{"id":759,"date":"2026-09-01T16:45:45","date_gmt":"2026-09-01T16:45:45","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/glutathione-skin-lightening-melasma-2025-systematic-review\/"},"modified":"2026-10-01T14:51:10","modified_gmt":"2026-10-01T14:51:10","slug":"%d8%a7%d9%84%d8%ac%d9%84%d9%88%d8%aa%d8%a7%d8%ab%d9%8a%d9%88%d9%86-%d9%88%d8%aa%d9%81%d8%aa%d9%8a%d8%ad-%d8%a7%d9%84%d8%a8%d8%b4%d8%b1%d8%a9-%d9%88%d8%a7%d9%84%d9%83%d9%84%d9%81-2025-%d9%85%d8%b1","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ar\/glutathione-skin-lightening-melasma-2025-systematic-review\/","title":{"rendered":"Glutathione \u0644\u062a\u0635\u0628\u063a \u0627\u0644\u062c\u0644\u062f: \u0645\u0627 \u0648\u062c\u062f\u062a\u0647 \u0645\u0631\u0627\u062c\u0639\u0629 2025"},"content":{"rendered":"

\u0648\u062c\u062f\u062a \u0645\u0631\u0627\u062c\u0639\u0629 \u0645\u0646\u0647\u062c\u064a\u0629 2025 \u0625\u0634\u0627\u0631\u0627\u062a \u0644\u0628\u0639\u0636 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062c\u0644\u0648\u062a\u0627\u062b\u064a\u0648\u0646 \u0627\u0644\u0645\u0648\u0636\u0639\u064a\u0629 \u0648\u0627\u0644\u0641\u0645\u0648\u064a\u0629\u060c \u0648\u0644\u0643\u0646\u0647\u0627 \u0648\u062b\u0642\u062a \u0623\u064a\u0636\u064b\u0627 \u0637\u0631\u0642\u064b\u0627 \u063a\u064a\u0631 \u0645\u062a\u062c\u0627\u0646\u0633\u0629 \u0648\u0645\u062e\u0627\u0637\u0631 \u0645\u062e\u062a\u0644\u0637\u0629 \u0644\u0644\u062a\u062d\u064a\u0632 \u0648\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u063a\u064a\u0631 \u0645\u0633\u062a\u062f\u0627\u0645\u0629 \u0648\u062d\u062f\u0648\u062f \u0623\u062f\u0644\u0629 \u063a\u064a\u0631 \u0645\u0648\u0627\u062a\u064a\u0629 \u0641\u064a \u0627\u0644\u0648\u0631\u064a\u062f.<\/p>

\u0627\u0644\u0623\u062f\u0644\u0629 \u0641\u064a \u0644\u0645\u062d\u0629<\/h2>
  • \u062d\u062f\u062f\u062a \u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629 \u062e\u0645\u0633 \u062a\u062c\u0627\u0631\u0628 \u0634\u0641\u0647\u064a\u0629 \u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0648\u062f\u0631\u0627\u0633\u0629 \u0634\u0641\u0647\u064a\u0629 \u0645\u0641\u062a\u0648\u062d\u0629 \u0627\u0644\u0630\u0631\u0627\u0639 \u0639\u0628\u0631 \u0639\u062f\u0629 \u0623\u0646\u0638\u0645\u0629.<\/li>
  • \u062a\u0645 \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u0649 \u062f\u0631\u0627\u0633\u0629 \u0648\u0627\u062d\u062f\u0629 \u0641\u0642\u0637 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0648\u0631\u064a\u062f \u062a\u0645 \u0627\u0644\u062a\u062d\u0643\u0645 \u0641\u064a\u0647\u0627 \u0628\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0648\u0647\u0645\u064a\u061b \u0644\u0645 \u064a\u0635\u0644 \u0641\u0631\u0642 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0625\u0644\u0649 \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u062a\u0642\u0644\u064a\u062f\u064a\u0629.<\/li>
  • \u062d\u0643\u0645 \u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0648\u0646 \u0639\u0644\u0649 \u0623\u0639\u062f\u0627\u062f \u0645\u062a\u0633\u0627\u0648\u064a\u0629 \u062a\u0642\u0631\u064a\u0628\u064b\u0627 \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0630\u0627\u062a \u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u062a\u062d\u064a\u0632 \u0627\u0644\u0645\u0646\u062e\u0641\u0636\u0629 \u0648\u0627\u0644\u0639\u0627\u0644\u064a\u0629\u060c \u0648\u0630\u0643\u0631\u0648\u0627 \u0623\u0646 \u0627\u0644\u062c\u0644\u0648\u062a\u0627\u062b\u064a\u0648\u0646 \u0627\u0644\u0648\u0631\u064a\u062f\u064a \u0645\u0648\u0627\u0646\u0639 \u0628\u0633\u0628\u0628 \u0641\u0639\u0627\u0644\u064a\u062a\u0647 \u0627\u0644\u0645\u062d\u062f\u0648\u062f\u0629 \u0648\u0622\u062b\u0627\u0631\u0647 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629.<\/li><\/ul><\/div><\/div>
    \"\u0645\u0631\u0627\u062c\u0639\u0629
    \u0627\u0644\u0631\u0633\u0645 \u0627\u0644\u062a\u0648\u0636\u064a\u062d\u064a \u0644\u0644\u0628\u062d\u062b \u0627\u0644\u062a\u062d\u0631\u064a\u0631\u064a \u0627\u0644\u0623\u0635\u0644\u064a. \u0625\u0646\u0647\u0627 \u0644\u064a\u0633\u062a \u0631\u0642\u0645 \u062f\u0631\u0627\u0633\u0629\u060c \u0623\u0648 \u0635\u0648\u0631\u0629 \u0645\u0631\u064a\u0636\u060c \u0623\u0648 \u0635\u0648\u0631\u0629 \u0644\u0644\u0645\u0646\u062a\u062c\u060c \u0623\u0648 \u0646\u062a\u064a\u062c\u0629 \u0641\u062d\u0635 \u0645\u0642\u062f\u0645\u0629 \u0623\u0648 \u062a\u0645\u062b\u064a\u0644 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0643\u062a\u0627\u0644\u0648\u062c.<\/figcaption><\/figure>

    \u0633\u062c\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/h2>

    \u0644\u0645 \u062a\u0642\u0645 \u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629 \u0628\u062a\u0642\u064a\u064a\u0645 \u062a\u062f\u062e\u0644 \u0645\u0648\u062d\u062f \u0648\u0627\u062d\u062f. \u0644\u0642\u062f \u062c\u0645\u0639\u062a \u0628\u064a\u0646 \u0627\u0644\u062a\u0631\u0643\u064a\u0632\u0627\u062a \u0627\u0644\u0645\u0648\u0636\u0639\u064a\u0629 \u0648\u0627\u0644\u0623\u0646\u0638\u0645\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u0648\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0645\u0646 \u0627\u0644\u0648\u062e\u0632 \u0628\u0627\u0644\u0625\u0628\u0631 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0648\u0623\u062f\u0628\u064a\u0627\u062a \u0648\u0631\u064a\u062f\u064a\u0629 \u0645\u062d\u062f\u0648\u062f\u0629 \u0644\u0644\u063a\u0627\u064a\u0629. \u062a\u0646\u062a\u062c \u0647\u0630\u0647 \u0627\u0644\u0637\u0631\u0642 \u0623\u0633\u0626\u0644\u0629 \u0645\u062e\u062a\u0644\u0641\u0629 \u062a\u062a\u0639\u0644\u0642 \u0628\u0627\u0644\u062a\u0639\u0631\u0636 \u0648\u0627\u0644\u0633\u0644\u0627\u0645\u0629\u060c \u0644\u0630\u0627 \u0644\u0627 \u064a\u0646\u0628\u063a\u064a \u062a\u0644\u062e\u064a\u0635\u0647\u0627 \u0643\u062a\u0623\u062b\u064a\u0631 \u0639\u0644\u0627\u062c\u064a \u0648\u0627\u062d\u062f.<\/p>

    \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0645\u0648\u0636\u0639\u064a\u0629<\/strong>\u0628\u0639\u0636 \u0627\u0644\u0645\u0632\u0627\u064a\u0627 \u0644\u0640 0.5% \u0639\u0644\u0649 0.1% \u0648\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0648\u0647\u0645\u064a<\/span><\/div>
    \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0634\u0641\u0647\u064a\u0629<\/strong>\u062e\u0645\u0633 \u062a\u062c\u0627\u0631\u0628 \u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u062f\u0631\u0627\u0633\u0629 \u0645\u0641\u062a\u0648\u062d\u0629 \u0627\u0644\u0630\u0631\u0627\u0639<\/span><\/div>
    \u0627\u0644\u0623\u062f\u0644\u0629 IV<\/strong>\u062f\u0631\u0627\u0633\u0629 \u0648\u0627\u062d\u062f\u0629 \u062e\u0627\u0636\u0639\u0629 \u0644\u0644\u062a\u062d\u0643\u0645 \u0627\u0644\u0648\u0647\u0645\u064a\u061b 6\/16 \u0645\u0642\u0627\u0628\u0644 3\/16\u061b \u0639 = 0.054<\/span><\/div>
    \u062e\u0637\u0631 \u0627\u0644\u062a\u062d\u064a\u0632<\/strong>\u0645\u062a\u0648\u0627\u0632\u0646 \u062a\u0642\u0631\u064a\u0628\u064b\u0627 \u0628\u064a\u0646 \u0627\u0644\u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0645\u0646\u062e\u0641\u0636\u0629 \u0648\u0627\u0644\u0639\u0627\u0644\u064a\u0629<\/span><\/div>
    \u062a\u0641\u0633\u064a\u0631<\/strong>\u0645\u0633\u0627\u0631 \u0645\u062d\u062f\u062f \u0648\u063a\u064a\u0631 \u0645\u062a\u062c\u0627\u0646\u0633 \u0648\u0644\u064a\u0633 \u0645\u0637\u0627\u0644\u0628\u0629 \u0639\u0627\u0644\u0645\u064a\u0629 \u0628\u0641\u0648\u0627\u0626\u062f \u0627\u0644\u0628\u0634\u0631\u0629<\/span><\/div><\/div><\/div>

    \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0641\u064a \u0627\u0644\u0633\u064a\u0627\u0642<\/h2>

    \u0623\u0628\u0644\u063a\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0648\u0631\u064a\u062f\u064a\u0629 \u0627\u0644\u0645\u0641\u0631\u062f\u0629 \u0627\u0644\u062a\u064a \u062a\u0645 \u0627\u0644\u062a\u062d\u0643\u0645 \u0641\u064a\u0647\u0627 \u0628\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0648\u0647\u0645\u064a \u0639\u0646 \u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0641\u064a 6 \u0644\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 16 \u0645\u0642\u0627\u0628\u0644 3 \u0644\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0641\u064a 16\u060c \u0645\u0639 P = 0.054. \u0631\u0641\u0636\u062a \u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629 \u0628\u0634\u0643\u0644 \u0635\u0631\u064a\u062d \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0648\u0631\u064a\u062f \u0628\u0633\u0628\u0628 \u0633\u062c\u0644 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0648\u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0631\u0629\u061b \u0625\u0646 \u062d\u0630\u0641 \u0647\u0630\u0627 \u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c \u0645\u0646 \u0634\u0623\u0646\u0647 \u0623\u0646 \u064a\u0634\u0648\u0647 \u0627\u0644\u0645\u0635\u062f\u0631 \u0645\u0627\u062f\u064a\u064b\u0627.<\/p>

    \u0648\u062c\u062f\u062a \u0645\u0631\u0627\u062c\u0639\u0629 \u0645\u0646\u0647\u062c\u064a\u0629 \u0633\u0627\u0628\u0642\u0629 \u0644\u0640 2019 \u0623\u0631\u0628\u0639 \u062f\u0631\u0627\u0633\u0627\u062a \u0633\u0631\u064a\u0631\u064a\u0629 \u0645\u0624\u0647\u0644\u0629 \u0641\u0642\u0637 \u0648\u0648\u0635\u0641\u062a \u0627\u0644\u0623\u062f\u0644\u0629 \u0628\u0623\u0646\u0647\u0627 \u063a\u064a\u0631 \u062d\u0627\u0633\u0645\u0629 \u0628\u0633\u0628\u0628 \u062c\u0648\u062f\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u0633\u0642\u0629. \u062a\u0639\u0645\u0644 \u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0644\u0627\u062d\u0642\u0629 \u0639\u0644\u0649 \u062a\u0648\u0633\u064a\u0639 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0648\u0644\u0643\u0646\u0647\u0627 \u0644\u0627 \u062a\u0644\u063a\u064a \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0627\u0644\u062d\u0630\u0631 \u0627\u0644\u062e\u0627\u0635 \u0628\u0627\u0644\u0637\u0631\u064a\u0642 \u0648\u0623\u0639\u0645\u0627\u0644 \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u062f\u0649 \u0627\u0644\u0637\u0648\u064a\u0644.<\/p>

    \u0645\u0627 \u0644\u0627 \u062a\u0633\u062a\u0637\u064a\u0639 \u0627\u0644\u0623\u062f\u0644\u0629 \u0625\u062b\u0628\u0627\u062a\u0647<\/h2>

    \u0625\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u0648\u0627\u0644\u0635\u064a\u063a \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0648\u0646\u0642\u0627\u0637 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u062a\u062d\u062f \u0645\u0646 \u0627\u0644\u062a\u062c\u0645\u064a\u0639 \u0648\u0627\u0644\u062a\u0639\u0645\u064a\u0645.<\/p>

    \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0645\u0624\u0634\u0631 \u0627\u0644\u0645\u064a\u0644\u0627\u0646\u064a\u0646 \u0644\u0627 \u062a\u0639\u0627\u062f\u0644 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062f\u0627\u0626\u0645 \u0644\u0627\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u0635\u0628\u0627\u063a.<\/p>

    \u0644\u0627 \u062a\u0648\u062c\u062f \u0645\u0631\u0627\u062c\u0639\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u062a\u062b\u0628\u062a \u0646\u0642\u0627\u0621 \u0623\u0648 \u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0623\u0648 \u0645\u0644\u0627\u0621\u0645\u0629 \u0645\u0627\u062f\u0629 \u0627\u0644\u0643\u062a\u0627\u0644\u0648\u062c.<\/p>","protected":false},"excerpt":{"rendered":"

    \u0648\u062c\u062f\u062a \u0645\u0631\u0627\u062c\u0639\u0629 \u0645\u0646\u0647\u062c\u064a\u0629 2025 \u0625\u0634\u0627\u0631\u0627\u062a \u0644\u0628\u0639\u0636 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062c\u0644\u0648\u062a\u0627\u062b\u064a\u0648\u0646 \u0627\u0644\u0645\u0648\u0636\u0639\u064a\u0629 \u0648\u0627\u0644\u0641\u0645\u0648\u064a\u0629\u060c \u0648\u0644\u0643\u0646\u0647\u0627 \u0648\u062b\u0642\u062a \u0623\u064a\u0636\u064b\u0627 \u0637\u0631\u0642\u064b\u0627 \u063a\u064a\u0631 \u0645\u062a\u062c\u0627\u0646\u0633\u0629 \u0648\u0645\u062e\u0627\u0637\u0631 \u0645\u062e\u062a\u0644\u0637\u0629 \u0644\u0644\u062a\u062d\u064a\u0632 \u0648\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u063a\u064a\u0631 \u0645\u0633\u062a\u062f\u0627\u0645\u0629 \u0648\u062d\u062f\u0648\u062f \u0623\u062f\u0644\u0629 \u063a\u064a\u0631 \u0645\u0648\u0627\u062a\u064a\u0629 \u0641\u064a \u0627\u0644\u0648\u0631\u064a\u062f.<\/p>","protected":false},"author":1,"featured_media":2769,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"333","pim_article_type":"Published evidence review","pim_evidence_level":"Systematic review of small heterogeneous clinical studies with mixed risk of bias","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. 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