{"id":791,"date":"2026-09-01T17:35:05","date_gmt":"2026-09-01T17:35:05","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\/"},"modified":"2026-09-08T07:30:41","modified_gmt":"2026-09-08T07:30:41","slug":"melanotan-ii-human-pilot-toxicity-regulatory-evidence","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ar\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\/","title":{"rendered":"Melanotan II: \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0637\u064a\u0627\u0631 \u0627\u0644\u0628\u0634\u0631\u064a \u0648\u0627\u0644\u0633\u0645\u064a\u0629 \u0648\u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629"},"content":{"rendered":"

\u0644\u0642\u062f \u062d\u062f\u062a Melanotan II \u0645\u0646 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u0639\u0631\u0636 \u0627\u0644\u0628\u0634\u0631\u064a \u0627\u0644\u0645\u0628\u0643\u0631 \u0648\u0648\u062b\u0642\u062a \u0627\u0644\u0623\u0636\u0631\u0627\u0631 \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u063a\u064a\u0631 \u0627\u0644\u0645\u0646\u0638\u0645. \u0644\u0627 \u064a\u0645\u0643\u0646 \u0644\u0637\u064a\u0627\u0631 \u0627\u0644\u062f\u0628\u0627\u063a\u0629 \u0627\u0644\u0645\u0643\u0648\u0646 \u0645\u0646 \u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u062e\u0627\u0635 \u0623\u0646 \u064a\u0641\u0648\u0642 \u062a\u0642\u0627\u0631\u064a\u0631 \u0627\u0644\u0633\u0645\u064a\u0629 \u0627\u0644\u0644\u0627\u062d\u0642\u0629 \u0623\u0648 \u062a\u062d\u0630\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0646\u0638\u0645\u064a\u0646 \u0627\u0644\u062d\u0627\u0644\u064a\u0629.<\/p>

\u0627\u0644\u0623\u062f\u0644\u0629 \u0641\u064a \u0644\u0645\u062d\u0629<\/h2>
  • \u0642\u0627\u0645 \u0627\u0644\u0637\u064a\u0627\u0631 1996 \u0628\u062a\u0633\u062c\u064a\u0644 \u062b\u0644\u0627\u062b\u0629 \u0645\u062a\u0637\u0648\u0639\u064a\u0646 \u0623\u0635\u062d\u0627\u0621 \u0645\u0646 \u0627\u0644\u0630\u0643\u0648\u0631 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 \u0648\u0627\u0633\u062a\u062e\u062f\u0645 \u0645\u062d\u0644\u0648\u0644 \u0645\u0644\u062d\u064a \u0645\u062a\u0646\u0627\u0648\u0628 \u0623\u0648 \u0623\u064a\u0627\u0645 Melanotan II.<\/li>
  • \u0641\u064a 0.03 \u0645\u0644\u063a\u0645 \/ \u0643\u063a\u0645\u060c \u0643\u0627\u0646 \u0623\u062d\u062f \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0627\u062b\u0646\u064a\u0646 \u064a\u0639\u0627\u0646\u064a \u0645\u0646 \u0627\u0644\u0646\u0639\u0627\u0633 \u0648\u0627\u0644\u062a\u0639\u0628 \u0641\u064a \u062f\u0631\u062c\u0629 II\u061b \u0643\u0645\u0627 \u062a\u0645 \u0627\u0644\u0625\u0628\u0644\u0627\u063a \u0639\u0646 \u0627\u0644\u063a\u062b\u064a\u0627\u0646 \u0648\u0627\u0644\u0627\u0646\u062a\u0635\u0627\u0628 \u0627\u0644\u062a\u0644\u0642\u0627\u0626\u064a \u0644\u0641\u062a\u0631\u0627\u062a \u0637\u0648\u064a\u0644\u0629.<\/li>
  • \u0623\u0639\u0642\u0628 \u0627\u0644\u062a\u0639\u0631\u0636 \u0627\u0644\u0645\u0624\u0643\u062f \u0644\u0640 6 mg \u0641\u064a \u0631\u062c\u0644 \u064a\u0628\u0644\u063a \u0645\u0646 \u0627\u0644\u0639\u0645\u0631 39 \u0639\u062f\u0645 \u0627\u0646\u062a\u0638\u0627\u0645 \u062f\u0642\u0627\u062a \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u062e\u0644\u0644 \u0627\u0644\u0643\u0644\u0648\u064a \u0648\u0627\u0631\u062a\u0641\u0627\u0639 CPK \u0645\u0646 1,760 \u0625\u0644\u0649 17,773 IU\/L.<\/li><\/ul><\/div><\/div>
    \"\u0645\u0631\u0627\u062c\u0639\u0629
    \u0631\u0633\u0645 \u062a\u0648\u0636\u064a\u062d\u064a \u062a\u062d\u0631\u064a\u0631\u064a \u062a\u0645 \u0625\u0646\u0634\u0627\u0624\u0647 \u0628\u0648\u0627\u0633\u0637\u0629 AI \u064a\u0648\u0636\u062d \u0633\u064a\u0631 \u0639\u0645\u0644 \u0627\u0644\u0628\u062d\u062b. \u0625\u0646\u0647\u0627 \u0644\u064a\u0633\u062a \u0631\u0642\u0645 \u062f\u0631\u0627\u0633\u0629 \u0623\u0648 \u0635\u0648\u0631\u0629 \u0645\u0631\u064a\u0636 \u0623\u0648 \u0635\u0648\u0631\u0629 \u0644\u0644\u0645\u0646\u062a\u062c \u0623\u0648 \u0646\u062a\u064a\u062c\u0629 \u0627\u062e\u062a\u0628\u0627\u0631 \u0623\u0648 \u0645\u062c\u0645\u0648\u0639\u0629 \u0643\u062a\u0627\u0644\u0648\u062c.<\/figcaption><\/figure>

    \u0633\u062c\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/h2>

    \u062a\u0645 \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0642\u0635\u064a\u0631\u0629 \u0627\u0644\u0645\u062f\u0649\u060c \u0648\u0644\u064a\u0633 \u0644\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0633\u0643\u0627\u0646. \u062b\u0644\u0627\u062b\u0629 \u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u063a\u064a\u0631 \u0643\u0627\u0641\u064a\u064a\u0646 \u0644\u062a\u0642\u062f\u064a\u0631 \u0627\u0644\u0623\u062d\u062f\u0627\u062b \u0627\u0644\u0633\u0644\u0628\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0634\u0627\u0626\u0639\u0629\u060c \u0648\u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0644\u0627 \u062a\u0624\u0643\u062f \u0635\u062d\u0629 \u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0625\u0646\u062a\u0631\u0646\u062a \u0627\u0644\u064a\u0648\u0645.<\/p>

    \u0637\u064a\u0627\u0631 1996<\/strong>3 \u0627\u0644\u0631\u062c\u0627\u0644 \u0627\u0644\u0623\u0635\u062d\u0627\u0621. \u0628\u0627\u0644\u062a\u0646\u0627\u0648\u0628 \u0627\u0644\u0645\u0627\u0644\u062d\u0629\/MT-II\u061b 0.01 \u0625\u0644\u0649 0.025 \u2013 0.03 \u0645\u0644\u063a\u0645 \/ \u0643\u063a\u0645<\/span><\/div>
    \u0625\u0634\u0627\u0631\u0627\u062a \u0627\u0644\u0637\u064a\u0627\u0631<\/strong>\u062a\u0635\u0628\u063a \u0641\u064a 2. \u062a\u0645 \u0627\u0644\u0625\u0628\u0644\u0627\u063a \u0639\u0646 \u0627\u0644\u063a\u062b\u064a\u0627\u0646 \u0648\u0627\u0644\u0646\u0639\u0627\u0633 \/ \u0627\u0644\u062a\u0639\u0628 \u0648\u0627\u0644\u0627\u0646\u062a\u0635\u0627\u0628<\/span><\/div>
    \u062d\u0627\u0644\u0629 2012<\/strong>\u0631\u062c\u0644 \u064a\u0628\u0644\u063a \u0645\u0646 \u0627\u0644\u0639\u0645\u0631 39\u061b \u062a\u0645 \u062a\u0623\u0643\u064a\u062f \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062a\u064a \u062a\u0645 \u0634\u0631\u0627\u0624\u0647\u0627 \u0639\u0628\u0631 \u0627\u0644\u0625\u0646\u062a\u0631\u0646\u062a \u0645\u0646 6 mg \u0628\u0648\u0627\u0633\u0637\u0629 \u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0643\u062a\u0644\u064a<\/span><\/div>
    \u0630\u0631\u0648\u0629 CPK<\/strong>17,773 IU\/L \u0641\u064a \u0633\u0627\u0639\u0627\u062a 12<\/span><\/div>
    \u0627\u0644\u062d\u062f\u0648\u062f \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629<\/strong>\u064a\u0635\u0641 FDA Melanotan II \u0628\u0623\u0646\u0647 \u062f\u0648\u0627\u0621 \u062c\u062f\u064a\u062f \u063a\u064a\u0631 \u0645\u0639\u062a\u0645\u062f. \u0639\u062b\u0631\u062a TGA \u0639\u0644\u0649 \u0645\u062d\u062a\u0648\u0649 \u0645\u0646\u062a\u062c \u063a\u064a\u0631 \u0645\u062a\u0646\u0627\u0633\u0642 \u0639\u0628\u0631 \u0627\u0644\u0625\u0646\u062a\u0631\u0646\u062a<\/span><\/div><\/div><\/div>

    \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0641\u064a \u0627\u0644\u0633\u064a\u0627\u0642<\/h2>

    \u0641\u064a \u062d\u0627\u0644\u0629 \u0639\u0644\u0645 \u0627\u0644\u0633\u0645\u0648\u0645 2012\u060c \u0648\u0635\u0644 \u0645\u0639\u062f\u0644 \u0636\u0631\u0628\u0627\u062a \u0627\u0644\u0642\u0644\u0628 \u0625\u0644\u0649 146 \u0646\u0628\u0636\u0629 \u0641\u064a \u0627\u0644\u062f\u0642\u064a\u0642\u0629\u060c \u0648\u0643\u0627\u0646 \u0627\u0644\u0643\u0631\u064a\u0627\u062a\u064a\u0646\u064a\u0646 2.25 \u0645\u0644\u063a\u0645\/\u062f\u064a\u0633\u064a\u0644\u062a\u0631\u060c \u0648\u0628\u0644\u063a CPK \u0630\u0631\u0648\u062a\u0647 \u0644\u0627\u062d\u0642\u064b\u0627 \u0639\u0646\u062f 17,773 IU\/L \u0648\u0627\u0633\u062a\u0645\u0631 \u0639\u0644\u0627\u062c \u0627\u0644\u0639\u0646\u0627\u064a\u0629 \u0627\u0644\u0645\u0631\u0643\u0632\u0629 \u062b\u0644\u0627\u062b\u0629 \u0623\u064a\u0627\u0645. \u0623\u0643\u062f \u0642\u064a\u0627\u0633 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0643\u062a\u0644\u064a \u0648\u062c\u0648\u062f Melanotan II \u0645\u0642\u0627\u0628\u0644 \u0627\u0644\u0645\u0639\u064a\u0627\u0631\u060c \u0645\u0645\u0627 \u064a\u0639\u0632\u0632 \u0625\u0633\u0646\u0627\u062f \u0627\u0644\u062a\u0639\u0631\u0636 \u0628\u064a\u0646\u0645\u0627 \u064a\u0638\u0644 \u062d\u0627\u0644\u0629 \u0648\u0627\u062d\u062f\u0629.<\/p>

    \u0641\u064a \u0623\u063a\u0633\u0637\u0633\/\u0622\u0628\u060c \u0623\u0641\u0627\u062f\u062a 2026\u060c TGA \u0627\u0644\u0623\u0633\u062a\u0631\u0627\u0644\u064a\u0629\u060c \u0623\u0646 \u062e\u0645\u0633 \u0632\u062c\u0627\u062c\u0627\u062a \u0631\u0630\u0627\u0630 \u0627\u0644\u0623\u0646\u0641 \u0627\u0644\u0645\u0636\u0628\u0648\u0637\u0629 \u062a\u062d\u0645\u0644 \u0639\u0644\u0627\u0645\u0629 30 mg \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0643\u0645\u064a\u0627\u062a \u062a\u0642\u062f\u064a\u0631\u064a\u0629 \u062a\u062a\u0631\u0627\u0648\u062d \u0645\u0646 22 \u0625\u0644\u0649 54 mg. \u064a\u0645\u062b\u0644 \u0647\u0630\u0627 \u0627\u0644\u062a\u0646\u0627\u0642\u0636 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645 \u0627\u0644\u062d\u0642\u064a\u0642\u064a \u062e\u0637\u0631\u064b\u0627 \u0639\u0644\u0649 \u062c\u0648\u062f\u0629 \u0627\u0644\u0645\u0646\u062a\u062c \u0648\u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0645\u0646\u0641\u0635\u0644\u0627\u064b \u0639\u0646 \u0639\u0644\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0644\u0644\u062c\u0632\u064a\u0621.<\/p>

    \u0645\u0627 \u0644\u0627 \u062a\u0633\u062a\u0637\u064a\u0639 \u0627\u0644\u0623\u062f\u0644\u0629 \u0625\u062b\u0628\u0627\u062a\u0647<\/h2>

    \u0644\u0627 \u064a\u0645\u0643\u0646 \u0644\u0644\u0639\u064a\u0646\u0629 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0627\u0644\u0645\u0643\u0648\u0646\u0629 \u0645\u0646 \u062b\u0644\u0627\u062b\u0629 \u0623\u0641\u0631\u0627\u062f \u0623\u0646 \u062a\u062b\u0628\u062a \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0623\u0648 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629.<\/p>

    \u0644\u0627 \u064a\u0645\u0643\u0646 \u0644\u062a\u0642\u0631\u064a\u0631 \u0627\u0644\u062d\u0627\u0644\u0629 \u062a\u0642\u062f\u064a\u0631 \u0645\u0639\u062f\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629\u060c \u0644\u0643\u0646\u0647 \u064a\u0645\u0643\u0646\u0647 \u062a\u0648\u062b\u064a\u0642 \u062d\u062f\u062b \u062e\u0637\u064a\u0631 \u0645\u0639\u0642\u0648\u0644.<\/p>

    \u0644\u0627 \u064a\u0645\u0643\u0646 \u0627\u0641\u062a\u0631\u0627\u0636 \u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u0645\u0646\u062a\u062c \u063a\u064a\u0631 \u0627\u0644\u0645\u0646\u0638\u0645 \u0645\u0646 \u0627\u0644\u0645\u0644\u0635\u0642\u060c \u0643\u0645\u0627 \u0623\u0646 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0628\u062d\u062b\u064a\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u0643\u062a\u0627\u0644\u0648\u062c \u0644\u064a\u0633\u062a \u0623\u062f\u0648\u064a\u0629 \u0645\u0639\u062a\u0645\u062f\u0629.<\/p>","protected":false},"excerpt":{"rendered":"

    \u0644\u0642\u062f \u062d\u062f\u062a Melanotan II \u0645\u0646 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u0639\u0631\u0636 \u0627\u0644\u0628\u0634\u0631\u064a \u0627\u0644\u0645\u0628\u0643\u0631 \u0648\u0648\u062b\u0642\u062a \u0627\u0644\u0623\u0636\u0631\u0627\u0631 \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u063a\u064a\u0631 \u0627\u0644\u0645\u0646\u0638\u0645. \u0644\u0627 \u064a\u0645\u0643\u0646 \u0644\u0637\u064a\u0627\u0631 \u0627\u0644\u062f\u0628\u0627\u063a\u0629 \u0627\u0644\u0645\u0643\u0648\u0646 \u0645\u0646 \u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u062e\u0627\u0635 \u0623\u0646 \u064a\u0641\u0648\u0642 \u062a\u0642\u0627\u0631\u064a\u0631 \u0627\u0644\u0633\u0645\u064a\u0629 \u0627\u0644\u0644\u0627\u062d\u0642\u0629 \u0623\u0648 \u062a\u062d\u0630\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0646\u0638\u0645\u064a\u0646 \u0627\u0644\u062d\u0627\u0644\u064a\u0629.<\/p>","protected":false},"author":1,"featured_media":775,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"350","pim_article_type":"Published evidence review","pim_evidence_level":"Three-person phase I pilot, case reports and current regulatory safety warnings","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, sample size, model\/population limits and regulatory scope are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary and official sources, numerical results, null findings, limitations, product-evidence boundary and image disclosure checked for batch 4.","pim_creation_method":"This article discusses the source records listed below, with the study models and limitations stated alongside the findings. AI-assisted drafting and image generation were used. 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