{"id":3099,"date":"2026-10-04T13:31:01","date_gmt":"2026-10-04T13:31:01","guid":{"rendered":"https:\/\/nhdbio.com\/?p=3099"},"modified":"2026-10-11T07:41:07","modified_gmt":"2026-10-11T07:41:07","slug":"mots-c-two-methionines-oxidation-mass-check","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ja\/mots-c-two-methionines-oxidation-mass-check\/","title":{"rendered":"MOTS-c\u3068+16 Da\u30b7\u30b0\u30ca\u30eb\uff1a\u9178\u5316\u5019\u88dc\u3092\u691c\u8a0e\u3059\u308b"},"content":{"rendered":"<p>MOTS-c\u306e\u30b7\u30b0\u30ca\u30eb\u306f\u3001\u4e88\u60f3\u3088\u308a\u7d0416 Da\u91cd\u304f\u73fe\u308c\u3066\u3044\u307e\u3059\u3002\u9178\u5316\u306f\u691c\u8a0e\u3059\u3079\u304d\u53ef\u80fd\u6027\u306e\u4e00\u3064\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u624b\u304c\u304b\u308a\u3092\u7406\u89e3\u3059\u308b\u306b\u306f\u3001\u307e\u305a\u8a72\u5f53\u3059\u308b\u30a2\u30df\u30ce\u9178\u3092\u898b\u3064\u3051\u3001\u30d7\u30ed\u30c3\u30c8\u304c\u5206\u5b50\u91cf\u3092\u793a\u3057\u3066\u3044\u308b\u306e\u304bm\/z\u3092\u793a\u3057\u3066\u3044\u308b\u306e\u304b\u3092\u78ba\u8a8d\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h2>2\u3064\u306eM\u306e\u6587\u5b57\u3092\u63a2\u3059<\/h2>\n<p>\u4e00\u822c\u7684\u306aMOTS-c\u53c2\u7167\u914d\u5217\u306fMRWQEMGYIFYPRKLR\u3067\u3059\u3002M\u306f\u30e1\u30c1\u30aa\u30cb\u30f3\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u5148\u982d\u304b\u3089\u6570\u3048\u308b\u3068\u30012\u3064\u306eM\u6b8b\u57fa\u306f1\u4f4d\u30686\u4f4d\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>Use the actual supplied sequence and end groups when evaluating a sample. The reference sequence is a starting point, not a replacement for the material\u2019s specification.<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/nhdbio.com\/wp-content\/plugins\/nhd-content-refresh\/teaching-images\/t13\/en\/1.png\" alt=\"\u56f3 1. \u6a19\u6e96\u7684\u306a MOTS-c \u6559\u80b2\u7528\u914d\u5217\u3067\u306f\u3001\u30e1\u30c1\u30aa\u30cb\u30f3\u306f\u4f4d\u7f6e 1 \u3068 6 \u306b\u3042\u308a\u307e\u3059\u3002\"><figcaption>\u56f31\u3002\u3053\u306eMOTS-c\u53c2\u7167\u306b\u304a\u3051\u308b\u30e1\u30c1\u30aa\u30cb\u30f3\u306f1\u4f4d\u30686\u4f4d\u306b\u3042\u308a\u307e\u3059\u3002<\/figcaption><\/figure>\n<h2>\u9178\u7d201\u500b\u3067\u7d0416 Da\u306b\u306a\u308b\u7406\u7531<\/h2>\n<p>\u9178\u7d20\u30921\u500b\u52a0\u3048\u308b\u3068\u3001Unimod\u306e\u9178\u5316\u8a18\u9332\u3067\u306f\u30e2\u30ce\u30a2\u30a4\u30bd\u30c8\u30d4\u30c3\u30af\u8cea\u91cf\u304c15.994915 Da\u5897\u52a0\u3057\u307e\u3059\u3002\u9178\u7d202\u500b\u3067\u306f\u3001\u5897\u52a0\u306f31.989830 Da\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u4f1a\u8a71\u3067\u306f\u3057\u3070\u3057\u3070+16\u304a\u3088\u3073+32\u3068\u77ed\u7e2e\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u4e38\u3081\u305f\u6570\u5024\u306f\u6709\u7528\u306a\u624b\u304c\u304b\u308a\u3067\u3059\u3002\u6b63\u78ba\u306a\u6bd4\u8f03\u306b\u306f\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u5024\u3068\u6b63\u3057\u3044\u5206\u5b50\u5f62\u614b\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/nhdbio.com\/wp-content\/plugins\/nhd-content-refresh\/teaching-images\/t13\/en\/2.png\" alt=\"\u56f3 2. 1\u3064\u307e\u305f\u306f2\u3064\u306e\u9178\u7d20\u539f\u5b50\u3092\u4ed8\u52a0\u3059\u308b\u3068\u3001\u4e2d\u6027\u30e2\u30ce\u30a2\u30a4\u30bd\u30c8\u30d4\u30c3\u30af\u8cea\u91cf\u306f 15.994915 \u307e\u305f\u306f 31.989830 Da \u30b7\u30d5\u30c8\u3057\u307e\u3059\u3002\"><figcaption>\u56f3 2\u3002\u9178\u7d20\u539f\u5b50\u30921\u3064\u307e\u305f\u306f2\u3064\u8ffd\u52a0\u3059\u308b\u3068\u3001\u8cea\u91cf\u306e\u5897\u52a0\u91cf\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/figcaption><\/figure>\n<h2>\u30b9\u30da\u30af\u30c8\u30eb\u304c 8 \u3057\u304b\u30b7\u30d5\u30c8\u3057\u306a\u3044\u3053\u3068\u304c\u3042\u308b\u7406\u7531<\/h2>\n<p>\u4e8c\u91cd\u96fb\u8377\u30a4\u30aa\u30f3\u306e\u5834\u5408\u3001\u8cea\u91cf\u5909\u5316\u30922\u3067\u5272\u308a\u307e\u3059\u3002\u9178\u7d201\u3064\u3067m\/z\u306f\u7d047.99746\u30b7\u30d5\u30c8\u3057\u307e\u3059\u3002\u9178\u7d20\u539f\u5b502\u3064\u3067\u306f\u7d0415.99492\u30b7\u30d5\u30c8\u3057\u307e\u3059\u3002<\/p>\n<p>So \u201ca shift of 16\u201d is unclear without saying which axis and charge you mean.<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/nhdbio.com\/wp-content\/plugins\/nhd-content-refresh\/teaching-images\/t13\/en\/3.png\" alt=\"\u56f33\u3002\u96fb\u83772\u3067\u306f\u30011\u9178\u7d20\u304a\u3088\u30732\u9178\u7d20\u5019\u88dc\u306e\u30b7\u30d5\u30c8\u306f\u305d\u308c\u305e\u308c\u7d047.9975\u304a\u3088\u307315.9949 m\/z\u306b\u306a\u308a\u307e\u3059\u3002\"><figcaption>\u56f33\u3002\u4e8c\u91cd\u96fb\u8377\u30a4\u30aa\u30f3\u3067\u306f\u3001m\/z\u306e\u5909\u5316\u306f\u8cea\u91cf\u5909\u5316\u306e\u534a\u5206\u3067\u3059\u3002<\/figcaption><\/figure>\n<h2>\u7dcf\u8cea\u91cf\u304b\u3089\u3001\u3069\u306eM\u304c\u5909\u5316\u3057\u305f\u304b\u5206\u304b\u308a\u307e\u3059\u304b\uff1f<\/h2>\n<p>\u305d\u308c\u3060\u3051\u3067\u306f\u5206\u304b\u308a\u307e\u305b\u3093\u3002\u3069\u3061\u3089\u306e\u30e1\u30c1\u30aa\u30cb\u30f3\u3067\u306e\u9178\u5316\u3067\u3082\u3001\u5b8c\u5168\u8cea\u91cf\u3067\u306f\u540c\u3058\u9178\u7d201\u3064\u5206\u306e\u5897\u52a0\u3092\u793a\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u9069\u5207\u306a\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u30c7\u30fc\u30bf\u3068\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u306b\u3088\u308b\u6bd4\u8f03\u304c\u3001\u4f4d\u7f6e\u3084\u4ee3\u66ff\u306e\u53ef\u80fd\u6027\u3092\u8abf\u3079\u308b\u306e\u306b\u5f79\u7acb\u3064\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u30b9\u30da\u30af\u30c8\u30eb\u304b\u3089\u306f\u3001\u5909\u5316\u304c\u3044\u3064\u8d77\u304d\u305f\u304b\u3082\u5206\u304b\u308a\u307e\u305b\u3093\u3002\u4fdd\u7ba1\u3068\u53d6\u308a\u6271\u3044\u306e\u8a18\u9332\u3092\u5206\u6790\u30c7\u30fc\u30bf\u3068\u4e00\u7dd2\u306b\u4fdd\u7ba1\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<h2>3\u4fa1\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u8a66\u3059<\/h2>\n<p>\u30d4\u30fc\u30af\u5f37\u5ea6\u3092\u9178\u5316\u306e\u91cd\u91cf\u30d1\u30fc\u30bb\u30f3\u30c8\u306b\u76f4\u63a5\u63db\u7b97\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u305d\u308c\u306b\u306f\u9069\u5207\u306a\u5b9a\u91cf\u6cd5\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<div class=\"exercise\"><strong>\u5bfe\u5fdc\u3059\u308b3\u4fa1\u30a4\u30aa\u30f3\u3067\u9178\u7d20\u304c1\u3064\u8ffd\u52a0\u3055\u308c\u305f\u5834\u5408\u3001m\/z\u306e\u30b7\u30d5\u30c8\u306f\u304a\u3088\u305d\u3044\u304f\u3089\u3067\u3059\u304b\uff1f<\/strong><\/p>\n<details>\n<summary>\u7b54\u3048\u3092\u898b\u308b<\/summary>\n<p>15.994915 \u00f7 3 \u2248 5.33164. That value alone still does not locate the change.<\/p>\n<\/details>\n<\/div>\n<h2>MOTS-c\u30b5\u30f3\u30d7\u30eb\u306b\u3064\u3044\u3066\u78ba\u8a8d\u3059\u3079\u304d\u3053\u3068<\/h2>\n<p>MOTS-c\u306b\u3064\u3044\u3066\u306f\u3001\u5b9f\u969b\u306e\u914d\u5217\u3068\u672b\u7aef\u57fa\u3092\u78ba\u8a8d\u3057\u3001\u540c\u4e00\u6027\u3084\u5b89\u5b9a\u6027\u306b\u95a2\u9023\u3059\u308b\u60c5\u5831\u304c\u5229\u7528\u53ef\u80fd\u304b\u3092\u5c0b\u306d\u3066\u304f\u3060\u3055\u3044\u3002\u3053\u306e\u30ec\u30c3\u30b9\u30f3\u3067\u306f\u8d77\u3053\u308a\u3046\u308b\u8cea\u91cf\u5909\u5316\u3092\u8aac\u660e\u3057\u307e\u3059\u304c\u3001\u30d0\u30c3\u30c1\u306e\u9178\u5316\u30ec\u30d9\u30eb\u3084\u4fdd\u5b58\u671f\u9593\u306b\u3064\u3044\u3066\u306f\u8ff0\u3079\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p><a href=\"https:\/\/nhdbio.com\/ja\/%e8%a3%bd%e5%93%81\/mots-c-human\/\">MOTS-c<\/a><\/p>\n<p><a href=\"https:\/\/nhdbio.com\/ja\/%e5%bc%95%e7%94%a8\/\">\u8cc7\u6750\u304a\u3088\u3073\u6587\u66f8\u306e\u8981\u4ef6\u306b\u3064\u3044\u3066NHD\u3068\u76f8\u8ac7\u3059\u308b<\/a> \u00b7 <a href=\"https:\/\/nhdbio.com\/ja\/%e5%88%86%e6%9e%90%e6%89%8b%e6%b3%95\/lc-ms-%e5%90%8c%e4%b8%80%e6%80%a7%e6%a4%9c%e8%a8%bc\/\">\u5206\u6790\u30ac\u30a4\u30c9\u3092\u7d9a\u3051\u308b<\/a><\/p>\n<footer><strong>\u51fa\u5178\u3068\u4f8b\u306e\u6ce8\u8a18<\/strong><\/p>\n<p>\u6570\u5024\u3068\u66f2\u7dda\u306f\u6559\u80b2\u7528\u306e\u4f8b\u3067\u3042\u308a\u3001\u88fd\u54c1\u30d0\u30c3\u30c1\u306e\u8a66\u9a13\u7d50\u679c\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u51fa\u5178\u78ba\u8a8d\u65e5\uff1a11 \u5e74 2026 \u6708\u3002<\/p>\n<ul>\n<li><a href=\"https:\/\/www.unimod.org\/modifications_view.php?editid1=35\">Unimod \u00b7 modification record 35<\/a><\/li>\n<li><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/protein-biology\/protein-biology-learning-center\/protein-biology-resource-library\/pierce-protein-methods\/overview-mass-spectrometry.html\">Thermo Fisher Scientific \u00b7 mass spectrometry<\/a><\/li>\n<li><a href=\"https:\/\/www.anaspec.com\/assets\/8a540d6b-5e0c-461e-ac6d-33f2d3f1e1f7\/tds-en-as-65587-mots-c.pdf\">AnaSpec \u00b7 MOTS-c reference sequence<\/a><\/li>\n<\/ul>\n<p>AI\u652f\u63f4\u306b\u3088\u308b\u57f7\u7b46\u304a\u3088\u3073\u60c5\u5831\u6e90\u306e\u30ec\u30d3\u30e5\u30fc\u3002\u30ab\u30bf\u30ed\u30b0\u8cc7\u6599\u306f\u7814\u7a76\u3001\u958b\u767a\u3001\u88fd\u9020\u7528\u3067\u3042\u308a\u3001\u4eba\u307e\u305f\u306f\u52d5\u7269\u3078\u306e\u4f7f\u7528\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<\/footer>","protected":false},"excerpt":{"rendered":"<p>MOTS-c\u306e2\u3064\u306e\u30e1\u30c1\u30aa\u30cb\u30f3\u3092\u898b\u3064\u3051\u3001\u6b21\u306b\u9178\u7d201\u3064\u306e\u8ffd\u52a0\u306b\u3088\u308b\u8cea\u91cf\u5909\u5316\u3092\u8ffd\u3044\u307e\u3057\u3087\u3046\u3002<\/p>","protected":false},"author":1,"featured_media":3973,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"352","pim_article_type":"Peptide buying and basics","pim_evidence_level":"Technical references and labeled calculations","pim_reviewer":"AI-assisted source and editorial check","pim_reviewed_date":"2026-10-11","pim_editorial_note":"Public data and labeled teaching calculations; not NHD batch results. Confirm project and document availability.","pim_review_status":"reviewed","pim_review_reason":"Teaching examples, arithmetic, source links and plain language checked; product enquiries linked.","pim_creation_method":"AI-assisted writing, source checks and illustrated cover.","pim_sources":"[{\"title\":\"Teaching reference \u2014 www.unimod.org \u2014 modifications_view.php\",\"note\":\"\",\"url\":\"https:\/\/www.unimod.org\/modifications_view.php?editid1=35\"},{\"title\":\"Teaching reference \u2014 www.thermofisher.com \u2014 overview-mass-spectrometry.html\",\"note\":\"\",\"url\":\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/protein-biology\/protein-biology-learning-center\/protein-biology-resource-library\/pierce-protein-methods\/overview-mass-spectrometry.html\"},{\"title\":\"Teaching reference \u2014 www.anaspec.com \u2014 tds-en-as-65587-mots-c.pdf\",\"note\":\"\",\"url\":\"https:\/\/www.anaspec.com\/assets\/8a540d6b-5e0c-461e-ac6d-33f2d3f1e1f7\/tds-en-as-65587-mots-c.pdf\"}]","footnotes":""},"categories":[20],"tags":[],"class_list":["post-3099","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evidence-quality-guides"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>MOTS-c and a +16 Da Signal: Work Through an Oxidation Candidate | NHD<\/title>\n<meta name=\"description\" content=\"Find MOTS-c\u2019s two methionines, then follow the mass change from one added oxygen.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nhdbio.com\/ja\/mots-c-two-methionines-oxidation-mass-check\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MOTS-c and a +16 Da Signal: Work Through an Oxidation Candidate\" \/>\n<meta property=\"og:description\" content=\"Find MOTS-c\u2019s two methionines, then follow the mass change from one added oxygen.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nhdbio.com\/ja\/mots-c-two-methionines-oxidation-mass-check\/\" \/>\n<meta property=\"og:site_name\" content=\"NHD\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-04T13:31:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-11T07:41:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/nhd-comic-3099.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"NHD Technical Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:description\" content=\"Peptide Raw Materials and Custom Peptide Synthesis\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"NHD Technical Team\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"2\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/nhdbio.com\\\/mots-c-two-methionines-oxidation-mass-check\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/mots-c-two-methionines-oxidation-mass-check\\\/\"},\"author\":{\"name\":\"NHD Technical Team\",\"@id\":\"https:\\\/\\\/nhdbio.com\\\/#\\\/schema\\\/person\\\/0ffb0dec7fda0f720073fc468fac6fc1\"},\"headline\":\"MOTS-c and a +16 Da Signal: Work Through an Oxidation Candidate\",\"datePublished\":\"2026-10-04T13:31:01+00:00\",\"dateModified\":\"2026-10-11T07:41:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/mots-c-two-methionines-oxidation-mass-check\\\/\"},\"wordCount\":452,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/nhdbio.com\\\/mots-c-two-methionines-oxidation-mass-check\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/nhdbio.com\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/nhd-comic-3099.jpg\",\"articleSection\":[\"Evidence &amp; 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