{"id":748,"date":"2026-09-01T16:45:45","date_gmt":"2026-09-01T16:45:45","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/aicar-acadesine-zmp-identity-ampk-evidence-boundary\/"},"modified":"2026-09-01T16:45:45","modified_gmt":"2026-09-01T16:45:45","slug":"aicar-acadesine-zmp-identity-ampk-evidence-boundary","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ar\/aicar-acadesine-zmp-identity-ampk-evidence-boundary\/","title":{"rendered":"\u062f\u0644\u064a\u0644 \u0647\u0648\u064a\u0629 AICAR: Acadesine \u0648ZMP \u0648\u062d\u062f\u0648\u062f \u0627\u0644\u0623\u062f\u0644\u0629 AMPK"},"content":{"rendered":"

\u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u062a\u0624\u062f\u064a \u062a\u0633\u0645\u064a\u0629 AICAR \u0625\u0644\u0649 \u0627\u0646\u0647\u064a\u0627\u0631 \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0633\u064a\u0646 \u0648\u0645\u0633\u062a\u0642\u0644\u0628\u0647 \u0627\u0644\u0645\u0641\u0633\u0641\u0631 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 ZMP \u0648\u0645\u0633\u0627\u0631 AMPK \u0628\u0623\u0643\u0645\u0644\u0647 \u0641\u064a \u062a\u0633\u0645\u064a\u0629 \u0648\u0627\u062d\u062f\u0629. \u064a\u062d\u062a\u0627\u062c \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u0644\u062a\u0643\u0631\u0627\u0631 \u0625\u0644\u0649 \u0625\u0628\u0642\u0627\u0621 \u0647\u0630\u0647 \u0627\u0644\u0645\u0641\u0627\u0647\u064a\u0645 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0645\u0646\u0641\u0635\u0644\u0629.<\/p>

\u0627\u0644\u0623\u062f\u0644\u0629 \u0641\u064a \u0644\u0645\u062d\u0629<\/h2>
  • Acadesine \u0647\u0648 AICA-riboside\u060c \u0648\u0647\u0648 \u0646\u0648\u0643\u0644\u064a\u0648\u0632\u064a\u062f \u0645\u0639 PubChem CID 17513 \u0648\u0627\u0644\u0648\u0632\u0646 \u0627\u0644\u062c\u0632\u064a\u0626\u064a 258.23 g\/mol.<\/li>
  • \u062a\u0641\u0633\u0641\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0633\u064a\u0646 \u0625\u0644\u0649 \u0631\u064a\u0628\u0648\u062a\u064a\u062f AICA\u060c \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0628\u0627\u0633\u0645 ZMP.<\/li>
  • \u062a\u0648\u062b\u0642 \u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0645\u0646\u0647\u062c\u064a\u0629 \u0644\u0640 2021 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062c\u0648\u0647\u0631\u064a\u0629 \u0645\u0633\u062a\u0642\u0644\u0629 \u0639\u0646 AMPK\u060c \u0644\u0630\u0627 \u0641\u0625\u0646 \"\u0646\u062a\u064a\u062c\u0629 AICAR\" \u0644\u064a\u0633\u062a \u062a\u0644\u0642\u0627\u0626\u064a\u064b\u0627 \"\u0646\u062a\u064a\u062c\u0629 AMPK\".<\/li><\/ul><\/div><\/div>
    \"\u0645\u062e\u062a\u0628\u0631
    \u0627\u0644\u062a\u0648\u0636\u064a\u062d \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u064a \u0627\u0644\u062a\u062d\u0631\u064a\u0631\u064a \u0627\u0644\u0623\u0635\u0644\u064a. \u0648\u0647\u064a \u0644\u0627 \u062a\u0635\u0648\u0631 \u0645\u0646\u062a\u062c\u064b\u0627 \u0645\u0632\u0648\u062f\u064b\u0627 \u0623\u0648 \u062f\u0641\u0639\u0629 \u062a\u0645 \u0625\u0635\u062f\u0627\u0631\u0647\u0627 \u0623\u0648 \u062a\u0631\u0643\u064a\u0628\u0629 \u0645\u0639\u062a\u0645\u062f\u0629 \u0623\u0648 \u0646\u062a\u064a\u062c\u0629 \u0627\u062e\u062a\u0628\u0627\u0631 \u0623\u0648 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0633\u0631\u064a\u0631\u064a.<\/figcaption><\/figure>

    \u0633\u062c\u0644 \u0627\u0644\u0647\u0648\u064a\u0629<\/h2>

    \u064a\u062c\u0628 \u0623\u0646 \u062a\u062d\u062a\u0648\u064a \u0627\u0644\u0634\u0647\u0627\u062f\u0629 \u0639\u0644\u0649 \u0627\u0633\u0645 \u0627\u0644\u0631\u064a\u0628\u0648\u0633\u064a\u062f \u0627\u0644\u0630\u064a \u062a\u0645 \u062a\u0648\u0641\u064a\u0631\u0647 \u0628\u0627\u0644\u0641\u0639\u0644 \u0648\u062a\u0630\u0643\u0631 \u0627\u0644\u0635\u064a\u063a\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u0627\u0644\u062d\u0633\u0627\u0628\u0627\u062a. \u064a\u062a\u0645 \u0625\u0646\u062a\u0627\u062c ZMP \u0628\u0639\u062f \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u062e\u0644\u0648\u064a\u061b \u0625\u0646\u0647 \u0644\u064a\u0633 \u0645\u0631\u0627\u062f\u0641\u064b\u0627 \u0644\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u0644\u0645 \u062a\u062a\u063a\u064a\u0631 \u0641\u064a \u0627\u0644\u0642\u0627\u0631\u0648\u0631\u0629.<\/p>

    \u0647\u0648\u064a\u0629 \u0627\u0644\u0643\u062a\u0627\u0644\u0648\u062c<\/strong>\u0623\u0643\u0627\u062f\u064a\u0633\u064a\u0646 \/ AICA-\u0631\u064a\u0628\u0648\u0633\u0627\u064a\u062f<\/span><\/div>
    \u0627\u0644\u0635\u064a\u063a\u0629 \u0648\u0627\u0644\u0643\u062a\u0644\u0629<\/strong>C9H14N4O5; 258.23 \u062c\u0645\/\u0645\u0648\u0644<\/span><\/div>
    \u0627\u0644\u0645\u0633\u062a\u0642\u0644\u0628 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627<\/strong>\u0631\u064a\u0628\u0648\u062a\u064a\u062f AICA \/ ZMP<\/span><\/div>
    \u0627\u0644\u0633\u062c\u0644 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u064a \u0627\u0644\u0623\u0633\u0627\u0633\u064a<\/strong>\u0627\u0644\u0647\u0648\u064a\u0629 \u0648\u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u062f\u0642\u064a\u0642 \u0648\u0627\u0644\u0643\u062a\u0644\u0629 \u0648\u0627\u0644\u0643\u0631\u0648\u0645\u0627\u062a\u0648\u063a\u0631\u0627\u0641\u064a\u0627 \u0648\u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u0643\u0645\u064a \u0648\u0631\u0628\u0637 \u0627\u0644\u062f\u0641\u0639\u0629<\/span><\/div><\/div><\/div>

    \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u064a\u0629 \u0648\u0627\u0644\u0623\u062f\u0644\u0629<\/h2>

    \u0648\u062c\u062f\u062a \u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0645\u0646\u0647\u062c\u064a\u0629 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u062a\u0634\u0645\u0644 \u062a\u062e\u0644\u064a\u0642 \u0627\u0644\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u0648\u0646\u0642\u0635 \u0627\u0644\u0623\u0643\u0633\u062c\u0629 \u0648\u0627\u0644\u062a\u0645\u062b\u064a\u0644 \u0627\u0644\u063a\u0630\u0627\u0626\u064a \u0648\u062f\u0648\u0631\u0629 \u0627\u0644\u062e\u0644\u064a\u0629 \u0648\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0648\u0627\u0644\u062a\u064a \u0644\u0627 \u064a\u0645\u0643\u0646 \u0627\u062e\u062a\u0632\u0627\u0644\u0647\u0627 \u0643\u0644\u0647\u0627 \u0625\u0644\u0649 \u062a\u0646\u0634\u064a\u0637 AMPK. \u0644\u0630\u0644\u0643 \u064a\u062c\u0628 \u0623\u0646 \u064a\u062c\u0645\u0639 \u062a\u0641\u0633\u064a\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u064a\u0646 AICAR \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0648\u0636\u0648\u0627\u0628\u0637 \u0627\u0644\u0645\u0633\u0627\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0623\u0648 \u0627\u0644\u0645\u062a\u0639\u0627\u0645\u062f \u062d\u064a\u062b\u0645\u0627 \u0623\u0645\u0643\u0646 \u0630\u0644\u0643.<\/p>

    \u0627\u0644\u0646\u0642\u0627\u0621 \u062d\u0633\u0628 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u0644\u0645\u0633\u0627\u062d\u0629 \u0644\u0627 \u064a\u064f\u0628\u0644\u063a \u0641\u064a \u062d\u062f \u0630\u0627\u062a\u0647 \u0639\u0646 \u0627\u0644\u0645\u0627\u0621 \u0623\u0648 \u0627\u0644\u0639\u062f\u0627\u062f\u0627\u062a \u0623\u0648 \u0627\u0644\u0645\u0630\u064a\u0628\u0627\u062a \u0627\u0644\u0645\u062a\u0628\u0642\u064a\u0629 \u0623\u0648 \u0645\u062d\u062a\u0648\u0649 AICAR \u0627\u0644\u0645\u0637\u0644\u0642. \u062a\u062c\u064a\u0628 \u0647\u0630\u0647 \u0627\u0644\u0642\u064a\u0627\u0633\u0627\u062a \u0639\u0644\u0649 \u0623\u0633\u0626\u0644\u0629 \u0645\u062e\u062a\u0644\u0641\u0629 \u0648\u0644\u0627 \u064a\u0646\u0628\u063a\u064a \u062f\u0645\u062c\u0647\u0627 \u0641\u064a \u0631\u0642\u0645 \u0648\u0627\u062d\u062f.<\/p>

    \u0627\u0644\u0642\u0627\u0639\u062f\u0629 \u0627\u0644\u062a\u062d\u0631\u064a\u0631\u064a\u0629<\/h2>

    \u0627\u0630\u0643\u0631 \u0627\u0644\u0645\u0627\u062f\u0629 \u0623\u0648 \u0627\u0644\u0646\u0645\u0648\u0630\u062c \u0623\u0648 \u0627\u0644\u0646\u0645\u0648\u0630\u062c \u0623\u0648 \u0627\u0644\u0633\u0643\u0627\u0646 \u0648\u0646\u0642\u0637\u0629 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u062f\u0639\u0645\u0647\u0627 \u0627\u0644\u0633\u062c\u0644 \u0627\u0644\u0645\u0633\u062a\u0634\u0647\u062f \u0628\u0647 \u0639\u0644\u0649 \u0648\u062c\u0647 \u0627\u0644\u062a\u062d\u062f\u064a\u062f. \u0644\u0627 \u062a\u0642\u0645 \u0628\u062a\u062d\u0648\u064a\u0644 \u0627\u0644\u0645\u0639\u0642\u0648\u0644\u064a\u0629 \u0627\u0644\u0622\u0644\u064a\u0629\u060c \u0623\u0648 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u064a\u0629\u060c \u0623\u0648 \u0645\u0644\u0635\u0642 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0646\u0647\u0627\u0626\u064a\u060c \u0623\u0648 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u064a \u0625\u0644\u0649 \u0645\u0637\u0627\u0644\u0628\u0629 \u0628\u0634\u0623\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0643\u062a\u0627\u0644\u0648\u062c \u063a\u064a\u0631 \u0630\u0627\u062a \u0635\u0644\u0629.<\/p>","protected":false},"excerpt":{"rendered":"

    \u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u062a\u0624\u062f\u064a \u062a\u0633\u0645\u064a\u0629 AICAR \u0625\u0644\u0649 \u0627\u0646\u0647\u064a\u0627\u0631 \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0633\u064a\u0646 \u0648\u0645\u0633\u062a\u0642\u0644\u0628\u0647 \u0627\u0644\u0645\u0641\u0633\u0641\u0631 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 ZMP \u0648\u0645\u0633\u0627\u0631 AMPK \u0628\u0623\u0643\u0645\u0644\u0647 \u0641\u064a \u062a\u0633\u0645\u064a\u0629 \u0648\u0627\u062d\u062f\u0629. \u064a\u062d\u062a\u0627\u062c \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u0644\u062a\u0643\u0631\u0627\u0631 \u0625\u0644\u0649 \u0625\u0628\u0642\u0627\u0621 \u0647\u0630\u0647 \u0627\u0644\u0645\u0641\u0627\u0647\u064a\u0645 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0645\u0646\u0641\u0635\u0644\u0629.<\/p>","protected":false},"author":1,"featured_media":732,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"313","pim_article_type":"Evidence and material-quality guide","pim_evidence_level":"Chemical-identity record plus systematic mechanistic review","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, study size, model\/population limits and relevant conflicts are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary\/regulatory sources, factual claims, numerical results, limitations and product-evidence boundary checked for batch 3.","pim_creation_method":"The editorial workflow began with linked PubMed primary papers, systematic reviews, PubChem identity records and FDA\/DailyMed regulatory records. Population or model, denominators, endpoints, numerical results, null findings, limitations and conflicts were extracted before drafting. AI-assisted drafting and original image generation were used; the final facts and evidence boundaries were checked against the linked records on 2026-09-02. This is not independent peer review.","pim_sources":"[{\"title\":\"AICAR in experimental diabetic polyneuropathy\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39795939\/\",\"note\":\"Primary 2024 mouse study; PMID 39795939.\"},{\"title\":\"Systematic review of AMPK-dependent and independent AICAr effects\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34064363\/\",\"note\":\"Mechanistic review; PMID 34064363.\"},{\"title\":\"PubChem Acadesine record\",\"url\":\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Acadesine\",\"note\":\"Identity, formula, mass and synonyms; CID 17513.\"}]","footnotes":""},"categories":[20],"tags":[],"class_list":["post-748","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evidence-quality-guides"],"yoast_head":"\nAICAR Identity Guide: Acadesine, ZMP and the AMPK Evidence Boundary<\/title>\n<meta name=\"description\" content=\"AICAR naming often collapses acadesine, its intracellular phosphorylated metabolite ZMP and an entire AMPK pathway into one label. Reproducible research ne\u2026\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nhdbio.com\/ar\/aicar-acadesine-zmp-identity-ampk-evidence-boundary\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AICAR Identity Guide: Acadesine, ZMP and the AMPK Evidence Boundary\" \/>\n<meta property=\"og:description\" content=\"AICAR naming often collapses acadesine, its intracellular phosphorylated metabolite ZMP and an entire AMPK pathway into one label. 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