{"id":749,"date":"2026-09-01T16:45:45","date_gmt":"2026-09-01T16:45:45","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/ara-290-cibinetide-small-fiber-neuropathy-and-dme-trials\/"},"modified":"2026-09-01T16:45:45","modified_gmt":"2026-09-01T16:45:45","slug":"ara-290-cibinetide-small-fiber-neuropathy-and-dme-trials","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ar\/ara-290-cibinetide-small-fiber-neuropathy-and-dme-trials\/","title":{"rendered":"ARA-290\/Cibinetide: \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0635\u0628\u064a \u0630\u0648 \u0627\u0644\u0623\u0644\u064a\u0627\u0641 \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u0648\u0628\u064a\u0627\u0646\u0627\u062a \u062a\u062c\u0631\u0628\u0629 DME"},"content":{"rendered":"

\u062a\u062a\u0636\u0645\u0646 \u0623\u062f\u0644\u0629 \u0627\u0644\u0633\u064a\u0628\u064a\u0646\u064a\u062a\u064a\u062f \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0633\u062a\u0643\u0634\u0627\u0641\u064a\u0629 \u0635\u063a\u064a\u0631\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0633\u0643\u0627\u0646\u064a\u0629 \u0645\u062e\u062a\u0644\u0641\u0629 \u062c\u062f\u064b\u0627. \u0623\u0628\u0644\u063a \u0637\u064a\u0627\u0631 \u0645\u0646 \u0645\u0631\u0636 \u0627\u0644\u0633\u0627\u0631\u0643\u0648\u064a\u062f \u0648\u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0635\u0628\u064a \u0644\u062f\u0649 \u0634\u062e\u0635 22 \u0639\u0646 \u0627\u062e\u062a\u0644\u0627\u0641 \u0641\u064a \u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0639\u0631\u0627\u0636\u060c \u0641\u064a \u062d\u064a\u0646 \u0623\u062e\u0637\u0623\u062a \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0648\u0630\u0645\u0629 \u0627\u0644\u0628\u0642\u0639\u064a\u0629 \u0627\u0644\u0633\u0643\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u0623\u062c\u0631\u064a\u062a \u0639\u0644\u0649 \u0634\u062e\u0635 9 \u0645\u0642\u0627\u064a\u064a\u0633\u0647\u0627 \u0627\u0644\u0639\u064a\u0646\u064a\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629.<\/p>

\u0627\u0644\u0623\u062f\u0644\u0629 \u0641\u064a \u0644\u0645\u062d\u0629<\/h2>
  • \u0642\u0627\u0645 \u0637\u064a\u0627\u0631 \u0627\u0644\u0633\u0627\u0631\u0643\u0648\u064a\u062f \u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a \u0628\u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0641\u064a 22: \u062a\u0644\u0642\u0649 12 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0648\u0647\u0645\u064a ARA-290 \u064810.<\/li>
  • \u0643\u0627\u0646 \u062a\u063a\u064a\u064a\u0631 SFNSL \u0641\u064a \u0627\u0644\u0623\u0633\u0628\u0648\u0639 4 \u0647\u0648 \u221211.5 \u00b1 3.04 \u0645\u0642\u0627\u0628\u0644 \u22122.9 \u00b1 3.34\u060c \u0628\u064a\u0646\u0645\u0627 \u062a\u062d\u0633\u0646\u062a \u062f\u0631\u062c\u0627\u062a \u0634\u062f\u0629 \u0627\u0644\u0623\u0644\u0645 \u0648\u0627\u0644\u062a\u0639\u0628 \u0628\u0634\u0643\u0644 \u0645\u0645\u0627\u062b\u0644 \u0641\u064a \u0643\u0644\u0627 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646.<\/li>
  • \u0641\u064a \u062f\u0631\u0627\u0633\u0629 DME\u060c \u062a\u0645 \u062a\u0633\u062c\u064a\u0644 9 \u0648\u0625\u0643\u0645\u0627\u0644 8\u061b \u0644\u0645 \u064a\u062a\u062d\u0633\u0646 \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u200b\u200b\u062d\u062f\u0629 \u0627\u0644\u0628\u0635\u0631 \u0648\u0633\u0645\u0643 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0648\u062d\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0648\u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u0645\u0648\u0639.<\/li><\/ul><\/div><\/div>
    \"\u0627\u0644\u062a\u0635\u0648\u064a\u0631
    \u0627\u0644\u0631\u0633\u0645 \u0627\u0644\u062a\u0648\u0636\u064a\u062d\u064a \u0644\u0644\u0628\u062d\u062b \u0627\u0644\u062a\u062d\u0631\u064a\u0631\u064a \u0627\u0644\u0623\u0635\u0644\u064a. \u0625\u0646\u0647\u0627 \u0644\u064a\u0633\u062a \u0631\u0642\u0645 \u062f\u0631\u0627\u0633\u0629\u060c \u0623\u0648 \u0635\u0648\u0631\u0629 \u0645\u0631\u064a\u0636\u060c \u0623\u0648 \u0635\u0648\u0631\u0629 \u0644\u0644\u0645\u0646\u062a\u062c\u060c \u0623\u0648 \u0646\u062a\u064a\u062c\u0629 \u0641\u062d\u0635 \u0645\u0642\u062f\u0645\u0629 \u0623\u0648 \u062a\u0645\u062b\u064a\u0644 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0643\u062a\u0627\u0644\u0648\u062c.<\/figcaption><\/figure>

    \u0633\u062c\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/h2>

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    \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0633\u0627\u0631\u0643\u0648\u064a\u062f<\/strong>\u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0627\u0644\u0627\u0633\u062a\u0643\u0634\u0627\u0641\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u064a\u0637\u0631 \u0639\u0644\u064a\u0647\u0627 \u0648\u0647\u0645\u064a. \u0646=22<\/span><\/div>
    \u062a\u063a\u064a\u064a\u0631 SFNSL<\/strong>\u221211.5 \u00b1 3.04 \u0645\u0642\u0627\u0628\u0644 \u22122.9 \u00b1 3.34 \u0641\u064a \u0627\u0644\u0623\u0633\u0628\u0648\u0639 4<\/span><\/div>
    \u062a\u0635\u0645\u064a\u0645 DME<\/strong>\u0645\u0631\u062d\u0644\u0629 \u0630\u0631\u0627\u0639 \u0648\u0627\u062d\u062f\u0629 2\u061b \u062a\u0645 \u062a\u0633\u062c\u064a\u0644 9\u060c \u0648\u062a\u0645 \u0625\u0643\u0645\u0627\u0644 8<\/span><\/div>
    \u0627\u0644\u062a\u062f\u0627\u0628\u064a\u0631 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 DME<\/strong>\u0644\u0627 \u064a\u0648\u062c\u062f \u062a\u062d\u0633\u0646 \u0643\u0628\u064a\u0631 \u0641\u064a BCVA \u0623\u0648 CRT \u0623\u0648 \u062d\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0623\u0648 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u0645\u0648\u0639<\/span><\/div>
    \u0627\u0644\u062a\u0641\u0633\u064a\u0631 \u0627\u0644\u0634\u0627\u0645\u0644<\/strong>\u0627\u0644\u0625\u0634\u0627\u0631\u0627\u062a \u062a\u0648\u0644\u062f \u0627\u0644\u0641\u0631\u0636\u064a\u0627\u062a\u060c \u0648\u0644\u064a\u0633\u062a \u062a\u0623\u0643\u064a\u062f\u064a\u0629<\/span><\/div><\/div><\/div>

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    \u0643\u0627\u0646 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0645\u0624\u0644\u0641\u064a \u0623\u0648\u0631\u0627\u0642 DME \u0645\u0633\u0624\u0648\u0644\u064a\u0646 \u0623\u0648 \u0645\u0627\u0644\u0643\u064a\u0646 \u0623\u0648 \u0645\u0633\u062a\u0634\u0627\u0631\u064a\u0646 \u0644\u0644\u0645\u0637\u0648\u0631. \u0648\u0647\u0630\u0627 \u0627\u0644\u0643\u0634\u0641 \u0644\u0627 \u064a\u0628\u0637\u0644 \u0627\u0644\u0646\u062a\u0627\u0626\u062c\u060c \u0644\u0643\u0646\u0647 \u064a\u0646\u062a\u0645\u064a \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0639\u0646\u062f\u0645\u0627 \u064a\u062d\u0643\u0645 \u0627\u0644\u0642\u0631\u0627\u0621 \u0639\u0644\u0649 \u062a\u062c\u0631\u0628\u0629 \u0627\u0633\u062a\u0643\u0634\u0627\u0641\u064a\u0629 \u0635\u063a\u064a\u0631\u0629.<\/p>

    \u0645\u0627 \u0644\u0627 \u062a\u0633\u062a\u0637\u064a\u0639 \u0627\u0644\u0623\u062f\u0644\u0629 \u0625\u062b\u0628\u0627\u062a\u0647<\/h2>

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    \u0644\u0627 \u064a\u0645\u0643\u0646 \u062f\u0645\u062c \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0648\u0646\u0642\u0627\u0637 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0641\u064a \u0645\u0637\u0627\u0644\u0628\u0629 \u0648\u0627\u062d\u062f\u0629 \u0648\u0627\u0633\u0639\u0629 \u0627\u0644\u0646\u0637\u0627\u0642 \"\u0644\u0625\u0635\u0644\u0627\u062d \u0627\u0644\u0623\u0639\u0635\u0627\u0628\".<\/p>

    \u0644\u0645 \u062a\u062b\u0628\u062a \u0623\u064a \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u062a\u064a\u0646 \u0645\u0639\u0627\u062f\u0644\u0629 \u0645\u0627\u062f\u0629 \u0627\u0644\u0643\u062a\u0627\u0644\u0648\u062c \u0623\u0648 \u062a\u062f\u0639\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u062e\u0627\u0631\u062c\u064a.<\/p>","protected":false},"excerpt":{"rendered":"

    \u062a\u062a\u0636\u0645\u0646 \u0623\u062f\u0644\u0629 \u0627\u0644\u0633\u064a\u0628\u064a\u0646\u064a\u062a\u064a\u062f \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0633\u062a\u0643\u0634\u0627\u0641\u064a\u0629 \u0635\u063a\u064a\u0631\u0629 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0633\u0643\u0627\u0646\u064a\u0629 \u0645\u062e\u062a\u0644\u0641\u0629 \u062c\u062f\u064b\u0627. \u0623\u0628\u0644\u063a \u0637\u064a\u0627\u0631 \u0645\u0646 \u0645\u0631\u0636 \u0627\u0644\u0633\u0627\u0631\u0643\u0648\u064a\u062f \u0648\u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0635\u0628\u064a \u0644\u062f\u0649 \u0634\u062e\u0635 22 \u0639\u0646 \u0627\u062e\u062a\u0644\u0627\u0641 \u0641\u064a \u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0639\u0631\u0627\u0636\u060c \u0641\u064a \u062d\u064a\u0646 \u0623\u062e\u0637\u0623\u062a \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0648\u0630\u0645\u0629 \u0627\u0644\u0628\u0642\u0639\u064a\u0629 \u0627\u0644\u0633\u0643\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u0623\u062c\u0631\u064a\u062a \u0639\u0644\u0649 \u0634\u062e\u0635 9 \u0645\u0642\u0627\u064a\u064a\u0633\u0647\u0627 \u0627\u0644\u0639\u064a\u0646\u064a\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629.<\/p>","protected":false},"author":1,"featured_media":733,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"315","pim_article_type":"Published evidence review","pim_evidence_level":"Small exploratory human trials; mixed endpoints and no confirmatory efficacy record","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. 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