{"id":753,"date":"2026-09-01T16:45:45","date_gmt":"2026-09-01T16:45:45","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/thymosin-alpha-1-tests-phase-3-sepsis-trial-2025\/"},"modified":"2026-09-01T16:45:45","modified_gmt":"2026-09-01T16:45:45","slug":"thymosin-alpha-1-tests-phase-3-sepsis-trial-2025","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ar\/thymosin-alpha-1-tests-phase-3-sepsis-trial-2025\/","title":{"rendered":"Thymosin Alpha-1 \u0641\u064a \u0627\u0644\u0625\u0646\u062a\u0627\u0646: \u0646\u062a\u064a\u062c\u0629 2025 TESTS 3"},"content":{"rendered":"

\u062a\u0639\u062a\u0628\u0631 \u062a\u062c\u0631\u0628\u0629 2025 TESTS \u0623\u0643\u062b\u0631 \u0625\u0641\u0627\u062f\u0629 \u0645\u0646 \u062a\u0642\u0627\u0631\u064a\u0631 \u0627\u0644\u0625\u0646\u062a\u0627\u0646 \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u0627\u0644\u0633\u0627\u0628\u0642\u0629: \u062a\u0645 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 1,106 \u0628\u0634\u0643\u0644 \u0639\u0634\u0648\u0627\u0626\u064a \u0639\u0628\u0631 \u0645\u0631\u0627\u0643\u0632 22\u060c \u0648\u0644\u0645 \u064a\u0642\u0644\u0644 \u062b\u064a\u0645\u0648\u0633\u064a\u0646 \u0623\u0644\u0641\u0627-1 \u0645\u0646 \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u062c\u0645\u064a\u0639 \u0623\u0633\u0628\u0627\u0628 28.<\/p>

\u0627\u0644\u0623\u062f\u0644\u0629 \u0641\u064a \u0644\u0645\u062d\u0629<\/h2>
  • \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0644\u0644\u0628\u0627\u0644\u063a\u064a\u0646 1,106\u061b \u062a\u0645 \u062a\u0636\u0645\u064a\u0646 1,089 \u0641\u064a \u062a\u062d\u0644\u064a\u0644 \u0646\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0639\u062f\u0644.<\/li>
  • \u0648\u0643\u0627\u0646 \u0645\u0639\u062f\u0644 \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0644\u0645\u062f\u0629 \u062b\u0645\u0627\u0646\u064a\u0629 \u0648\u0639\u0634\u0631\u064a\u0646 \u064a\u0648\u0645\u0627 23.4% \u0645\u0639 \u062b\u064a\u0645\u0648\u0633\u064a\u0646 \u0623\u0644\u0641\u0627-1 \u064824.1% \u0645\u0639 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0648\u0647\u0645\u064a.<\/li>
  • \u0643\u0627\u0646\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u062e\u0637\u0631 0.99 (95% CI 0.77 \u2013 1.27\u061b P = 0.93)\u060c \u0648\u0644\u0645 \u062a\u062e\u062a\u0644\u0641 \u0623\u064a \u0646\u062a\u0627\u0626\u062c \u062b\u0627\u0646\u0648\u064a\u0629 \u0623\u0648 \u0646\u062a\u0627\u0626\u062c \u062a\u062a\u0639\u0644\u0642 \u0628\u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631.<\/li><\/ul><\/div><\/div>
    \"\u062a\u0635\u0648\u0631
    \u0627\u0644\u0631\u0633\u0645 \u0627\u0644\u062a\u0648\u0636\u064a\u062d\u064a \u0644\u0644\u0628\u062d\u062b \u0627\u0644\u062a\u062d\u0631\u064a\u0631\u064a \u0627\u0644\u0623\u0635\u0644\u064a. \u0625\u0646\u0647\u0627 \u0644\u064a\u0633\u062a \u0631\u0642\u0645 \u062f\u0631\u0627\u0633\u0629\u060c \u0623\u0648 \u0635\u0648\u0631\u0629 \u0645\u0631\u064a\u0636\u060c \u0623\u0648 \u0635\u0648\u0631\u0629 \u0644\u0644\u0645\u0646\u062a\u062c\u060c \u0623\u0648 \u0646\u062a\u064a\u062c\u0629 \u0641\u062d\u0635 \u0645\u0642\u062f\u0645\u0629 \u0623\u0648 \u062a\u0645\u062b\u064a\u0644 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0643\u062a\u0627\u0644\u0648\u062c.<\/figcaption><\/figure>

    \u0633\u062c\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/h2>

    \u0648\u0643\u0627\u0646\u062a \u0646\u0642\u0637\u0629 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0647\u064a \u0627\u0644\u0648\u0641\u0627\u0629 \u0644\u0623\u064a \u0633\u0628\u0628 \u062e\u0644\u0627\u0644 \u0623\u064a\u0627\u0645 28. \u0644\u0627 \u062a\u0648\u0641\u0631 \u0646\u0633\u0628\u0629 \u062e\u0637\u0631 \u0627\u0644\u0648\u062d\u062f\u0629 \u0627\u0644\u0642\u0631\u064a\u0628\u0629 \u0648\u0641\u0627\u0635\u0644 \u0627\u0644\u062b\u0642\u0629 \u0627\u0644\u0645\u0639\u0628\u0631 \u0648\u0627\u062d\u062f \u0623\u064a \u062f\u0644\u064a\u0644 \u0648\u0627\u0636\u062d \u0639\u0644\u0649 \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0639\u062f\u0644 \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0641\u064a \u0625\u062c\u0645\u0627\u0644\u064a \u0645\u062c\u062a\u0645\u0639 \u0627\u0644\u062a\u062c\u0631\u0628\u0629.<\/p>

    \u062a\u0635\u0645\u064a\u0645<\/strong>\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0645\u0631\u0627\u0643\u0632\u060c \u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629\u060c \u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a\u0629\u060c \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u064a\u0637\u0631 \u0639\u0644\u064a\u0647\u0627 \u0648\u0647\u0645\u064a 3<\/span><\/div>
    \u0645\u0648\u0627\u0642\u0639<\/strong>\u0645\u0631\u0627\u0643\u0632 22 \u0641\u064a \u0627\u0644\u0635\u064a\u0646<\/span><\/div>
    \u062a\u0639\u062f\u064a\u0644 ITT<\/strong>542 \u062b\u064a\u0645\u0648\u0633\u064a\u0646 \u0623\u0644\u0641\u0627-1\u061b \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0648\u0647\u0645\u064a 547<\/span><\/div>
    \u0648\u0641\u064a\u0627\u062a 28 \u064a\u0648\u0645<\/strong>23.4% \u0645\u0642\u0627\u0628\u0644 24.1%<\/span><\/div>
    \u062a\u0642\u062f\u064a\u0631 \u0627\u0644\u062a\u0623\u062b\u064a\u0631<\/strong>\u0627\u0644\u0645\u0648\u0627\u0631\u062f \u0627\u0644\u0628\u0634\u0631\u064a\u0629 0.99\u061b 95% \u0633\u064a 0.77-1.27\u061b \u0639 = 0.93<\/span><\/div><\/div><\/div>

    \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0641\u064a \u0627\u0644\u0633\u064a\u0627\u0642<\/h2>

    \u0648\u0644\u062f\u062a \u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0641\u0631\u0639\u064a\u0629 \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0645\u0633\u0628\u0642\u064b\u0627 \u062d\u0633\u0628 \u0627\u0644\u0639\u0645\u0631 \u0648\u0645\u0631\u0636 \u0627\u0644\u0633\u0643\u0631\u064a \u0625\u0634\u0627\u0631\u0627\u062a \u062a\u0641\u0627\u0636\u0644\u064a\u0629 \u0645\u062d\u062a\u0645\u0644\u0629. \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0641\u0631\u0639\u064a\u0629 \u0645\u0641\u064a\u062f\u0629 \u0644\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629\u060c \u0644\u0643\u0646\u0647\u0627 \u0644\u0627 \u062a\u0639\u0643\u0633 \u0646\u062a\u064a\u062c\u0629 \u0623\u0648\u0644\u064a\u0629 \u0645\u062d\u0627\u064a\u062f\u0629 \u0648\u0644\u0627 \u064a\u0646\u0628\u063a\u064a \u0627\u0644\u0625\u0639\u0644\u0627\u0646 \u0639\u0646\u0647\u0627 \u0643\u0645\u0624\u0634\u0631\u0627\u062a \u062b\u0627\u0628\u062a\u0629.<\/p>

    \u0642\u0627\u0645 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u062a\u0644\u0648\u064a 2025 \u0628\u062a\u062c\u0645\u064a\u0639 \u062a\u062c\u0627\u0631\u0628 11 \u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0645\u0639 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0641\u064a 1,927 \u0648\u0648\u062c\u062f \u0646\u0633\u0628\u0629 \u0627\u0644\u0623\u0631\u062c\u062d\u064a\u0629 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 \u0644\u0640 0.73. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0644\u0645 \u062a\u0643\u0646 \u0645\u062c\u0645\u0648\u0639\u0627\u062a\u0647\u0627 \u0627\u0644\u0641\u0631\u0639\u064a\u0629 \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062c\u0648\u062f\u0629 \u0648\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0645\u0631\u0627\u0643\u0632 \u0630\u0627\u062a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629\u060c \u0648\u062d\u0643\u0645 \u062a\u062d\u0644\u064a\u0644 \u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0639\u0644\u0649 \u0627\u0644\u0639\u064a\u0646\u0629 \u0627\u0644\u0645\u062a\u0627\u062d\u0629 \u0628\u0623\u0646\u0647\u0627 \u063a\u064a\u0631 \u0643\u0627\u0641\u064a\u0629. \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0641\u0625\u0646 \u0646\u062a\u064a\u062c\u0629 TESTS \u0627\u0644\u0643\u0628\u064a\u0631\u0629 \u062a\u0646\u062a\u0645\u064a \u0625\u0644\u0649 \u0645\u0631\u0643\u0632 \u0623\u064a \u0645\u0644\u062e\u0635 \u062d\u0627\u0644\u064a.<\/p>

    \u0645\u0627 \u0644\u0627 \u062a\u0633\u062a\u0637\u064a\u0639 \u0627\u0644\u0623\u062f\u0644\u0629 \u0625\u062b\u0628\u0627\u062a\u0647<\/h2>

    \u0642\u062f \u0644\u0627 \u062a\u0645\u062b\u0644 \u062a\u062c\u0631\u0628\u0629 \u0648\u0637\u0646\u064a\u0629 \u0648\u0627\u062d\u062f\u0629 \u0643\u0644 \u0646\u0638\u0627\u0645 \u0635\u062d\u064a \u0623\u0648 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0638\u0627\u0647\u0631\u064a \u0644\u0644\u0625\u0646\u062a\u0627\u0646.<\/p>

    \u062a\u062a\u0637\u0644\u0628 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0641\u0631\u0639\u064a\u0629 \u062a\u0623\u0643\u064a\u062f\u064b\u0627 \u0648\u064a\u062c\u0628 \u0623\u0646 \u062a\u0638\u0644 \u0645\u0635\u062f\u0631\u064b\u0627 \u0644\u0644\u0641\u0631\u0636\u064a\u0627\u062a.<\/p>

    \u0625\u0646 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u0646\u0647\u0627\u0626\u064a \u0644\u0627 \u062a\u062b\u0628\u062a \u0635\u062d\u0629 \u0645\u062c\u0645\u0648\u0639\u0629 \u0628\u062d\u062b\u064a\u0629 \u063a\u064a\u0631 \u0630\u0627\u062a \u0635\u0644\u0629.<\/p>","protected":false},"excerpt":{"rendered":"

    \u062a\u0639\u062a\u0628\u0631 \u062a\u062c\u0631\u0628\u0629 2025 TESTS \u0623\u0643\u062b\u0631 \u0625\u0641\u0627\u062f\u0629 \u0645\u0646 \u062a\u0642\u0627\u0631\u064a\u0631 \u0627\u0644\u0625\u0646\u062a\u0627\u0646 \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u0627\u0644\u0633\u0627\u0628\u0642\u0629: \u062a\u0645 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 1,106 \u0628\u0634\u0643\u0644 \u0639\u0634\u0648\u0627\u0626\u064a \u0639\u0628\u0631 \u0645\u0631\u0627\u0643\u0632 22\u060c \u0648\u0644\u0645 \u064a\u0642\u0644\u0644 \u062b\u064a\u0645\u0648\u0633\u064a\u0646 \u0623\u0644\u0641\u0627-1 \u0645\u0646 \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u062c\u0645\u064a\u0639 \u0623\u0633\u0628\u0627\u0628 28.<\/p>","protected":false},"author":1,"featured_media":737,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"369","pim_article_type":"Published evidence review","pim_evidence_level":"Large multicenter randomized phase 3 human trial with a neutral primary outcome","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, study size, model\/population limits and relevant conflicts are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary\/regulatory sources, factual claims, numerical results, limitations and product-evidence boundary checked for batch 3.","pim_creation_method":"The editorial workflow began with linked PubMed primary papers, systematic reviews, PubChem identity records and FDA\/DailyMed regulatory records. Population or model, denominators, endpoints, numerical results, null findings, limitations and conflicts were extracted before drafting. AI-assisted drafting and original image generation were used; the final facts and evidence boundaries were checked against the linked records on 2026-09-02. This is not independent peer review.","pim_sources":"[{\"title\":\"TESTS phase 3 thymosin alpha-1 sepsis trial\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39814420\/\",\"note\":\"Primary 2025 multicenter trial; PMID 39814420.\"},{\"title\":\"2025 thymosin alpha-1 sepsis meta-analysis\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40969554\/\",\"note\":\"Eleven RCTs with quality and trial-sequential analyses; PMID 40969554.\"},{\"title\":\"PubChem Thymalfasin record\",\"url\":\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Thymalfasin\",\"note\":\"Sequence, formula, mass and synonym record; CID 16130571.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-753","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"\nThymosin Alpha-1 in Sepsis: The 2025 TESTS Phase 3 Result<\/title>\n<meta name=\"description\" content=\"The 2025 TESTS trial is more informative than earlier small sepsis reports: 1,106 adults were randomized across 22 centers, and thymosin alpha-1 did not re\u2026\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nhdbio.com\/ar\/thymosin-alpha-1-tests-phase-3-sepsis-trial-2025\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thymosin Alpha-1 in Sepsis: The 2025 TESTS Phase 3 Result\" \/>\n<meta property=\"og:description\" content=\"The 2025 TESTS trial is more informative than earlier small sepsis reports: 1,106 adults were randomized across 22 centers, and thymosin alpha-1 did not re\u2026\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nhdbio.com\/ar\/thymosin-alpha-1-tests-phase-3-sepsis-trial-2025\/\" \/>\n<meta property=\"og:site_name\" content=\"NHD\" \/>\n<meta property=\"article:published_time\" 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