u062f \u0627\u0644\u0628\u062d\u062b\u061f<\/h3>\n<p>\u0625\u0646\u0647\u0627 \u062a\u0630\u0643\u0651\u0631 \u0627\u0644\u0642\u0631\u0627\u0621 \u0628\u0641\u062d\u0635 \u0647\u0648\u064a\u0629 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0643\u0627\u0645\u0644\u0629 \u0648\u062a\u0639\u062f\u064a\u0644\u0627\u062a\u0647\u0627. \u064a\u062c\u0628 \u062a\u0633\u062c\u064a\u0644 \u0627\u0633\u0645 \u0627\u0644\u0645\u0646\u062a\u062c\u060c \u0648\u0646\u0635 \u0627\u0644\u062a\u0633\u0644\u0633\u0644\u060c \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0645\u0636\u0627\u0641\u0629\u060c \u0648\u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0645\u0648\u0631\u064e\u0651\u062f \u0645\u0639\u064b\u0627. \u0641\u0627\u0644\u062c\u0632\u064a\u0621 \u0627\u0644\u0645\u0648\u0635\u0648\u0641 \u0641\u064a \u0648\u0631\u0642\u0629 \u0628\u062d\u062b\u064a\u0629 \u0644\u0627 \u064a\u062b\u0628\u062a \u062a\u0644\u0642\u0627\u0626\u064a\u064b\u0627 \u0647\u0648\u064a\u0629 \u0623\u0648 \u0646\u0642\u0627\u0621 \u0623\u0648 \u0648\u0638\u064a\u0641\u0629 \u0623\u064a \u062f\u0641\u0639\u0629 \u0645\u0646 \u0627\u0644\u0643\u062a\u0627\u0644\u0648\u062c.<\/p>\n<figure class=\"nhd-cp-diagram\"><figcaption class=\"nhd-cp-flow-title\">\u062b\u0644\u0627\u062b \u062e\u0637\u0648\u0627\u062a \u0644\u0642\u0631\u0627\u0621\u0629 \u062f\u0631\u0627\u0633\u0629 \u0628\u0646\u064a\u0648\u064a\u0629<\/figcaption><div class=\"nhd-cp-steps\">\n<div class=\"nhd-cp-step\"><b>\u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u0644\u0628\u0646\u064a\u0648\u064a\u0629<\/b><span>\u0627\u0644\u0633\u0624\u0627\u0644 \u0627\u0644\u0623\u0633\u0627\u0633\u064a: \u0643\u064a\u0641 \u064a\u0631\u062a\u0628\u0637 \u0627\u0644\u0628\u0628\u062a\u064a\u062f \u0628\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629<\/span><\/div>\n<div class=\"nhd-cp-step\"><b>\u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629<\/b><span>\u0627\u0644\u0633\u0624\u0627\u0644 \u0627\u0644\u0623\u0633\u0627\u0633\u064a: \u0623\u064a \u0627\u0644\u0625\u0634\u0627\u0631\u0627\u062a \u062a\u062a\u063a\u064a\u0631 \u0628\u0639\u062f \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637<\/span><\/div>\n<div class=\"nhd-cp-step\"><b>\u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0628\u0634\u0631\u064a\u0629<\/b><span>\u0627\u0644\u0633\u0624\u0627\u0644 \u0627\u0644\u0623\u0633\u0627\u0633\u064a: \u0643\u064a\u0641 \u062a\u062a\u063a\u064a\u0631 \u0642\u064a\u0627\u0633\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0633\u0643\u0627\u0646\u064a\u0629 \u0645\u0639\u064a\u0646\u0629<\/span><\/div>\n<\/div><figcaption>\u0645\u0644\u062e\u0635 \u062a\u0639\u0644\u064a\u0645\u064a. \u0631\u0627\u062c\u0639 \u0627\u0644\u0634\u0631\u062d \u0648\u0627\u0644\u0645\u0635\u0627\u062f\u0631 \u0627\u0644\u0623\u0635\u0644\u064a\u0629\u061b \u0647\u0630\u0627 \u0644\u064a\u0633 \u0646\u0645\u0648\u0630\u062c\u064b\u0627 \u062c\u0632\u064a\u0626\u064a\u064b\u0627 \u0628\u0645\u0642\u064a\u0627\u0633 \u0631\u0633\u0645 \u0648\u0644\u0627 \u0646\u062a\u064a\u062c\u0629 \u0627\u062e\u062a\u0628\u0627\u0631 \u0645\u0646\u062a\u062c.<\/figcaption><\/figure>\n<div class=\"nhd-cp-table\">\n<table>\n<caption>\u062b\u0644\u0627\u062b \u062e\u0637\u0648\u0627\u062a \u0644\u0642\u0631\u0627\u0621\u0629 \u062f\u0631\u0627\u0633\u0629 \u0628\u0646\u064a\u0648\u064a\u0629<\/caption>\n<thead>\n<tr>\n<th scope=\"col\">\u0645\u0633\u062a\u0648\u0649<\/th>\n<th scope=\"col\">\u0627\u0644\u0633\u0624\u0627\u0644 \u0627\u0644\u0623\u0633\u0627\u0633\u064a<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u0644\u0628\u0646\u064a\u0648\u064a\u0629<\/td>\n<td>\u0643\u064a\u0641 \u064a\u0631\u062a\u0628\u0637 \u0627\u0644\u0628\u0628\u062a\u064a\u062f \u0628\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629<\/td>\n<\/tr>\n<tr>\n<td>\u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629<\/td>\n<td>\u0623\u064a \u0627\u0644\u0625\u0634\u0627\u0631\u0627\u062a \u062a\u062a\u063a\u064a\u0631 \u0628\u0639\u062f \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637<\/td>\n<\/tr>\n<tr>\n<td>\u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0628\u0634\u0631\u064a\u0629<\/td>\n<td>\u0643\u064a\u0641 \u062a\u062a\u063a\u064a\u0631 \u062a\u062f\u0627\u0628\u064a\u0631 \u0645\u062d\u062f\u062f\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0633\u0643\u0627\u0646\u064a\u0629 \u0645\u0639\u064a\u0646\u0629<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<details>\n<summary>Try judging for yourself: can &quot;three receptors&quot; be understood as a mixture of three peptides?<\/summary>\n<p>\u0644\u0627. \u0625\u0646\u0647\u0627 \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u062c\u0632\u064a\u0621 \u0646\u0641\u0633\u0647 \u0639\u0644\u0649 \u062b\u0644\u0627\u062b\u0629 \u0623\u0646\u0648\u0627\u0639 \u0645\u0646 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a. \u0623\u0645\u0627 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0645\u0627\u062f\u0629 \u062e\u0644\u064a\u0637\u064b\u0627\u060c \u0641\u064a\u062c\u0628 \u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646\u0647 \u0628\u0634\u0643\u0644 \u0645\u0646\u0641\u0635\u0644 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0646\u0638\u0631 \u0625\u0644\u0649 \u062a\u0631\u0643\u064a\u0628\u0647\u0627 \u0627\u0644\u0643\u0627\u0645\u0644.<\/p>\n<\/details>\n<section class=\"nhd-cp-depth\">\n<h3>\u0623\u064a\u0646 \u064a\u0645\u0643\u0646\u0643 \u0641\u062d\u0635 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0628\u0646\u064a\u0648\u064a\u0629 \u0627\u0644\u0641\u0639\u0644\u064a\u0629\u061f<\/h3>\n<p>The deposited complexes are GLP-1R, PDB 8YW3 at 2.68 \u00c5; GIPR, 8YW4 at 3.26 \u00c5; and GCGR, 8YW5 at 2.84 \u00c5. One \u00e5ngstr\u00f6m is 0.1 nm. These describe overall cryo-EM resolution, not efficacy or binding percentages.<\/p>\n<h3>\u0627\u0641\u0635\u0644 \u0628\u064a\u0646 \u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u0644\u0628\u0646\u064a\u0648\u064a\u0629 \u0648\u0627\u0644\u0642\u064a\u0627\u0633 \u0627\u0644\u0648\u0638\u064a\u0641\u064a<\/h3>\n<p>\u064a\u0639\u0631\u0636 \u0627\u0644\u0634\u0643\u0644 1b \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0645\u062c\u0647\u0631\u064a \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0628\u0627\u0644\u062a\u0628\u0631\u064a\u062f \u0627\u0644\u062b\u0644\u0627\u062b\u061b \u0648\u064a\u0641\u062d\u0635 \u0627\u0644\u0634\u0643\u0644 1e \u0641\u0639\u0627\u0644\u064a\u0629 cAMP \u0628\u0639\u062f \u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644. \u0627\u0644\u0645\u0646\u0637\u0642 \u0647\u0648 \u062a\u062d\u062f\u064a\u062f \u0646\u0642\u0637\u0629 \u062a\u0644\u0627\u0645\u0633\u060c \u0648\u062a\u063a\u064a\u064a\u0631 \u0645\u0648\u0642\u0639\u060c \u0648\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u062e\u0644\u0648\u064a\u0629. \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0628\u0646\u064a\u0648\u064a\u0629 \u0648\u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u064a\u0643\u0645\u0644 \u0628\u0639\u0636\u0647\u0627 \u0628\u0639\u0636\u064b\u0627\u061b \u0648\u0644\u0627 \u064a\u0643\u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0645\u0642\u0646\u0639 \u0628\u0635\u0631\u064a\u064b\u0627 \u0648\u062d\u062f\u0647.<\/p>\n<h3>\u062a\u062d\u0642\u0642 \u0645\u0646 \u0627\u0644\u0645\u0646\u0627\u0637\u0642 \u0627\u0644\u062a\u064a \u0644\u0645 \u064a\u062a\u0645 \u062a\u062d\u062f\u064a\u062f\u0647\u0627<\/h3>\n<p>\u064a\u0641\u0633\u0651\u0631 \u0627\u0644\u0646\u0645\u0648\u0630\u062c \u0627\u0644\u0628\u0646\u064a\u0648\u064a \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629\u061b \u0648\u0647\u0648 \u0644\u064a\u0633 \u0635\u0648\u0631\u0629 \u0643\u0627\u0645\u0644\u0629 \u0644\u062e\u0644\u064a\u0629 \u062d\u064a\u0629. \u0641\u064a PDB\u060c \u062a\u062d\u0642\u0642 \u0645\u0646 \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0648\u062a\u0642\u0631\u064a\u0631 \u0627\u0644\u062a\u062d\u0642\u0642 \u0648\u0627\u0644\u0645\u0646\u0627\u0637\u0642 \u063a\u064a\u0631 \u0627\u0644\u0645\u064f\u0646\u0645\u0630\u062c\u0629. \u0627\u0628\u062f\u0623 \u0628\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0628\u0628\u062a\u064a\u062f \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0648\u0628\u0631\u0648\u062a\u064a\u0646 G \u0642\u0628\u0644 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0644\u0627\u0645\u0633\u0627\u062a \u0627\u0644\u0630\u0631\u064a\u0629 \u0627\u0644\u0641\u0631\u062f\u064a\u0629.<\/p>\n<p class=\"nhd-cp-source\"><a href=\"https:\/\/www.rcsb.org\/structure\/8YW3\" target=\"_blank\" rel=\"noopener\">PDB 8YW3: Retatrutide\u2013GLP-1R\u2013Gs structure<\/a> \u00b7 2024<\/p>\n<p class=\"nhd-cp-source\"><a href=\"https:\/\/www.rcsb.org\/structure\/8YW4\" target=\"_blank\" rel=\"noopener\">PDB 8YW4: Retatrutide\u2013GIPR\u2013Gs structure<\/a> \u00b7 2024<\/p>\n<p class=\"nhd-cp-source\"><a href=\"https:\/\/www.rcsb.org\/structure\/8YW5\" target=\"_blank\" rel=\"noopener\">PDB 8YW5: Retatrutide\u2013GCGR\u2013Gs structure<\/a> \u00b7 2024<\/p>\n<\/section>\n<h3>\u0627\u0644\u0645\u0635\u0627\u062f\u0631 \u0627\u0644\u0623\u0635\u0644\u064a\u0629 \u0648\u0642\u0631\u0627\u0621\u0627\u062a \u0625\u0636\u0627\u0641\u064a\u0629<\/h3>\n<ul class=\"nhd-cp-source\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41421-024-00700-0\" target=\"_blank\" rel=\"noopener\">\u062a\u0641\u0627\u0639\u0644\u0627\u062a Retatrutide \u0645\u0639 \u062b\u0644\u0627\u062b\u0629 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a<\/a> \u00b7 2024<\/li>\n<\/ul>\n<p class=\"nhd-cp-source\">\u062a\u0645 \u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u062f\u0631 \u0641\u064a 2026-10-13. \u062a\u0646\u0637\u0628\u0642 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0639\u0644\u0649 \u0627\u0644\u0646\u0645\u0627\u0630\u062c \u0648\u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062a\u064a \u062f\u064f\u0631\u0633\u062a. \u062c\u0648\u062f\u0629 \u0627\u0644\u062f\u0641\u0639\u0629 \u062a\u062a\u0637\u0644\u0628 \u0633\u062c\u0644\u0627\u062a \u0644\u0644\u062f\u0641\u0639\u0629 \u0627\u0644\u0641\u0639\u0644\u064a\u0629.<\/p>\n<h3>\u0645\u0648\u0627\u062f \u0627\u0644\u0628\u062d\u062b \u0630\u0627\u062a \u0627\u0644\u0635\u0644\u0629<\/h3>\n<div class=\"nhd-cp-products\"><a class=\"nhd-cp-product\" href=\"https:\/\/nhdbio.com\/ar\/%d8%a7%d9%84%d9%85%d9%86%d8%aa%d8%ac%d8%a7%d8%aa\/%d8%b1%d9%8a%d8%aa%d8%a7%d8%aa%d8%b1%d9%88%d8%aa%d9%8a%d8%af\/\"><strong>\u0631\u064a\u062a\u0627\u062a\u0631\u0648\u062a\u0627\u064a\u062f<\/strong><span>\u0627\u0637\u0651\u0644\u0639 \u0639\u0644\u0649 \u0647\u0648\u064a\u0629 \u0627\u0644\u0645\u0627\u062f\u0629 \u0648\u0627\u0644\u0645\u0648\u0627\u0635\u0641\u0627\u062a \u0648\u0627\u0644\u062a\u063a\u0644\u064a\u0641\u061b \u064a\u0645\u0643\u0646 \u0637\u0631\u062d \u0627\u062d\u062a\u064a\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u0648\u062b\u064a\u0642 \u0639\u0628\u0631 \u0627\u0633\u062a\u0641\u0633\u0627\u0631.<\/span><\/a><\/div>\n<p><a href=\"https:\/\/nhdbio.com\/ar\/%d8%a7%d9%82%d8%aa%d8%a8%d8%a7%d8%b3\/\">\u0627\u0633\u0623\u0644 \u0639\u0646 \u0627\u0644\u0645\u0648\u0627\u0635\u0641\u0627\u062a \u0648\u0627\u0644\u0643\u0645\u064a\u0629 \u0648\u0627\u0644\u0648\u062b\u0627\u0626\u0642 \u0627\u0644\u0645\u0637\u0644\u0648\u0628\u0629<\/a><\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Retatrutide&#8217;s &#8220;three receptors&#8221; means the same molecule can act on three types of receptors. It is not three peptides in one vial, and it is not three receptors each contributing a fixed one-third of the effect.<\/p>","protected":false},"author":1,"featured_media":4580,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"359","pim_article_type":"Published research explained","pim_evidence_level":"Primary references and labeled teaching examples","pim_reviewer":"AI-assisted source and editorial check","pim_reviewed_date":"2026-10-13","pim_editorial_note":"Editorial illustrations are not experimental photographs. Teaching values are labeled.","pim_review_status":"reviewed","pim_review_reason":"Reviewed source scope, numerical examples, natural Chinese, product links and content layout.","pim_creation_method":"AI-assisted writing","pim_sources":"[{\"title\":\"Retatrutide interactions with three receptors\",\"note\":\"Retatrutide interactions with three receptors\",\"url\":\"https:\/\/www.nature.com\/articles\/s41421-024-00700-0\"},{\"title\":\"PDB 8YW3: Retatrutide\u2013GLP-1R\u2013Gs structure\",\"note\":\"PDB 8YW3: Retatrutide\u2013GLP-1R\u2013Gs structure\",\"url\":\"https:\/\/www.rcsb.org\/structure\/8YW3\"},{\"title\":\"PDB 8YW4: Retatrutide\u2013GIPR\u2013Gs structure\",\"note\":\"PDB 8YW4: Retatrutide\u2013GIPR\u2013Gs structure\",\"url\":\"https:\/\/www.rcsb.org\/structure\/8YW4\"},{\"title\":\"PDB 8YW5: Retatrutide\u2013GCGR\u2013Gs structure\",\"note\":\"PDB 8YW5: Retatrutide\u2013GCGR\u2013Gs structure\",\"url\":\"https:\/\/www.rcsb.org\/structure\/8YW5\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-4567","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How can one peptide bind three receptors? Retatrutide explained | NHD<\/title>\n<meta name=\"description\" content=\"Retatrutide&#039;s &quot;three receptors&quot; means the same molecule can act on three types of receptors. It is not three peptides in one vial, and it is not three receptors each contributing a fixed one-third of the effect.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nhdbio.com\/ar\/\u0634\u0631\u062d-\u0628\u0646\u064a\u0629-\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a-\u0631\u064a\u062a\u0627\u062a\u0631\u0648\u062a\u0627\u064a\u062f-\u0627\u0644\u062b\u0644\u0627\u062b\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How can one peptide bind three receptors? Retatrutide explained\" \/>\n<meta property=\"og:description\" content=\"Retatrutide&#039;s &quot;three receptors&quot; means the same molecule can act on three types of receptors. It is not three peptides in one vial, and it is not three receptors each contributing a fixed one-third of the effect.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nhdbio.com\/ar\/\u0634\u0631\u062d-\u0628\u0646\u064a\u0629-\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a-\u0631\u064a\u062a\u0627\u062a\u0631\u0648\u062a\u0627\u064a\u062f-\u0627\u0644\u062b\u0644\u0627\u062b\/\" \/>\n<meta property=\"og:site_name\" content=\"NHD\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-13T16:14:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/nhd-knowledge-20261013-11.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1672\" \/>\n\t<meta property=\"og:image:height\" content=\"941\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"NHD Technical Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:description\" content=\"Peptide Raw Materials and Custom Peptide Synthesis\" \/>\n<meta name=\"twitter:label1\" content=\"\u0643\u064f\u062a\u0628 \u0628\u0648\u0627\u0633\u0637\u0629\" \/>\n\t<meta name=\"twitter:data1\" content=\"NHD Technical Team\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0648\u0642\u062a \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u064f\u0642\u062f\u0651\u0631\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 \u062f\u0642\u0627\u0626\u0642\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/nhdbio.com\\\/retatrutide-three-receptor-structure-explained\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/retatrutide-three-receptor-structure-explained\\\/\"},\"author\":{\"name\":\"NHD Technical Team\",\"@id\":\"https:\\\/\\\/nhdbio.com\\\/#\\\/schema\\\/person\\\/0ffb0dec7fda0f720073fc468fac6fc1\"},\"headline\":\"How can one peptide bind three receptors? 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