{"id":4388,"date":"2026-10-12T08:33:08","date_gmt":"2026-10-12T08:33:08","guid":{"rendered":"https:\/\/nhdbio.com\/?p=4388"},"modified":"2026-10-12T08:33:08","modified_gmt":"2026-10-12T08:33:08","slug":"ll37-%e7%89%87%e6%ae%b5%e7%b3%96%e5%9f%ba%e5%8c%96%e9%87%91%e5%b1%9e%e7%bb%93%e5%90%88","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/cn\/ll37-fragment-glycosylation-metal-binding\/","title":{"rendered":"\u7ed9LL-37\u7247\u6bb5\u52a0\u4e0a\u7cd6\uff0c\u7814\u7a76\u4eba\u5458\u60f3\u89c2\u5bdf\u4ec0\u4e48\uff1f"},"content":{"rendered":"<div class=\"notranslate\" data-no-translation lang=\"zh-CN\"><div class=\"nhd-news-lesson\"><figure class=\"cover\"><img src=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/nhd-news-20261012-19.webp\" alt=\"\u7cd6\u57fa\u8fde\u63a5\u4e0e\u80bd\u5206\u5b50\u6027\u8d28\u7814\u7a76\u7684\u4e3b\u9898\u63d2\u753b\" width=\"1672\" height=\"941\"><figcaption>\u4e3b\u9898\u7f16\u8f91\u63d2\u753b\uff0c\u975e\u5b9e\u9a8c\u7167\u7247\u3002<\/figcaption><\/figure><p class=\"lead\">\u80bd\u8fde\u63a5\u4e00\u4e2a\u7cd6\u57fa\u540e\uff0c\u7ed3\u6784\u548c\u4e0e\u91d1\u5c5e\u7684\u76f8\u4e92\u4f5c\u7528\u53ef\u80fd\u53d1\u751f\u53d8\u5316\u3002\u8fd9\u9879\u7814\u7a76\u5e76\u6ca1\u6709\u5ba3\u79f0\u7cd6\u5316\u8ba9LL-37\u6291\u83cc\u66f4\u5f3a\uff0c\u800c\u662f\u5728\u62c6\u89e3\u4e00\u4e2a\u66f4\u57fa\u7840\u7684\u95ee\u9898\uff1a\u8fd9\u4e00\u5c0f\u5757\u7cd6\u7a76\u7adf\u6539\u53d8\u4e86\u4ec0\u4e48\u3002<\/p><section class=\"section\" id=\"section-1\"><h2>\u4e0d\u662f\u98df\u7269\u91cc\u7684\u7cd6\uff0c\u4e5f\u4e0d\u662f\u968f\u4fbf\u6df7\u7cd6<\/h2><p>\u8fd9\u91cc\u7684\u7cd6\u57fa\u5316\uff0c\u662f\u628a\u7cd6\u7ed3\u6784\u8fde\u63a5\u5230\u80bd\u7684\u7279\u5b9a\u4f4d\u7f6e\u3002\u5b83\u662f\u660e\u786e\u7684\u5206\u5b50\u6539\u9020\uff0c\u4e0d\u662f\u5f80\u80bd\u6eb6\u6db2\u91cc\u52a0\u5165\u7cd6\u7c89\u3002<\/p><p>\u7814\u7a76\u7528\u7684\u662fLL-37\u7684C\u7aef\u7247\u6bb5\uff0c\u5e76\u5236\u5907\u4e86\u4e0d\u540c\u8fde\u63a5\u65b9\u5f0f\u7684\u7cd6\u80bd\u3002\u5b8c\u6574LL-37\u3001\u672a\u4fee\u9970\u7247\u6bb5\u548c\u7cd6\u5316\u7247\u6bb5\uff0c\u9700\u8981\u4f5c\u4e3a\u4e0d\u540c\u6750\u6599\u5bf9\u5f85\u3002<\/p><\/section><section class=\"section\" id=\"section-2\"><h2>\u4f5c\u8005\u5148\u770b\u4e86\u5b83\u4e0e\u91d1\u5c5e\u600e\u6837\u7ed3\u5408<\/h2><p>\u7814\u7a76\u68c0\u6d4b\u80bd\u4e0e\u94dc\u3001\u9530\u79bb\u5b50\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u4e0d\u540c\u6750\u6599\u5f62\u6210\u7684\u662f\u8f83\u5f31\u3001\u77ed\u6682\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u672a\u7cd6\u5316\u53c2\u7167\u80bd\u8868\u73b0\u51fa\u8f83\u9ad8\u7684\u4eb2\u548c\u7a0b\u5ea6\u3002<a class=\"source-ref\" href=\"#sources\" aria-label=\"\u67e5\u770b\u539f\u59cb\u6765\u6e90\">[1]<\/a><\/p><p>\u201c\u80fd\u7ed3\u5408\u201d\u8fd8\u9700\u8981\u8bf4\u660e\u7ed3\u5408\u6709\u591a\u7a33\u5b9a\u3002\u50cf\u63e1\u4e00\u4e0b\u624b\u4e0e\u957f\u671f\u56fa\u5b9a\u5728\u4e00\u8d77\u5e76\u4e0d\u4e00\u6837\uff0c\u4e0d\u80fd\u628a\u77ed\u6682\u91d1\u5c5e\u63a5\u89e6\u4e00\u6982\u53eb\u4f5c\u7a33\u5b9a\u590d\u5408\u7269\u3002<\/p><\/section><section class=\"section\" id=\"section-3\"><h2>\u7cd6\u57fa\u8ba9\u80bd\u66f4\u4e0d\u7075\u6d3b\uff0c\u4f46\u6574\u4f53\u5f62\u72b6\u53d8\u5316\u4e0d\u5927<\/h2><p>\u5206\u5b50\u6a21\u62df\u63d0\u793a\uff0c\u8fde\u63a5\u7cd6\u57fa\u540e\uff0c\u7247\u6bb5\u7684\u6d3b\u52a8\u7075\u6d3b\u6027\u964d\u4f4e\uff0c\u4f46\u6574\u4f53\u5f62\u72b6\u6ca1\u6709\u660e\u663e\u6539\u53d8\u3002\u7cd6\u90e8\u5206\u5076\u5c14\u4e5f\u53c2\u4e0e\u91d1\u5c5e\u63a5\u89e6\u3002<a class=\"source-ref\" href=\"#sources\" aria-label=\"\u67e5\u770b\u539f\u59cb\u6765\u6e90\">[1]<\/a><\/p><p>\u8fd9\u8bf4\u660e\u5206\u5b50\u7684\u53d8\u5316\u53ef\u80fd\u5f88\u7ec6\u5fae\u3002\u4e00\u5c0f\u5757\u4fee\u9970\u4e0d\u4e00\u5b9a\u8ba9\u5916\u5f62\u7ffb\u5929\u8986\u5730\uff0c\u4e5f\u53ef\u80fd\u4e3b\u8981\u5f71\u54cd\u6446\u52a8\u5e45\u5ea6\u6216\u5c40\u90e8\u76f8\u4e92\u4f5c\u7528\u3002<\/p><\/section><section class=\"section\" id=\"section-4\"><h2>\u7ec6\u80de\u6bd2\u6027\u4f4e\uff0c\u80fd\u56de\u7b54\u54ea\u4e00\u5c42\u95ee\u9898\uff1f<\/h2><p>\u4f5c\u8005\u5728\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u548cT\u7ec6\u80de\u4e2d\u6d4b\u8bd5\uff0c\u62a5\u544a\u4e86\u76f8\u5e94\u6d53\u5ea6\u8303\u56f4\u5185\u8f83\u4f4e\u7684\u6bd2\u6027\u3002\u5b83\u5e2e\u52a9\u5224\u65ad\u8fd9\u4e9b\u6750\u6599\u5728\u6240\u6d4b\u6761\u4ef6\u4e0b\u5bf9\u7ec6\u80de\u662f\u5426\u9020\u6210\u660e\u663e\u5f71\u54cd\u3002<\/p><p>\u7ec6\u80de\u6bd2\u6027\u6d4b\u8bd5\u4e0d\u80fd\u66ff\u4ee3\u4eba\u4f53\u957f\u671f\u5b89\u5168\u6027\uff1b\u5b83\u4e5f\u6ca1\u6709\u76f4\u63a5\u544a\u8bc9\u6211\u4eec\u7247\u6bb5\u5728\u611f\u67d3\u90e8\u4f4d\u662f\u5426\u6709\u6548\u3002\u5b89\u5168\u6027\u548c\u6297\u83cc\u4f5c\u7528\u9700\u8981\u5404\u81ea\u7684\u5b9e\u9a8c\u3002<\/p><\/section><section class=\"section\" id=\"section-5\"><h2>\u4e3a\u4ec0\u4e48\u8fd9\u79cd\u57fa\u7840\u7814\u7a76\u4e5f\u6709\u7528\uff1f<\/h2><p>\u5f00\u53d1\u4fee\u9970\u80bd\u4e4b\u524d\uff0c\u5148\u7406\u89e3\u7ed3\u6784\u3001\u7075\u6d3b\u6027\u548c\u7ed3\u5408\u884c\u4e3a\uff0c\u53ef\u4ee5\u5e2e\u52a9\u540e\u9762\u66f4\u6709\u9488\u5bf9\u6027\u5730\u8bbe\u8ba1\u5206\u5b50\u3002\u5426\u5219\uff0c\u5bb9\u6613\u628a\u6bcf\u79cd\u4fee\u9970\u90fd\u9ed8\u8ba4\u6210\u201c\u589e\u5f3a\u201d\u3002<\/p><p>\u8bba\u6587\u660e\u786e\u628a\u7cd6\u5316\u4e3b\u8981\u5f53\u4f5c\u7814\u7a76\u4fee\u9970\u5f71\u54cd\u7684\u5316\u5b66\u6a21\u578b\u3002\u51c6\u786e\u4ecb\u7ecd\u5b83\u7684\u4ef7\u503c\uff0c\u5e94\u653e\u5728\u5206\u5b50\u8bbe\u8ba1\u4e0a\uff0c\u800c\u4e0d\u662f\u7f16\u51fa\u66f4\u5f3a\u6297\u83cc\u529f\u6548\u3002<\/p><\/section><section class=\"section\" id=\"section-6\"><h2>\u6a21\u62df\u7ed3\u679c\u80fd\u4ee3\u66ff\u5b9e\u9a8c\u5417\uff1f<\/h2><p>\u6a21\u62df\u6709\u52a9\u4e8e\u7406\u89e3\u5206\u5b50\u53ef\u80fd\u600e\u6837\u8fd0\u52a8\uff0c\u4e5f\u80fd\u63d0\u51fa\u503c\u5f97\u6d4b\u8bd5\u7684\u89e3\u91ca\u3002\u4f46\u5b83\u4f9d\u8d56\u6a21\u578b\u548c\u8ba1\u7b97\u6761\u4ef6\uff0c\u6700\u597d\u4e0e\u7ed3\u5408\u3001\u7ed3\u6784\u6216\u7ec6\u80de\u5b9e\u9a8c\u4e92\u76f8\u6838\u5bf9\u3002<\/p><p>\u7814\u7a76\u4fee\u9970\u80bd\u65f6\uff0c\u53ef\u4ee5\u628a\u76ee\u6807\u5199\u5177\u4f53\uff1a\u60f3\u6539\u53d8\u7a33\u5b9a\u6027\u3001\u7ed3\u5408\u884c\u4e3a\uff0c\u8fd8\u662f\u7ec6\u80de\u4f5c\u7528\uff1f\u5148\u786e\u5b9a\u95ee\u9898\uff0c\u518d\u9009\u62e9\u68c0\u6d4b\uff0c\u901a\u5e38\u6bd4\u7b3c\u7edf\u8ffd\u6c42\u201c\u589e\u5f3a\u6d3b\u6027\u201d\u66f4\u6e05\u695a\u3002<\/p><\/section><aside class=\"takeaway\"><strong>\u8bfb\u8fd9\u7bc7\u65f6\uff0c\u8bb0\u4f4f\u8fd9\u4e00\u70b9<\/strong><p>\u7cd6\u5316\u6539\u53d8\u4e86\u90e8\u5206\u5206\u5b50\u884c\u4e3a\uff1b\u8fd9\u7bc7\u6ca1\u6709\u8bc1\u660e\u6297\u83cc\u4f5c\u7528\u589e\u5f3a\u3002<\/p><\/aside><section class=\"materials\" id=\"materials\"><div class=\"eyebrow\">\u76f8\u5173\u7814\u7a76\u6750\u6599<\/div><h2>\u67e5\u770b\u6750\u6599\u4e0e\u5206\u6790\u8d44\u6599<\/h2><p class=\"materials-intro\">\u53ef\u67e5\u770bLL-37\u6bcd\u4f53\u8d44\u6599\uff0c\u7cd6\u5316\u7247\u6bb5\u9700\u8981\u53e6\u884c\u5b9a\u5236\u5e76\u786e\u8ba4\u7cd6\u57fa\u8fde\u63a5\u4f4d\u7f6e\u3002\u4e24\u8005\u7684\u5b9e\u9a8c\u7ed3\u679c\u4e0d\u80fd\u4e92\u6362\u3002<\/p><div class=\"product-grid\"><article class=\"product-card\"><div class=\"card-head\"><div><div class=\"product-label\">\u6297\u83cc\u80bd\u4e0e\u7ec6\u80de\u673a\u5236\u7814\u7a76<\/div><h3>LL-37<\/h3><\/div><\/div><div class=\"card-body\"><p>\u6bcd\u4f53\u80bd\u4e0e\u6539\u9020\u7247\u6bb5\u5206\u522b\u6838\u5bf9\uff0c\u786e\u8ba4\u5e8f\u5217\u548c\u672b\u7aef\u3002<\/p><a href=\"https:\/\/nhdbio.com\/cn\/%e4%ba%a7%e5%93%81\/ll-37\/\" target=\"_blank\" rel=\"noopener\">\u67e5\u770b\u4ea7\u54c1\u8d44\u6599 \u2192<\/a><\/div><\/article><article class=\"product-card\"><div class=\"card-head\"><div><div class=\"product-label\">\u5e8f\u5217\u3001\u4fee\u9970\u4e0e\u5206\u6790\u8981\u6c42<\/div><h3>\u5b9a\u5236\u80bd\u670d\u52a1<\/h3><\/div><\/div><div class=\"card-body\"><p>\u8bf4\u660e\u9700\u8981\u7684\u5e8f\u5217\u3001\u672b\u7aef\u5f62\u5f0f\u3001\u6570\u91cf\u53ca\u68c0\u6d4b\u8981\u6c42\uff0c\u6309\u9879\u76ee\u786e\u8ba4\u4ea4\u4ed8\u8303\u56f4\u3002<\/p><a href=\"https:\/\/nhdbio.com\/cn\/%e6%9c%8d%e5%8a%a1\/%e5%ae%9a%e5%88%b6%e8%82%bd%e5%90%88%e6%88%90\/\" target=\"_blank\" rel=\"noopener\">\u4e86\u89e3\u5b9a\u5236\u670d\u52a1 \u2192<\/a><\/div><\/article><\/div><\/section><section class=\"sources\" id=\"sources\"><h2>\u539f\u59cb\u8d44\u6599<\/h2><div>\u8d44\u6599\u65e5\u671f\uff1a2026-02-28 \u00b7 \u7cd6\u80bd\u5408\u6210\u4e0e\u7406\u5316\u6027\u8d28\u7814\u7a76<\/div><ul><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41780202\/\" target=\"_blank\" rel=\"noopener\">Influence of N- and O-glycosylation on structural properties and biological activity of a C-terminal LL-37 fragment. \u2197<\/a><\/li><li><a href=\"https:\/\/doi.org\/10.1016\/j.carres.2026.109872\" target=\"_blank\" rel=\"noopener\">\u8bba\u6587 DOI\uff1a10.1016\/j.carres.2026.109872 \u2197<\/a><\/li><\/ul><\/section><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>\u80bd\u8fde\u63a5\u4e00\u4e2a\u7cd6\u57fa\u540e\uff0c\u7ed3\u6784\u548c\u4e0e\u91d1\u5c5e\u7684\u76f8\u4e92\u4f5c\u7528\u53ef\u80fd\u53d1\u751f\u53d8\u5316\u3002\u8fd9\u9879\u7814\u7a76\u5e76\u6ca1\u6709\u5ba3\u79f0\u7cd6\u5316\u8ba9LL-37\u6291\u83cc\u66f4\u5f3a\uff0c\u800c\u662f\u5728\u62c6\u89e3\u4e00\u4e2a\u66f4\u57fa\u7840\u7684\u95ee\u9898\uff1a\u8fd9\u4e00\u5c0f\u5757\u7cd6\u7a76\u7adf\u6539\u53d8\u4e86\u4ec0\u4e48\u3002<\/p>","protected":false},"author":1,"featured_media":4387,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"348","pim_article_type":"Published research explained","pim_evidence_level":"Glycopeptide synthesis and physicochemical property research","pim_reviewer":"AI-assisted source and editorial check","pim_reviewed_date":"2026-10-12","pim_editorial_note":"Original public sources, study populations and limitations are linked. 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This study does not claim that glycosylation makes LL-37 more antibacterial; instead, it breaks down a more basic question: what exactly does this small sugar change?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nhdbio.com\/cn\/ll37-\u7247\u6bb5\u7cd6\u57fa\u5316\u91d1\u5c5e\u7ed3\u5408\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Adding sugar to an LL-37 fragment: what changes did researchers investigate?\" \/>\n<meta property=\"og:description\" content=\"Once a sugar group is attached to a peptide, its structure and its interactions with metals may change. 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