{"id":3536,"date":"2026-10-05T16:08:03","date_gmt":"2026-10-05T16:08:03","guid":{"rendered":"https:\/\/nhdbio.com\/?p=3536"},"modified":"2026-10-05T16:08:03","modified_gmt":"2026-10-05T16:08:03","slug":"ll37%e7%9a%ae%e8%82%a4%e7%bb%86%e8%83%9e%e8%bf%81%e7%a7%bbegfr%e7%a0%94%e7%a9%b6%e8%a7%a3%e6%9e%90","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/cn\/ll37-skin-cell-migration-egfr-research-explained\/","title":{"rendered":"LL-37 \u4e0e\u76ae\u80a4\u4fee\u590d\u7814\u7a76\uff1a\u4e0d\u6b62\u4e8e\u6297\u83cc\u4f5c\u7528"},"content":{"rendered":"<p>LL-37 \u7814\u7a76\u540c\u65f6\u6db5\u76d6\u6297\u83cc\u6d3b\u6027\u548c\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u3002\u4e00\u9879\u76ae\u80a4\u7ec6\u80de\u8fc1\u79fb\u7814\u7a76\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u8fd9\u662f\u4e24\u4e2a\u72ec\u7acb\u7684\u95ee\u9898\uff0c\u800c\u540e\u7eed\u8bd5\u9a8c\u5219\u8bf4\u660e\u4e86\u8fd9\u4e00\u533a\u5206\u4e3a\u4f55\u91cd\u8981\u3002<\/p>\n<h2>\u6740\u706d\u7ec6\u83cc\u548c\u63a8\u52a8\u76ae\u80a4\u7ec6\u80de\u8fc1\u79fb\u662f\u4e24\u79cd\u4e0d\u540c\u7684\u6548\u5e94<\/h2>\n<p>\u6297\u83cc\u5b9e\u9a8c\u63a2\u7a76\u7684\u662f\u5728\u7279\u5b9a\u6d4b\u8bd5\u6761\u4ef6\u4e0b\uff0c\u67d0\u79cd\u80bd\u662f\u5426\u80fd\u6291\u5236\u7ec6\u83cc\u3002\u7ec6\u80de\u8fc1\u79fb\u5b9e\u9a8c\u63a2\u7a76\u7684\u5219\u662f\u7ec6\u80de\u662f\u5426\u53d1\u751f\u79fb\u52a8\u3002\u5373\u4fbf\u4e24\u8005\u90fd\u53ef\u80fd\u4e0e\u4f24\u53e3\u7814\u7a76\u76f8\u5173\uff0c\u5b83\u4eec\u4ecd\u662f\u4e0d\u540c\u7684\u7ed3\u679c\u3002\u5bf9\u4e8e LL-37\uff0c\u5148\u770b\u6e05\u7814\u7a76\u7c7b\u578b\u53ef\u4ee5\u907f\u514d\u4e00\u4e2a\u5e38\u89c1\u8bef\u89e3\uff1a\u6297\u83cc\u7ed3\u679c\u5e76\u4e0d\u81ea\u52a8\u8868\u660e\u76ae\u80a4\u4fee\u590d\u66f4\u5feb\u3002<\/p>\n<h2>\u4ec0\u4e48\u662f\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\uff1f<\/h2>\n<p>\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u662f\u6784\u6210\u76ae\u80a4\u5916\u5c42\u5927\u90e8\u5206\u7684\u7ec6\u80de\u3002\u8fc1\u79fb\u6307\u7684\u662f\u79fb\u52a8\uff0c\u800c\u4e0d\u53ea\u662f\u4ea7\u751f\u66f4\u591a\u7ec6\u80de\u3002\u5728\u7ec6\u80de\u5b9e\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u6d4b\u91cf\u67d0\u79cd\u5b9e\u9a8c\u6761\u4ef6\u662f\u5426\u4f1a\u6539\u53d8\u8fd9\u79cd\u79fb\u52a8\u3002\u5b8c\u6574\u7684\u4f24\u53e3\u8fd8\u6d89\u53ca\u5176\u4ed6\u7ec6\u80de\u3001\u8840\u6db2\u4f9b\u5e94\u3001\u529b\u5b66\u6761\u4ef6\u548c\u8bb8\u591a\u4fe1\u53f7\u4f20\u5bfc\u8fc7\u7a0b\uff0c\u56e0\u6b64\u8fc1\u79fb\u5b9e\u9a8c\u53ea\u8003\u5bdf\u4e86\u66f4\u5927\u95ee\u9898\u4e2d\u7684\u4e00\u4e2a\u90e8\u5206\u3002<\/p>\n<h2>2005 \u5b9e\u9a8c\u4e2d\u7684\u4e24\u4e2a\u660e\u786e\u6570\u5b57<\/h2>\n<p>Tokumaru \u53ca\u5176\u540c\u4e8b\u62a5\u544a\uff0c\u5728\u4ed6\u4eec\u7684 Boyden \u5c0f\u5ba4\u5b9e\u9a8c\u4e2d\uff0c\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u8fc1\u79fb\u5728 1 \u5fae\u514b\/mL LL-37 \u65f6\u8fbe\u5230\u6700\u5927\u3002\u4ed6\u4eec\u8fd8\u89c2\u5bdf\u5230 10 \u5206\u949f\u540e\u51fa\u73b0 EGFR \u78f7\u9178\u5316\u3002EGFR \u662f\u4e00\u79cd\u53c2\u4e0e\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u7684\u53d7\u4f53\uff1b\u78f7\u9178\u5316\u662f\u6fc0\u6d3b\u7684\u751f\u5316\u6807\u5fd7\u3002\u8fd9\u4e9b\u6570\u5b57\u63cf\u8ff0\u7684\u662f\u90a3\u9879\u7ec6\u80de\u5b9e\u9a8c\u3002\u5b83\u4eec\u4e0d\u662f\u4f24\u53e3\u6108\u5408\u901f\u7387\u3001\u4eba\u4f53\u6cbb\u7597\u7528\u91cf\uff0c\u4e5f\u4e0d\u662f\u4f7f\u7528\u7814\u7a76\u6750\u6599\u7684\u64cd\u4f5c\u8bf4\u660e\u3002 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16177113\/\">\u9605\u8bfb\u539f\u59cb\u7814\u7a76<\/a>.<\/p>\n<h2>\u4e3a\u4ec0\u4e48\u963b\u65ad\u4e00\u6761\u901a\u8def\u6709\u52a9\u4e8e\u89e3\u91ca\u8fd9\u4e00\u7ed3\u679c<\/h2>\n<p>\u7814\u7a76\u4eba\u5458\u6d4b\u8bd5\u4e86\u6240\u63d0\u51fa\u901a\u8def\u4e2d\u5404\u4e2a\u6b65\u9aa4\u7684\u6291\u5236\u5242\u3002\u963b\u65ad\u8fd9\u4e9b\u6b65\u9aa4\u53ef\u9632\u6b62 LL-37 \u8bf1\u5bfc\u7684\u8fc1\u79fb\u53cd\u5e94\u3002\u8fd9\u6bd4\u4ec5\u89c2\u5bdf\u79fb\u52a8\u66f4\u6709\u4fe1\u606f\u91cf\uff1a\u5b83\u6709\u52a9\u4e8e\u5c06\u8be5\u53cd\u5e94\u4e0e\u6d89\u53ca HB-EGF\u3001EGFR \u548c STAT3 \u7684\u4fe1\u53f7\u673a\u5236\u8054\u7cfb\u8d77\u6765\u3002\u7b80\u5316\u901a\u8def\u56fe\u663e\u793a\u7684\u662f\u6240\u63d0\u51fa\u7684\u5173\u7cfb\uff0c\u800c\u4e0d\u662f\u5206\u5b50\u7ed3\u6784\u6216\u6d3b\u4f53\u76ae\u80a4\u7684\u5b8c\u6574\u590d\u6742\u6027\u3002<\/p>\n<figure class=\"wp-block-image\"><a href=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/ll37-diagram.png\" target=\"_blank\" rel=\"noopener\"><img src=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/ll37-diagram.png\" alt=\"LL-37 \u76ae\u80a4\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u7b80\u56fe\uff1a\u7ec6\u80de\u8fc1\u79fb\u4e0e\u4e34\u5e8a\u4e0a\u7684\u4f24\u53e3\u6108\u5408\u662f\u4e0d\u540c\u6982\u5ff5\u3002\" width=\"1600\" height=\"900\" loading=\"lazy\" decoding=\"async\" style=\"width:100%;height:auto\"><\/a><figcaption>\u7b80\u5316\u7814\u7a76\u56fe\uff1a\u7ec6\u80de\u8fc1\u79fb\u662f\u4e00\u4e2a\u7814\u7a76\u7ec8\u70b9\uff0c\u4e0d\u662f\u4e34\u5e8a\u6108\u5408\u7ed3\u679c\u3002\u70b9\u51fb\u56fe\u7247\u53ef\u67e5\u770b\u5168\u5c3a\u5bf8\u3002<\/figcaption><\/figure>\n<h2>\u5f53\u914d\u5236\u4ea7\u54c1\u5728\u4eba\u4f53\u4e2d\u6d4b\u8bd5\u65f6\u53d1\u751f\u4e86\u4ec0\u4e48\uff1f<\/h2>\n<p>2021 HEAL LL-37 \u8bd5\u9a8c\u7814\u7a76\u4e86\u5c40\u90e8 LL-37 \u8054\u5408\u538b\u529b\u6cbb\u7597\uff0c\u5728 148 \u540d\u60a3\u6709\u96be\u4ee5\u6108\u5408\u7684\u9759\u8109\u6027\u817f\u90e8\u6e83\u75a1\u7684\u63a5\u53d7\u6cbb\u7597\u60a3\u8005\u4e2d\u8fdb\u884c\u3002\u603b\u4f53\u7597\u6548\u5206\u6790\u672a\u53d1\u73b0\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u6709\u663e\u8457\u6108\u5408\u6539\u5584\u3002\u4e00\u4e2a\u6e83\u75a1\u8f83\u5927\u7684\u4e8b\u540e\u4e9a\u7ec4\u663e\u793a\u51fa\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u7684\u4fe1\u53f7\u3002\u8fd9\u5e76\u4e0d\u80fd\u53d6\u6d88\u7ec6\u80de\u53d1\u73b0\uff1a\u8fd9\u4e9b\u7814\u7a76\u63d0\u51fa\u7684\u95ee\u9898\u4e0d\u540c\u3002\u5b83\u786e\u5b9e\u8bf4\u660e\u4e86\u4e3a\u4ec0\u4e48\u6709\u524d\u666f\u7684\u673a\u5236\u4e0d\u5e94\u88ab\u8868\u8ff0\u4e3a\u5df2\u8bc1\u5b9e\u7684\u4e34\u5e8a\u76ca\u5904\u3002 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34687253\/\">\u9605\u8bfb\u8fd9\u9879\u7814\u7a76<\/a>.<\/p>\n<h2>\u6839\u636e\u95ee\u9898\u9009\u62e9\u6750\u6599<\/h2>\n<p>\u6d4b\u91cf\u7ec6\u83cc\u751f\u957f\u7684\u9879\u76ee\u4e0d\u540c\u4e8e\u6d4b\u91cf\u7ec6\u80de\u79fb\u52a8\u6216\u53d7\u4f53\u6fc0\u6d3b\u7684\u9879\u76ee\u3002\u8bf4\u660e\u4f60\u7684\u6750\u6599\u9700\u8981\u652f\u6301\u54ea\u4e2a\u95ee\u9898\u3002\u5bf9\u4e8e\u6297\u83cc\u65b9\u9762\uff0c\u6211\u4eec\u7684 <a href=\"https:\/\/nhdbio.com\/cn\/ll37-%e6%8a%97%e8%8f%8c%e7%9b%90%e5%9f%b9%e5%85%bb%e5%9f%ba%e8%83%b6%e6%9d%9f%e7%a0%94%e7%a9%b6\/\">LL-37 \u6d4b\u8bd5\u4ecb\u8d28\u6307\u5357<\/a> \u89e3\u91ca\u4e86\u53e6\u4e00\u4e2a\u53ef\u80fd\u6539\u53d8\u7ed3\u679c\u7684\u56e0\u7d20\u3002\u54a8\u8be2 LL-37 \u65f6\uff0c\u8bf7\u5305\u62ec\u6240\u9700\u7684\u5206\u5b50\u5f62\u5f0f\u3001\u6570\u91cf\u548c\u5206\u6790\u6587\u6863\u3002\u5df2\u53d1\u8868\u7684\u751f\u7269\u5b66\u4e0d\u80fd\u66ff\u4ee3\u4f60\u81ea\u5df1\u5de5\u4f5c\u4e2d\u6240\u7528\u6750\u6599\u7684\u8eab\u4efd\u8bb0\u5f55\u3002<\/p>\n<h2>\u6d4f\u89c8\u76f8\u5173\u7684 NHD \u4ea7\u54c1<\/h2>\n<p>\u8bf7\u53c2\u9605 <a href=\"https:\/\/nhdbio.com\/cn\/%e4%ba%a7%e5%93%81\/ll-37\/\">LL-37 \u4ea7\u54c1\u8bb0\u5f55<\/a> \u4ee5\u83b7\u53d6\u76ee\u5f55\u4fe1\u606f\u3002 <a href=\"https:\/\/nhdbio.com\/cn\/%e5%bc%95%e7%94%a8\/\">\u53d1\u9001\u4f60\u7684\u6570\u91cf\u548c\u6587\u4ef6\u8981\u6c42\u4ee5\u83b7\u53d6\u62a5\u4ef7<\/a>\u3002\u4f9b\u5e94\u60c5\u51b5\u548c\u4efb\u4f55\u6279\u6b21\u6587\u4ef6\u7684\u8303\u56f4\u9700\u8981\u786e\u8ba4\u3002<\/p>\n<h2>\u539f\u59cb\u7814\u7a76<\/h2>\n<ul>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16177113\/\">Keratinocyte migration and EGFR signaling \u2014 2005 original study<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34687253\/\">HEAL LL-37 phase IIb trial \u2014 2021 original study<\/a><\/li>\n<\/ul>\n<p>\u5df2\u6838\u67e5\u6765\u6e90 5 \u5341\u6708 2026\u3002\u672c\u8bf4\u660e\u4f7f\u7528\u53ef\u8bbf\u95ee\u7684\u539f\u59cb\u6458\u8981\u548c\u56fe\u6ce8\u3002\u8be5\u793a\u610f\u56fe\u4e3a\u7b80\u5316\u8bf4\u660e\uff0c\u5e76\u975e\u5b9e\u9a8c\u56fe\u50cf\u3002NHD \u76ee\u5f55\u6750\u6599\u4ec5\u7528\u4e8e\u5408\u683c\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u3001\u5f00\u53d1\u548c\u751f\u4ea7\u54a8\u8be2\uff0c\u4e0d\u5f97\u7528\u4e8e\u4eba\u7c7b\u6216\u517d\u533b\u7528\u9014\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>LL-37 \u7814\u7a76\u540c\u65f6\u6db5\u76d6\u6297\u83cc\u6d3b\u6027\u548c\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u3002\u4e00\u9879\u76ae\u80a4\u7ec6\u80de\u8fc1\u79fb\u7814\u7a76\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u8fd9\u662f\u4e24\u4e2a\u72ec\u7acb\u7684\u95ee\u9898\uff0c\u800c\u540e\u7eed\u8bd5\u9a8c\u5219\u8bf4\u660e\u4e86\u8fd9\u4e00\u533a\u5206\u4e3a\u4f55\u91cd\u8981\u3002<\/p>","protected":false},"author":1,"featured_media":3946,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"348","pim_article_type":"Published study explanation","pim_evidence_level":"Mechanistic study with separate clinical context","pim_reviewer":"Codex AI editorial","pim_reviewed_date":"2026-10-06","pim_editorial_note":"AI-assisted editorial review; not independent human peer review. Experimental endpoints and catalogue material are distinguished.","pim_review_status":"reviewed","pim_review_reason":"Primary-source, numeric, duplicate-intent and readability checks completed.","pim_creation_method":"AI-assisted writing; deterministic explanatory diagram.","pim_sources":"[{\"title\":\"Keratinocyte migration and EGFR signaling \u2014 2005 original study\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16177113\/\",\"note\":\"Original study; checked 2026-10-05.\"},{\"title\":\"HEAL LL-37 phase IIb trial \u2014 2021 original study\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34687253\/\",\"note\":\"Original study; checked 2026-10-05.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-3536","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>LL-37 and skin repair research: more than an antibacterial effect<\/title>\n<meta name=\"description\" content=\"LL-37 research includes both antibacterial activity and cell signaling. 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