{"id":791,"date":"2026-09-01T17:35:05","date_gmt":"2026-09-01T17:35:05","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\/"},"modified":"2026-09-08T07:30:41","modified_gmt":"2026-09-08T07:30:41","slug":"melanotan-ii-human-pilot-toxicity-regulatory-evidence","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/cn\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\/","title":{"rendered":"Melanotan II\uff1a\u4eba\u7c7b\u98de\u884c\u5458\u6570\u636e\u3001\u6bd2\u6027\u548c\u76d1\u7ba1\u72b6\u51b5"},"content":{"rendered":"<p class=\"pim-standfirst wp-block-paragraph\">Melanotan II \u7684\u65e9\u671f\u4eba\u7c7b\u66b4\u9732\u6570\u636e\u6709\u9650\uff0c\u5e76\u8bb0\u5f55\u4e86\u4e0d\u53d7\u76d1\u7ba1\u4f7f\u7528\u9020\u6210\u7684\u5371\u5bb3\u3002\u4e09\u4eba\u6652\u9ed1\u98de\u884c\u5458\u7684\u5f71\u54cd\u4e0d\u80fd\u8d85\u8fc7\u540e\u6765\u7684\u6bd2\u6027\u62a5\u544a\u6216\u5f53\u524d\u76d1\u7ba1\u673a\u6784\u7684\u8b66\u544a\u3002<\/p><div class=\"wp-block-group pim-key-takeaways\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><h2 class=\"wp-block-heading\">\u8bc1\u636e\u4e00\u76ee\u4e86\u7136<\/h2><ul class=\"wp-block-list\"><li>1996 \u5355\u76f2\u8bd5\u9a8c\u62db\u52df\u4e86\u4e09\u540d\u5065\u5eb7\u7537\u6027\u5fd7\u613f\u8005\uff0c\u5e76\u4ea4\u66ff\u4f7f\u7528\u751f\u7406\u76d0\u6c34\u6216 Melanotan II \u5929\u3002<\/li><li>\u5728 0.03 mg\/kg \u5242\u91cf\u4e0b\uff0c\u4e24\u540d\u53c2\u4e0e\u8005\u4e4b\u4e00\u51fa\u73b0 II \u7ea7\u55dc\u7761\u548c\u75b2\u52b3\uff1b\u8fd8\u62a5\u544a\u4e86\u6076\u5fc3\u548c\u957f\u65f6\u95f4\u81ea\u53d1\u52c3\u8d77\u3002<\/li><li>\u4e00\u540d 39 \u5c81\u7537\u6027\u786e\u8bca 6 mg \u66b4\u9732\u540e\uff0c\u51fa\u73b0\u5fc3\u52a8\u8fc7\u901f\u3001\u80be\u529f\u80fd\u969c\u788d\uff0cCPK \u4ece 1,760 \u4e0a\u5347\u81f3 17,773 IU\/L\u3002<\/li><\/ul><\/div><\/div><figure class=\"wp-block-image size-full pim-article-figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1672\" height=\"941\" src=\"http:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/melanotan-ii-evidence.webp\" alt=\"\u8bb0\u5f55\u4e34\u5e8a\u6bd2\u7406\u5b66\u6848\u4f8b\u56de\u987e\" class=\"wp-image-775\" srcset=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/melanotan-ii-evidence.webp 1672w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/melanotan-ii-evidence-300x169.webp 300w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/melanotan-ii-evidence-1024x576.webp 1024w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/melanotan-ii-evidence-768x432.webp 768w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/melanotan-ii-evidence-1536x864.webp 1536w\" sizes=\"auto, (max-width: 1672px) 100vw, 1672px\" \/><figcaption class=\"wp-element-caption\">AI \u751f\u6210\u7684\u7f16\u8f91\u63d2\u56fe\u8bf4\u660e\u4e86\u7814\u7a76\u5de5\u4f5c\u6d41\u7a0b\u3002\u5b83\u4e0d\u662f\u7814\u7a76\u56fe\u3001\u60a3\u8005\u56fe\u50cf\u3001\u4ea7\u54c1\u7167\u7247\u3001\u5316\u9a8c\u7ed3\u679c\u6216\u76ee\u5f55\u6279\u6b21\u3002<\/figcaption><\/figure><h2 class=\"wp-block-heading\">\u5b66\u4e60\u8bb0\u5f55<\/h2><p class=\"wp-block-paragraph\">\u7b2c\u4e00\u9636\u6bb5\u8bd5\u70b9\u7684\u76ee\u7684\u662f\u89c2\u5bdf\u77ed\u671f\u5f71\u54cd\uff0c\u800c\u4e0d\u662f\u5efa\u7acb\u4eba\u53e3\u5b89\u5168\u3002\u4e09\u4e2a\u53c2\u4e0e\u8005\u4e0d\u8db3\u4ee5\u4f30\u8ba1\u4e0d\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u7ed3\u679c\u4e5f\u4e0d\u80fd\u9a8c\u8bc1\u5f53\u4eca\u7684\u4e92\u8054\u7f51\u4ea7\u54c1\u3002<\/p><div class=\"wp-block-group pim-evidence-table\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"pim-evidence-row\"><strong>1996\u98de\u884c\u5458<\/strong><span>3 \u5065\u5eb7\u7537\u6027\uff1b\u4ea4\u66ff\u751f\u7406\u76d0\u6c34\/MT-II\uff1b 0.01 \u81f3 0.025\u20130.03 \u6beb\u514b\/\u5343\u514b<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u5bfc\u9891\u4fe1\u53f7<\/strong><span>2 \u4e2d\u7684\u8272\u7d20\u6c89\u7740\uff1b\u636e\u62a5\u544a\u51fa\u73b0\u6076\u5fc3\u3001\u55dc\u7761\/\u75b2\u52b3\u548c\u52c3\u8d77<\/span><\/div><div class=\"pim-evidence-row\"><strong>2012\u6848\u4f8b<\/strong><span>39\u5c81\u7537\u5b50\uff1b 6 mg \u7f51\u8d2d\u7269\u8d28\u7ecf\u8d28\u8c31\u786e\u8ba4<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u5cf0\u503cCPK<\/strong><span>17,773 IU\/L \u5728 12 \u65f6\u95f4<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u76d1\u7ba1\u8fb9\u754c<\/strong><span>FDA\u5c06Melanotan II\u63cf\u8ff0\u4e3a\u672a\u7ecf\u6279\u51c6\u7684\u65b0\u836f\uff1b TGA\u53d1\u73b0\u7f51\u4e0a\u4ea7\u54c1\u5185\u5bb9\u4e0d\u4e00\u81f4<\/span><\/div><\/div><\/div><h2 class=\"wp-block-heading\">\u4e0a\u4e0b\u6587\u4e2d\u7684\u7ed3\u679c<\/h2><p class=\"wp-block-paragraph\">\u57282012\u6bd2\u7406\u5b66\u75c5\u4f8b\u4e2d\uff0c\u5fc3\u7387\u8fbe\u5230146\u6bcf\u5206\u949f\u6b21\uff0c\u808c\u9150\u4e3a2.25 mg\/dL\uff0cCPK\u968f\u540e\u572817,773 IU\/L\u8fbe\u5230\u5cf0\u503c\uff0c\u91cd\u75c7\u76d1\u62a4\u6cbb\u7597\u6301\u7eed\u4e09\u5929\u3002\u8d28\u8c31\u5206\u6790\u8bc1\u5b9e Melanotan II \u7b26\u5408\u6807\u51c6\uff0c\u5728\u4fdd\u7559\u5355\u4e00\u75c5\u4f8b\u7684\u540c\u65f6\u52a0\u5f3a\u4e86\u66b4\u9732\u5f52\u56e0\u3002<\/p><p class=\"wp-block-paragraph\">8 \u6708 2026\uff0c\u6fb3\u5927\u5229\u4e9a TGA \u62a5\u544a\u79f0\uff0c\u67e5\u83b7\u7684 5 \u4e2a\u6807\u6709 30 mg \u7684\u9f3b\u55b7\u96fe\u74f6\u4e2d\u4f30\u8ba1\u542b\u91cf\u4ece 22 \u5230 54 mg \u4e0d\u7b49\u3002\u8fd9\u79cd\u73b0\u5b9e\u4e16\u754c\u7684\u4e0d\u4e00\u81f4\u662f\u4e0e\u5206\u5b50\u836f\u7406\u5b66\u65e0\u5173\u7684\u4ea7\u54c1\u8d28\u91cf\u548c\u5242\u91cf\u98ce\u9669\u3002<\/p><h2 class=\"wp-block-heading\">\u8bc1\u636e\u65e0\u6cd5\u8bc1\u5b9e\u4ec0\u4e48<\/h2><p class=\"wp-block-paragraph\">\u4e09\u4e2a\u8bd5\u70b9\u6837\u672c\u65e0\u6cd5\u786e\u5b9a\u5b89\u5168\u6027\u6216\u6709\u6548\u6027\u3002<\/p><p class=\"wp-block-paragraph\">\u75c5\u4f8b\u62a5\u544a\u65e0\u6cd5\u4f30\u8ba1\u53d1\u75c5\u7387\uff0c\u4f46\u53ef\u4ee5\u8bb0\u5f55\u53ef\u80fd\u7684\u4e25\u91cd\u4e8b\u4ef6\u3002<\/p><p class=\"wp-block-paragraph\">\u4e0d\u80fd\u4ece\u6807\u7b7e\u4e2d\u63a8\u65ad\u51fa\u4e0d\u53d7\u7ba1\u5236\u7684\u4ea7\u54c1\u6210\u5206\uff0c\u5e76\u4e14\u76ee\u5f55\u7814\u7a76\u6750\u6599\u4e0d\u662f\u6279\u51c6\u7684\u836f\u7269\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>Melanotan II \u7684\u65e9\u671f\u4eba\u7c7b\u66b4\u9732\u6570\u636e\u6709\u9650\uff0c\u5e76\u8bb0\u5f55\u4e86\u4e0d\u53d7\u76d1\u7ba1\u4f7f\u7528\u9020\u6210\u7684\u5371\u5bb3\u3002\u4e09\u4eba\u6652\u9ed1\u98de\u884c\u5458\u7684\u5f71\u54cd\u4e0d\u80fd\u8d85\u8fc7\u540e\u6765\u7684\u6bd2\u6027\u62a5\u544a\u6216\u5f53\u524d\u76d1\u7ba1\u673a\u6784\u7684\u8b66\u544a\u3002<\/p>","protected":false},"author":1,"featured_media":775,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"350","pim_article_type":"Published evidence review","pim_evidence_level":"Three-person phase I pilot, case reports and current regulatory safety warnings","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, sample size, model\/population limits and regulatory scope are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary and official sources, numerical results, null findings, limitations, product-evidence boundary and image disclosure checked for batch 4.","pim_creation_method":"This article discusses the source records listed below, with the study models and limitations stated alongside the findings. AI-assisted drafting and image generation were used. The reference list identifies the records behind this article; it is not an independent peer review or verification of a supplied catalog lot.","pim_sources":"[{\"title\":\"Melanotan II pilot phase I study\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8637402\/\",\"note\":\"Three-person single-blind pilot; PMID 8637402.\"},{\"title\":\"Melanotan II systemic toxicity and rhabdomyolysis\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23121206\/\",\"note\":\"Mass-spectrometry-confirmed case report; PMID 23121206.\"},{\"title\":\"TGA finds inconsistent Melanotan II content\",\"url\":\"https:\/\/www.tga.gov.au\/safety\/safety-monitoring-and-information\/safety-alerts\/melanotan-ii-tanning-peptide-products-found-be-inconsistently-dosed\",\"note\":\"Official August 2026 laboratory-testing safety alert.\"},{\"title\":\"FDA Melanotan II enforcement record\",\"url\":\"https:\/\/www.fda.gov\/regulatory-information\/electronic-reading-room\/notice-opportunity-hearing-nooh-manookian-edward-8516\",\"note\":\"Official record describing Melanotan II as an unapproved new drug.\"},{\"title\":\"PubChem Melanotan II record\",\"url\":\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/melanotan-II\",\"note\":\"Cyclic sequence, formula and molecular weight; CID 92432.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-791","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Melanotan II: Human Pilot Data, Toxicity and Regulatory Status<\/title>\n<meta name=\"description\" content=\"Melanotan II has limited early human exposure data and documented harms from unregulated use. 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A three-person tanning pilot cannot outweigh later toxicity r\u2026\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nhdbio.com\/cn\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\/\" \/>\n<meta property=\"og:site_name\" content=\"NHD\" \/>\n<meta property=\"article:published_time\" content=\"2026-09-01T17:35:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-08T07:30:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/melanotan-ii-evidence.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1672\" \/>\n\t<meta property=\"og:image:height\" content=\"941\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"NHD Technical Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:description\" content=\"Peptide Raw Materials and Custom Peptide Synthesis\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"NHD Technical Team\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9884\u8ba1\u9605\u8bfb\u65f6\u95f4\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 \u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/nhdbio.com\\\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\\\/\"},\"author\":{\"name\":\"NHD Technical Team\",\"@id\":\"https:\\\/\\\/nhdbio.com\\\/#\\\/schema\\\/person\\\/0ffb0dec7fda0f720073fc468fac6fc1\"},\"headline\":\"Melanotan II: Human Pilot Data, Toxicity and Regulatory Status\",\"datePublished\":\"2026-09-01T17:35:05+00:00\",\"dateModified\":\"2026-09-08T07:30:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\\\/\"},\"wordCount\":334,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/nhdbio.com\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/melanotan-ii-evidence.webp\",\"articleSection\":[\"Published Study Reviews\"],\"inLanguage\":\"zh-Hans\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/nhdbio.com\\\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/nhdbio.com\\\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\\\/\",\"url\":\"https:\\\/\\\/nhdbio.com\\\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\\\/\",\"name\":\"Melanotan II: Human Pilot Data, Toxicity and Regulatory Status\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/melanotan-ii-human-pilot-toxicity-regulatory-evidence\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/nhdbio.com\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/melanotan-ii-evidence.webp\",\"datePublished\":\"2026-09-01T17:35:05+00:00\",\"dateModified\":\"2026-09-08T07:30:41+00:00\",\"description\":\"Melanotan II has limited early human exposure data and documented harms from unregulated use. 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