{"id":3777,"date":"2026-10-09T18:10:07","date_gmt":"2026-10-09T18:10:07","guid":{"rendered":"https:\/\/nhdbio.com\/?p=3777"},"modified":"2026-10-10T07:26:04","modified_gmt":"2026-10-10T07:26:04","slug":"ss31-%e6%94%be%e5%b0%84%e7%b7%9a%e5%bf%83%e7%ad%8b%e7%b4%b0%e8%83%9e%e8%80%81%e5%8c%96%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ja\/ss31-radiation-cardiomyocyte-senescence-cell-study\/","title":{"rendered":"SS-31\u3068\u653e\u5c04\u7dda\u5f8c\u306e\u7d30\u80de\u8001\u5316\uff1a\u5b9f\u9a13\u5ba4\u3067\u4f55\u304c\u5909\u308f\u3063\u305f\u306e\u304b\uff1f"},"content":{"rendered":"<p>\u7d30\u80de\u306f\u3001\u6b63\u5e38\u306a\u5897\u6b96\u306b\u623b\u308b\u3053\u3068\u306a\u304f\u3001\u30b9\u30c8\u30ec\u30b9\u95a2\u9023\u30de\u30fc\u30ab\u30fc\u304c\u6e1b\u5c11\u3057\u305f\u3088\u3046\u306b\u898b\u3048\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u533a\u5225\u306f\u3001\u65b0\u3057\u3044SS-31\u653e\u5c04\u7dda\u7814\u7a76\u304b\u3089\u5f97\u3089\u308c\u308b\u6700\u3082\u6709\u7528\u306a\u6559\u8a13\u3067\u3059\u3002<\/p>\n<h2>\u5b9f\u9a13\u5ba4\u306e\u7d30\u80de\u3067\u3042\u308a\u3001\u60a3\u8005\u3067\u306f\u306a\u3044<\/h2>\n<p>Researchers studied rat H9C2 cardiomyoblasts and human stem-cell-derived heart cells. In the H9C2 model, a 10 Gy radiation exposure was followed by a seven-day readout. With 1 \u03bcM SS-31, SA-\u03b2-gal-positive staining fell from about 67% to 38%, using the rounded abstract values.<\/p>\n<table>\n<thead>\n<tr>\n<th>H9C2\u7d30\u80de\u306e\u72b6\u614b<\/th>\n<th>SA-\u03b2-gal-positive cells<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u653e\u5c04\u7dda\u30e2\u30c7\u30eb<\/td>\n<td>\u7d0467%<\/td>\n<\/tr>\n<tr>\n<td>SS-31\u3092\u7528\u3044\u305f\u653e\u5c04\u7dda\u30e2\u30c7\u30eb<\/td>\n<td>38%\u306b\u3064\u3044\u3066<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<figure><img decoding=\"async\" src=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/ss31-radiation.png\" alt=\"SS-31\u653e\u5c04\u7dda\u7d30\u80de\u7814\u7a76\u67d3\u8272\u6bd4\u8f03\" width=\"1650\" loading=\"lazy\" style=\"max-width:100%;height:auto\"><figcaption>\u4e38\u3081\u3089\u308c\u305f\u6284\u9332\u5024\u306e\u539f\u56f3\u3092\u518d\u63cf\u753b\u3057\u305f\u3082\u306e\u3002\u3053\u308c\u306f\u4e00\u3064\u306e\u7d30\u80de\u67d3\u8272\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3092\u793a\u3059\u3002\u30d2\u30c8\u306e\u5e74\u9f62\u3001\u5bff\u547d\u3001\u5fc3\u6a5f\u80fd\u306e\u5c3a\u5ea6\u3067\u306f\u306a\u3044\u3002<\/figcaption><\/figure>\n<h2>\u305d\u306e\u67d3\u8272\u304b\u3089\u4f55\u304c\u5206\u304b\u308b\u306e\u304b\uff1f<\/h2>\n<p>SA-\u03b2-gal is a senescence-associated marker. The researchers also examined other markers, mitochondrial stress and inflammatory signals. Several findings changed in a favorable direction, but SS-31 did not restore radiation-inhibited cell proliferation.<\/p>\n<p>In plain language: the cells looked less senescent by selected tests, yet they did not simply start growing normally again. \u201cA marker improved\u201d and \u201cthe cells fully recovered\u201d are different claims.<\/p>\n<h2>\u898b\u51fa\u3057\u306e\u524d\u306b\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3092\u8aad\u3080<\/h2>\n<p>\u305d\u306e\u5272\u5408\u304c\u4f55\u3092\u6570\u3048\u3066\u3044\u308b\u306e\u304b\u3092\u554f\u3046\u3002\u3053\u3053\u3067\u306f\u7279\u5b9a\u306e\u67d3\u8272\u306b\u967d\u6027\u306e\u7d30\u80de\u3092\u6570\u3048\u3066\u3044\u308b\u3002\u52a9\u304b\u3063\u305f\u4eba\u6570\u3001\u5ef6\u3073\u305f\u5bff\u547d\u3001\u4fee\u5fa9\u3055\u308c\u305f\u5fc3\u81d3\u3092\u6570\u3048\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u3002<\/p>\n<p>\u540c\u69d8\u306b\u3001\u6fc3\u5ea6\u3068\u653e\u5c04\u7dda\u66dd\u9732\u306f\u5b9f\u9a13\u6761\u4ef6\u3092\u7279\u5b9a\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u4eba\u3078\u306e\u6295\u4e0e\u6307\u91dd\u3067\u306f\u306a\u3044\u3002\u5b9f\u9a13\u5ba4\u30e2\u30c7\u30eb\u306f\u554f\u3044\u3092\u7814\u7a76\u3057\u3084\u3059\u304f\u3059\u308b\u304c\u3001\u3088\u308a\u5b8c\u5168\u306a\u7cfb\u3067\u305d\u306e\u554f\u3044\u3092\u691c\u8a3c\u3059\u308b\u5fc5\u8981\u6027\u3092\u306a\u304f\u3059\u3082\u306e\u3067\u306f\u306a\u3044\u3002<\/p>\n<h2>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6e2c\u5b9a\u304c\u91cd\u8981\u3067\u3042\u308b\u7406\u7531<\/h2>\n<p>The study linked the senescence findings with mitochondrial observations. That gives researchers a direction for follow-up experiments, rather than a reason to reduce the result to \u201cmore energy.\u201d<\/p>\n<p>\u65b0\u3057\u3044\u5b9f\u9a13\u3067\u306f\u3001\u307e\u305a\u4e3b\u8981\u306a\u8aad\u307f\u51fa\u3057\u3092\u66f8\u304d\u7559\u3081\u308b\u3002\u305d\u308c\u304c\u67d3\u8272\u3067\u3042\u308c\u3070\u3001\u9069\u5207\u306a\u5834\u5408\u306b\u306f\u6a5f\u80fd\u307e\u305f\u306f\u5897\u6b96\u306e\u5225\u306e\u6e2c\u5b9a\u3092\u52a0\u3048\u308b\u3002\u305d\u3046\u3057\u306a\u3051\u308c\u3070\u3001\u4e00\u3064\u306e\u8a66\u9a13\u3067\u306e\u597d\u307e\u3057\u3044\u7d50\u679c\u304c\u3001\u5225\u306e\u672a\u89e3\u6c7a\u306e\u554f\u984c\u3092\u96a0\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n<h2>\u4f55\u304c\u672a\u89e3\u660e\u306e\u307e\u307e\u304b\uff1f<\/h2>\n<p>\u8457\u8005\u3089\u306fin-vivo\u691c\u8a3c\u3092\u6c42\u3081\u3066\u3044\u308b\u3002\u3053\u306e\u5b9f\u9a13\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u4e2d\u306e\u81e8\u5e8a\u7684\u4fdd\u8b77\u3092\u78ba\u7acb\u3057\u305f\u308a\u3001\u30d2\u30c8\u306e\u8001\u5316\u306e\u9006\u8ee2\u3092\u8a3c\u660e\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3002\u305d\u308c\u3089\u306f\u7570\u306a\u308b\u8a3c\u62e0\u3092\u8981\u3059\u308b\u3088\u308a\u5927\u304d\u306a\u554f\u3044\u3067\u3042\u308b\u3002<\/p>\n<p>\u5b9f\u7528\u7684\u306a\u4fa1\u5024\u306f\u3001\u3088\u308a\u5177\u4f53\u7684\u306a\u7814\u7a76\u4eee\u8aac\u3067\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5909\u5316\u306f\u3001\u653e\u5c04\u7dda\u95a2\u9023\u8001\u5316\u306e\u9078\u629e\u3055\u308c\u305f\u7279\u5fb4\u3092\u5909\u3048\u3046\u308b\u306e\u304b\u3001\u305d\u3057\u3066\u3069\u306e\u7279\u5fb4\u304c\u5909\u308f\u3089\u306a\u3044\u307e\u307e\u306a\u306e\u304b\u3001\u3068\u3044\u3046\u4eee\u8aac\u3067\u3059\u3002<\/p>\n<h2>\u95a2\u9023\u3059\u308bNHD\u7814\u7a76\u8cc7\u6599<\/h2>\n<p>\u305d\u306e <a href=\"https:\/\/nhdbio.com\/ja\/%e8%a3%bd%e5%93%81\/ss-31-%e3%82%a8%e3%83%a9%e3%83%9f%e3%83%97%e3%83%ac%e3%83%81%e3%83%89\/\">NHD SS-31 \/ Elamipretide\u30da\u30fc\u30b8<\/a> \u95a2\u9023\u3059\u308b\u7814\u7a76\u5ba4\u30ab\u30bf\u30ed\u30b0\u6750\u6599\u3092\u7279\u5b9a\u3059\u308b\u3002\u3042\u306a\u305f\u306e\u30a2\u30c3\u30bb\u30a4\u3067\u5229\u7528\u53ef\u80fd\u306a\u30d0\u30ea\u30a2\u30f3\u30c8\u304a\u3088\u3073\u5206\u6790\u8a18\u9332\u306b\u3064\u3044\u3066\u5c0b\u306d\u3066\u304f\u3060\u3055\u3044\u3002\u672c\u8ad6\u6587\u306fNHD\u30d0\u30c3\u30c1\u3092\u691c\u8a3c\u3057\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u30e9\u30dc\u306b\u95a2\u3059\u308b\u304a\u554f\u3044\u5408\u308f\u305b\u3067\u306f\u3001\u6750\u6599\u3001\u6570\u91cf\u3001\u4e88\u5b9a\u3057\u3066\u3044\u308b\u8a66\u9a13\u3001\u5fc5\u8981\u306a\u66f8\u985e\u3092\u304a\u77e5\u3089\u305b\u304f\u3060\u3055\u3044\u3002 <a href=\"https:\/\/nhdbio.com\/ja\/%e5%bc%95%e7%94%a8\/\">\u8cc7\u6599\u306e\u9078\u629e\u80a2\u3068\u5229\u7528\u53ef\u80fd\u306a\u6587\u66f8\u306b\u3064\u3044\u3066 NHD \u306b\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044<\/a>.<\/p>\n<h2>\u7d9a\u304d\u3092\u8aad\u3080<\/h2>\n<p><a href=\"https:\/\/nhdbio.com\/ja\/ss31-%e3%82%ab%e3%83%ab%e3%82%b8%e3%82%aa%e3%83%aa%e3%83%94%e3%83%b3%e3%81%ae%e3%83%9f%e3%83%88%e3%82%b3%e3%83%b3%e3%83%89%e3%83%aa%e3%82%a2%e3%82%a8%e3%83%8d%e3%83%ab%e3%82%ae%e3%83%bc%e6%a9%9f\/\">SS-31\u3001\u30ab\u30eb\u30b8\u30aa\u30ea\u30d4\u30f3\u304a\u3088\u3073\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7814\u7a76<\/a> \u3068 <a href=\"https:\/\/nhdbio.com\/ja\/ss31-%e5%8a%a0%e9%bd%a2%e7%ad%8b%e3%81%aeatp%e7%94%a3%e7%94%9f%e3%81%a8%e3%83%9f%e3%83%88%e3%82%b3%e3%83%b3%e3%83%89%e3%83%aa%e3%82%a2%e5%90%ab%e9%87%8f%e3%81%ae%e6%af%94%e8%bc%83\/\">ATP\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u542b\u91cf\u304c\u7570\u306a\u308b\u6e2c\u5b9a\u5024\u3067\u3042\u308b\u7406\u7531<\/a>.<\/p>\n<h2>\u539f\u5178<\/h2>\n<p><a href=\"https:\/\/academic.oup.com\/jrr\/article\/67\/4\/525\/8735112\">Xie et al., Journal of Radiation Research 67(4):525\u2013537; DOI 10.1093\/jrr\/rrag048<\/a>. 10 October 2026\u306b\u78ba\u8a8d\u3002AI\u652f\u63f4\u306b\u3088\u308b\u7de8\u96c6\u30ec\u30d3\u30e5\u30fc\u3067\u56f3\u3001\u7814\u7a76\u306e\u80cc\u666f\u3001\u5e73\u6613\u306a\u8a00\u8449\u9063\u3044\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u306f\u72ec\u7acb\u3057\u305f\u67fb\u8aad\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>NHD \u30ab\u30bf\u30ed\u30b0\u88fd\u54c1\u306f\u5b9f\u9a13\u5ba4\u3067\u306e\u7814\u7a76\u3001\u958b\u767a\u3001\u88fd\u9020\u7528\u3067\u3042\u308a\u3001\u4eba\u307e\u305f\u306f\u52d5\u7269\u3078\u306e\u4f7f\u7528\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u516c\u8868\u3055\u308c\u305f\u7814\u7a76\u306f NHD \u306e\u30ed\u30c3\u30c8\u3092\u8a8d\u8a3c\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30ab\u30bf\u30ed\u30b0\u88fd\u54c1\u306f\u81e8\u5e8a\u8a66\u9a13\u85ac\u307e\u305f\u306f\u8a66\u9a13\u6e08\u307f\u5316\u7ca7\u54c1\u51e6\u65b9\u3068\u4e92\u63db\u6027\u304c\u3042\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>2026\u7d30\u80de\u7814\u7a76\u3067\u306f\u3001SS-31\u306b\u3088\u308a\u8001\u5316\u30de\u30fc\u30ab\u30fc\u967d\u6027\u7d30\u80de\u304c\u6e1b\u5c11\u3057\u305f\u300267%\u306838%\u306e\u7d50\u679c\u3092\u7406\u89e3\u3057\u3001\u305d\u308c\u304c\u30d2\u30c8\u306e\u8001\u5316\u304c\u9006\u8ee2\u3057\u305f\u3053\u3068\u3092\u610f\u5473\u3057\u306a\u3044\u7406\u7531\u3092\u7406\u89e3\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>","protected":false},"author":1,"featured_media":3913,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"364","pim_article_type":"Research evidence explained","pim_evidence_level":"Cell experiments in rat H9C2 and human stem-cell-derived cardiomyocytes","pim_reviewer":"Codex AI editorial","pim_reviewed_date":"2026-10-10","pim_editorial_note":"AI-assisted source and readability checks, not independent peer review.","pim_review_status":"reviewed","pim_review_reason":"Primary sources and corrections checked; study populations and limitations retained; product-family links and enquiry paths reviewed; plain-language edit completed.","pim_creation_method":"AI-assisted writing","pim_sources":"[]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-3777","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>SS-31 and Cell Aging After Radiation: What Changed in the Lab?<\/title>\n<meta name=\"description\" content=\"A 2026 cell study found fewer senescence-marker-positive cells with SS-31. Understand the 67% versus 38% result and why it does not mean human aging was reversed.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nhdbio.com\/ja\/ss31-\u653e\u5c04\u7dda\u5fc3\u7b4b\u7d30\u80de\u8001\u5316\u7d30\u80de\u7814\u7a76\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SS-31 and Cell Aging After Radiation: What Changed in the Lab?\" \/>\n<meta property=\"og:description\" content=\"A 2026 cell study found fewer senescence-marker-positive cells with SS-31. 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