{"id":749,"date":"2026-09-01T16:45:45","date_gmt":"2026-09-01T16:45:45","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/ara-290-cibinetide-small-fiber-neuropathy-and-dme-trials\/"},"modified":"2026-09-01T16:45:45","modified_gmt":"2026-09-01T16:45:45","slug":"ara-290-cibinetide-small-fiber-neuropathy-and-dme-trials","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/cn\/ara-290-cibinetide-small-fiber-neuropathy-and-dme-trials\/","title":{"rendered":"ARA-290\/Cibinetide\uff1a\u5c0f\u7ea4\u7ef4\u795e\u7ecf\u75c5\u548c DME \u8bd5\u9a8c\u6570\u636e"},"content":{"rendered":"<p class=\"pim-standfirst wp-block-paragraph\">\u4eba\u7c7b\u897f\u5bbe\u80bd\u8bc1\u636e\u5305\u62ec\u9488\u5bf9\u4e0d\u540c\u4eba\u7fa4\u7684\u5c0f\u578b\u63a2\u7d22\u6027\u7814\u7a76\u3002\u4e00\u9879 22 \u4eba\u7ed3\u8282\u75c5\u795e\u7ecf\u75c5\u8bd5\u70b9\u62a5\u544a\u4e86\u75c7\u72b6\u8bc4\u5206\u5dee\u5f02\uff0c\u800c\u4e00\u9879 9 \u4eba\u7cd6\u5c3f\u75c5\u9ec4\u6591\u6c34\u80bf\u7814\u7a76\u9519\u8fc7\u4e86\u4e3b\u8981\u7684\u773c\u90e8\u6d4b\u91cf\u7ed3\u679c\u3002<\/p><div class=\"wp-block-group pim-key-takeaways\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><h2 class=\"wp-block-heading\">\u8bc1\u636e\u4e00\u76ee\u4e86\u7136<\/h2><ul class=\"wp-block-list\"><li>\u968f\u673a\u7ed3\u8282\u75c5\u8bd5\u9a8c\u62db\u52df\u4e86 22 \u53c2\u4e0e\u8005\uff1a12 \u63a5\u53d7 ARA-290 \u548c 10 \u5b89\u6170\u5242\u3002<\/li><li>4 \u5468\u7684 SFNSL \u53d8\u5316\u4e3a -11.5 \u00b1 3.04 \u4e0e -2.9 \u00b1 3.34\uff0c\u800c\u4e24\u7ec4\u7684\u75bc\u75db\u5f3a\u5ea6\u548c\u75b2\u52b3\u8bc4\u5206\u6539\u5584\u76f8\u4f3c\u3002<\/li><li>\u5728DME\u7814\u7a76\u4e2d\uff0c9\u5165\u7ec4\u5e76\u5b8c\u62108\uff1b\u5e73\u5747\u89c6\u529b\u3001\u89c6\u7f51\u819c\u539a\u5ea6\u3001\u89c6\u7f51\u819c\u654f\u611f\u6027\u548c\u6cea\u6db2\u4ea7\u751f\u91cf\u6ca1\u6709\u6539\u5584\u3002<\/li><\/ul><\/div><\/div><figure class=\"wp-block-image size-full pim-article-figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1672\" height=\"941\" src=\"http:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence.webp\" alt=\"\u897f\u5bbe\u80bd\u7684\u89d2\u819c\u548c\u5468\u56f4\u5c0f\u795e\u7ecf\u7ea4\u7ef4\u7814\u7a76\u6210\u50cf\" class=\"wp-image-733\" srcset=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence.webp 1672w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence-300x169.webp 300w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence-1024x576.webp 1024w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence-768x432.webp 768w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence-1536x864.webp 1536w\" sizes=\"auto, (max-width: 1672px) 100vw, 1672px\" \/><figcaption class=\"wp-element-caption\">\u539f\u59cb\u7f16\u8f91\u7814\u7a76\u63d2\u56fe\u3002\u5b83\u4e0d\u662f\u7814\u7a76\u56fe\u3001\u60a3\u8005\u56fe\u50cf\u3001\u4ea7\u54c1\u7167\u7247\u3001\u63d0\u4f9b\u7684\u5316\u9a8c\u7ed3\u679c\u6216\u76ee\u5f55\u6279\u6b21\u7684\u8868\u793a\u3002<\/figcaption><\/figure><h2 class=\"wp-block-heading\">\u5b66\u4e60\u8bb0\u5f55<\/h2><p class=\"wp-block-paragraph\">\u795e\u7ecf\u75c5\u98de\u884c\u5458\u62a5\u544a\u8bf4\uff0c\u5c0f\u7ea4\u7ef4\u795e\u7ecf\u75c5\u7b5b\u67e5\u540d\u5355\u4e2d\u7684\u7ec4\u95f4\u53d8\u5316\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u7136\u800c\uff0c\u4e24\u7ec4\u7684\u77ed\u6682\u75bc\u75db\u91cf\u8868\u548c\u75b2\u52b3\u8bc4\u5206\u5747\u663e\u7740\u6539\u5584\uff0c\u4f46\u6548\u679c\u76f8\u5f53\uff0c\u800c\u6291\u90c1\u91cf\u8868\u6ca1\u6709\u53d8\u5316\u3002<\/p><div class=\"wp-block-group pim-evidence-table\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"pim-evidence-row\"><strong>\u7ed3\u8282\u75c5\u8bbe\u8ba1<\/strong><span>\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u7167\u63a2\u7d22\u6027\u8bd5\u70b9\uff1b n=22<\/span><\/div><div class=\"pim-evidence-row\"><strong>SFNSL \u53d8\u5316<\/strong><span>4 \u5468\u65f6\u7684 \u221211.5 \u00b1 3.04 \u4e0e \u22122.9 \u00b1 3.34<\/span><\/div><div class=\"pim-evidence-row\"><strong>DME\u8bbe\u8ba1<\/strong><span>\u5355\u81c2\u76f82\uff1b 9 \u5df2\u6ce8\u518c\uff0c8 \u5df2\u5b8c\u6210<\/span><\/div><div class=\"pim-evidence-row\"><strong>DME\u4e3b\u8981\u63aa\u65bd<\/strong><span>BCVA\u3001CRT\u3001\u89c6\u7f51\u819c\u654f\u611f\u6027\u6216\u6cea\u6db2\u4ea7\u751f\u6ca1\u6709\u660e\u663e\u6539\u5584<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u6574\u4f53\u89e3\u8bfb<\/strong><span>\u4fe1\u53f7\u662f\u5047\u8bbe\u751f\u6210\u6027\u7684\uff0c\u800c\u4e0d\u662f\u9a8c\u8bc1\u6027\u7684<\/span><\/div><\/div><\/div><h2 class=\"wp-block-heading\">\u4e0a\u4e0b\u6587\u4e2d\u7684\u7ed3\u679c<\/h2><p class=\"wp-block-paragraph\">2020 \u7cd6\u5c3f\u75c5\u9ec4\u6591\u6c34\u80bf\u7814\u7a76\u7684\u89c4\u6a21\u751a\u81f3\u66f4\u5c0f\u3002\u5728 12 \u5468\uff0c\u5e73\u5747 BCVA \u53d8\u5316 -2.9 \u00b1 5.0\uff0c\u4e2d\u592e\u89c6\u7f51\u819c\u539a\u5ea6\u53d8\u5316 10 \u00b1 94.6 \u00b5m\uff0c\u4e2d\u592e\u89c6\u7f51\u819c\u7075\u654f\u5ea6\u53d8\u5316 -0.53 \u00b1 1.9 dB\u3002\u60a3\u8005\u62a5\u544a\u7684\u89c6\u89c9\u529f\u80fd\u7efc\u5408\u6539\u5584\u4e3a 2.7 \u00b1 3.1\uff0c\u4f46\u8bbe\u8ba1\u662f\u63cf\u8ff0\u6027\u7684\u4e14\u4e0d\u53d7\u63a7\u5236\u3002<\/p><p class=\"wp-block-paragraph\">DME \u8bba\u6587\u7684\u51e0\u4f4d\u4f5c\u8005\u662f\u5f00\u53d1\u5546\u7684\u5b98\u5458\u3001\u4e1a\u4e3b\u6216\u987e\u95ee\u3002\u8fd9\u79cd\u62ab\u9732\u5e76\u4e0d\u4f1a\u4f7f\u7ed3\u679c\u65e0\u6548\uff0c\u4f46\u5f53\u8bfb\u8005\u5224\u65ad\u4e00\u9879\u5c0f\u578b\u63a2\u7d22\u6027\u8bd5\u9a8c\u65f6\uff0c\u5b83\u5c5e\u4e8e\u6570\u636e\u7684\u4e00\u90e8\u5206\u3002<\/p><h2 class=\"wp-block-heading\">\u8bc1\u636e\u65e0\u6cd5\u8bc1\u5b9e\u4ec0\u4e48<\/h2><p class=\"wp-block-paragraph\">\u5c0f\u6837\u672c\u548c\u77ed\u968f\u8bbf\u4f7f\u5f97\u6548\u679c\u4f30\u8ba1\u4e0d\u7a33\u5b9a\u3002<\/p><p class=\"wp-block-paragraph\">\u4e0d\u540c\u7684\u75be\u75c5\u548c\u7ec8\u70b9\u4e0d\u80fd\u5408\u5e76\u6210\u4e00\u4e2a\u5e7f\u6cdb\u7684\u201c\u795e\u7ecf\u4fee\u590d\u201d\u4e3b\u5f20\u3002<\/p><p class=\"wp-block-paragraph\">\u4e24\u9879\u7814\u7a76\u5747\u672a\u5efa\u7acb\u4e0e\u76ee\u5f55\u6750\u6599\u7684\u7b49\u6548\u6027\uff0c\u4e5f\u4e0d\u652f\u6301\u5728\u7814\u7a76\u4e4b\u5916\u4f7f\u7528\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u4eba\u7c7b\u897f\u5bbe\u80bd\u8bc1\u636e\u5305\u62ec\u9488\u5bf9\u4e0d\u540c\u4eba\u7fa4\u7684\u5c0f\u578b\u63a2\u7d22\u6027\u7814\u7a76\u3002\u4e00\u9879 22 \u4eba\u7ed3\u8282\u75c5\u795e\u7ecf\u75c5\u8bd5\u70b9\u62a5\u544a\u4e86\u75c7\u72b6\u8bc4\u5206\u5dee\u5f02\uff0c\u800c\u4e00\u9879 9 \u4eba\u7cd6\u5c3f\u75c5\u9ec4\u6591\u6c34\u80bf\u7814\u7a76\u9519\u8fc7\u4e86\u4e3b\u8981\u7684\u773c\u90e8\u6d4b\u91cf\u7ed3\u679c\u3002<\/p>","protected":false},"author":1,"featured_media":733,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"315","pim_article_type":"Published evidence review","pim_evidence_level":"Small exploratory human trials; mixed endpoints and no confirmatory efficacy record","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, study size, model\/population limits and relevant conflicts are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary\/regulatory sources, factual claims, numerical results, limitations and product-evidence boundary checked for batch 3.","pim_creation_method":"The editorial workflow began with linked PubMed primary papers, systematic reviews, PubChem identity records and FDA\/DailyMed regulatory records. Population or model, denominators, endpoints, numerical results, null findings, limitations and conflicts were extracted before drafting. AI-assisted drafting and original image generation were used; the final facts and evidence boundaries were checked against the linked records on 2026-09-02. This is not independent peer review.","pim_sources":"[{\"title\":\"Randomized ARA-290 sarcoidosis-neuropathy pilot\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23168581\/\",\"note\":\"Primary exploratory trial; PMID 23168581.\"},{\"title\":\"Phase 2 cibinetide diabetic macular edema study\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32674280\/\",\"note\":\"Nine-person study with null principal ocular measures; PMID 32674280.\"},{\"title\":\"PubChem Cibinetide record\",\"url\":\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Cibinetide\",\"note\":\"Sequence, synonyms, formula and mass; CID 91810664.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-749","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>ARA-290\/Cibinetide: Small-Fiber Neuropathy and DME Trial Data<\/title>\n<meta name=\"description\" content=\"Human cibinetide evidence includes small exploratory studies with very different populations. 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