{"id":792,"date":"2026-09-01T17:35:05","date_gmt":"2026-09-01T17:35:05","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/melanotan-ii-cyclic-peptide-identity-quality-guide\/"},"modified":"2026-09-08T07:30:41","modified_gmt":"2026-09-08T07:30:41","slug":"melanotan-ii-cyclic-peptide-identity-quality-guide","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/de\/melanotan-ii-cyclic-peptide-identity-quality-guide\/","title":{"rendered":"Melanotan II Identity Guide: Zyklischer Ablauf und Qualit\u00e4tsrisiken"},"content":{"rendered":"

Melanotan II is a cyclic heptapeptide analogue of \u03b1-MSH. Its lactam ring, D-phenylalanine and terminal modifications are identity-defining.<\/p>

Evidence at a glance<\/h2>
  • PubChem lists formula C50H69N15O9, molecular weight 1024.2 g\/mol and CID 92432.<\/li>
  • The condensed sequence is Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-NH2, with a side-chain lactam bridge.<\/li>
  • Regulator testing of online products found large between-bottle content differences, so appearance and label strength are not identity evidence.<\/li><\/ul><\/div><\/div>
    \"Documentary
    AI-generated editorial illustration illustrating an analytical workflow. It does not depict a supplied product, released lot, approved formulation or assay result.<\/figcaption><\/figure>

    Identity record<\/h2>

    A linear peptide with the same residue list is not Melanotan II. Ring closure changes mass, conformation and chromatographic behavior; stereochemistry at D-Phe also needs to match the reference.<\/p>

    Sequence<\/strong>Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2<\/span><\/div>
    Formula and mass<\/strong>C50H69N15O9; 1024.2 g\/mol<\/span><\/div>
    PubChem<\/strong>CID 92432<\/span><\/div>
    Critical features<\/strong>N-acetylation, norleucine, D-Phe, lactam closure and C-terminal amide<\/span><\/div>
    Core tests<\/strong>Intact mass, peptide mapping, ring\/sequence evidence, purity, content and aggregation<\/span><\/div><\/div><\/div>

    Analytical and evidence boundary<\/h2>

    Peptide-related impurities and aggregation can create immunogenicity concerns for some routes. FDA\u2019s compounding safety page explicitly identifies these concerns for Melanotan II.<\/p>

    Do not use \u201ctanning peptide\u201d as if it were an approved indication. The FDA record describes Melanotan II as an unapproved new drug, and research-use copy should not provide consumer administration guidance.<\/p>

    Editorial rule<\/h2>

    State the exact material, form, model or population and endpoint supported by the cited record. Do not convert mechanistic plausibility, an animal result, an official finished-drug label or an analytical test into a claim about an unrelated catalog lot.<\/p>","protected":false},"excerpt":{"rendered":"

    Melanotan II ist ein zyklisches Heptapeptid-Analogon von \u03b1-MSH. Sein Lactamring, D-Phenylalanin und terminale Modifikationen sind identit\u00e4tsbestimmend.<\/p>","protected":false},"author":1,"featured_media":776,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"350","pim_article_type":"Evidence and material-quality guide","pim_evidence_level":"PubChem identity, primary human exposure and regulator-tested product data","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, sample size, model\/population limits and regulatory scope are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary and official sources, numerical results, null findings, limitations, product-evidence boundary and image disclosure checked for batch 4.","pim_creation_method":"This article discusses the source records listed below, with the study models and limitations stated alongside the findings. AI-assisted drafting and image generation were used. The reference list identifies the records behind this article; it is not an independent peer review or verification of a supplied catalog lot.","pim_sources":"[{\"title\":\"Melanotan II pilot phase I study\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8637402\/\",\"note\":\"Three-person single-blind pilot; PMID 8637402.\"},{\"title\":\"Melanotan II systemic toxicity and rhabdomyolysis\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23121206\/\",\"note\":\"Mass-spectrometry-confirmed case report; PMID 23121206.\"},{\"title\":\"TGA finds inconsistent Melanotan II content\",\"url\":\"https:\/\/www.tga.gov.au\/safety\/safety-monitoring-and-information\/safety-alerts\/melanotan-ii-tanning-peptide-products-found-be-inconsistently-dosed\",\"note\":\"Official August 2026 laboratory-testing safety alert.\"},{\"title\":\"FDA Melanotan II enforcement record\",\"url\":\"https:\/\/www.fda.gov\/regulatory-information\/electronic-reading-room\/notice-opportunity-hearing-nooh-manookian-edward-8516\",\"note\":\"Official record describing Melanotan II as an unapproved new drug.\"},{\"title\":\"PubChem Melanotan II record\",\"url\":\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/melanotan-II\",\"note\":\"Cyclic sequence, formula and molecular weight; CID 92432.\"}]","footnotes":""},"categories":[20],"tags":[],"class_list":["post-792","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evidence-quality-guides"],"yoast_head":"\nMelanotan II Identity Guide: Cyclic Sequence and Quality Risks<\/title>\n<meta name=\"description\" content=\"Melanotan II is a cyclic heptapeptide analogue of \u03b1-MSH. 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