{"id":3553,"date":"2026-10-05T16:40:08","date_gmt":"2026-10-05T16:40:08","guid":{"rendered":"https:\/\/nhdbio.com\/?p=3553"},"modified":"2026-10-09T08:29:54","modified_gmt":"2026-10-09T08:29:54","slug":"%e3%83%ac%e3%82%bf%e3%83%88%e3%83%ab%e3%83%81%e3%83%89%e3%81%ae%e8%82%9d%e8%84%82%e8%82%aamri%e7%9b%b8%e5%af%be%e5%a4%89%e5%8c%96%e3%81%ae%e8%a7%a3%e8%aa%ac","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ja\/retatrutide-liver-fat-mri-relative-change-explained\/","title":{"rendered":"\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u3068\u809d\u8102\u80aa\uff1a82.4%\u306e\u6e1b\u5c11\u304c\u610f\u5473\u3059\u308b\u3053\u3068\u3001\u305d\u3057\u3066\u610f\u5473\u3057\u306a\u3044\u3053\u3068"},"content":{"rendered":"<p>\u809d\u81d3\u306e\u8102\u80aa\u306e\u7d50\u679c\u306f\u3001\u4f53\u91cd\u306e\u7d50\u679c\u3068\u9593\u9055\u3048\u3084\u3059\u3044\u3067\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u306fMRI\u3092\u4f7f\u3063\u3066\u809d\u81d3\u5185\u306e\u8102\u80aa\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002\u3053\u3053\u3067\u306f\u3001\u5831\u544a\u3055\u308c\u305f82.4%\u306e\u76f8\u5bfe\u7684\u6e1b\u5c11\u306e\u8aad\u307f\u65b9\u3001\u8a66\u9a13\u3055\u308c\u305f\u81e8\u5e8a\u7528\u88fd\u5264\u306b\u3064\u3044\u3066\u305d\u308c\u304c\u4f55\u3092\u8a00\u3063\u3066\u3044\u308b\u304b\u3001\u305d\u3057\u3066\u3069\u306e\u3088\u3046\u306a\u7591\u554f\u304c\u6b8b\u308b\u304b\u3092\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n<h2>\u809d\u306e\u8102\u80aa\u3068\u809d\u306e\u7622\u75d5\u5316\u306f\u5225\u306e\u554f\u3044\u3067\u3059<\/h2>\n<p>Fat can accumulate in the liver. Scarring, also called fibrosis, is a different feature of liver disease. A study that measures fat does not automatically measure how much scarring has reversed. Read the test and the endpoint first: a liver-fat result answers a more specific question than the phrase \u201cimproved liver health.\u201d<\/p>\n<h2>\u7814\u7a76\u304c\u6e2c\u5b9a\u3057\u305f\u3082\u306e<\/h2>\n<p>2024\u306e\u7b2c2a\u76f8\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\u306b\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u809d\u8102\u80aa\u304c\u5c11\u306a\u304f\u3068\u308210%\u3067\u3042\u3063\u305f98\u540d\u306e\u53c2\u52a0\u8005\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u3088\u308a\u9577\u3044\u80a5\u6e80\u8a66\u9a13\u306e\u4e00\u90e8\u3067\u3057\u305f\u3002\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001MRI\u30d9\u30fc\u30b9\u306e\u8a55\u4fa1\u3092\u7528\u3044\u3066\u6e2c\u5b9a\u3055\u308c\u305f24\u9031\u6642\u70b9\u3067\u306e\u809d\u8102\u80aa\u306e\u76f8\u5bfe\u5909\u5316\u3067\u3057\u305f\u3002\u305d\u306e <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38858523\/\">\u539f\u8457\u8ad6\u6587<\/a> \u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3068\u753b\u50cf\u5316\u65b9\u6cd5\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2>\u898b\u51fa\u3057\u306e\u80cc\u666f\u306b\u3042\u308b\u6570\u5b57<\/h2>\n<p>Across the four retatrutide groups, the mean relative changes were \u221242.9%, \u221257.0%, \u221281.4% and \u221282.4%; placebo was +0.3%. These are group estimates under a defined clinical protocol. The diagram highlights the largest reported reduction and the placebo estimate, rather than pretending to show individual scans or a universal response.<\/p>\n<figure class=\"wp-block-image\"><a href=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/retatrutide-liver-fat-mri-relative-change-explained.png\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/retatrutide-liver-fat-mri-relative-change-explained.png\" alt=\"\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u3068\u809d\u8102\u80aa\uff1a82.4% \u6e1b\u5c11\u304c\u610f\u5473\u3059\u308b\u3053\u3068\u2014\u305d\u3057\u3066\u610f\u5473\u3057\u306a\u3044\u3053\u3068 \u2014 \u51fa\u5178\u8868\u793a\u4ed8\u304d\u7814\u7a76\u8981\u7d04\" width=\"1600\" height=\"900\" loading=\"lazy\" style=\"width:100%;height:auto\"><\/a><figcaption>\u516c\u958b\u3055\u308c\u305f24\u9031\u306e\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\u63a8\u5b9a\u5024\u3002\u9078\u629e\u3055\u308c\u305f\u30b0\u30eb\u30fc\u30d7\u306f\u30d7\u30fc\u30eb\u3055\u308c\u305f\u7d50\u679c\u3067\u306f\u306a\u304f\u3001\u809d\u8102\u80aa\u306f\u7dda\u7dad\u75c7\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5143\u306e\u7814\u7a76\u5024\u306f\u518d\u63cf\u753b\u3055\u308c\u3066\u3044\u308b\u304b\u3001\u95a2\u4fc2\u306f\u30e9\u30d9\u30eb\u3069\u304a\u308a\u306b\u7c21\u7565\u5316\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5b9f\u9a13\u5ba4\u306e\u5199\u771f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30af\u30ea\u30c3\u30af\u3057\u3066\u62e1\u5927\u3002<\/figcaption><\/figure>\n<h2>\u76f8\u5bfe\u5909\u5316\u306b\u306f\u958b\u59cb\u5024\u304c\u5fc5\u8981\u3067\u3059<\/h2>\n<p>Here is an illustrative calculation, not a participant result. If liver fat started at 20% and fell by 82.4% relative to that starting value, the final value would be 20% \u00d7 0.176 = 3.52%. The absolute decrease would be 16.48 percentage points. This explains why an 82.4% relative reduction does not mean subtracting 82.4 percentage points from a scan.<\/p>\n<h2>\u305d\u306e\u6570\u5024\u3067\u306f\u4f9d\u7136\u3068\u3057\u3066\u7b54\u3048\u3089\u308c\u3066\u3044\u306a\u3044\u3053\u3068<\/h2>\n<p>\u3053\u306e\u7814\u7a76\u306f\u3001\u305d\u306e\u96c6\u56e3\u306b\u304a\u3044\u3066\u809d\u8102\u80aa\u3078\u306e\u52b9\u679c\u3092\u652f\u6301\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u6570\u5024\u3060\u3051\u3067\u306f\u3001\u7dda\u7dad\u5316\u306e\u9006\u8ee2\u3001\u3042\u3089\u3086\u308b\u809d\u30ea\u30b9\u30af\u306e\u6392\u9664\u3001\u307e\u305f\u306f\u5225\u306e\u96c6\u56e3\u3067\u306e\u540c\u3058\u53cd\u5fdc\u3092\u78ba\u7acb\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u753b\u50cf\u691c\u67fb\u306f\u3001\u4e00\u3064\u306e\u7279\u5fb4\u3092\u7e70\u308a\u8fd4\u3057\u5b9a\u91cf\u5316\u3067\u304d\u308b\u305f\u3081\u6709\u7528\u3067\u3059\u3002\u305d\u308c\u3067\u3082\u4e00\u3064\u306e\u7279\u5fb4\u3067\u3042\u308a\u3001\u809d\u75be\u60a3\u306e\u5b8c\u5168\u306a\u8a18\u8ff0\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h2>\u306a\u305c\u3053\u306e\u30c8\u30d4\u30c3\u30af\u304c\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u88fd\u54c1\u306b\u5c5e\u3059\u308b\u306e\u304b<\/h2>\n<p>\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u306f\u4e09\u91cd\u53d7\u5bb9\u4f53\u30a2\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306e <a href=\"https:\/\/nhdbio.com\/ja\/%e3%83%ac%e3%82%bf%e3%83%88%e3%83%ab%e3%83%81%e3%83%89%ef%bc%88%e3%83%88%e3%83%aa%e3%83%97%e3%83%ab%e3%82%a2%e3%82%b4%e3%83%8b%e3%82%b9%e3%83%88%ef%bc%89%e3%81%ae%e7%ac%ac2%e7%9b%b8%e8%a9%a6%e9%a8%93\/\">\u4e09\u91cd\u30a2\u30b4\u30cb\u30b9\u30c8\u30a8\u30d3\u30c7\u30f3\u30b9\u30ac\u30a4\u30c9<\/a> \u80cc\u666f\u3092\u8aac\u660e\u3057\u3066\u3044\u307e\u3059\u3002 <a href=\"https:\/\/nhdbio.com\/ja\/%e8%a3%bd%e5%93%81\/%e3%83%ac%e3%82%bf%e3%83%88%e3%83%ab%e3%83%81%e3%83%89\/\">NHD \u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u30da\u30fc\u30b8<\/a> \u95a2\u9023\u3059\u308b\u30ab\u30bf\u30ed\u30b0\u9805\u76ee\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u5b9f\u9a13\u5ba4\u3067\u306e\u4f5c\u696d\u3067\u306f\u3001\u5206\u5b50\u5f62\u614b\u3068\u5206\u6790\u7bc4\u56f2\u3092\u6307\u5b9a\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u81e8\u5e8aMRI\u306e\u7d50\u679c\u306f\u3001\u30ab\u30bf\u30ed\u30b0\u30d0\u30c3\u30c1\u3092\u8a3c\u660e\u3057\u305f\u308a\u3001\u30d2\u30c8\u3078\u306e\u4f7f\u7528\u3078\u306e\u9069\u5408\u6027\u3092\u78ba\u7acb\u3057\u305f\u308a\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<section id=\"nhd-reader-guide-20261009\">\n<h2>\u809d\u8102\u80aa\u306e\u5272\u5408\u306f\u3001\u4f53\u91cd\u306e\u5272\u5408\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u78ba\u8a8d<\/th>\n<th>\u305d\u308c\u304c\u4f1d\u3048\u308b\u3053\u3068<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u4f55\u304c\u6e2c\u5b9a\u3055\u308c\u307e\u3057\u305f\u304b\uff1f<\/td>\n<td>\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u753b\u50cf\u8a3a\u65ad\u3092\u7528\u3044\u3066\u809d\u8102\u80aa\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u4e00\u3064\u306e\u81d3\u5668\u5185\u3067\u306e\u6e2c\u5b9a\u3067\u3042\u308a\u3001\u6e1b\u5c11\u3057\u305f\u7dcf\u4f53\u91cd\u306e\u5272\u5408\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u5909\u5316\u306f\u3069\u306e\u3088\u3046\u306b\u8a08\u7b97\u3055\u308c\u307e\u3057\u305f\u304b\uff1f<\/td>\n<td>\u305d\u306e\u6570\u5024\u304c\u3001\u958b\u59cb\u6642\u306e\u809d\u8102\u80aa\u5024\u304b\u3089\u306e\u76f8\u5bfe\u5909\u5316\u306a\u306e\u304b\u3001\u30d1\u30fc\u30bb\u30f3\u30c8\u30dd\u30a4\u30f3\u30c8\u306e\u5909\u5316\u306a\u306e\u304b\u3092\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u5206\u6bcd\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u4f55\u306e\u6750\u6599\u304c\u8a66\u9a13\u3055\u308c\u307e\u3057\u305f\u304b\uff1f<\/td>\n<td>\u81e8\u5e8a\u7528\u88fd\u5264\u3068\u30d7\u30ed\u30c8\u30b3\u30eb\u306f\u8a66\u9a13\u306b\u5c5e\u3057\u307e\u3059\u3002\u305d\u308c\u3089\u306f\u30ab\u30bf\u30ed\u30b0\u7814\u7a76\u7528\u6750\u6599\u3092\u691c\u8a3c\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u7814\u7a76\u5ba4\u3067\u306e\u8abf\u9054\u306b\u3064\u3044\u3066\u306f\u3001 <a href=\"https:\/\/nhdbio.com\/ja\/%e8%a3%bd%e5%93%81\/%e3%83%ac%e3%82%bf%e3%83%88%e3%83%ab%e3%83%81%e3%83%89\/\">\u95a2\u9023\u3059\u308b NHD \u30ab\u30bf\u30ed\u30b0\u8cc7\u6599\u3092\u78ba\u8a8d\u3059\u308b<\/a> \u9078\u629e\u3057\u305f\u30d0\u30ea\u30a2\u30f3\u30c8\u3001\u91cf\u306e\u57fa\u6e96\u3001\u304a\u3088\u3073\u5229\u7528\u53ef\u80fd\u306a\u8a18\u9332\u3092\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002 <a href=\"https:\/\/nhdbio.com\/ja\/%e5%bc%95%e7%94%a8\/\">\u7814\u7a76\u306b\u95a2\u3059\u308b\u304a\u554f\u3044\u5408\u308f\u305b\u3092\u9001\u4fe1\u3059\u308b<\/a> \u3053\u308c\u3089\u306e\u8981\u4ef6\u3092\u6e80\u305f\u3059\u5834\u5408\u3001\u5f15\u7528\u3055\u308c\u305f\u5b9f\u9a13\u306f NHD \u30ed\u30c3\u30c8\u306e\u8a66\u9a13\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<\/section>\n<h2>\u95a2\u9023\u88fd\u54c1\u3068\u304a\u554f\u3044\u5408\u308f\u305b<\/h2>\n<ul>\n<li><a href=\"https:\/\/nhdbio.com\/ja\/%e8%a3%bd%e5%93%81\/%e3%83%ac%e3%82%bf%e3%83%88%e3%83%ab%e3%83%81%e3%83%89\/\">\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9<\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/nhdbio.com\/ja\/%e5%bc%95%e7%94%a8\/\">\u5fc5\u8981\u306a\u7269\u8cea\u3001\u6570\u91cf\u3001\u5206\u6790\u6587\u66f8\u306b\u3064\u3044\u3066 NHD \u306b\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044<\/a>\u3002\u5728\u5eab\u3001\u4fa1\u683c\u3001\u5229\u7528\u53ef\u80fd\u306a\u30d0\u30c3\u30c1\u8a18\u9332\u306f\u78ba\u8a8d\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<h2>\u72ec\u81ea\u7814\u7a76<\/h2>\n<ul>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38858523\/\">Original publication \u2014 PubMed 38858523<\/a><\/li>\n<\/ul>\n<p>\u60c5\u5831\u6e90\u78ba\u8a8d\u65e5 6 \u5e74 2026 \u6708\u3002AI\u652f\u63f4\u306b\u3088\u308b\u7de8\u96c6\u30ec\u30d3\u30e5\u30fc\u306f\u3001\u51fa\u5178\u306e\u5e30\u5c5e\u3001\u6570\u5024\u306e\u6b63\u78ba\u6027\u3001\u8aad\u307f\u3084\u3059\u3055\u3092\u5bfe\u8c61\u3068\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u72ec\u7acb\u3057\u305f\u67fb\u8aad\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002NHD 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