{"id":3558,"date":"2026-10-05T16:40:52","date_gmt":"2026-10-05T16:40:52","guid":{"rendered":"https:\/\/nhdbio.com\/?p=3558"},"modified":"2026-10-09T08:30:27","modified_gmt":"2026-10-09T08:30:27","slug":"ll37-%e3%83%90%e3%82%a4%e3%82%aa%e3%83%95%e3%82%a3%e3%83%ab%e3%83%a0%e5%af%be%e7%b4%b0%e8%8f%8c%e5%a2%97%e6%ae%96%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ja\/ll37-biofilm-versus-bacterial-growth-study\/","title":{"rendered":"LL-37 \u3068\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\uff1a\u4ed8\u7740\u3092\u6b62\u3081\u308b\u3053\u3068\u3068\u5897\u6b96\u3092\u6b62\u3081\u308b\u3053\u3068\u306f\u5225\u7269\u3067\u3059"},"content":{"rendered":"<p>\u30da\u30d7\u30c1\u30c9\u306f\u3001\u540c\u3058\u6fc3\u5ea6\u3067\u7d30\u83cc\u306e\u5897\u6b96\u3092\u6b62\u3081\u306a\u304f\u3066\u3082\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u5f62\u6210\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002LL-37\u306e\u7814\u7a76\u306f\u305d\u306e\u9055\u3044\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u5404\u8a66\u9a13\u304c\u4f55\u3092\u6e2c\u5b9a\u3059\u308b\u304b\u3092\u7406\u89e3\u3059\u308b\u3068\u3001\u7d50\u679c\u3092\u305a\u3063\u3068\u6bd4\u8f03\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<h2>\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h2>\n<p>\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3068\u306f\u3001\u8868\u9762\u306b\u4ed8\u7740\u3057\u3001\u5468\u56f2\u306e\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306b\u56f2\u307e\u308c\u305f\u5fae\u751f\u7269\u306e\u5171\u540c\u4f53\u3067\u3059\u3002\u901a\u5e38\u306e\u5897\u6b96\u30a2\u30c3\u30bb\u30a4\u306f\u3001\u8a66\u9a13\u6761\u4ef6\u4e0b\u3067\u7d30\u83cc\u304c\u5897\u6b96\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u307e\u3059\u3002\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u30a2\u30c3\u30bb\u30a4\u306f\u3001\u7d30\u83cc\u304c\u4ed8\u7740\u3057\u3066\u305d\u306e\u5171\u540c\u4f53\u3092\u5f62\u6210\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3042\u308b\u7269\u8cea\u304c\u4e00\u65b9\u306e\u6319\u52d5\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3082\u3001\u7d30\u83cc\u306e\u5897\u6b96\u3092\u5b8c\u5168\u306b\u6b62\u3081\u308b\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002<\/p>\n<h2>\u4e00\u3064\u306e\u5b9f\u9a13\u5ba4\u7814\u7a76\u304b\u3089\u306e\u4e8c\u3064\u306e\u6fc3\u5ea6<\/h2>\n<p>A <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18591225\/\">2008 LL-37 \u7814\u7a76<\/a> 0.5 \u30de\u30a4\u30af\u30ed\u30b0\u30e9\u30e0\/\u30df\u30ea\u30ea\u30c3\u30c8\u30eb\u3067\u306e\u7dd1\u81bf\u83cc\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u5f62\u6210\u306e\u963b\u5bb3\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u6700\u5c0f\u767a\u80b2\u963b\u6b62\u6fc3\u5ea6\uff08MIC\uff09\u306f 64 \u30de\u30a4\u30af\u30ed\u30b0\u30e9\u30e0\/\u30df\u30ea\u30ea\u30c3\u30c8\u30eb\u3067\u3057\u305f\u3002MIC\u306f\u3001\u6307\u5b9a\u3055\u308c\u305f\u8a66\u9a13\u6761\u4ef6\u4e0b\u3067\u306e\u6210\u9577\u963b\u5bb3\u95be\u5024\u3092\u793a\u3057\u307e\u3059\u3002\u3088\u308a\u4f4e\u3044\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u6fc3\u5ea6\u306f\u3001\u7570\u306a\u308b\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3092\u6307\u3057\u307e\u3059\u3002<\/p>\n<h2>Why \u201c128 times stronger\u201d would be misleading<\/h2>\n<p>Dividing 64 by 0.5 gives 128. That arithmetic is correct, but the interpretation \u201c128 times stronger\u201d is not. The calculation compares two different assays, not two measures of the same potency. A more accurate summary is that the biofilm-formation response occurred below the growth-inhibition threshold in that experimental setup.<\/p>\n<figure class=\"wp-block-image\"><a href=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/ll37-biofilm-versus-bacterial-growth-study.png\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/ll37-biofilm-versus-bacterial-growth-study.png\" alt=\"LL-37 \u3068\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\uff1a\u4ed8\u7740\u3092\u6b62\u3081\u308b\u3053\u3068\u306f\u5897\u6b96\u3092\u6b62\u3081\u308b\u3053\u3068\u3068\u306f\u7570\u306a\u308b \u2014 \u51fa\u5178\u8868\u793a\u4ed8\u304d\u7814\u7a76\u6982\u8981\" width=\"1600\" height=\"900\" loading=\"lazy\" style=\"width:100%;height:auto\"><\/a><figcaption>\u7dd1\u81bf\u83cc\uff08P. aeruginosa\uff09\u306b\u3064\u3044\u3066\u5831\u544a\u3055\u308c\u305fin vitro\u6fc3\u5ea6\u3002\u7570\u306a\u308b\u30a2\u30c3\u30bb\u30a4\u3067\u3042\u308a\u3001\u6bd4\u8f03\u81e8\u5e8a\u529b\u4fa1\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5143\u306e\u7814\u7a76\u5024\u3092\u63cf\u304d\u76f4\u3057\u305f\u3082\u306e\u3001\u307e\u305f\u306f\u95a2\u4fc2\u3092\u7c21\u7565\u5316\u3057\u305f\u3082\u306e\u3067\u3001\u8868\u793a\u306b\u5f93\u3044\u307e\u3059\u3002\u5b9f\u9a13\u5ba4\u5199\u771f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30af\u30ea\u30c3\u30af\u3067\u62e1\u5927\u3002<\/figcaption><\/figure>\n<h2>\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u7d30\u83cc\u306e\u6319\u52d5\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3057\u305f<\/h2>\n<p>\u8457\u8005\u3089\u306f\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306b\u95a2\u9023\u3059\u308b\u4ed8\u7740\u3001twitching\u904b\u52d5\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u540c\u3058\u6fc3\u5ea6\u3067\u5e83\u7bc4\u306a\u5897\u6b96\u963b\u5bb3\u304c\u306a\u304f\u3066\u3082\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u304c\u5909\u308f\u308a\u3046\u308b\u7406\u7531\u3092\u8aac\u660e\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u7d30\u83cc\u304c\u8868\u9762\u4e0a\u3067\u3069\u306e\u3088\u3046\u306b\u7d44\u7e54\u5316\u3059\u308b\u304b\u3068\u3044\u3046\u7814\u7a76\u8ab2\u984c\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001LL-37 \u304c\u3059\u3079\u3066\u306e\u6210\u719f\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u9664\u53bb\u3059\u308b\u3001\u307e\u305f\u306f\u4eba\u306b\u304a\u3051\u308b\u611f\u67d3\u75c7\u3092\u6cbb\u7642\u3059\u308b\u3053\u3068\u3092\u8a3c\u660e\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h2>\u57f9\u5730\u3068\u6bb5\u968e\u3092\u78ba\u8a8d\u3059\u308b<\/h2>\n<p>\u6bd4\u8f03\u3092\u884c\u3046\u969b\u306f\u3001\u3069\u306e\u682a\u3001\u57f9\u5730\u3001\u8868\u9762\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u6bb5\u968e\u304c\u8a66\u9a13\u3055\u308c\u305f\u306e\u304b\u3092\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u5f62\u6210\u306e\u4e88\u9632\u3068\u3001\u78ba\u7acb\u3055\u308c\u305f\u7fa4\u96c6\u306e\u7834\u58ca\u306f\u5225\u306e\u8ab2\u984c\u3067\u3059\u3002\u5f53\u793e\u306e <a href=\"https:\/\/nhdbio.com\/ja\/ll37-%e6%8a%97%e8%8f%8c%e6%80%a7%e5%a1%a9%e5%9f%b9%e5%9c%b0mic%e7%a0%94%e7%a9%b6\/\">LL-37 \u57f9\u5730\u304a\u3088\u3073 MIC \u30ac\u30a4\u30c9<\/a> \u3067\u306f\u3001\u5869\u3068\u57f9\u990a\u6761\u4ef6\u3082\u91cd\u8981\u3067\u3042\u308b\u7406\u7531\u3092\u8aac\u660e\u3057\u3066\u3044\u307e\u3059\u3002\u6761\u4ef6\u304c\u793a\u3055\u308c\u3066\u3044\u306a\u3044\u6570\u5024\u306f\u3001\u6709\u610f\u7fa9\u306b\u518d\u5229\u7528\u3059\u308b\u3053\u3068\u304c\u96e3\u3057\u3044\u3067\u3059\u3002<\/p>\n<h2>\u5b9f\u9a13\u5ba4\u304b\u3089\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u5411\u3051\u88fd\u54c1\u306e\u3054\u6848\u5185<\/h2>\n<p>\u305d\u306e <a href=\"https:\/\/nhdbio.com\/ja\/%e8%a3%bd%e5%93%81\/ll-37\/\">LL-37 \u88fd\u54c1\u30da\u30fc\u30b8<\/a> is the related catalogue entry. For a biofilm project, identify whether you plan to measure attachment, biofilm biomass or bacterial growth. Describe the molecular form and document requirements along with the quantity. This makes the enquiry more useful than asking only for an \u201cantibacterial peptide.\u201d<\/p>\n<section id=\"nhd-reader-guide-20261009\">\n<h2>\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306e\u6e1b\u5c11\u3068\u751f\u83cc\u6570\u306e\u6e1b\u5c11\u306f\u7570\u306a\u308b\u77e5\u898b\u3067\u3059<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u78ba\u8a8d<\/th>\n<th>\u305d\u308c\u304c\u4f1d\u3048\u308b\u3053\u3068<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u6e2c\u5b9a<\/td>\n<td>\u30a2\u30c3\u30bb\u30a4\u306b\u5fdc\u3058\u3066\u3001\u4ed8\u7740\u3057\u305f\u96c6\u56e3\u307e\u305f\u306f\u305d\u306e\u69cb\u6210\u7269\u8cea\u3092\u6e2c\u5b9a\u3057\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u5897\u6b96\u6e2c\u5b9a<\/td>\n<td>\u9078\u629e\u3057\u305f\u57f9\u990a\u6761\u4ef6\u4e0b\u3067\u306e\u5897\u6b96\u3092\u8ffd\u8de1\u3057\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u751f\u5b58\u7387\u6e2c\u5b9a<\/td>\n<td>\u8a18\u8f09\u3055\u308c\u305f\u65b9\u6cd5\u3092\u7528\u3044\u3066\u751f\u7269\u304c\u751f\u304d\u3066\u3044\u308b\u304b\u3092\u554f\u3044\u5408\u308f\u305b\u307e\u3059\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u7814\u7a76\u5ba4\u3067\u306e\u8abf\u9054\u306b\u3064\u3044\u3066\u306f\u3001 <a href=\"https:\/\/nhdbio.com\/ja\/%e8%a3%bd%e5%93%81\/ll-37\/\">\u95a2\u9023\u3059\u308b NHD \u30ab\u30bf\u30ed\u30b0\u8cc7\u6599\u3092\u78ba\u8a8d\u3059\u308b<\/a> \u9078\u629e\u3057\u305f\u30d0\u30ea\u30a2\u30f3\u30c8\u3001\u91cf\u306e\u57fa\u6e96\u3001\u304a\u3088\u3073\u5229\u7528\u53ef\u80fd\u306a\u8a18\u9332\u3092\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002 <a href=\"https:\/\/nhdbio.com\/ja\/%e5%bc%95%e7%94%a8\/\">\u7814\u7a76\u306b\u95a2\u3059\u308b\u304a\u554f\u3044\u5408\u308f\u305b\u3092\u9001\u4fe1\u3059\u308b<\/a> \u3053\u308c\u3089\u306e\u8981\u4ef6\u3092\u6e80\u305f\u3059\u5834\u5408\u3001\u5f15\u7528\u3055\u308c\u305f\u5b9f\u9a13\u306f NHD \u30ed\u30c3\u30c8\u306e\u8a66\u9a13\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<\/section>\n<h2>\u95a2\u9023\u88fd\u54c1\u3068\u304a\u554f\u3044\u5408\u308f\u305b<\/h2>\n<ul>\n<li><a href=\"https:\/\/nhdbio.com\/ja\/%e8%a3%bd%e5%93%81\/ll-37\/\">LL-37<\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/nhdbio.com\/ja\/%e5%bc%95%e7%94%a8\/\">\u5fc5\u8981\u306a\u7269\u8cea\u3001\u6570\u91cf\u3001\u5206\u6790\u6587\u66f8\u306b\u3064\u3044\u3066 NHD \u306b\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044<\/a>\u3002\u5728\u5eab\u3001\u4fa1\u683c\u3001\u5229\u7528\u53ef\u80fd\u306a\u30d0\u30c3\u30c1\u8a18\u9332\u306f\u78ba\u8a8d\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<h2>\u72ec\u81ea\u7814\u7a76<\/h2>\n<ul>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18591225\/\">Original publication \u2014 PubMed 18591225<\/a><\/li>\n<\/ul>\n<p>\u60c5\u5831\u6e90\u78ba\u8a8d\u65e5 6 \u5e74 2026 \u6708\u3002AI\u652f\u63f4\u306b\u3088\u308b\u7de8\u96c6\u30ec\u30d3\u30e5\u30fc\u306f\u3001\u51fa\u5178\u306e\u5e30\u5c5e\u3001\u6570\u5024\u306e\u6b63\u78ba\u6027\u3001\u8aad\u307f\u3084\u3059\u3055\u3092\u5bfe\u8c61\u3068\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u72ec\u7acb\u3057\u305f\u67fb\u8aad\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002NHD \u306e\u30ab\u30bf\u30ed\u30b0\u8cc7\u6599\u306f\u3001\u8cc7\u683c\u3092\u6709\u3059\u308b\u7814\u7a76\u6240\u3067\u306e\u7814\u7a76\u3001\u958b\u767a\u3001\u88fd\u9020\u7528\u3067\u3042\u308a\u3001\u4eba\u307e\u305f\u306f\u52d5\u7269\u3078\u306e\u4f7f\u7528\u3092\u76ee\u7684\u3068\u3057\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u30da\u30d7\u30c1\u30c9\u306f\u3001\u540c\u3058\u6fc3\u5ea6\u3067\u7d30\u83cc\u306e\u5897\u6b96\u3092\u6b62\u3081\u306a\u304f\u3066\u3082\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u5f62\u6210\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002LL-37\u306e\u7814\u7a76\u306f\u305d\u306e\u9055\u3044\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u5404\u8a66\u9a13\u304c\u4f55\u3092\u6e2c\u5b9a\u3059\u308b\u304b\u3092\u7406\u89e3\u3059\u308b\u3068\u3001\u7d50\u679c\u3092\u305a\u3063\u3068\u6bd4\u8f03\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>","protected":false},"author":1,"featured_media":3937,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"348","pim_article_type":"Published study explanation","pim_evidence_level":"Original study explained with model and endpoint limitations","pim_reviewer":"Codex AI editorial","pim_reviewed_date":"2026-10-09","pim_editorial_note":"AI-assisted editorial review, not independent peer review.","pim_review_status":"reviewed","pim_review_reason":"Readability, endpoint definitions, existing-source preservation, related product and quote-link checks.","pim_creation_method":"AI-assisted writing and deterministic explanatory figure","pim_sources":"[]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-3558","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>LL-37 Biofilm Research: Attachment vs Bacterial Growth<\/title>\n<meta name=\"description\" content=\"A peptide can reduce biofilm formation without stopping bacterial growth at the same concentration. 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