{"id":2695,"date":"2026-09-26T04:34:36","date_gmt":"2026-09-26T04:34:36","guid":{"rendered":"https:\/\/nhdbio.com\/temporin-a-counterion-selectivity-136-022-060-study\/"},"modified":"2026-10-01T14:29:48","modified_gmt":"2026-10-01T14:29:48","slug":"%e3%83%86%e3%83%b3%e3%83%9d%e3%83%aa%e3%83%b3a%e3%81%ae%e5%af%be%e3%82%a4%e3%82%aa%e3%83%b3%e9%81%b8%e6%8a%9e%e6%80%a7%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e7%a0%94%e7%a9%b6-136-022-060","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ja\/temporin-a-counterion-selectivity-136-022-060-study\/","title":{"rendered":"\u30c6\u30f3\u30dd\u30ea\u30f3A\u306e\u5869\u5f62\u614b\uff1a\u5bfe\u30a4\u30aa\u30f3\u306b\u3088\u3063\u3066\u9078\u629e\u6027\u6307\u6570\u304c\u5909\u5316\u3059\u308b\u7406\u7531"},"content":{"rendered":"<p>in vitro\u3067\u306e\u6297\u83cc\u6027\u8a66\u9a13\u306e\u7d50\u679c\u304b\u3089\u3001\u306a\u305c\u5869\u5f62\u614b\u304c\u6750\u6599\u306e\u7d44\u6210\u306b\u542b\u307e\u308c\u308b\u3079\u304d\u306a\u306e\u304b\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002.<\/p>\n<h2>\u3053\u306e\u7814\u7a76\u3067\u5b9f\u969b\u306b\u691c\u8a3c\u3055\u308c\u305f\u3053\u3068<\/h2>\n<p>\u7814\u7a76\u8005\u3089\u306f\u30015\u7a2e\u985e\u306e\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u306e\u9162\u9178\u5869\u3001\u5869\u5316\u7269\u3001\u304a\u3088\u3073\u30c8\u30ea\u30d5\u30eb\u30aa\u30ed\u9162\u9178\u5869\u3092\u8abf\u88fd\u3057\u3001\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306b\u5bfe\u3059\u308b\u6d3b\u6027\u3092\u3001\u8d64\u8840\u7403\u6eb6\u8840\u304a\u3088\u3073\u7d30\u80de\u30d9\u30fc\u30b9\u306e\u6bd2\u6027\u3068\u3068\u3082\u306b\u6e2c\u5b9a\u3057\u305f\u3002 \u30c6\u30f3\u30dd\u30ea\u30f3A\u306b\u3064\u3044\u3066\u306f\u3001\u88686\u306b\u793a\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001TFA\u5869\u306e\u9078\u629e\u6027\u6307\u6570\u306f1.34\u3001\u9162\u9178\u5869\u306f0.22\u3001\u5869\u5316\u7269\u5869\u306f0.60\u3067\u3042\u3063\u305f\u3002\u305d\u306e\u4ed6\u306e\u8a66\u9a13\u5bfe\u8c61\u30da\u30d7\u30c1\u30c9\u306b\u3064\u3044\u3066\u306f\u3001\u5869\u306e\u6027\u80fd\u306b\u4e00\u8cab\u3057\u305f\u9806\u4f4d\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002.<\/p>\n<h2>\u6587\u8108\u3092\u8e0f\u307e\u3048\u3066\u8aad\u3080\u4fa1\u5024\u306e\u3042\u308b\u6570\u5b57<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u7814\u7a76\u624b\u6cd5<\/th>\n<th>\u5831\u544a\u3055\u308c\u305f\u7d50\u679c<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u30c6\u30f3\u30dd\u30ea\u30f3A TFA<\/td>\n<td>1.34\uff08\u88686\uff09<\/td>\n<\/tr>\n<tr>\n<td>\u9162\u9178\u30c6\u30f3\u30dd\u30ea\u30f3A<\/td>\n<td>0.22<\/td>\n<\/tr>\n<tr>\n<td>\u30c6\u30f3\u30dd\u30ea\u30f3A\u5869\u5316\u7269<\/td>\n<td>0.60<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u9078\u629e\u6027\u6307\u6570\u306f\u3001\u672c\u8ad6\u6587\u306e\u8a66\u9a13\u7d50\u679c\u306b\u57fa\u3065\u304f\u6bd4\u7387\u3067\u3042\u308a\u3001\u81e8\u5e8a\u7684\u306a\u6709\u52b9\u6027\u3084\u5b89\u5168\u6027\u306e\u30b9\u30b3\u30a2\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u6bd4\u8f03\u306b\u304a\u3044\u3066\u6570\u5024\u304c\u6700\u3082\u9ad8\u3044\u304b\u3089\u3068\u3044\u3063\u3066\u3001TFA\u304c\u666e\u904d\u7684\u306b\u597d\u307e\u3057\u3044\u5869\u3067\u3042\u308b\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002\u540c\u7814\u7a76\u3067\u306f\u3001\u30da\u30d7\u30c1\u30c9\u306b\u4f9d\u5b58\u3059\u308b\u5dee\u7570\u3084\u8907\u6570\u306e\u8a66\u9a13\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u3064\u3044\u3066\u3082\u8a00\u53ca\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8a66\u9a13\u5bfe\u8c61\u3068\u306a\u3063\u305f\u30ed\u30c3\u30c8\u3001\u5fae\u751f\u7269\u3001\u304a\u3088\u3073\u7d30\u80de\u7cfb\u304c\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u7bc4\u56f2\u3092\u5b9a\u7fa9\u3057\u3066\u3044\u307e\u3059\u3002.<\/p>\n<h2>\u306a\u305c\u3053\u306e\u8ad6\u6587\u306b\u306f1.36\u3082\u542b\u307e\u308c\u3066\u3044\u308b\u306e\u304b<\/h2>\n<p>\u3053\u306e\u8b70\u8ad6\u3067\u306f\u3001\u30c6\u30f3\u30dd\u30ea\u30f3A\u30c8\u30ea\u30d5\u30eb\u30aa\u30ed\u9162\u9178\u5869\u306e\u5024\u3068\u3057\u30661.36\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u306e\u306b\u5bfe\u3057\u3001\u88686\u3067\u306f1.34\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u8868\u306b\u8a18\u8f09\u3055\u308c\u305fIC50\u50247.91 \u00b5g\/mL\u3092\u5e73\u5747MIC\u50245.9 \u00b5g\/mL\u3067\u5272\u308b\u3068\u3001\u7d041.34\u3068\u306a\u308b\u3002 \u4e21\u6570\u5024\u3092\u4e92\u63db\u6027\u304c\u3042\u308b\u3082\u306e\u3068\u3057\u3066\u6271\u3046\u306e\u3067\u306f\u306a\u304f\u3001\u8868\u306e\u5024\u3092\u63a1\u7528\u3057\u3001\u4e0d\u4e00\u81f4\u304c\u3042\u308b\u3053\u3068\u3092\u660e\u8a18\u3059\u308b\u3002\u3053\u306e\u4fee\u6b63\u306b\u3088\u3063\u3066\u3001\u751f\u7269\u5b66\u7684\u30a2\u30c3\u30bb\u30a4\u306b\u304a\u3051\u308b\u4e0d\u78ba\u5b9f\u6027\u304c\u89e3\u6d88\u3055\u308c\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u81e8\u5e8a\u7684\u5b89\u5168\u57df\u304c\u78ba\u7acb\u3055\u308c\u308b\u308f\u3051\u3067\u3082\u306a\u3044\u3002.<\/p>\n<h2>\u898b\u7a4d\u4f9d\u983c\u66f8\uff08RFQ\uff09\u3084\u5b9f\u9a13\u8a08\u753b\u66f8\u306b\u8a18\u8f09\u3059\u3079\u304d\u5185\u5bb9<\/h2>\n<p>\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u306e\u5b9f\u9a13\u3092\u518d\u73fe\u3059\u308b\u969b\u306f\u3001\u30da\u30d7\u30c1\u30c9\u914d\u5217\u3068\u5bfe\u30a4\u30aa\u30f3\u3092\u4f75\u305b\u3066\u660e\u8a18\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u6fc3\u5ea6\u304c\u300c\u7dcf\u5869\u8cea\u91cf\u300d\u3068\u3057\u3066\u8868\u3055\u308c\u3066\u3044\u308b\u306e\u304b\u3001\u305d\u308c\u3068\u3082\u300c\u30da\u30d7\u30c1\u30c9\u542b\u6709\u91cf\u300d\u3068\u3057\u3066\u8868\u3055\u308c\u3066\u3044\u308b\u306e\u304b\u3092\u8a18\u9332\u3057\u3001\u7cbe\u88fd\u6eb6\u5a92\u304b\u3089\u63a8\u6e2c\u3055\u308c\u308b\u540d\u79f0\u3067\u306f\u306a\u304f\u3001\u5b9f\u969b\u306b\u6e2c\u5b9a\u3055\u308c\u305f\u5bfe\u30a4\u30aa\u30f3\u306e\u7d44\u6210\u3092\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u751f\u7269\u5b66\u7684\u7d50\u679c\u3092\u6bd4\u8f03\u3059\u308b\u306e\u306f\u3001\u6750\u6599\u304a\u3088\u3073\u30a2\u30c3\u30bb\u30a4\u6761\u4ef6\u3092\u7d71\u4e00\u3057\u305f\u5f8c\u306e\u307f\u306b\u3057\u3066\u304f\u3060\u3055\u3044\u3002.<\/p>\n<h2>\u8a3c\u62e0\u306e\u5883\u754c\u7dda<\/h2>\n<p>\u672c\u8a18\u4e8b\u306f\u3001\u5916\u90e8\u306b\u3088\u308bin vitro\u7814\u7a76\u3092\u307e\u3068\u3081\u305f\u3082\u306e\u3067\u3059\u3002\u672c\u8a18\u4e8b\u306f\u3001\u3044\u304b\u306a\u308b\u6cbb\u7642\u6cd5\u306e\u63a8\u5968\u3082\u884c\u308f\u305a\u3001\u30d2\u30c8\u306b\u304a\u3051\u308b\u6cbb\u7642\u52b9\u679c\u3092\u4e3b\u5f35\u3059\u308b\u3082\u306e\u3067\u3082\u306a\u304f\u3001NHD\u30ed\u30c3\u30c8\u306e\u7d50\u679c\u306b\u3064\u3044\u3066\u3082\u5831\u544a\u3057\u3066\u3044\u307e\u305b\u3093\u3002.<\/p>\n<h2>\u60c5\u5831\u6e90\u3068\u4eca\u5f8c\u306e\u5bfe\u5fdc<\/h2>\n<p>\u4e00\u6b21\u8abf\u67fb\uff1a <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5917001\/\">\u7279\u5b9a\u306e\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u306e\u6297\u30d6\u30c9\u30a6\u7403\u83cc\u6d3b\u6027\u304a\u3088\u3073\u7d30\u80de\u6bd2\u6027\u306b\u5bfe\u3059\u308b\u5bfe\u30a4\u30aa\u30f3\u52b9\u679c<\/a>. \u3053\u308c\u3089\u306e\u5916\u90e8\u30c7\u30fc\u30bf\u306f\u3001NHD\u30ed\u30c3\u30c8\u306e\u8a66\u9a13\u7d50\u679c\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002.<\/p>\n<p>\u95a2\u9023\u3059\u308bNHD\u30ac\u30a4\u30c9\uff1a <a href=\"https:\/\/nhdbio.com\/ja\/%e3%83%9a%e3%83%97%e3%83%81%e3%83%89%e3%80%81%e5%af%be%e3%82%a4%e3%82%aa%e3%83%b3%e3%80%81%e6%b0%b4%e3%80%81%e6%ae%8b%e7%95%99%e6%ba%b6%e5%aa%92%e3%80%81%e6%ad%a3%e5%91%b3%e5%86%85%e5%ae%b9%e9%87%8f\/\">\u95a2\u9023\u8a18\u4e8b\u3092\u8aad\u3080<\/a>. \u6750\u6599\u306b\u95a2\u3059\u308b\u5177\u4f53\u7684\u306a\u8cea\u554f\u306b\u3064\u3044\u3066\u306f\u3001, <a href=\"https:\/\/nhdbio.com\/ja\/%e5%bc%95%e7%94%a8\/\">\u66f8\u9762\u306b\u3088\u308b\u898b\u7a4d\u3082\u308a\u306e\u4f9d\u983c<\/a> \u305d\u306e\u9806\u5e8f\u3001\u91d1\u984d\u3001\u4f7f\u7528\u76ee\u7684\u3001\u304a\u3088\u3073\u5fc5\u8981\u306a\u8a18\u9332\u306b\u3064\u3044\u3066\u3002.<\/p>","protected":false},"excerpt":{"rendered":"<p>in vitro\u3067\u306e\u6297\u83cc\u6027\u8a66\u9a13\u306e\u7d50\u679c\u304b\u3089\u3001\u306a\u305c\u5869\u5f62\u614b\u304c\u6750\u6599\u306e\u7d44\u6210\u306b\u542b\u307e\u308c\u308b\u3079\u304d\u306a\u306e\u304b\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002.<\/p>","protected":false},"author":1,"featured_media":2742,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"","pim_article_type":"Primary-literature evidence note","pim_evidence_level":"External laboratory or process evidence; not clinical or NHD lot validation","pim_reviewer":"AI-assisted source cross-check (not independent expert peer review)","pim_reviewed_date":"2026-09-28","pim_editorial_note":"This article summarizes external in-vitro research. It makes no treatment recommendation, claims no human outcome, and does not report an NHD lot result.","pim_review_status":"reviewed","pim_review_reason":"","pim_creation_method":"AI-assisted writing and source verification. Numerical claims were checked against the linked full-text records, with source inconsistencies identified in the article. This is not independent scientific peer review or verification of a supplied lot.","pim_sources":"[{\"title\":\"Counter-ion effect on antistaphylococcal activity and cytotoxicity of selected antimicrobial peptides\",\"url\":\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5917001\/\",\"note\":\"\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-2695","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Temporin A Salt Forms: Why Selectivity Index Changed Across Counterions - NHD<\/title>\n<meta name=\"description\" content=\"An in-vitro antimicrobial study shows why the salt form belongs in the material identity. 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