{"id":4364,"date":"2026-10-12T08:32:58","date_gmt":"2026-10-12T08:32:58","guid":{"rendered":"https:\/\/nhdbio.com\/?p=4364"},"modified":"2026-10-12T08:32:58","modified_gmt":"2026-10-12T08:32:58","slug":"ss31-tfp-%e7%bc%ba%e4%b9%8f-%e5%bf%83%e7%a3%b7%e8%84%82-%e5%8a%9f%e8%83%bd","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/cn\/ss31-tfp-deficiency-cardiolipin-function\/","title":{"rendered":"SS-31\u6539\u5584\u8010\u529b\uff0c\u5374\u6ca1\u6539\u53d8\u5fc3\u78f7\u8102\u542b\u91cf\uff1a\u4e3a\u4ec0\u4e48\u4e0d\u77db\u76fe\uff1f"},"content":{"rendered":"<div class=\"notranslate\" data-no-translation lang=\"zh-CN\"><div class=\"nhd-news-lesson\"><figure class=\"cover\"><img src=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/nhd-news-20261012-16.webp\" alt=\"\u7ebf\u7c92\u4f53\u529f\u80fd\u4e0e\u4e0d\u540c\u538b\u529b\u6d4b\u8bd5\u7684\u4e3b\u9898\u63d2\u753b\" width=\"1672\" height=\"941\"><figcaption>\u4e3b\u9898\u7f16\u8f91\u63d2\u753b\uff0c\u975e\u5b9e\u9a8c\u7167\u7247\u3002<\/figcaption><\/figure><p class=\"lead\">\u4e00\u79cd\u80bd\u4e0e\u7ebf\u7c92\u4f53\u819c\u4e0a\u7684\u5fc3\u78f7\u8102\u7ed3\u5408\uff0c\u662f\u5426\u5c31\u4e00\u5b9a\u8981\u8ba9\u5fc3\u78f7\u8102\u53d8\u591a\u624d\u6709\u4f5c\u7528\uff1fSS-31\u7684\u4e00\u9879\u7814\u7a76\u7ed9\u51fa\u53e6\u4e00\u79cd\u601d\u8def\uff1a\u6570\u91cf\u4e0d\u53d8\u65f6\uff0c\u529f\u80fd\u4ecd\u53ef\u80fd\u53d1\u751f\u53d8\u5316\u3002<\/p><section class=\"section\" id=\"section-1\"><h2>TFP\u7f3a\u9677\uff0c\u53ef\u4ee5\u7406\u89e3\u4e3a\u8102\u80aa\u5229\u7528\u73af\u8282\u51fa\u4e86\u95ee\u9898<\/h2><p>\u7ebf\u7c92\u4f53\u8981\u628a\u957f\u94fe\u8102\u80aa\u5206\u6b65\u5904\u7406\uff0c\u624d\u80fd\u7528\u4e8e\u4f9b\u80fd\u3002\u7ebf\u7c92\u4f53\u4e09\u529f\u80fd\u86cb\u767d\uff0c\u7b80\u79f0TFP\uff0c\u53c2\u4e0e\u8fd9\u4e2a\u8fc7\u7a0b\u3002\u9057\u4f20\u7f3a\u9677\u53ef\u80fd\u8ba9\u76f8\u5173\u6b65\u9aa4\u8fd0\u8f6c\u4e0d\u987a\u3002<\/p><p>\u7814\u7a76\u4f7f\u7528\u03b2TFP\u7f3a\u9677\u5c0f\u9f20\u548c\u60a3\u8005\u6765\u6e90\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u89c2\u5bdfSS-31\uff0c\u4e5f\u53ebelamipretide\uff0c\u662f\u5426\u6539\u53d8\u7ebf\u7c92\u4f53\u529f\u80fd\u3002\u5b83\u6ca1\u6709\u76f4\u63a5\u7ed9\u60a3\u8005\u5f00\u5c55\u7597\u6548\u8bd5\u9a8c\u3002<\/p><\/section><section class=\"section\" id=\"section-2\"><h2>\u5fc3\u78f7\u8102\u5728\u54ea\u91cc\uff1f<\/h2><p>\u5fc3\u78f7\u8102\u662f\u7ebf\u7c92\u4f53\u5185\u819c\u4e2d\u7684\u4e00\u79cd\u8102\u8d28\uff0c\u4e0e\u819c\u7ed3\u6784\u548c\u80fd\u91cf\u76f8\u5173\u86cb\u767d\u7684\u5de5\u4f5c\u73af\u5883\u6709\u5173\u3002\u5b83\u4e0d\u662f\u5fc3\u810f\u4e13\u6709\u7684\u201c\u8102\u80aa\u201d\uff0c\u540d\u5b57\u91cc\u7684\u201c\u5fc3\u201d\u5bb9\u6613\u9020\u6210\u8bef\u89e3\u3002<a class=\"source-ref\" href=\"#sources\" aria-label=\"\u67e5\u770b\u539f\u59cb\u6765\u6e90\">[1]<\/a><\/p><p>SS-31\u80fd\u591f\u4e0e\u5fc3\u78f7\u8102\u76f8\u4e92\u4f5c\u7528\u3002\u7814\u7a76\u56e0\u6b64\u65e2\u770b\u80fd\u91cf\u5229\u7528\u8868\u73b0\uff0c\u4e5f\u68c0\u67e5\u5fc3\u78f7\u8102\u7684\u603b\u91cf\u548c\u7ec4\u6210\uff0c\u770b\u770b\u529f\u80fd\u53d8\u5316\u662f\u5426\u4f34\u968f\u6750\u6599\u6570\u91cf\u53d8\u5316\u3002<\/p><\/section><section class=\"section\" id=\"section-3\"><h2>\u8fd9\u6b21\u51fa\u73b0\u4e86\u54ea\u79cd\u7ec4\u5408\u7ed3\u679c\uff1f<\/h2><p>\u5904\u7406\u540e\u7684\u7f3a\u9677\u5c0f\u9f20\u8fd0\u52a8\u8010\u529b\u6539\u5584\uff0c\u90e8\u5206\u809d\u7ebf\u7c92\u4f53\u8102\u80aa\u6c27\u5316\u548c\u547c\u5438\u94fe\u76f8\u5173\u9176\u6d3b\u6027\u63d0\u9ad8\uff1b\u4f46\u51b7\u8010\u53d7\u6ca1\u6709\u6539\u53d8\uff0c\u5fc3\u78f7\u8102\u542b\u91cf\u4e0e\u7ec4\u6210\u4e5f\u6ca1\u6709\u660e\u663e\u6539\u53d8\u3002<a class=\"source-ref\" href=\"#sources\" aria-label=\"\u67e5\u770b\u539f\u59cb\u6765\u6e90\">[1]<\/a><\/p><p>\u8fd9\u8bf4\u660e\u4e0d\u540c\u6307\u6807\u53ef\u4ee5\u671d\u4e0d\u540c\u65b9\u5411\u8d70\u3002\u8fd0\u52a8\u8868\u73b0\u6539\u5584\uff0c\u4e0d\u80fd\u76f4\u63a5\u5199\u6210\u6240\u6709\u80fd\u91cf\u538b\u529b\u90fd\u5f97\u5230\u89e3\u51b3\uff1b\u819c\u4e2d\u8102\u8d28\u6570\u91cf\u4e0d\u53d8\uff0c\u4e5f\u4e0d\u80fd\u636e\u6b64\u5426\u8ba4\u529f\u80fd\u53d8\u5316\u3002<\/p><\/section><section class=\"section\" id=\"section-4\"><h2>\u6570\u91cf\u4e0d\u53d8\uff0c\u529f\u80fd\u4e3a\u4ec0\u4e48\u53ef\u80fd\u6539\u53d8\uff1f<\/h2><p>\u5c31\u50cf\u4e00\u53f0\u673a\u5668\u96f6\u4ef6\u6570\u6ca1\u53d8\uff0c\u96f6\u4ef6\u4e4b\u95f4\u914d\u5408\u5f97\u66f4\u597d\uff0c\u8fd0\u8f6c\u4e5f\u53ef\u80fd\u6539\u5584\u3002\u4f5c\u8005\u63d0\u51fa\uff0cSS-31\u53ef\u80fd\u5e2e\u52a9\u8102\u80aa\u6c27\u5316\u76f8\u5173\u9176\u4e0e\u547c\u5438\u94fe\u66f4\u7a33\u5b9a\u5730\u534f\u540c\u5de5\u4f5c\u3002<\/p><p>\u8fd9\u662f\u4e0e\u7ed3\u679c\u76f8\u7b26\u7684\u673a\u5236\u89e3\u91ca\uff0c\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u5b9e\u9a8c\u68c0\u9a8c\u3002\u60a3\u8005\u6765\u6e90\u7ec6\u80de\u4e2d\u7684\u53cd\u5e94\u53ef\u80fd\u53d7\u5230\u57fa\u56e0\u578b\u5f71\u54cd\uff0c\u4e5f\u63d0\u793a\u4e0d\u540c\u7f3a\u9677\u4e0d\u80fd\u4e00\u6982\u800c\u8bba\u3002<\/p><\/section><section class=\"section\" id=\"section-5\"><h2>\u5bf9\u540e\u7eed\u5b9e\u9a8c\u6709\u4ec0\u4e48\u542f\u53d1\uff1f<\/h2><p>\u8bbe\u8ba1\u7ebf\u7c92\u4f53\u7814\u7a76\u65f6\uff0c\u53ef\u4ee5\u628a\u819c\u8102\u7ec4\u6210\u3001\u9176\u6d3b\u6027\u3001\u4f9b\u80fd\u548c\u6574\u4f53\u529f\u80fd\u5206\u522b\u6d4b\u91cf\u3002\u82e5\u53ea\u6d4b\u4e00\u4e2a\u6307\u6807\uff0c\u5f88\u96be\u77e5\u9053\u6539\u5584\u53d1\u751f\u5728\u54ea\u4e00\u5c42\u3002<\/p><p>\u8fd9\u7bc7\u63d0\u4f9b\u4e86TFP\u7f3a\u9677\u76f8\u5173\u7684\u4e34\u5e8a\u524d\u4f9d\u636e\u3002\u5b83\u6ca1\u6709\u8bc1\u660eSS-31\u80fd\u7ea0\u6b63\u9057\u4f20\u7f3a\u9677\uff0c\u4e5f\u4e0d\u80fd\u636e\u6b64\u63a8\u5e7f\u4e3a\u6240\u6709\u75b2\u52b3\u6216\u7ebf\u7c92\u4f53\u75be\u75c5\u7684\u901a\u7528\u6cbb\u7597\u3002<\/p><\/section><section class=\"section\" id=\"section-6\"><h2>\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ed3\u679c\uff0c\u80fd\u4ee3\u8868\u6240\u6709\u5668\u5b98\u5417\uff1f<\/h2><p>\u8fd9\u79cd\u7ec6\u80de\u4fbf\u4e8e\u57f9\u517b\u548c\u68c0\u6d4b\uff0c\u4f46\u808c\u8089\u3001\u5fc3\u810f\u3001\u795e\u7ecf\u7b49\u7ec4\u7ec7\u7684\u4efb\u52a1\u4e0d\u540c\u3002\u60a3\u8005\u6765\u6e90\u8ba9\u6a21\u578b\u66f4\u63a5\u8fd1\u7279\u5b9a\u9057\u4f20\u80cc\u666f\uff0c\u4e0d\u4ee3\u8868\u5b83\u5305\u542b\u4e86\u6240\u6709\u5668\u5b98\u53cd\u5e94\u3002<\/p><p>\u590d\u73b0\u5b9e\u9a8c\u65f6\u5e94\u8bb0\u5f55\u7ec6\u80de\u6765\u6e90\u3001\u57fa\u56e0\u578b\u548c\u57f9\u517b\u6761\u4ef6\u3002\u82e5\u4e0d\u540c\u6765\u6e90\u7ec6\u80de\u53cd\u5e94\u4e0d\u540c\uff0c\u8fd9\u53ef\u80fd\u662f\u503c\u5f97\u7ee7\u7eed\u7814\u7a76\u7684\u4fe1\u606f\uff0c\u4e0d\u5e94\u7b80\u5355\u628a\u5b83\u4eec\u5e73\u5747\u6210\u4e00\u4e2a\u901a\u7528\u6548\u679c\u3002<\/p><\/section><aside class=\"takeaway\"><strong>\u8bfb\u8fd9\u7bc7\u65f6\uff0c\u8bb0\u4f4f\u8fd9\u4e00\u70b9<\/strong><p>\u5fc3\u78f7\u8102\u542b\u91cf\u4e0d\u53d8\u4e0e\u529f\u80fd\u6539\u5584\u53ef\u4ee5\u540c\u65f6\u6210\u7acb\uff1b\u8010\u529b\u548c\u51b7\u8010\u53d7\u4e5f\u9700\u8981\u5206\u522b\u770b\u3002<\/p><\/aside><section class=\"materials\" id=\"materials\"><div class=\"eyebrow\">\u76f8\u5173\u7814\u7a76\u6750\u6599<\/div><h2>\u67e5\u770b\u6750\u6599\u4e0e\u5206\u6790\u8d44\u6599<\/h2><p class=\"materials-intro\">SS-31\u76ee\u5f55\u8d44\u6599\u53ef\u7528\u4e8e\u6838\u5bf9\u7ebf\u7c92\u4f53\u76f8\u5173\u7814\u7a76\u6750\u6599\u7684\u5f62\u5f0f\u4e0e\u5206\u6790\u6587\u4ef6\u3002\u60a3\u8005\u7ec6\u80de\u5b9e\u9a8c\u4ecd\u4e0d\u7b49\u4e8e\u4eba\u4f53\u7597\u6548\u9a8c\u8bc1\u3002<\/p><div class=\"product-grid\"><article class=\"product-card\"><div class=\"card-head\"><div><div class=\"product-label\">\u7ebf\u7c92\u4f53\u529f\u80fd\u7814\u7a76<\/div><h3>SS-31 \u00b7 Elamipretide<\/h3><\/div><\/div><div class=\"card-body\"><p>\u67e5\u770b\u6750\u6599\u5f62\u5f0f\u53ca\u5206\u6790\u4fe1\u606f\uff0c\u6309\u9879\u76ee\u786e\u8ba4\u89c4\u683c\u3002<\/p><a href=\"https:\/\/nhdbio.com\/cn\/%e4%ba%a7%e5%93%81\/ss-31-%e5%9f%83%e6%8b%89%e7%b1%b3%e6%99%ae%e9%9b%b7%e8%82%bd\/\" target=\"_blank\" rel=\"noopener\">\u67e5\u770b\u4ea7\u54c1\u8d44\u6599 \u2192<\/a><\/div><\/article><\/div><\/section><section class=\"sources\" id=\"sources\"><h2>\u539f\u59cb\u8d44\u6599<\/h2><div>\u8d44\u6599\u65e5\u671f\uff1a2026-01-01 \u00b7 \u9057\u4f20\u7f3a\u9677\u5c0f\u9f20\uff0b\u60a3\u8005\u6765\u6e90\u7ec6\u80de<\/div><ul><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41500837\/\" target=\"_blank\" rel=\"noopener\">Elamipretide Improves Mitochondrial Function in Mitochondrial Trifunctional Protein-Deficient Mice and Human Fibroblasts. \u2197<\/a><\/li><li><a href=\"https:\/\/doi.org\/10.1002\/jimd.70132\" target=\"_blank\" rel=\"noopener\">\u8bba\u6587 DOI\uff1a10.1002\/jimd.70132 \u2197<\/a><\/li><\/ul><\/section><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>\u4e00\u79cd\u80bd\u4e0e\u7ebf\u7c92\u4f53\u819c\u4e0a\u7684\u5fc3\u78f7\u8102\u7ed3\u5408\uff0c\u662f\u5426\u5c31\u4e00\u5b9a\u8981\u8ba9\u5fc3\u78f7\u8102\u53d8\u591a\u624d\u6709\u4f5c\u7528\uff1fSS-31\u7684\u4e00\u9879\u7814\u7a76\u7ed9\u51fa\u53e6\u4e00\u79cd\u601d\u8def\uff1a\u6570\u91cf\u4e0d\u53d8\u65f6\uff0c\u529f\u80fd\u4ecd\u53ef\u80fd\u53d1\u751f\u53d8\u5316\u3002<\/p>","protected":false},"author":1,"featured_media":4363,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"364","pim_article_type":"Published research explained","pim_evidence_level":"Genetically defective mice + patient-derived cells","pim_reviewer":"AI-assisted source and editorial check","pim_reviewed_date":"2026-10-12","pim_editorial_note":"Original public sources, study populations and limitations are linked. 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