{"id":788,"date":"2026-09-01T17:35:05","date_gmt":"2026-09-01T17:35:05","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/sermorelin-ghrh-1-29-amide-identity-lcms-guide\/"},"modified":"2026-09-08T07:30:41","modified_gmt":"2026-09-08T07:30:41","slug":"sermorelin-ghrh-1-29-amide-identity-lcms-guide","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/de\/sermorelin-ghrh-1-29-amide-identity-lcms-guide\/","title":{"rendered":"Sermorelin-Identit\u00e4tsleitfaden: GHRH(1\u201329)-Amid und LC-MS"},"content":{"rendered":"<p class=\"pim-standfirst wp-block-paragraph\">Sermorelin ist ein amidiertes 29-Restpeptid, das der aktiven N-terminalen Region des menschlichen GHRH entspricht. Das C-terminale Amid ist identit\u00e4tsbestimmend.<\/p><div class=\"wp-block-group pim-key-takeaways\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><h2 class=\"wp-block-heading\">Beweise auf einen Blick<\/h2><ul class=\"wp-block-list\"><li>PubChem listet die Formel C149H246N44O42S und das Molekulargewicht 3357.9 g\/mol f\u00fcr Sermorelin auf.<\/li><li>Die Reihenfolge ist YADAIFTNSYRKVLGQLSARKLLQDIMSR-NH2.<\/li><li>Eine validierte Plasma-LC-HRMS\/MS-Methode ergab niedrigere Nachweisgrenzen unter 50 pg\/ml mit einer Wiederfindung von 19\u201337% und einer Ungenauigkeit unter 20%.<\/li><\/ul><\/div><\/div><figure class=\"wp-block-image size-full pim-article-figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1672\" height=\"941\" src=\"http:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality.webp\" alt=\"Dokumentarfilm LC-MS Core-Facility-Szene\" class=\"wp-image-772\" srcset=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality.webp 1672w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality-300x169.webp 300w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality-1024x576.webp 1024w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality-768x432.webp 768w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality-1536x864.webp 1536w\" sizes=\"auto, (max-width: 1672px) 100vw, 1672px\" \/><figcaption class=\"wp-element-caption\">Von AI generierte redaktionelle Illustration zur Veranschaulichung eines analytischen Arbeitsablaufs. Es stellt kein geliefertes Produkt, keine freigegebene Charge, keine genehmigte Formulierung oder kein Testergebnis dar.<\/figcaption><\/figure><h2 class=\"wp-block-heading\">Identit\u00e4tsdatensatz<\/h2><p class=\"wp-block-paragraph\">F\u00fcr die freie Base Sermorelin und Sermorelin-Acetat ist eine separate Massen- und Inhaltserfassung erforderlich. Auf dem Etikett sollte deutlich gemacht werden, ob sich die Katalogmenge auf das Gesamtmaterial oder das Peptid\u00e4quivalent bezieht.<\/p><div class=\"wp-block-group pim-evidence-table\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"pim-evidence-row\"><strong>L\u00e4nge<\/strong><span>29 Aminos\u00e4uren<\/span><\/div><div class=\"pim-evidence-row\"><strong>Terminalform<\/strong><span>C-terminales Amid<\/span><\/div><div class=\"pim-evidence-row\"><strong>Formel und Masse<\/strong><span>C149H246N44O42S; 3357.9 g\/mol<\/span><\/div><div class=\"pim-evidence-row\"><strong>PubChem<\/strong><span>CID 16132413<\/span><\/div><div class=\"pim-evidence-row\"><strong>Human-Plasma-Methode<\/strong><span>Immunaffinit\u00e4tsreinigung plus Nano-UHPLC-HRMS\/MS<\/span><\/div><\/div><\/div><h2 class=\"wp-block-heading\">Analyse- und Beweisgrenze<\/h2><p class=\"wp-block-paragraph\">Die 2016-Nachweisstudie zeigte die analytische Wiederfindung von Sermorelin und verwandten GHRH-Analoga aus angereichertem menschlichem Plasma. Es handelte sich um eine Anti-Doping-Methodenvalidierungsstudie, nicht um eine therapeutische Wirksamkeitsstudie.<\/p><p class=\"wp-block-paragraph\">Eine vollst\u00e4ndige Chargenaufzeichnung sollte Sequenz- oder hochaufl\u00f6sende Informationen zu intakter Masse, Chromatographie, Inhaltsbasis, Wasser und Gegenionen enthalten. Eine Plasmanachweisgrenze ersetzt nicht die Produktfreigabespezifikationen.<\/p><h2 class=\"wp-block-heading\">Redaktionelle Regel<\/h2><p class=\"wp-block-paragraph\">Geben Sie das genaue Material, die Form, das Modell oder die Population und den Endpunkt an, die durch den zitierten Datensatz unterst\u00fctzt werden. Wandeln Sie keine mechanistische Plausibilit\u00e4t, ein Tierergebnis, ein offizielles Etikett eines Fertigarzneimittels oder einen analytischen Test in eine Aussage \u00fcber eine nicht verwandte Katalogcharge um.<\/p>","protected":false},"excerpt":{"rendered":"<p>Sermorelin ist ein amidiertes 29-Restpeptid, das der aktiven N-terminalen Region des menschlichen GHRH entspricht. Das C-terminale Amid ist identit\u00e4tsbestimmend.<\/p>","protected":false},"author":1,"featured_media":772,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"362","pim_article_type":"Evidence and material-quality guide","pim_evidence_level":"PubChem sequence identity plus validated human-plasma detection literature","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, sample size, model\/population limits and regulatory scope are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary and official sources, numerical results, null findings, limitations, product-evidence boundary and image disclosure checked for batch 4.","pim_creation_method":"This article discusses the source records listed below, with the study models and limitations stated alongside the findings. AI-assisted drafting and image generation were used. The reference list identifies the records behind this article; it is not an independent peer review or verification of a supplied catalog lot.","pim_sources":"[{\"title\":\"GRF1-29 stimulation in normal subjects\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6240568\/\",\"note\":\"Primary human physiology study; PMID 6240568.\"},{\"title\":\"Low-dose GHRH(1\u201329)-amide dose-response study\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7921207\/\",\"note\":\"Primary human dose-response study; PMID 7921207.\"},{\"title\":\"Sermorelin pediatric review\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18031173\/\",\"note\":\"Historical diagnostic and pediatric treatment review; PMID 18031173.\"},{\"title\":\"GHRH analog detection in human plasma\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26879649\/\",\"note\":\"Validated LC-HRMS\/MS method; PMID 26879649.\"},{\"title\":\"PubChem Sermorelin record\",\"url\":\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Sermorelin\",\"note\":\"Sequence, formula and molecular weight; CID 16132413.\"}]","footnotes":""},"categories":[20],"tags":[],"class_list":["post-788","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evidence-quality-guides"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Sermorelin Identity Guide: GHRH(1\u201329)-Amide and LC-MS<\/title>\n<meta name=\"description\" content=\"Sermorelin is an amidated 29-residue peptide corresponding to the active N-terminal region of human GHRH. 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