{"id":3688,"date":"2026-10-09T08:36:05","date_gmt":"2026-10-09T08:36:05","guid":{"rendered":"https:\/\/nhdbio.com\/?p=3688"},"modified":"2026-10-10T07:26:37","modified_gmt":"2026-10-10T07:26:37","slug":"%e8%82%bd%e5%ae%9e%e9%aa%8c%e9%9a%8f%e6%9c%ba%e5%8c%96%e7%9b%b2%e6%b3%95","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/cn\/peptide-experiment-randomization-blinding\/","title":{"rendered":"\u80bd\u7814\u7a76\uff1a\u901a\u4fd7\u8bed\u8a00\u89e3\u91ca\u968f\u673a\u5316\u4e0e\u76f2\u6cd5"},"content":{"rendered":"

\u4e00\u4e2a\u5b9e\u9a8c\u5373\u4f7f\u4f7f\u7528\u4e86\u7ecf\u8fc7\u4ed4\u7ec6\u9274\u5b9a\u7684\u80bd\u6750\u6599\uff0c\u4ecd\u53ef\u80fd\u7ed9\u51fa\u5177\u6709\u8bef\u5bfc\u6027\u7684\u6bd4\u8f83\u7ed3\u679c\u3002\u5982\u679c\u4e00\u7ec4\u603b\u662f\u88ab\u6700\u5148\u5904\u7406\u3001\u7531\u4e0d\u540c\u7684\u4eba\u6d4b\u91cf\uff0c\u6216\u88ab\u5206\u914d\u4e86\u6700\u5065\u5eb7\u7684\u8d77\u59cb\u6837\u672c\uff0c\u90a3\u4e48\u6750\u6599\u5c31\u4e0d\u518d\u662f\u552f\u4e00\u7684\u5dee\u5f02\u3002\u826f\u597d\u7684\u8bbe\u8ba1\u4f7f\u8fd9\u4e9b\u7ade\u4e89\u6027\u89e3\u91ca\u66f4\u5bb9\u6613\u88ab\u68c0\u67e5\u3002<\/p>\n

\u968f\u673a\u5316\uff1a\u5728\u4e0d\u6311\u9009\u504f\u597d\u6837\u672c\u7684\u60c5\u51b5\u4e0b\u51b3\u5b9a\u5206\u7ec4<\/h2>\n

\u968f\u673a\u5316\u6d89\u53ca\u5b9e\u9a8c\u5355\u5143\u5982\u4f55\u88ab\u5206\u914d\u5230\u5404\u7ec4\u3002\u5b83\u65e8\u5728\u907f\u514d\u6709\u610f\u6216\u53ef\u9884\u6d4b\u7684\u5206\u914d\u504f\u5411\u67d0\u4e00\u6761\u4ef6\u3002\u8fd9\u4e0e\u5728\u5206\u7ec4\u5df2\u7ecf\u786e\u5b9a\u4e4b\u540e\u518d\u79fb\u52a8\u8bd5\u7ba1\u662f\u4e0d\u540c\u7684\u3002<\/p>\n

NIH’s \u4e34\u5e8a\u524d\u62a5\u544a\u539f\u5219<\/a> \u8981\u6c42\u7814\u7a76\u4eba\u5458\u63cf\u8ff0\u968f\u673a\u5316\u548c\u76f2\u6cd5\u7ed3\u679c\u8bc4\u4f30\uff0c\u81f3\u5c11\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\u5982\u6b64\u3002\u672c\u6307\u5357\u89e3\u91ca\u8bbe\u8ba1\u95ee\u9898\uff0c\u800c\u4e0d\u662f\u89c4\u5b9a\u901a\u7528\u65b9\u6848\u3002<\/p>\n

\u4e00\u4e2a\u5e73\u8861\u7684\u793a\u4f8b\uff0c\u800c\u975e\u6837\u672c\u91cf\u5efa\u8bae<\/h2>\n

\u5047\u8bbe 12 \u4e2a\u5408\u683c\u6837\u672c\u5206\u4e3a\u4e09\u4e2a\u5904\u7406\u533a\u7ec4\uff0c\u6bcf\u7ec4\u56db\u4e2a\u3002\u4e00\u4e2a\u8ba1\u5212\u8bbe\u8ba1\u5c06\u6bcf\u4e2a\u533a\u7ec4\u4e2d\u7684\u4e24\u4e2a\u6837\u672c\u5206\u914d\u5230\u6761\u4ef6 A\uff0c\u4e24\u4e2a\u5206\u914d\u5230\u6761\u4ef6 B\uff0c\u5206\u914d\u5728\u533a\u7ec4\u5185\u968f\u673a\u5316\u3002\u5728\u4e09\u4e2a\u533a\u7ec4\u4e2d\uff0c\u6bcf\u4e2a\u6761\u4ef6\u6709\u516d\u4e2a\u6837\u672c\u3002<\/p>\n\n\n\n\n\n\n\n
\u5904\u7406\u533a\u7ec4<\/th>\n\u6761\u4ef6 A<\/th>\n\u6761\u4ef6 B<\/th>\n<\/tr>\n<\/thead>\n
1<\/td>\n2 \u4e2a\u6837\u672c<\/td>\n2 \u4e2a\u6837\u672c<\/td>\n<\/tr>\n
2<\/td>\n2 \u4e2a\u6837\u672c<\/td>\n2 \u4e2a\u6837\u672c<\/td>\n<\/tr>\n
3<\/td>\n2 \u4e2a\u6837\u672c<\/td>\n2 \u4e2a\u6837\u672c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u8fd9\u4e9b\u6570\u5b57\u662f\u865a\u6784\u7684\uff0c\u7528\u4ee5\u8bf4\u660e\u5e73\u8861\u3002\u5b83\u4eec\u4e0d\u662f NHD \u6570\u636e\uff0c\u4e5f\u4e0d\u8bc1\u660e\u516d\u4e2a\u6837\u672c\u8db3\u591f\u3002\u5408\u683c\u6027\u3001\u72ec\u7acb\u6027\u3001\u9884\u671f\u53d8\u5f02\u548c\u79d1\u5b66\u95ee\u9898\u51b3\u5b9a\u5408\u9002\u7684\u8bbe\u8ba1\u548c\u5206\u6790\u3002<\/p>\n

\u8fd9\u4e2a\u793a\u4f8b\u7684\u91cd\u8981\u7279\u70b9\u662f\u6bcf\u4e2a\u5904\u7406\u533a\u7ec4\u90fd\u540c\u65f6\u5305\u542b\u4e24\u79cd\u6761\u4ef6\u3002\u5982\u679c\u6240\u6709 A \u6837\u54c1\u90fd\u5728\u4e0a\u5348\u5904\u7406\u3001\u6240\u6709 B \u6837\u54c1\u90fd\u5728\u4e0b\u5348\u5904\u7406\uff0c\u5904\u7406\u6761\u4ef6\u548c\u5904\u7406\u65f6\u95f4\u5c31\u96be\u4ee5\u5206\u5f00\u3002<\/p>\n

\u8bbe\u76f2\uff1a\u5728\u4e0d\u77e5\u9053\u9884\u671f\u7b54\u6848\u7684\u60c5\u51b5\u4e0b\u8bc4\u4f30\u7ed3\u679c<\/h2>\n

\u8bbe\u76f2\u5173\u7cfb\u7684\u662f\u8c01\u5728\u6267\u884c\u76f8\u5173\u6b65\u9aa4\u6216\u8bc4\u4f30\u7ed3\u679c\u65f6\u77e5\u9053\u5206\u7ec4\u8eab\u4efd\u3002\u4f8b\u5982\uff0c\u5728\u6d4b\u91cf\u7ec6\u80de\u56fe\u50cf\u7ec8\u70b9\u7684\u8bc4\u4f30\u8005\u53ef\u4ee5\u4f7f\u7528\u7f16\u7801\u540e\u7684\u56fe\u50cf\uff0c\u5982\u679c\u8bbe\u8ba1\u5141\u8bb8\u8fd9\u6837\u505a\u3002\u7f16\u7801\u5e94\u4fdd\u7559\u4e0e\u539f\u59cb\u8bb0\u5f55\u7684\u5173\u8054\uff0c\u4ee5\u4fbf\u4e4b\u540e\u53ef\u4ee5\u6838\u67e5\u7ed3\u679c\u3002<\/p>\n

Not every experimental step can be blinded. Record which steps were blinded, which were not, and why. A label saying \u201cblinded\u201d is less useful than an accurate description of who knew what and when.<\/p>\n

\u4fdd\u6301\u6392\u9664\u89c4\u5219\u4e00\u81f4<\/h2>\n

\u5728\u67e5\u770b\u5904\u7406\u7ed3\u679c\u4e4b\u524d\uff0c\u5148\u5b9a\u4e49\u53ef\u7528\u6837\u672c\u548c\u8d28\u91cf\u6807\u51c6\u3002\u5982\u679c\u67d0\u4e2a\u6d4b\u91cf\u672a\u8fbe\u5230\u9884\u5148\u8bbe\u5b9a\u7684\u6807\u51c6\uff0c\u5e94\u8fde\u540c\u8bb0\u5f55\u4fdd\u7559\u539f\u56e0\u3002\u9009\u62e9\u6027\u6392\u9664\u540e\u770b\u8d77\u6765\u5747\u8861\u7684\u5206\u7ec4\uff0c\u5e76\u4e0d\u7b49\u540c\u4e8e\u4ece\u4e00\u5f00\u59cb\u5c31\u662f\u516c\u5e73\u7684\u6bd4\u8f83\u3002<\/p>\n

\u7269\u8d28\u8eab\u4efd\u4ecd\u7136\u662f\u4e00\u4e2a\u72ec\u7acb\u7684\u95ee\u9898<\/h2>\n

\u968f\u673a\u5316\u4e0d\u80fd\u9a8c\u8bc1\u5c0f\u74f6\u4e2d\u88c5\u7684\u662f\u4ec0\u4e48\u3002\u5728\u89c4\u5212\u6d89\u53ca\u4ee5\u4e0b\u5185\u5bb9\u7684\u7814\u7a76\u65f6 GHK-Cu<\/a> \u6216 BPC-157<\/a>\uff0c\u8bb0\u5f55\u786e\u5207\u7684\u6750\u6599\u3001\u4f9b\u5e94\u5f62\u5f0f\u3001\u6570\u91cf\u57fa\u51c6\u548c\u53ef\u83b7\u5f97\u7684\u6279\u6b21\u6587\u4ef6\u3002\u5df2\u53d1\u8868\u7684\u7ec6\u80de\u6216\u52a8\u7269\u7814\u7a76\u7ed3\u679c\u5e76\u4e0d\u8bc1\u660e\u6240\u4f9b\u5e94\u7684\u76ee\u5f55\u6750\u6599\u5177\u6709\u4efb\u4f55\u76ca\u5904\u3002<\/p>\n

\u53d1\u9001\u7814\u7a76\u54a8\u8be2<\/a> \u5e76\u9644\u4e0a\u60a8\u7684\u9879\u76ee\u6240\u9700\u7684\u6750\u6599\u8eab\u4efd\u548c\u8bb0\u5f55\u3002\u8fd9\u4e9b\u76ee\u5f55\u6750\u6599\u4ec5\u4f9b\u5b9e\u9a8c\u5ba4\u7814\u7a76\u3001\u5f00\u53d1\u548c\u5236\u9020\u4f7f\u7528\uff0c\u4e0d\u7528\u4e8e\u4eba\u7c7b\u6216\u517d\u533b\u7528\u9014\u3002<\/p>","protected":false},"excerpt":{"rendered":"

\u516c\u5e73\u7684\u6bd4\u8f83\u5728\u7b2c\u4e00\u4e2a\u7ed3\u679c\u51fa\u73b0\u4e4b\u524d\u5c31\u5df2\u7ecf\u5f00\u59cb\u3002\u4e86\u89e3\u968f\u673a\u5316\u3001\u5747\u8861\u5904\u7406\u548c\u76f2\u6cd5\u8bc4\u4f30\u5982\u4f55\u56de\u7b54\u4e0d\u540c\u7684\u5b9e\u9a8c\u8bbe\u8ba1\u95ee\u9898\u3002<\/p>","protected":false},"author":1,"featured_media":3931,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"329,318","pim_article_type":"Research methods explained","pim_evidence_level":"Authoritative guidance and explicitly labeled planning examples","pim_reviewer":"Codex AI editorial","pim_reviewed_date":"2026-10-09","pim_editorial_note":"AI-assisted source and readability checks, not independent peer review.","pim_review_status":"reviewed","pim_review_reason":"Source attribution, illustrative arithmetic, product relevance and plain-language checks.","pim_creation_method":"AI-assisted writing","pim_sources":"[]","footnotes":""},"categories":[20],"tags":[],"class_list":["post-3688","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evidence-quality-guides"],"yoast_head":"\nPeptide Research: Randomization and Blinding in Plain Language<\/title>\n<meta name=\"description\" content=\"A fair comparison starts before the first result. 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