{"id":789,"date":"2026-09-01T17:35:05","date_gmt":"2026-09-01T17:35:05","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/igf-1-lr3-fermentation-and-animal-evidence-review\/"},"modified":"2026-09-08T07:30:41","modified_gmt":"2026-09-08T07:30:41","slug":"igf-1-lr3-fermentation-and-animal-evidence-review","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ar\/igf-1-lr3-fermentation-and-animal-evidence-review\/","title":{"rendered":"\u062f\u0644\u064a\u0644 IGF-1 LR3: \u0627\u0644\u062a\u062e\u0645\u064a\u0631 \u0648\u0627\u0644\u0645\u0627\u0634\u064a\u0629 \u0648\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062e\u0627\u0644\u064a\u0629"},"content":{"rendered":"

\u062a\u062f\u0648\u0631 \u0623\u062f\u0628\u064a\u0627\u062a Direct Long R3 IGF-1 \u0625\u0644\u0649 \u062d\u062f \u0643\u0628\u064a\u0631 \u062d\u0648\u0644 \u0627\u0644\u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0645\u0624\u062a\u0644\u0641 \u0648\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u0627\u0646. \u062a\u063a\u064a\u0631\u062a \u0628\u0639\u0636 \u0646\u0642\u0627\u0637 \u0627\u0644\u0646\u0647\u0627\u064a\u0629\u060c \u0641\u064a \u062d\u064a\u0646 \u0644\u0645 \u062a\u062c\u062f \u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0628\u0648\u064a\u0636\u0627\u062a 739 \u0623\u064a \u0641\u0631\u0642 \u0641\u064a \u0627\u0644\u062a\u0642\u062f\u0645 \u0627\u0644\u0627\u0646\u062a\u0635\u0627\u0641\u064a \u0623\u0648 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0628\u0631\u0645\u062c.<\/p>

\u0627\u0644\u0623\u062f\u0644\u0629 \u0641\u064a \u0644\u0645\u062d\u0629<\/h2>
  • \u0623\u0641\u0627\u062f\u062a \u062f\u0631\u0627\u0633\u0629 2023 Pichia \u0639\u0646 1 g\/L \u0644\u0627\u0646\u062f\u0645\u0627\u062c xylanase-TEV-LR3 IGF-1 \u0641\u064a \u0645\u0641\u0627\u0639\u0644 \u062d\u064a\u0648\u064a 15 L.<\/li>
  • \u0642\u0627\u0645\u062a \u062f\u0631\u0627\u0633\u0629 2020 \u0628\u062a\u062d\u0644\u064a\u0644 \u0645\u062c\u0645\u0639\u0627\u062a \u0627\u0644\u0628\u0648\u064a\u0636\u0627\u062a \u0627\u0644\u0631\u0643\u0627\u0645\u064a\u0629 \u0627\u0644\u0628\u0642\u0631\u064a\u0629 739 \u0641\u064a \u0645\u062c\u0645\u0639\u0627\u062a 10 \u0648\u0644\u0645 \u062a\u062c\u062f \u0623\u064a \u0641\u0631\u0642 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0641\u064a \u0627\u0644\u062a\u0642\u062f\u0645 \u0627\u0644\u0627\u0646\u062a\u0635\u0627\u0641\u064a \u0623\u0648 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0628\u0631\u0645\u062c.<\/li>
  • \u0623\u0641\u0627\u062f\u062a \u062f\u0631\u0627\u0633\u0629 1999 \u0639\u0646 \u0627\u0644\u0628\u0642\u0631\u0629 \u0628\u0648\u062c\u0648\u062f \u0645\u064a\u0648\u0644 \u0646\u062d\u0648 \u0627\u0644\u062d\u0641\u0627\u0638 \u0639\u0644\u0649 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0644\u062d\u0648\u0638 \u0641\u064a \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u0628\u0644\u0627\u0632\u0645\u0627 \u0648\u0627\u0644\u062c\u0644\u0648\u0643\u0648\u0632\u060c \u0648\u0644\u064a\u0633 \u0641\u064a \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0627\u0628\u062a\u0646\u0627\u0626\u064a\u0629 \u0627\u0644\u0628\u0634\u0631\u064a\u0629.<\/li><\/ul><\/div><\/div>
    \"\u0633\u064a\u0631
    \u0631\u0633\u0645 \u062a\u0648\u0636\u064a\u062d\u064a \u062a\u062d\u0631\u064a\u0631\u064a \u062a\u0645 \u0625\u0646\u0634\u0627\u0624\u0647 \u0628\u0648\u0627\u0633\u0637\u0629 AI \u064a\u0648\u0636\u062d \u0633\u064a\u0631 \u0639\u0645\u0644 \u0627\u0644\u0628\u062d\u062b. \u0625\u0646\u0647\u0627 \u0644\u064a\u0633\u062a \u0631\u0642\u0645 \u062f\u0631\u0627\u0633\u0629 \u0623\u0648 \u0635\u0648\u0631\u0629 \u0645\u0631\u064a\u0636 \u0623\u0648 \u0635\u0648\u0631\u0629 \u0644\u0644\u0645\u0646\u062a\u062c \u0623\u0648 \u0646\u062a\u064a\u062c\u0629 \u0627\u062e\u062a\u0628\u0627\u0631 \u0623\u0648 \u0645\u062c\u0645\u0648\u0639\u0629 \u0643\u062a\u0627\u0644\u0648\u062c.<\/figcaption><\/figure>

    \u0633\u062c\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/h2>

    \u0627\u0633\u062a\u062e\u062f\u0645\u062a \u0648\u0631\u0642\u0629 2023 \u0627\u0644\u0632\u064a\u0644\u0627\u0646\u0627\u0632 \u0643\u0634\u0631\u064a\u0643 \u0627\u0646\u062f\u0645\u0627\u062c\u064a \u0644\u0631\u0641\u0639 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u062c\u0627\u0646\u0633 \u0641\u064a Pichia Pastoris. \u0623\u0638\u0647\u0631 IGF-1 \u0627\u0644\u0645\u0646\u0642\u0649 \u0648LR3 IGF-1 \u0646\u0634\u0627\u0637 \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0645\u0634\u0627\u0628\u0647\u064b\u0627 \u0644\u0644\u0645\u0639\u064a\u0627\u0631\u060c \u0644\u0643\u0646 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0625\u0646\u062a\u0627\u062c \u0648\u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u062d\u064a\u0648\u064a \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u0644\u0627 \u064a\u062b\u0628\u062a\u0627\u0646 \u062a\u0623\u062b\u064a\u0631\u064b\u0627 \u0633\u0631\u064a\u0631\u064a\u064b\u0627.<\/p>

    \u0625\u0646\u062a\u0627\u062c 2023<\/strong>Pichia Pastoris\u060c \u0645\u0641\u0627\u0639\u0644 \u062d\u064a\u0648\u064a 15 L\u060c \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0627\u0646\u062f\u0645\u0627\u062c 1 \u062c\u0631\u0627\u0645\/\u0644\u062a\u0631 \u062a\u0642\u0631\u064a\u0628\u064b\u0627<\/span><\/div>
    \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0628\u0648\u064a\u0636\u0627\u062a 2020<\/strong>739 \u0645\u0648\u0627\u0646\u0639 \u0627\u0644\u062d\u0645\u0644 \u0627\u0644\u0641\u0645\u0648\u064a\u0629 \u0627\u0644\u0628\u0642\u0631\u064a\u0629\u061b 10 \u062d\u0645\u0627\u0645\u0627\u062a \u0633\u0628\u0627\u062d\u0629 100 \u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645\/\u0645\u0644\u061b 22-24 \u0633\u0627\u0639\u0629<\/span><\/div>
    \u0646\u062a\u0627\u0626\u062c \u0641\u0627\u0631\u063a\u0629<\/strong>\u0644\u0627 \u064a\u0648\u062c\u062f \u0641\u0631\u0642 \u0641\u064a \u0627\u0644\u062a\u0642\u062f\u0645 \u0627\u0644\u0627\u0646\u062a\u0635\u0627\u0641\u064a \u0623\u0648 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0628\u0631\u0645\u062c (P> 0.05)<\/span><\/div>
    \u0646\u0645\u0648\u0630\u062c 1999<\/strong>\u0639\u062c\u0648\u0644 \u0627\u0644\u0628\u0642\u0631 \u0627\u0644\u0645\u0642\u064a\u062f\u0629 \u0627\u0644\u062a\u063a\u0630\u064a\u0629 \u0623\u062b\u0646\u0627\u0621 \u0636\u062e 8 \u0644\u0645\u062f\u0629 \u0633\u0627\u0639\u0629 IV<\/span><\/div>
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    \u0645\u0627 \u0644\u0627 \u062a\u0633\u062a\u0637\u064a\u0639 \u0627\u0644\u0623\u062f\u0644\u0629 \u0625\u062b\u0628\u0627\u062a\u0647<\/h2>

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    \u062a\u062a\u0637\u0644\u0628 \u0646\u062a\u0627\u0626\u062c \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0627\u0634\u064a\u0629 \u0648\u0627\u0644\u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0627\u0644\u0643\u0627\u0645\u0644\u0629 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0635\u064a\u062f\u0644\u0629 \u0648\u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0642\u0628\u0644 \u0627\u0644\u062a\u0631\u062c\u0645\u0629.<\/p>

    \u0625\u0646 \u0627\u0644\u0623\u062f\u0628\u064a\u0627\u062a \u0627\u0644\u0645\u0628\u0627\u0634\u0631\u0629 \u063a\u064a\u0631 \u0645\u062a\u062c\u0627\u0646\u0633\u0629 \u0644\u0644\u063a\u0627\u064a\u0629 \u0628\u062d\u064a\u062b \u0644\u0627 \u062a\u062f\u0639\u0645 \u0622\u0644\u064a\u0629 \u0639\u0627\u0644\u0645\u064a\u0629 \u0648\u0627\u062d\u062f\u0629 \u0623\u0648 \u0645\u0637\u0627\u0644\u0628\u0629 \u0628\u0627\u0644\u0645\u0646\u0641\u0639\u0629.<\/p>","protected":false},"excerpt":{"rendered":"

    \u062a\u062f\u0648\u0631 \u0623\u062f\u0628\u064a\u0627\u062a Direct Long R3 IGF-1 \u0625\u0644\u0649 \u062d\u062f \u0643\u0628\u064a\u0631 \u062d\u0648\u0644 \u0627\u0644\u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0645\u0624\u062a\u0644\u0641 \u0648\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u0627\u0646. \u062a\u063a\u064a\u0631\u062a \u0628\u0639\u0636 \u0646\u0642\u0627\u0637 \u0627\u0644\u0646\u0647\u0627\u064a\u0629\u060c \u0641\u064a \u062d\u064a\u0646 \u0644\u0645 \u062a\u062c\u062f \u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0628\u0648\u064a\u0636\u0627\u062a 739 \u0623\u064a \u0641\u0631\u0642 \u0641\u064a \u0627\u0644\u062a\u0642\u062f\u0645 \u0627\u0644\u0627\u0646\u062a\u0635\u0627\u0641\u064a \u0623\u0648 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0628\u0631\u0645\u062c.<\/p>","protected":false},"author":1,"featured_media":773,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"340","pim_article_type":"Published evidence review","pim_evidence_level":"Recombinant-production, cell and cattle studies; no controlled human efficacy trial","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, sample size, model\/population limits and regulatory scope are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary and official sources, numerical results, null findings, limitations, product-evidence boundary and image disclosure checked for batch 4.","pim_creation_method":"This article discusses the source records listed below, with the study models and limitations stated alongside the findings. AI-assisted drafting and image generation were used. 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