{"id":3765,"date":"2026-10-09T18:09:46","date_gmt":"2026-10-09T18:09:46","guid":{"rendered":"https:\/\/nhdbio.com\/?p=3765"},"modified":"2026-10-10T07:26:06","modified_gmt":"2026-10-10T07:26:06","slug":"retatrutide-triumph1-%e7%9d%a1%e7%9c%a0%e5%91%bc%e5%90%b8%e6%9a%82%e5%81%9c-%e8%86%9d%e5%85%b3%e8%8a%82%e7%96%bc%e7%97%9b-%e7%bb%93%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/cn\/retatrutide-triumph1-sleep-apnea-knee-pain-results\/","title":{"rendered":"Retatrutide \u8d85\u8d8a\u51cf\u91cd\uff1aTRIUMPH-1 \u4e2d\u7684\u7761\u7720\u547c\u5438\u6682\u505c\u4e0e\u819d\u75db"},"content":{"rendered":"

\u4e00\u5219\u51cf\u80a5\u5934\u6761\u7559\u4e0b\u4e00\u4e2a\u663e\u800c\u6613\u89c1\u7684\u95ee\u9898\uff1a\u8fd8\u6709\u5176\u4ed6\u65b9\u9762\u6539\u5584\u5417\uff1fTRIUMPH-1\u8003\u5bdf\u4e86\u819d\u75db\u548c\u7761\u7720\u4e2d\u547c\u5438\u4e2d\u65ad\uff0c\u4ee5\u53ca\u4f53\u91cd\u3002<\/p>\n

\u8c01\u53c2\u4e0e\u4e86\uff1f<\/h2>\n

\u8be53\u671f\u8bd5\u9a8c\u5c062,339\u540d\u65e0\u7cd6\u5c3f\u75c5\u7684\u80a5\u80d6\u6210\u4eba\u968f\u673a\u5206\u7ec4\uff0c\u5e76\u968f\u8bbf80\u5468\u3002\u5176\u819d\u9aa8\u5173\u8282\u708e\u4e9a\u7ec4\u5305\u62ec574\u4eba\uff1b\u963b\u585e\u6027\u7761\u7720\u547c\u5438\u6682\u505c\u4e9a\u7ec4\u5305\u62ec243\u4eba\u3002<\/p>\n

\u9664\u4f53\u91cd\u5916\u8fd8\u6709\u4ec0\u4e48\u53d8\u5316\uff1f<\/h2>\n\n\n\n\n\n\n
\u7b2c80\u5468\u4e0e\u5b89\u6170\u5242\u6bd4\u8f83\u7684\u62a5\u544aITT\u7ed3\u679c<\/th>\n9 mg \u8bd5\u9a8c\u7ec4<\/th>\n12 mg \u8bd5\u9a8c\u7ec4<\/th>\n<\/tr>\n<\/thead>\n
WOMAC \u819d\u5173\u8282\u75bc\u75db\u8bc4\u5206\u7684\u989d\u5916\u964d\u4f4e<\/td>\n1.4 \u5206<\/td>\n1.6 \u5206<\/td>\n<\/tr>\n
Additional reduction in apnea\u2013hypopnea index (AHI)<\/td>\n24.7 \u6b21\/\u5c0f\u65f6<\/td>\n22.5 \u6b21\/\u5c0f\u65f6<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

These are adjusted between-group differences, not total changes from baseline. All four comparisons had p<0.001. The pain scale runs from 1 to 10, with higher scores meaning worse pain. AHI counts breathing interruptions or reductions per hour of sleep. The paper’s primary subgroup analysis used a hybrid estimand; the table consistently uses its separately reported intention-to-treat (ITT) analysis.<\/p>\n

\"TRIUMPH-1
\u5bf9\u6240\u9009\u62a5\u544aITT\u5dee\u5f02\u7684\u539f\u521b\u91cd\u7ed8\u3002\u5404\u9762\u677f\u5355\u4f4d\u4e0d\u540c\uff1b\u5176\u67f1\u9ad8\u4e0d\u80fd\u7528\u4e8e\u5bf9\u8fd9\u4e24\u9879\u83b7\u76ca\u8fdb\u884c\u6392\u5e8f\u3002<\/figcaption><\/figure>\n

\u5982\u4f55\u89e3\u8bfb\u8fd9\u4e9b\u6570\u5b57<\/h2>\n

Think of the placebo group as the comparison line. \u201cAdditional reduction\u201d asks how much more the trial group changed than that line. It does not tell you where an individual finished.<\/p>\n

For example, a difference in events per hour cannot, on its own, tell you that someone’s breathing became normal. Likewise, a lower pain score is not an image showing repaired cartilage. The measurement tells us which question the study answered.<\/p>\n

\u628a\u83b7\u76ca\u548c\u8010\u53d7\u6027\u653e\u5728\u4e00\u8d77\u8003\u8651<\/h2>\n

\u80c3\u80a0\u9053\u4e8b\u4ef6\u662f\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002\u793c\u6765\u516c\u53f8\u8d44\u52a9\u4e86\u8fd9\u9879\u8bd5\u9a8c\u3002\u4e9a\u7ec4\u53d1\u73b0\u5e94\u59cb\u7ec8\u9644\u5c5e\u4e8e\u8fd9\u4e00\u4eba\u7fa4\u3001\u6301\u7eed\u65f6\u95f4\u548c\u5206\u6790\uff0c\u800c\u4e0d\u662f\u53d8\u6210\u5bf9\u6240\u6709\u4eba\u7684\u627f\u8bfa\u3002<\/p>\n

\u4e3a\u4ec0\u4e48\u8fd9\u4e0eTRIUMPH-2\u4e0d\u540c<\/h2>\n

\u6211\u4eec\u7684TRIUMPH-2\u6587\u7ae0\u6db5\u76d6\u7684\u662f\u9488\u5bf92\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u4e00\u9879\u4e0d\u540c\u7814\u7a76\u3002\u6bd4\u8f83\u4e24\u8005\u65f6\uff0c\u8bf7\u5148\u770b\u53c2\u4e0e\u4eba\u7fa4\u3002\u5206\u5b50\u540d\u79f0\u76f8\u540c\u5e76\u4e0d\u610f\u5473\u7740\u7814\u7a76\u4eba\u7fa4\u53ef\u4ee5\u4e92\u6362\u3002<\/p>\n

\u5728\u7814\u7a76\u89c4\u5212\u4e2d\uff0c\u6709\u7528\u7684\u95ee\u9898\u5305\u62ec\uff1a\u54ea\u4e2a\u7ec8\u70b9\u91cd\u8981\u3001\u9700\u8981\u54ea\u79cd\u5bf9\u7167\uff0c\u4ee5\u53ca\u8be5\u5b9e\u9a8c\u80fd\u5426\u533a\u5206\u76f4\u63a5\u6548\u5e94\u4e0e\u4f34\u968f\u4f53\u91cd\u53d8\u5316\u800c\u51fa\u73b0\u7684\u6548\u5e94\u3002<\/p>\n

\u76f8\u5173 NHD \u7814\u7a76\u6750\u6599<\/h2>\n

\u8be5 NHD Retatrutide\u4ea7\u54c1\u9875\u9762<\/a> \u6807\u8bc6\u76f8\u5173\u7684\u5b9e\u9a8c\u5ba4\u76ee\u5f55\u9009\u9879\u3002\u8bf7\u6838\u5bf9\u60a8\u5b9e\u9a8c\u6240\u9700\u7684\u76ee\u6807\u6750\u6599\u53ca\u53ef\u7528\u8bb0\u5f55\u3002\u672c\u4e34\u5e8a\u8bd5\u9a8c\u672a\u8bc1\u660e NHD \u6750\u6599\u7684\u6548\u679c\u3002<\/p>\n

\u5982\u9700\u5b9e\u9a8c\u5ba4\u54a8\u8be2\uff0c\u8bf7\u544a\u77e5\u6211\u4eec\u6750\u6599\u3001\u6570\u91cf\u3001\u8ba1\u5212\u68c0\u6d4b\u548c\u6240\u9700\u6587\u4ef6\u3002 \u5411 NHD \u54a8\u8be2\u6750\u6599\u9009\u9879\u548c\u53ef\u63d0\u4f9b\u7684\u6587\u6863<\/a>.<\/p>\n

\u7ee7\u7eed\u9605\u8bfb<\/h2>\n

TRIUMPH-2\uff1a\u4f53\u91cd\u548c\u8840\u7cd6\u7ed3\u679c<\/a> \u548c \u66ff\u5c14\u6cca\u80bd\uff1a\u7406\u89e3AHI\u7ec8\u70b9<\/a>.<\/p>\n

\u539f\u59cb\u6765\u6e90<\/h2>\n

Jastreboff \u7b49\uff0cNEJM\uff0c29 \u5e74 2026 \u6708\uff1bDOI 10.1056\/NEJMoa2604169<\/a>\u3002\u5df2\u6838\u5bf9 10 \u5e74 2026 \u6708\u3002AI \u8f85\u52a9\u7f16\u8f91\u5ba1\u67e5\u6838\u5bf9\u4e86\u56fe\u8868\u3001\u7814\u7a76\u80cc\u666f\u548c\u901a\u4fd7\u8bed\u8a00\u8868\u8ff0\uff1b\u8fd9\u4e0d\u662f\u72ec\u7acb\u540c\u884c\u8bc4\u5ba1\u3002<\/p>\n

NHD \u76ee\u5f55\u6750\u6599\u4ec5\u7528\u4e8e\u5b9e\u9a8c\u5ba4\u7814\u7a76\u3001\u5f00\u53d1\u548c\u751f\u4ea7\uff0c\u4e0d\u7528\u4e8e\u4eba\u7c7b\u6216\u517d\u533b\u7528\u9014\u3002\u5df2\u53d1\u8868\u7684\u7814\u7a76\u5e76\u4e0d\u8ba4\u8bc1 NHD \u6279\u6b21\u3002\u76ee\u5f55\u6750\u6599\u4e0d\u80fd\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u836f\u7269\u6216\u7ecf\u8fc7\u6d4b\u8bd5\u7684\u5316\u5986\u54c1\u914d\u65b9\u4e92\u6362\u3002<\/p>","protected":false},"excerpt":{"rendered":"

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