{"id":476,"date":"2026-08-28T06:56:06","date_gmt":"2026-08-28T06:56:06","guid":{"rendered":"https:\/\/nhdbio.com\/aod-9604-options-trial-null-weight-loss-result\/"},"modified":"2026-09-01T09:40:18","modified_gmt":"2026-09-01T09:40:18","slug":"aod-9604-options-trial-null-weight-loss-result","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/cn\/aod-9604-options-trial-null-weight-loss-result\/","title":{"rendered":"AOD-9604 OPTIONS \u7814\u7a76\uff1a\u4e3b\u8981\u7ed3\u679c\u3001\u65e0\u6548\u7ed3\u679c\u548c\u8bc1\u636e\u9650\u5236"},"content":{"rendered":"<p class=\"pim-standfirst wp-block-paragraph\">AOD-9604 \u8d85\u8d8a\u4e86\u52a8\u7269\u5de5\u4f5c\uff0c\u8fdb\u5165\u4e86\u80a5\u80d6\u53d1\u5c55\u9879\u76ee\u3002 FDA \u7684 2024 \u5ba1\u67e5\u8bb0\u5f55\u8868\u660e\uff0c\u5927\u578b OPTIONS \u7814\u7a76\u5e76\u672a\u663e\u793a\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u4f53\u91cd\u51cf\u8f7b\uff0c\u5e76\u4e14\u80a5\u80d6\u7684\u53d1\u5c55\u88ab\u7ec8\u6b62\u3002<\/p><div class=\"wp-block-group pim-key-takeaways\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><h2 class=\"wp-block-heading\">\u8bb0\u5f55\u663e\u793a\u4ec0\u4e48<\/h2><ul class=\"wp-block-list\"><li>FDA\u7b80\u62a5\u8bb0\u5f55\u4e86536\u5165\u7ec4\u548c502\u968f\u673a\u53c2\u4e0e\u8005\uff1b\u590d\u5236\u7684\u8d5e\u52a9\u5546\u56fe\u6807\u8bb0\u4e3a\u201c\u6240\u6709\u6570\u636e N=503\u201d\u3002<\/li><li>\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c12 \u548c 24 \u5468\u7684\u4f53\u91cd\u51cf\u8f7b\u5e45\u5ea6\u592a\u5c0f\uff0c\u65e0\u6cd5\u8fbe\u5230\u7edf\u8ba1\u663e\u7740\u6027\u3002<\/li><li>FDA \u65e0\u6cd5\u627e\u5230\u5305\u542b\u7814\u7a76\u65b9\u6cd5\u548c\u521d\u6b65\u7597\u6548\u8be6\u7ec6\u4fe1\u606f\u7684\u5b8c\u6574\u533b\u5b66\u671f\u520a\u51fa\u7248\u7269\u3002<\/li><\/ul><\/div><\/div><figure class=\"wp-block-image size-full pim-article-figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1536\" height=\"1024\" src=\"http:\/\/nhdbio.com\/wp-content\/uploads\/2026\/08\/gh-secretagogue-research-20260828.png\" alt=\"\u79d1\u5b66\u5bb6\u5ba1\u67e5\u8109\u52a8\u751f\u957f\u6fc0\u7d20\u548c IGF-1 \u7814\u7a76\u6570\u636e\" class=\"wp-image-459\" srcset=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/08\/gh-secretagogue-research-20260828.png 1536w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/08\/gh-secretagogue-research-20260828-300x200.png 300w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/08\/gh-secretagogue-research-20260828-1024x683.png 1024w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/08\/gh-secretagogue-research-20260828-768x512.png 768w\" sizes=\"auto, (max-width: 1536px) 100vw, 1536px\" \/><figcaption class=\"wp-element-caption\">\u7814\u7a76\u80cc\u666f\u7684\u539f\u59cb\u793e\u8bba\u63d2\u56fe\u3002\u5b83\u4e0d\u662f\u7814\u7a76\u56fe\u3001\u60a3\u8005\u56fe\u50cf\u3001\u63d0\u4f9b\u7684\u4ea7\u54c1\u7167\u7247\u6216\u8bd5\u9a8c\u6750\u6599\u7684\u8868\u793a\u3002<\/figcaption><\/figure><h2 class=\"wp-block-heading\">\u5b66\u4e60\u8bb0\u5f55<\/h2><p class=\"wp-block-paragraph\">FDA \u7b80\u62a5\u5f15\u7528\u4e86\u7533\u529e\u8005\u7684\u7ed3\u8bba\uff0c\u5373\u66f4\u5e7f\u6cdb\u7684\u7814\u7a76\u4eba\u7fa4\u6ca1\u6709\u4e00\u81f4\u7684\u53cd\u5e94\uff0c\u5e76\u4e14\u7ed3\u679c\u4e0d\u652f\u6301\u5546\u4e1a\u6027\u80a5\u80d6\u7684\u53d1\u5c55\u3002\u8fd9\u79cd\u8d1f\u9762\u8bb0\u5f55\u6bd4\u5b64\u7acb\u7684\u65e9\u671f\u4fe1\u53f7\u66f4\u6709\u5206\u91cf\u3002<\/p><div class=\"wp-block-group pim-evidence-table\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"pim-evidence-row\"><strong>\u7a0b\u5e8f<\/strong><span>OPTIONS IIb\u671f\u80a5\u80d6\u53d1\u5c55\u7814\u7a76<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u5df2\u6ce8\u518c<\/strong><span>536 \u53c2\u4e0e\u8005<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u968f\u673a\u5316<\/strong><span>502 FDA \u53d9\u4e8b\u7684\u53c2\u4e0e\u8005<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u8d5e\u52a9\u5546\u4eba\u7269\u6807\u7b7e<\/strong><span>\u6240\u6709\u6570\u636e\uff0cN=503\uff1b\u8f6c\u8f7d\u4e8eFDA\u7b80\u62a5<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u521d\u6b65\u89e3\u8bfb<\/strong><span>\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u51cf\u80a5\u6548\u679c\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u53d1\u5c55\u6210\u679c<\/strong><span>\u80a5\u80d6\u8ba1\u5212\u7ec8\u6b62<\/span><\/div><\/div><\/div><h2 class=\"wp-block-heading\">\u4e0a\u4e0b\u6587\u4e2d\u7684\u7ed3\u679c<\/h2><p class=\"wp-block-paragraph\">\u53d1\u8868\u5dee\u8ddd\u5f88\u91cd\u8981\u3002\u5982\u679c\u6ca1\u6709\u5b8c\u6574\u7684\u540c\u884c\u8bc4\u5ba1\u62a5\u544a\uff0c\u8bfb\u8005\u5c31\u65e0\u6cd5\u72ec\u7acb\u68c0\u67e5\u6240\u6709\u9884\u5148\u6307\u5b9a\u7684\u5206\u6790\u3001\u7f3a\u5931\u6570\u636e\u5904\u7406\u548c\u5c0f\u7ec4\u51b3\u7b56\u3002<\/p><p class=\"wp-block-paragraph\">\u56e0\u6b64\uff0cAOD-9604 \u5e94\u88ab\u63cf\u8ff0\u4e3a\u7814\u7a76\u6027 GH \u7247\u6bb5\uff0c\u5176\u80a5\u80d6\u53d1\u5c55\u7ec8\u70b9\u5931\u8d25\uff0c\u800c\u4e0d\u662f\u4e34\u5e8a\u8bc1\u660e\u7684\u201c\u8102\u80aa\u71c3\u70e7\u80bd\u201d\u3002<\/p><h2 class=\"wp-block-heading\">\u8fd9\u9879\u7814\u7a76\u65e0\u6cd5\u56de\u7b54\u4ec0\u4e48<\/h2><p class=\"wp-block-paragraph\">\u6700\u91cd\u8981\u7684\u5927\u578b\u8bd5\u9a8c\u7ec6\u8282\u4f4d\u4e8e\u76d1\u7ba1\u548c\u516c\u53f8\u8bb0\u5f55\u4e2d\uff0c\u800c\u4e0d\u662f\u5b8c\u6574\u7684\u540c\u884c\u8bc4\u5ba1\u8bd5\u9a8c\u62a5\u544a\u3002<\/p><p class=\"wp-block-paragraph\">\u80a5\u80d6\u53d1\u5c55\u7684\u5931\u8d25\u5e76\u4e0d\u80fd\u56de\u7b54\u6240\u6709\u5b9e\u9a8c\u5ba4\u95ee\u9898\uff0c\u4f46\u5b83\u76f4\u63a5\u4e0e\u4eba\u7c7b\u81ea\u4fe1\u7684\u51cf\u80a5\u4e3b\u5f20\u76f8\u77db\u76fe\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>AOD-9604 \u8d85\u8d8a\u4e86\u52a8\u7269\u5de5\u4f5c\uff0c\u8fdb\u5165\u4e86\u80a5\u80d6\u53d1\u5c55\u9879\u76ee\u3002 FDA \u7684 2024 \u5ba1\u67e5\u8bb0\u5f55\u8868\u660e\uff0c\u5927\u578b OPTIONS \u7814\u7a76\u5e76\u672a\u663e\u793a\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u4f53\u91cd\u51cf\u8f7b\uff0c\u5e76\u4e14\u80a5\u80d6\u7684\u53d1\u5c55\u88ab\u7ec8\u6b62\u3002<\/p>","protected":false},"author":1,"featured_media":641,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"314","pim_article_type":"Published study case","pim_evidence_level":"FDA-reviewed development record; pivotal result not published as a full journal trial","pim_reviewer":"NHD evidence editorial workflow","pim_reviewed_date":"2026-08-28","pim_editorial_note":"Source-checked on 2026-08-28. Null findings and study limitations are retained. This is not independent peer review, medical advice, a customer case, or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"At least two linked primary or authoritative records and an explicit evidence boundary are present.","pim_creation_method":"The editorial workflow starts with linked peer-reviewed papers, trial registries or regulatory records; extracts the population or model, endpoints, numerical results and limitations; and separates the studied intervention from catalog material. AI-assisted drafting was used to structure the first version. Claims, figures, evidence labels and limitations were checked against the linked records in the site editorial workflow. This is not independent peer review.","pim_sources":"[{\"title\":\"FDA December 2024 AOD-9604 briefing document\",\"url\":\"https:\/\/www.fda.gov\/media\/183584\/download\",\"note\":\"FDA review of effectiveness, safety and the OPTIONS result.\"},{\"title\":\"AOD-9604 development review\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15134286\/\",\"note\":\"Contemporaneous development summary; PMID 15134286.\"},{\"title\":\"FDA December 2024 PCAC meeting record\",\"url\":\"https:\/\/www.fda.gov\/advisory-committees\/advisory-committee-calendar\/updated-meeting-time-and-public-participation-information-december-4-2024-meeting-pharmacy\",\"note\":\"Regulatory meeting context.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-476","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>AOD-9604 OPTIONS Study: Primary Outcome, Null Result and Evidence Limits - NHD<\/title>\n<meta name=\"description\" content=\"AOD-9604 progressed beyond animal work into an obesity-development program. 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