{"id":4348,"date":"2026-10-12T08:32:52","date_gmt":"2026-10-12T08:32:52","guid":{"rendered":"https:\/\/nhdbio.com\/?p=4348"},"modified":"2026-10-12T08:32:52","modified_gmt":"2026-10-12T08:32:52","slug":"motsc-%e9%ab%98%e6%b0%a7%e8%82%ba-nrf2-%e5%b0%8f%e9%bc%a0","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/cn\/motsc-hyperoxia-lung-nrf2-mice\/","title":{"rendered":"\u6c27\u6c14\u592a\u591a\u4e5f\u4f1a\u4f24\u80ba\uff1fMOTS-c\u9ad8\u6c27\u5c0f\u9f20\u7814\u7a76\u8bb2\u4e86\u4ec0\u4e48"},"content":{"rendered":"<div class=\"notranslate\" data-no-translation lang=\"zh-CN\"><div class=\"nhd-news-lesson\"><figure class=\"cover\"><img src=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/nhd-news-20261012-14.webp\" alt=\"\u9ad8\u6c27\u73af\u5883\u4e0e\u80ba\u53d1\u80b2\u7814\u7a76\u7684\u4e3b\u9898\u63d2\u753b\" width=\"1672\" height=\"941\"><figcaption>\u4e3b\u9898\u7f16\u8f91\u63d2\u753b\uff0c\u975e\u5b9e\u9a8c\u7167\u7247\u3002<\/figcaption><\/figure><p class=\"lead\">\u6c27\u6c14\u662f\u5fc5\u9700\u7684\uff0c\u4f46\u957f\u65f6\u95f4\u5904\u5728\u8fc7\u9ad8\u6c27\u6d53\u5ea6\u4e0b\uff0c\u4e5f\u53ef\u80fd\u7ed9\u6b63\u5728\u53d1\u80b2\u7684\u80ba\u5e26\u6765\u538b\u529b\u3002\u7814\u7a76\u8005\u7528\u8fd9\u79cd\u73af\u5883\u5efa\u7acb\u5c0f\u9f20\u6a21\u578b\uff0c\u89c2\u5bdfMOTS-c\u662f\u5426\u5f71\u54cd\u80ba\u6ce1\u548c\u5c0f\u8840\u7ba1\u7684\u53d1\u80b2\u3002<\/p><section class=\"section\" id=\"section-1\"><h2>\u8fd9\u91cc\u7684\u9ad8\u6c27\uff0c\u662f\u5b9e\u9a8c\u73af\u5883<\/h2><p>\u7814\u7a76\u752870%\u6c27\u73af\u5883\u5efa\u7acb\u65b0\u751f\u5c0f\u9f20\u7684\u80ba\u53d1\u80b2\u635f\u4f24\u6a21\u578b\u3002\u8fd9\u4e0e\u4e00\u822c\u7a7a\u6c14\u73af\u5883\u4e0d\u540c\uff0c\u76ee\u7684\u662f\u8ba9\u80ba\u90e8\u51fa\u73b0\u53ef\u7814\u7a76\u7684\u6c27\u5316\u538b\u529b\u3002<\/p><p>\u80ba\u6ce1\u53ef\u4ee5\u7406\u89e3\u4e3a\u4ea4\u6362\u6c14\u4f53\u7684\u5c0f\u5355\u5143\uff0c\u5c0f\u8840\u7ba1\u8d1f\u8d23\u628a\u6c14\u4f53\u4ea4\u6362\u4e0e\u8840\u6db2\u8fd0\u8f93\u63a5\u8d77\u6765\u3002\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u4e24\u8005\u76f8\u4e92\u914d\u5408\uff0c\u56e0\u6b64\u7814\u7a76\u540c\u65f6\u770b\u80ba\u6ce1\u7ed3\u6784\u548c\u8840\u7ba1\u3002<\/p><\/section><section class=\"section\" id=\"section-2\"><h2>\u5c0f\u9f20\u4e4b\u5916\uff0c\u4f5c\u8005\u8fd8\u770b\u4e86\u8840\u7ba1\u7ec6\u80de<\/h2><p>\u8bba\u6587\u8fd8\u4f7f\u7528\u4eba\u8110\u9759\u8109\u5185\u76ae\u7ec6\u80de\uff0c\u89c2\u5bdf\u9ad8\u6c27\u6761\u4ef6\u4e0b\u7684\u5b58\u6d3b\u3001\u7ec6\u80de\u6b7b\u4ea1\u548c\u7ba1\u6837\u7ed3\u6784\u5f62\u6210\u3002\u5185\u76ae\u7ec6\u80de\u662f\u8840\u7ba1\u5185\u4fa7\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002<a class=\"source-ref\" href=\"#sources\" aria-label=\"\u67e5\u770b\u539f\u59cb\u6765\u6e90\">[1]<\/a><\/p><p>\u57f9\u517b\u76bf\u4e2d\u7684\u7ba1\u6837\u7ed3\u6784\u53ef\u4ee5\u5e2e\u52a9\u89c2\u5bdf\u8840\u7ba1\u5f62\u6210\u76f8\u5173\u80fd\u529b\uff0c\u5374\u4e0d\u662f\u4e00\u6761\u771f\u6b63\u63a5\u901a\u8840\u6db2\u5faa\u73af\u7684\u8840\u7ba1\uff0c\u66f4\u4e0d\u80fd\u76f4\u63a5\u4ee3\u66ff\u52a8\u7269\u80ba\u90e8\u68c0\u67e5\u3002<\/p><\/section><section class=\"section\" id=\"section-3\"><h2>MOTS-c\u5904\u7406\u540e\uff0c\u54ea\u4e9b\u65b9\u9762\u6709\u53d8\u5316\uff1f<\/h2><p>\u7814\u7a76\u62a5\u544a\uff0c\u5c0f\u9f20\u7684\u751f\u957f\u8fdf\u7f13\u3001\u80ba\u6ce1\u7ed3\u6784\u7b80\u5316\u548c\u80ba\u8840\u7ba1\u5f02\u5e38\u5f97\u5230\u7f13\u89e3\u3002\u7ec6\u80de\u5b9e\u9a8c\u4e5f\u770b\u5230\u5b58\u6d3b\u548c\u7ba1\u6837\u7ed3\u6784\u5f62\u6210\u65b9\u9762\u7684\u6539\u5584\uff0c\u5e76\u89c2\u5bdf\u5230\u708e\u75c7\u3001\u6c27\u5316\u538b\u529b\u6307\u6807\u4e0b\u964d\u3002<a class=\"source-ref\" href=\"#sources\" aria-label=\"\u67e5\u770b\u539f\u59cb\u6765\u6e90\">[1]<\/a><\/p><p>\u8fd9\u4e9b\u53d8\u5316\u5f7c\u6b64\u6709\u5173\uff0c\u4f46\u5404\u81ea\u4ecd\u9700\u8981\u5bf9\u5e94\u7684\u6d4b\u91cf\u3002\u4e0d\u80fd\u7528\u4e00\u53e5\u201c\u80ba\u529f\u80fd\u6062\u590d\u201d\u66ff\u4ee3\u6ca1\u6709\u5b9e\u9645\u6d4b\u5230\u7684\u5b8c\u6574\u547c\u5438\u7ed3\u5c40\u3002<\/p><\/section><section class=\"section\" id=\"section-4\"><h2>Nrf2\u5728\u8fd9\u91cc\u626e\u6f14\u4ec0\u4e48\u89d2\u8272\uff1f<\/h2><p>Nrf2\u662f\u53c2\u4e0e\u7ec6\u80de\u5e94\u5bf9\u538b\u529b\u7684\u4e00\u79cd\u8c03\u8282\u56e0\u5b50\u3002\u4f5c\u8005\u4f7f\u7528\u6291\u5236\u5b83\u7684\u5de5\u5177\u6216\u7f3a\u5c11\u5b83\u7684\u5c0f\u9f20\uff0c\u68c0\u67e5MOTS-c\u7684\u4f5c\u7528\u8fd8\u80fd\u4e0d\u80fd\u4fdd\u7559\u3002<\/p><p>\u5f53\u8fd9\u4e2a\u73af\u8282\u88ab\u963b\u65ad\u65f6\uff0c\u591a\u9879\u6539\u5584\u88ab\u62b5\u6d88\u3002\u8fd9\u6bd4\u5355\u7eaf\u770b\u5230Nrf2\u589e\u52a0\u66f4\u8fdb\u4e00\u6b65\uff0c\u56e0\u4e3a\u5b83\u5728\u68c0\u9a8c\uff1a\u89c2\u5bdf\u5230\u7684\u4f5c\u7528\u662f\u5426\u9700\u8981\u8fd9\u6761\u901a\u8def\u3002<\/p><\/section><section class=\"section\" id=\"section-5\"><h2>\u4e3a\u4ec0\u4e48\u8fd8\u4e0d\u80fd\u5199\u6210\u4eba\u7c7b\u65e9\u4ea7\u513f\u6cbb\u7597\uff1f<\/h2><p>\u52a8\u7269\u80ba\u7684\u53d1\u80b2\u3001\u635f\u4f24\u6761\u4ef6\u548c\u4eba\u4f53\u4e34\u5e8a\u7167\u62a4\u5e76\u4e0d\u76f8\u540c\u3002\u4eba\u4f53\u8fd8\u6d89\u53ca\u547c\u5438\u652f\u6301\u3001\u611f\u67d3\u3001\u8425\u517b\u7b49\u8bb8\u591a\u56e0\u7d20\uff0c\u6750\u6599\u5b89\u5168\u6027\u4e5f\u9700\u8981\u5355\u72ec\u7814\u7a76\u3002<\/p><p>\u8fd9\u9879\u5de5\u4f5c\u7684\u4ef7\u503c\uff0c\u662f\u628aMOTS-c\u3001\u6c27\u5316\u538b\u529b\u548c\u53d1\u80b2\u4e2d\u7684\u80ba\u8840\u7ba1\u8054\u7cfb\u8d77\u6765\uff0c\u63d0\u51fa\u53ef\u7ee7\u7eed\u68c0\u9a8c\u7684\u673a\u5236\u3002\u5b83\u6ca1\u6709\u63d0\u4f9b\u4eba\u4f53\u65b0\u751f\u513f\u6cbb\u7597\u6548\u679c\u6216\u7528\u836f\u65b9\u6848\u3002<\/p><\/section><section class=\"section\" id=\"section-6\"><h2>\u7ba1\u6837\u7ed3\u6784\u5f62\u6210\uff0c\u662f\u5426\u7b49\u4e8e\u5df2\u7ecf\u957f\u51fa\u6b63\u5e38\u8840\u7ba1\uff1f<\/h2><p>\u7ec6\u80de\u5728\u57f9\u517b\u6761\u4ef6\u4e0b\u5f62\u6210\u7c7b\u4f3c\u7ba1\u9053\u7684\u7ed3\u6784\uff0c\u662f\u7814\u7a76\u8840\u7ba1\u5f62\u6210\u80fd\u529b\u7684\u4e00\u79cd\u529e\u6cd5\u3002\u5b83\u6ca1\u6709\u5b8c\u6574\u8840\u6d41\uff0c\u4e5f\u7f3a\u5c11\u771f\u6b63\u7ec4\u7ec7\u91cc\u7684\u8bb8\u591a\u56e0\u7d20\u3002<\/p><p>\u628a\u57f9\u517b\u76bf\u7ed3\u679c\u4e0e\u52a8\u7269\u80ba\u7ec4\u7ec7\u89c2\u5bdf\u4e00\u8d77\u8bfb\uff0c\u53ef\u4ee5\u770b\u5230\u4ece\u5355\u7c7b\u7ec6\u80de\u5230\u8f83\u5b8c\u6574\u7ec4\u7ec7\u7684\u8054\u7cfb\u3002\u4e24\u4e2a\u5c42\u6b21\u76f8\u4e92\u652f\u6301\u65f6\u66f4\u6709\u610f\u4e49\uff0c\u5374\u4ecd\u7136\u9700\u8981\u4eba\u4f53\u7814\u7a76\u3002<\/p><\/section><aside class=\"takeaway\"><strong>\u8bfb\u8fd9\u7bc7\u65f6\uff0c\u8bb0\u4f4f\u8fd9\u4e00\u70b9<\/strong><p>\u9ad8\u6c27\u6a21\u578b\u5e2e\u52a9\u7814\u7a76\u80ba\u53d1\u80b2\u538b\u529b\uff1bNrf2\u963b\u65ad\u5b9e\u9a8c\u652f\u6301\u673a\u5236\u5224\u65ad\uff0c\u4f46\u4ecd\u5c5e\u4e8e\u4e34\u5e8a\u524d\u8bc1\u636e\u3002<\/p><\/aside><section class=\"materials\" id=\"materials\"><div class=\"eyebrow\">\u76f8\u5173\u7814\u7a76\u6750\u6599<\/div><h2>\u67e5\u770b\u6750\u6599\u4e0e\u5206\u6790\u8d44\u6599<\/h2><p class=\"materials-intro\">\u53ef\u4eceMOTS-c\u76ee\u5f55\u8d44\u6599\u6838\u5bf9\u76f8\u5173\u7814\u7a76\u6750\u6599\uff0c\u53e6\u884c\u786e\u8ba4\u7ec6\u80de\u5b9e\u9a8c\u548c\u5206\u6790\u6761\u4ef6\u3002\u672c\u6587\u4e0d\u63d0\u4f9b\u65b0\u751f\u513f\u4f7f\u7528\u5efa\u8bae\u3002<\/p><div class=\"product-grid\"><article class=\"product-card\"><div class=\"card-head\"><div><div class=\"product-label\">\u7ebf\u7c92\u4f53\u6765\u6e90\u80bd\u7814\u7a76<\/div><h3>MOTS-c<\/h3><\/div><\/div><div class=\"card-body\"><p>\u6838\u5bf9\u5e8f\u5217\u3001\u5f62\u5f0f\u53ca\u6279\u6b21\u5206\u6790\uff0c\u5339\u914d\u5b9e\u9a8c\u6a21\u578b\u3002<\/p><a href=\"https:\/\/nhdbio.com\/cn\/products\/mots-c-human\/\" target=\"_blank\" rel=\"noopener\">\u67e5\u770b\u4ea7\u54c1\u8d44\u6599 \u2192<\/a><\/div><\/article><\/div><\/section><section class=\"sources\" id=\"sources\"><h2>\u539f\u59cb\u8d44\u6599<\/h2><div>\u8d44\u6599\u65e5\u671f\uff1a2026-03-07 \u00b7 \u9ad8\u6c27\u5c0f\u9f20\uff0b\u5185\u76ae\u7ec6\u80de\u7814\u7a76<\/div><ul><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41802484\/\" target=\"_blank\" rel=\"noopener\">Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway. \u2197<\/a><\/li><li><a href=\"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178726\" target=\"_blank\" rel=\"noopener\">\u8bba\u6587 DOI\uff1a10.1016\/j.ejphar.2026.178726 \u2197<\/a><\/li><\/ul><\/section><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>\u6c27\u6c14\u662f\u5fc5\u9700\u7684\uff0c\u4f46\u957f\u65f6\u95f4\u5904\u5728\u8fc7\u9ad8\u6c27\u6d53\u5ea6\u4e0b\uff0c\u4e5f\u53ef\u80fd\u7ed9\u6b63\u5728\u53d1\u80b2\u7684\u80ba\u5e26\u6765\u538b\u529b\u3002\u7814\u7a76\u8005\u7528\u8fd9\u79cd\u73af\u5883\u5efa\u7acb\u5c0f\u9f20\u6a21\u578b\uff0c\u89c2\u5bdfMOTS-c\u662f\u5426\u5f71\u54cd\u80ba\u6ce1\u548c\u5c0f\u8840\u7ba1\u7684\u53d1\u80b2\u3002<\/p>","protected":false},"author":1,"featured_media":4347,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"352","pim_article_type":"Published research explained","pim_evidence_level":"Hyperoxia mouse + endothelial cell study","pim_reviewer":"AI-assisted source and editorial check","pim_reviewed_date":"2026-10-12","pim_editorial_note":"Original public sources, study populations and limitations are linked. Editorial illustrations are not experimental photographs.","pim_review_status":"reviewed","pim_review_reason":"Reviewed Chinese source, protected scientific values and links, unique illustration, related product families and responsive layout checked.","pim_creation_method":"AI-assisted writing","pim_sources":"[{\"title\":\"Research news reference \u2014 pubmed.ncbi.nlm.nih.gov \u2014 news-14\",\"note\":\"\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41802484\/\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-4348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>MOTS-c and excess oxygen: what did a newborn mouse lung study find? | NHD<\/title>\n<meta name=\"description\" content=\"Oxygen is essential, but being exposed to too high a concentration for a long time may also put stress on the developing lung. 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