{"id":788,"date":"2026-09-01T17:35:05","date_gmt":"2026-09-01T17:35:05","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/sermorelin-ghrh-1-29-amide-identity-lcms-guide\/"},"modified":"2026-09-08T07:30:41","modified_gmt":"2026-09-08T07:30:41","slug":"sermorelin-ghrh-1-29-amide-identity-lcms-guide","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/fr\/sermorelin-ghrh-1-29-amide-identity-lcms-guide\/","title":{"rendered":"Guide d'identit\u00e9 Sermorelin\u00a0: GHRH(1\u201329)-Amide et LC-MS"},"content":{"rendered":"<p class=\"pim-standfirst wp-block-paragraph\">Sermorelin est un peptide r\u00e9siduaire 29 amid\u00e9 correspondant \u00e0 la r\u00e9gion N-terminale active du GHRH humain. L\u2019amide C-terminal d\u00e9finit l\u2019identit\u00e9.<\/p><div class=\"wp-block-group pim-key-takeaways\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><h2 class=\"wp-block-heading\">Les preuves en un coup d'\u0153il<\/h2><ul class=\"wp-block-list\"><li>PubChem r\u00e9pertorie la formule C149H246N44O42S et le poids mol\u00e9culaire 3357.9 g\/mol pour Sermorelin.<\/li><li>La s\u00e9quence est YADAIFTNSYRKVLGQLSARKLLQDIMSR-NH2.<\/li><li>Une m\u00e9thode LC-HRMS\/MS plasmatique valid\u00e9e a rapport\u00e9 des limites inf\u00e9rieures de d\u00e9tection inf\u00e9rieures \u00e0 50 pg\/mL avec r\u00e9cup\u00e9ration de 19 \u2013 37% et impr\u00e9cision inf\u00e9rieure \u00e0 20%.<\/li><\/ul><\/div><\/div><figure class=\"wp-block-image size-full pim-article-figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1672\" height=\"941\" src=\"http:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality.webp\" alt=\"Sc\u00e8ne de la plateforme documentaire LC-MS\" class=\"wp-image-772\" srcset=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality.webp 1672w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality-300x169.webp 300w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality-1024x576.webp 1024w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality-768x432.webp 768w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/sermorelin-quality-1536x864.webp 1536w\" sizes=\"auto, (max-width: 1672px) 100vw, 1672px\" \/><figcaption class=\"wp-element-caption\">Illustration \u00e9ditoriale g\u00e9n\u00e9r\u00e9e par AI illustrant un flux de travail analytique. Il ne repr\u00e9sente pas un produit fourni, un lot lib\u00e9r\u00e9, une formulation approuv\u00e9e ou un r\u00e9sultat d'analyse.<\/figcaption><\/figure><h2 class=\"wp-block-heading\">Fiche d'identit\u00e9<\/h2><p class=\"wp-block-paragraph\">Les Sermorelin et les ac\u00e9tates Sermorelin \u00e0 base libre n\u00e9cessitent une comptabilit\u00e9 de masse et de contenu distincte. L'\u00e9tiquette doit indiquer clairement si la quantit\u00e9 catalogue fait r\u00e9f\u00e9rence au mat\u00e9riel total ou \u00e0 l'\u00e9quivalent peptidique.<\/p><div class=\"wp-block-group pim-evidence-table\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"pim-evidence-row\"><strong>Longueur<\/strong><span>Acides amin\u00e9s 29<\/span><\/div><div class=\"pim-evidence-row\"><strong>Formulaire de terminal<\/strong><span>Amide C-terminal<\/span><\/div><div class=\"pim-evidence-row\"><strong>Formule et masse<\/strong><span>C149H246N44O42S\u00a0; 3357.9g\/mol<\/span><\/div><div class=\"pim-evidence-row\"><strong>PubChem<\/strong><span>CID 16132413<\/span><\/div><div class=\"pim-evidence-row\"><strong>M\u00e9thode plasma humain<\/strong><span>Purification par immunoaffinit\u00e9 et nano-UHPLC-HRMS\/MS<\/span><\/div><\/div><\/div><h2 class=\"wp-block-heading\">Limite analytique et de preuve<\/h2><p class=\"wp-block-paragraph\">L'\u00e9tude de d\u00e9tection du 2016 a d\u00e9montr\u00e9 une r\u00e9cup\u00e9ration analytique du plasma humain enrichi pour le Sermorelin et les analogues du GHRH associ\u00e9s. Il s\u2019agissait d\u2019une \u00e9tude de validation de m\u00e9thode antidopage et non d\u2019une \u00e9tude d\u2019efficacit\u00e9 th\u00e9rapeutique.<\/p><p class=\"wp-block-paragraph\">Un enregistrement de lot complet doit combiner des informations sur la s\u00e9quence ou la masse intacte \u00e0 haute r\u00e9solution, la chromatographie, la base du contenu, l'eau et les contre-ions. Une limite de d\u00e9tection du plasma ne remplace pas les sp\u00e9cifications de lib\u00e9ration du produit.<\/p><h2 class=\"wp-block-heading\">R\u00e8gle \u00e9ditoriale<\/h2><p class=\"wp-block-paragraph\">Indiquez le mat\u00e9riau exact, la forme, le mod\u00e8le ou la population et le point final pris en charge par l'enregistrement cit\u00e9. Ne convertissez pas la plausibilit\u00e9 m\u00e9caniste, un r\u00e9sultat animal, une \u00e9tiquette officielle d'un m\u00e9dicament fini ou un test analytique en une all\u00e9gation concernant un lot du catalogue sans rapport.<\/p>","protected":false},"excerpt":{"rendered":"<p>Sermorelin est un peptide r\u00e9siduaire 29 amid\u00e9 correspondant \u00e0 la r\u00e9gion N-terminale active du GHRH humain. L\u2019amide C-terminal d\u00e9finit l\u2019identit\u00e9.<\/p>","protected":false},"author":1,"featured_media":772,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"362","pim_article_type":"Evidence and material-quality guide","pim_evidence_level":"PubChem sequence identity plus validated human-plasma detection literature","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, sample size, model\/population limits and regulatory scope are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary and official sources, numerical results, null findings, limitations, product-evidence boundary and image disclosure checked for batch 4.","pim_creation_method":"This article discusses the source records listed below, with the study models and limitations stated alongside the findings. AI-assisted drafting and image generation were used. The reference list identifies the records behind this article; it is not an independent peer review or verification of a supplied catalog lot.","pim_sources":"[{\"title\":\"GRF1-29 stimulation in normal subjects\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6240568\/\",\"note\":\"Primary human physiology study; PMID 6240568.\"},{\"title\":\"Low-dose GHRH(1\u201329)-amide dose-response study\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7921207\/\",\"note\":\"Primary human dose-response study; PMID 7921207.\"},{\"title\":\"Sermorelin pediatric review\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18031173\/\",\"note\":\"Historical diagnostic and pediatric treatment review; PMID 18031173.\"},{\"title\":\"GHRH analog detection in human plasma\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26879649\/\",\"note\":\"Validated LC-HRMS\/MS method; PMID 26879649.\"},{\"title\":\"PubChem Sermorelin record\",\"url\":\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Sermorelin\",\"note\":\"Sequence, formula and molecular weight; CID 16132413.\"}]","footnotes":""},"categories":[20],"tags":[],"class_list":["post-788","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evidence-quality-guides"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Sermorelin Identity Guide: GHRH(1\u201329)-Amide and LC-MS<\/title>\n<meta name=\"description\" content=\"Sermorelin is an amidated 29-residue peptide corresponding to the active N-terminal region of human GHRH. 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