{"id":466,"date":"2026-08-28T06:56:05","date_gmt":"2026-08-28T06:56:05","guid":{"rendered":"https:\/\/nhdbio.com\/ibutamoren-mk-677-two-year-older-adult-trial-data\/"},"modified":"2026-08-28T07:31:46","modified_gmt":"2026-08-28T07:31:46","slug":"ibutamoren-mk-677-two-year-older-adult-trial-data","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/cn\/ibutamoren-mk-677-two-year-older-adult-trial-data\/","title":{"rendered":"\u5e03\u83ab\u4f26 (MK-677) \u5728\u8001\u5e74\u4eba\u4e2d\u7684\u5e94\u7528\uff1a\u4e24\u5e74\u8eab\u4f53\u6210\u5206\u6570\u636e\u548c\u7f3a\u5931\u7684\u529f\u80fd\u589e\u76ca"},"content":{"rendered":"<p class=\"pim-standfirst wp-block-paragraph\">\u5728 65 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kg\u3002<\/li><li>\u8fd9\u79cd\u53d8\u5316\u5e76\u6ca1\u6709\u8f6c\u5316\u4e3a\u529b\u91cf\u6216\u8eab\u4f53\u529f\u80fd\u7684\u6539\u5584\u3002<\/li><li>\u7a7a\u8179\u8840\u7cd6\u5347\u9ad80.3 mmol\/L\uff0c\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u964d\u4f4e\u3002<\/li><\/ul><\/div><\/div><figure class=\"wp-block-image size-full pim-article-figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1536\" height=\"1024\" src=\"http:\/\/nhdbio.com\/wp-content\/uploads\/2026\/08\/gh-secretagogue-research-20260828.png\" alt=\"\u79d1\u5b66\u5bb6\u5ba1\u67e5\u8109\u52a8\u751f\u957f\u6fc0\u7d20\u548c IGF-1 \u7814\u7a76\u6570\u636e\" class=\"wp-image-459\" srcset=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/08\/gh-secretagogue-research-20260828.png 1536w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/08\/gh-secretagogue-research-20260828-300x200.png 300w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/08\/gh-secretagogue-research-20260828-1024x683.png 1024w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/08\/gh-secretagogue-research-20260828-768x512.png 768w\" sizes=\"auto, (max-width: 1536px) 100vw, 1536px\" \/><figcaption class=\"wp-element-caption\">\u7814\u7a76\u80cc\u666f\u7684\u539f\u59cb\u793e\u8bba\u63d2\u56fe\u3002\u5b83\u4e0d\u662f\u7814\u7a76\u56fe\u3001\u60a3\u8005\u56fe\u50cf\u3001\u63d0\u4f9b\u7684\u4ea7\u54c1\u7167\u7247\u6216\u8bd5\u9a8c\u6750\u6599\u7684\u8868\u793a\u3002<\/figcaption><\/figure><h2 class=\"wp-block-heading\">\u5b66\u4e60\u8bb0\u5f55<\/h2><p class=\"wp-block-paragraph\">\u8be5\u8bd5\u9a8c\u8bf4\u660e\u4e86\u4e3a\u4ec0\u4e48\u66ff\u4ee3\u7ec8\u70b9\u6216\u7ec4\u5408\u7ec8\u70b9\u4e0d\u80fd\u4ee3\u66ff\u60a3\u8005\u76f8\u5173\u7ed3\u679c\u3002\u63d0\u9ad8 GH \u548c IGF-1 \u4ee5\u53ca\u6539\u53d8\u53bb\u8102\u4f53\u91cd\u5e76\u6ca1\u6709\u6539\u5584\u6d4b\u91cf\u7684\u529f\u80fd\u7ed3\u679c\u3002<\/p><div class=\"wp-block-group pim-evidence-table\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"pim-evidence-row\"><strong>\u53c2\u52a0\u8005<\/strong><span>65 \u5e74\u9f84\u4e3a 60\u201381 \u5c81\u7684\u5065\u5eb7\u6210\u5e74\u4eba<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u671f\u95f4<\/strong><span>\u6700\u591a 24 \u4e2a\u6708<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u53bb\u8102\u4f53\u91cd<\/strong><span>+1.1 \u5343\u514b vs -0.5 \u5343\u514b<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u4f53\u91cd<\/strong><span>+2.7 \u516c\u65a4 vs +0.8 \u516c\u65a4<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u529f\u80fd<\/strong><span>\u529b\u91cf\u6216\u8eab\u4f53\u673a\u80fd\u6ca1\u6709\u6539\u5584<\/span><\/div><\/div><\/div><h2 class=\"wp-block-heading\">\u4e0a\u4e0b\u6587\u4e2d\u7684\u7ed3\u679c<\/h2><p class=\"wp-block-paragraph\">\u4f5c\u8005\u8fd8\u62a5\u544a\u4e86\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u98df\u6b32\u589e\u52a0\u3001\u8f7b\u5fae\u77ed\u6682\u7684\u4e0b\u80a2\u6c34\u80bf\u548c\u808c\u8089\u75bc\u75db\u3002\u8840\u7cd6\u7ed3\u679c\u6b63\u671d\u7740\u4e0d\u5229\u7684\u65b9\u5411\u53d1\u5c55\uff0c\u4e0e\u53bb\u8102\u4f53\u91cd\u7ed3\u679c\u4e00\u6837\u503c\u5f97\u91cd\u89c6\u3002<\/p><p class=\"wp-block-paragraph\">\u53e6\u4e00\u9879\u9acb\u90e8\u9aa8\u6298 IIb \u671f\u7814\u7a76\u62db\u52df\u4e86 123 \u8001\u5e74\u60a3\u8005\uff0c\u5e76\u5728\u51fa\u73b0\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u5b89\u5168\u4fe1\u53f7\u540e\u63d0\u524d\u7ed3\u675f\u3002\u5176\u6df7\u5408\u529f\u80fd\u7ed3\u679c\u5e76\u4e0d\u80fd\u4fee\u590d\u8be5\u98ce\u9669\u4fe1\u53f7\u3002<\/p><h2 class=\"wp-block-heading\">\u8fd9\u9879\u7814\u7a76\u65e0\u6cd5\u56de\u7b54\u4ec0\u4e48<\/h2><p class=\"wp-block-paragraph\">\u7814\u7a76\u5bf9\u8c61\u662f\u5065\u5eb7\u7684\u8001\u5e74\u4eba\uff0c\u800c\u4e0d\u662f\u8fd0\u52a8\u5458\u6216\u5bfb\u6c42\u8eab\u4f53\u91cd\u7ec4\u7684\u4eba\u3002<\/p><p class=\"wp-block-paragraph\">\u6570\u636e\u6765\u81ea\u5b9a\u4e49\u7684\u7814\u7a76\u4ea7\u54c1\u548c\u65b9\u6848\uff0c\u800c\u4e0d\u662f\u672a\u7ecf\u9a8c\u8bc1\u7684\u5546\u4e1a\u6750\u6599\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u5728 65 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Null findings and study limitations are retained. This is not independent peer review, medical advice, a customer case, or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"At least two linked primary or authoritative records and an explicit evidence boundary are present.","pim_creation_method":"The editorial workflow starts with linked peer-reviewed papers, trial registries or regulatory records; extracts the population or model, endpoints, numerical results and limitations; and separates the studied intervention from catalog material. AI-assisted drafting was used to structure the first version. Claims, figures, evidence labels and limitations were checked against the linked records in the site editorial workflow. This is not independent peer review.","pim_sources":"[{\"title\":\"MK-677 in healthy older adults: two-year randomized trial\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18981485\/\",\"note\":\"Body composition, function and glucose findings; PMID 18981485.\"},{\"title\":\"MK-0677 phase IIb hip-fracture study\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21067829\/\",\"note\":\"Early termination after CHF signal; PMID 21067829.\"},{\"title\":\"FDA Pharmacy Compounding Advisory Committee meeting materials\",\"url\":\"https:\/\/www.fda.gov\/advisory-committees\/advisory-committee-calendar\/october-29-2024-meeting-pharmacy-compounding-advisory-committee-10292024\",\"note\":\"FDA assessment materials for ibutamoren and ipamorelin.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-466","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Ibutamoren in Older Adults: Two-Year Trial Results<\/title>\n<meta name=\"description\" content=\"A two-year trial in 65 healthy older adults is often quoted for lean-mass change. 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