{"id":747,"date":"2026-09-01T16:45:45","date_gmt":"2026-09-01T16:45:45","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/aicar-diabetic-polyneuropathy-2024-mouse-study\/"},"modified":"2026-09-01T16:45:45","modified_gmt":"2026-09-01T16:45:45","slug":"aicar-diabetic-polyneuropathy-2024-mouse-study","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ar\/aicar-diabetic-polyneuropathy-2024-mouse-study\/","title":{"rendered":"AICAR \u0641\u064a \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0623\u0639\u0635\u0627\u0628 \u0627\u0644\u0633\u0643\u0631\u064a: \u0645\u0627 \u0648\u062c\u062f\u062a\u0647 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u0627\u0648\u0633 2024"},"content":{"rendered":"

\u0623\u0641\u0627\u062f\u062a \u062f\u0631\u0627\u0633\u0629 2024 \u0639\u0646 \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u062a\u062f\u0627\u0628\u064a\u0631 \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0635\u0628\u064a \u0648\u0639\u0643\u0633\u0647\u0627 \u0628\u0639\u062f \u0627\u0644\u062a\u0639\u0631\u0636 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a \u0644\u0640 AICAR \u0641\u064a \u0646\u0645\u0627\u0630\u062c \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 1 \u0648\u0645\u0631\u0636 \u0627\u0644\u0633\u0643\u0631\u064a \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 2. \u064a\u0639\u062f \u0627\u0644\u0639\u0645\u0644 \u062f\u0644\u064a\u0644\u064b\u0627 \u0622\u0644\u064a\u064b\u0627 \u0645\u0641\u064a\u062f\u064b\u0627\u060c \u0648\u0644\u0643\u0646\u0647 \u0644\u064a\u0633 \u0646\u062a\u064a\u062c\u0629 \u0639\u0644\u0627\u062c \u0628\u0634\u0631\u064a.<\/p>

\u0627\u0644\u0623\u062f\u0644\u0629 \u0641\u064a \u0644\u0645\u062d\u0629<\/h2>
  • \u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0639\u0644\u0649 \u0627\u0644\u0641\u0626\u0631\u0627\u0646\u060c \u0648\u0644\u064a\u0633 \u0627\u0644\u0628\u0634\u0631.<\/li>
  • \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u062a\u064a \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0646\u0638\u0627\u0645 \u063a\u0630\u0627\u0626\u064a \u0639\u0627\u0644\u064a \u0627\u0644\u062f\u0647\u0648\u0646\u060c \u0632\u0627\u062f\u062a \u0646\u0633\u0628\u0629 AMPK \u0627\u0644\u0645\u0641\u0633\u0641\u0631 \u0625\u0644\u0649 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a \u062d\u0648\u0627\u0644\u064a \u062b\u0644\u0627\u062b\u0629 \u0623\u0636\u0639\u0627\u0641 \u0648\u0632\u0627\u062f\u062a LC3-II \u062d\u0648\u0627\u0644\u064a \u0627\u0644\u0636\u0639\u0641.<\/li>
  • \u062d\u062f\u062b\u062a \u0646\u062a\u0627\u0626\u062c \u062a\u0646\u0641\u0633 \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627 \u0648\u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0623\u0639\u0635\u0627\u0628 \u062c\u0646\u0628\u064b\u0627 \u0625\u0644\u0649 \u062c\u0646\u0628 \u0645\u0639 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u0647\u0627\u0632\u064a\u0629 \u0639\u0644\u0649 \u062d\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0623\u0646\u0633\u0648\u0644\u064a\u0646 \u0648\u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u062c\u0644\u0648\u0643\u0648\u0632 \u0648\u0627\u0644\u062f\u0647\u0648\u0646.<\/li><\/ul><\/div><\/div>
    \"\u0628\u062d\u062b
    \u0627\u0644\u0631\u0633\u0645 \u0627\u0644\u062a\u0648\u0636\u064a\u062d\u064a \u0644\u0644\u0628\u062d\u062b \u0627\u0644\u062a\u062d\u0631\u064a\u0631\u064a \u0627\u0644\u0623\u0635\u0644\u064a. \u0625\u0646\u0647\u0627 \u0644\u064a\u0633\u062a \u0631\u0642\u0645 \u062f\u0631\u0627\u0633\u0629\u060c \u0623\u0648 \u0635\u0648\u0631\u0629 \u0645\u0631\u064a\u0636\u060c \u0623\u0648 \u0635\u0648\u0631\u0629 \u0644\u0644\u0645\u0646\u062a\u062c\u060c \u0623\u0648 \u0646\u062a\u064a\u062c\u0629 \u0641\u062d\u0635 \u0645\u0642\u062f\u0645\u0629 \u0623\u0648 \u062a\u0645\u062b\u064a\u0644 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0643\u062a\u0627\u0644\u0648\u062c.<\/figcaption><\/figure>

    \u0633\u062c\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/h2>

    \u0642\u0627\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0628\u0642\u064a\u0627\u0633 \u0627\u0644\u062a\u0648\u0635\u064a\u0644 \u0627\u0644\u0639\u0635\u0628\u064a\u060c \u0648\u0627\u0644\u0633\u0644\u0648\u0643 \u0627\u0644\u062d\u0633\u064a\u060c \u0648\u0627\u0644\u062a\u0646\u0641\u0633 \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627\u060c \u0648\u0627\u0644\u0639\u0644\u0627\u0645\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0646\u0634\u0637\u0627\u0631 \u0627\u0644\u0645\u064a\u062a\u0648\u0643\u0648\u0646\u062f\u0631\u064a\u0627\u060c \u0648\u062a\u062c\u0645\u064a\u0639 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0628\u0644\u0639\u0645\u064a\u0629 \u0627\u0644\u0630\u0627\u062a\u064a\u0629. \u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0627\u0644\u0646\u0638\u0627\u0645 \u0627\u0644\u063a\u0630\u0627\u0626\u064a \u0639\u0627\u0644\u064a \u0627\u0644\u062f\u0647\u0648\u0646\u060c \u0627\u0646\u062e\u0641\u0636 \u0627\u0644\u062a\u0646\u0641\u0633 3 \u0627\u0644\u0645\u062d\u0641\u0632 \u0628\u0648\u0627\u0633\u0637\u0629 ADP \u0625\u0644\u0649 120 \u00b1 20 nmol O\u2082\/min\u060c \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0640 220 \u00b1 20 \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0630\u0627\u062a \u0627\u0644\u0646\u0638\u0627\u0645 \u0627\u0644\u063a\u0630\u0627\u0626\u064a \u0627\u0644\u0645\u062a\u062d\u0643\u0645\u061b \u0643\u0627\u0646\u062a \u0642\u064a\u0645\u0629 HFD+AICAR \u0627\u0644\u0645\u0628\u0644\u063a \u0639\u0646\u0647\u0627 \u0647\u064a 240 \u00b1 30.<\/p>

    \u0646\u0645\u0648\u0630\u062c<\/strong>\u0646\u0645\u0627\u0630\u062c \u0627\u0644\u0641\u0623\u0631\u0629 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 1 \u0648\u0627\u0644\u0646\u0648\u0639 2 \u0627\u0644\u0633\u0643\u0631\u064a<\/span><\/div>
    \u0642\u0631\u0627\u0621\u0627\u062a AMPK<\/strong>\u0645\u0627 \u064a\u0642\u0631\u0628 \u0645\u0646 \u062b\u0644\u0627\u062b\u0629 \u0623\u0636\u0639\u0627\u0641 \u0646\u0633\u0628\u0629 \u0627\u0644\u0641\u0633\u0641\u0631\u0629 \/ \u0625\u062c\u0645\u0627\u0644\u064a AMPK \u0641\u064a HFD + AICAR \u0645\u0642\u0627\u0628\u0644 HFD<\/span><\/div>
    LC3-II<\/strong>\u0632\u064a\u0627\u062f\u0629 \u0645\u0636\u0627\u0639\u0641\u0629 \u062a\u0642\u0631\u064a\u0628\u064b\u0627<\/span><\/div>
    \u062d\u0627\u0644\u0629 \u0627\u0644\u062a\u0646\u0641\u0633 3<\/strong>120 \u00b1 20 HFD\u061b \u0627\u0644\u062a\u062d\u0643\u0645 220 \u00b1 20\u061b 240 \u00b1 30 HFD+AICAR \u0646\u0627\u0646\u0648\u0645\u0648\u0644 O\u2082\/\u062f\u0642\u064a\u0642\u0629<\/span><\/div>
    \u062a\u0631\u062c\u0645\u0629<\/strong>\u0645\u0627 \u0642\u0628\u0644 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629. \u0644\u0645 \u062a\u062b\u0628\u062a \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0628\u0634\u0631\u064a<\/span><\/div><\/div><\/div>

    \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0641\u064a \u0627\u0644\u0633\u064a\u0627\u0642<\/h2>

    \u0648\u0635\u0641\u062a \u0627\u0644\u0648\u0631\u0642\u0629 \u0646\u0641\u0633\u0647\u0627 \u0639\u0643\u0633 \u0627\u0644\u0639\u062c\u0632 \u0627\u0644\u062b\u0627\u0628\u062a \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0633\u062a\u0631\u0628\u062a\u0648\u0632\u0648\u062a\u0648\u0633\u064a\u0646 \u0648\u0627\u0644\u0633\u0643\u0631\u064a. \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0645\u062b\u064a\u0631\u0629 \u0644\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u0645\u0646 \u0627\u0644\u0646\u0627\u062d\u064a\u0629 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629\u060c \u0644\u0643\u0646 \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0644\u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0644\u0627 \u064a\u0645\u062b\u0644 \u062c\u0631\u0639\u0629 \u0628\u0634\u0631\u064a\u0629 \u0648\u0644\u0627 \u064a\u0646\u0628\u063a\u064a \u0623\u0628\u062f\u064b\u0627 \u0625\u0639\u0627\u062f\u0629 \u062a\u0646\u0633\u064a\u0642\u0647 \u0643\u062c\u0631\u0639\u0629 \u0648\u0627\u062d\u062f\u0629.<\/p>

    \u0623\u062f\u0649 \u0627\u0644\u062a\u062f\u062e\u0644 \u0623\u064a\u0636\u064b\u0627 \u0625\u0644\u0649 \u062a\u063a\u064a\u064a\u0631 \u062d\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0623\u0646\u0633\u0648\u0644\u064a\u0646 \u0648\u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u062c\u0644\u0648\u0643\u0648\u0632 \u0648\u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u062f\u0647\u0648\u0646. \u0648\u0647\u0630\u0627 \u064a\u062c\u0639\u0644 \u0645\u0646 \u063a\u064a\u0631 \u0627\u0644\u0622\u0645\u0646 \u0648\u0635\u0641 \u0643\u0644 \u0646\u062a\u064a\u062c\u0629 \u0643\u062f\u0644\u064a\u0644 \u0639\u0644\u0649 \u0622\u0644\u064a\u0629 AMPK \u0648\u0627\u062d\u062f\u0629 \u0641\u0642\u0637.<\/p>

    \u0645\u0627 \u0644\u0627 \u062a\u0633\u062a\u0637\u064a\u0639 \u0627\u0644\u0623\u062f\u0644\u0629 \u0625\u062b\u0628\u0627\u062a\u0647<\/h2>

    \u0644\u0645 \u064a\u062a\u0645 \u062a\u0636\u0645\u064a\u0646 \u0623\u064a \u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0623\u0648 \u0646\u0642\u0637\u0629 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0623\u0648 \u0645\u062c\u0645\u0648\u0639\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0628\u0634\u0631\u064a\u0629.<\/p>

    \u062a\u062d\u062f \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629 \u0648\u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0646\u0638\u0627\u0645\u064a\u0629 \u0645\u0646 \u0625\u0633\u0646\u0627\u062f \u0622\u0644\u064a\u0629 \u0648\u0627\u062d\u062f\u0629.<\/p>

    \u0644\u0627 \u062a\u062a\u062d\u0642\u0642 \u0627\u0644\u0648\u0631\u0642\u0629 \u0645\u0646 \u0647\u0648\u064a\u0629 \u0623\u0648 \u0646\u0642\u0627\u0621 \u0623\u0648 \u0645\u062d\u062a\u0648\u0649 \u0623\u0648 \u0645\u062f\u0649 \u0645\u0644\u0627\u0621\u0645\u0629 \u0623\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0643\u062a\u0627\u0644\u0648\u062c.<\/p>","protected":false},"excerpt":{"rendered":"

    \u0623\u0641\u0627\u062f\u062a \u062f\u0631\u0627\u0633\u0629 2024 \u0639\u0646 \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u062a\u062f\u0627\u0628\u064a\u0631 \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0635\u0628\u064a \u0648\u0639\u0643\u0633\u0647\u0627 \u0628\u0639\u062f \u0627\u0644\u062a\u0639\u0631\u0636 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a \u0644\u0640 AICAR \u0641\u064a \u0646\u0645\u0627\u0630\u062c \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 1 \u0648\u0645\u0631\u0636 \u0627\u0644\u0633\u0643\u0631\u064a \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 2. \u064a\u0639\u062f \u0627\u0644\u0639\u0645\u0644 \u062f\u0644\u064a\u0644\u064b\u0627 \u0622\u0644\u064a\u064b\u0627 \u0645\u0641\u064a\u062f\u064b\u0627\u060c \u0648\u0644\u0643\u0646\u0647 \u0644\u064a\u0633 \u0646\u062a\u064a\u062c\u0629 \u0639\u0644\u0627\u062c \u0628\u0634\u0631\u064a.<\/p>","protected":false},"author":1,"featured_media":731,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"313","pim_article_type":"Published evidence review","pim_evidence_level":"Controlled mouse-model study with biochemical and functional endpoints; no human efficacy trial","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, study size, model\/population limits and relevant conflicts are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary\/regulatory sources, factual claims, numerical results, limitations and product-evidence boundary checked for batch 3.","pim_creation_method":"The editorial workflow began with linked PubMed primary papers, systematic reviews, PubChem identity records and FDA\/DailyMed regulatory records. Population or model, denominators, endpoints, numerical results, null findings, limitations and conflicts were extracted before drafting. AI-assisted drafting and original image generation were used; the final facts and evidence boundaries were checked against the linked records on 2026-09-02. This is not independent peer review.","pim_sources":"[{\"title\":\"AICAR in experimental diabetic polyneuropathy\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39795939\/\",\"note\":\"Primary 2024 mouse study; PMID 39795939.\"},{\"title\":\"Systematic review of AMPK-dependent and independent AICAr effects\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34064363\/\",\"note\":\"Mechanistic review; PMID 34064363.\"},{\"title\":\"PubChem Acadesine record\",\"url\":\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Acadesine\",\"note\":\"Identity, formula, mass and synonyms; CID 17513.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-747","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"\nAICAR in Diabetic Polyneuropathy: What the 2024 Mouse Study Found<\/title>\n<meta name=\"description\" content=\"A 2024 study reported prevention and reversal of neuropathy measures after experimental AICAR exposure in mouse models of type 1 and type 2 diabetes. The w\u2026\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nhdbio.com\/ar\/aicar-diabetic-polyneuropathy-2024-mouse-study\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AICAR in Diabetic Polyneuropathy: What the 2024 Mouse Study Found\" \/>\n<meta property=\"og:description\" content=\"A 2024 study reported prevention and reversal of neuropathy measures after experimental AICAR exposure in mouse models of type 1 and type 2 diabetes. 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