{"id":4340,"date":"2026-10-12T08:32:51","date_gmt":"2026-10-12T08:32:51","guid":{"rendered":"https:\/\/nhdbio.com\/?p=4340"},"modified":"2026-10-12T08:32:51","modified_gmt":"2026-10-12T08:32:51","slug":"motsc-c26-kachexie-teilweise-muskelerhaltung","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/de\/motsc-c26-cachexia-partial-muscle-preservation\/","title":{"rendered":"MOTS-c bewahrte etwas Muskelmasse: Warum sank das K\u00f6rpergewicht trotzdem?"},"content":{"rendered":"
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Editorial illustration, not an experimental photograph.<\/figcaption><\/figure>\n

Weight loss in cachexia is not just about eating less; it can also come with ongoing muscle loss. A C26 tumor mouse study found that MOTS-c partially protected muscle but did not stop overall wasting. Both results can be true at the same time.<\/p>\n

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Body weight is many parts added together<\/h2>\n

Body weight includes muscle, fat, water, organs, and more. Tumor mice are also affected by the tumor itself, so the scale alone cannot tell us whether muscle has been preserved.<\/p>\n

To study whether a material can protect muscle, we need to look directly at specific muscle weights, tissue changes, and function. If we only watch total weight, it is easy to miss local changes.<\/p>\n<\/section>\n

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The C26 model studies tumor-related wasting<\/h2>\n

The authors used male mice to form a Colon-26 tumor model and also did myotube cell experiments. Myotubes can be understood as cells in culture that are close to the form of muscle fibers.[1]<\/a><\/p>\n

They help study whether MOTS-c affects energy and breakdown signals in muscle. This is not a muscle-building experiment in healthy people, and it does not prove any treatment effect on the tumor itself.<\/p>\n<\/section>\n

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The quadriceps muscle was about 12% higher\u2014compared with whom?<\/h2>\n

The paper reports that after MOTS-c treatment, quadriceps weight was about 12% higher than in mice that also had tumors but received control treatment. The comparison group was another group of tumor-bearing mice, not healthy mice.[1]<\/a><\/p>\n

At the same time, the drop in overall body weight and fat was not prevented. Some muscles doing better does not mean the whole body has recovered, and a result from one muscle cannot be applied to all muscle groups or all functions.<\/p>\n