{"id":4588,"date":"2026-10-13T16:14:44","date_gmt":"2026-10-13T16:14:44","guid":{"rendered":"https:\/\/nhdbio.com\/?p=4588"},"modified":"2026-10-13T16:14:44","modified_gmt":"2026-10-13T16:14:44","slug":"ll37-%e8%87%aa%e5%b7%b1dna%e5%85%8d%e7%96%ab%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b6%e3%81%ae%e8%a7%a3%e8%aa%ac","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ja\/ll37-self-dna-immune-cell-study-explained\/","title":{"rendered":"LL-37 \u3068\u81ea\u5df1DNA\uff1a\u3053\u308c\u3089\u304c\u514d\u75ab\u7d30\u80de\u306b\u5230\u9054\u3059\u308b\u3068\u4f55\u304c\u8d77\u3053\u308b\u306e\u304b\uff1f"},"content":{"rendered":"<section class=\"nhd-cp-topic\" id=\"nhd-cp-topic-knowledge-20261013-13\">\n<p class=\"nhd-cp-lead\">LL-37\u306f\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u3067\u3059\u304c\u3001\u305d\u306e\u7814\u7a76\u306f\u7d30\u83cc\u3060\u3051\u306b\u3068\u3069\u307e\u308a\u307e\u305b\u3093\u30022007\u306e\u4e3b\u8981\u7814\u7a76\u3067\u306f\u3001\u30d2\u30c8DNA\u3078\u306e\u7d50\u5408\u304c\u514d\u75ab\u7d30\u80de\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/10\/nhd-knowledge-20261013-13.webp\" alt=\"\u3053\u306e\u30ac\u30a4\u30c9\u3067\u6271\u3046\u30c8\u30d4\u30c3\u30af\u306e\u30b3\u30df\u30c3\u30af\u30a4\u30e9\u30b9\u30c8\"><figcaption>\u7de8\u96c6\u7528\u30a4\u30e9\u30b9\u30c8\u3067\u3042\u308a\u3001\u5b9f\u9a13\u5199\u771f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/figcaption><\/figure>\n<h3>\u3053\u306e\u7814\u7a76\u306f\u6700\u521d\u306b\u4f55\u3092\u554f\u3044\u304b\u3051\u305f\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/h3>\n<p>\u7814\u7a76\u8005\u305f\u3061\u306f\u4e7e\u766c\u306b\u95a2\u9023\u3059\u308b\u514d\u75ab\u6d3b\u6027\u5316\u306b\u6ce8\u76ee\u3057\u3001\u3042\u308b\u7a2e\u306e\u514d\u75ab\u7d30\u80de\u306b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u3092\u7523\u751f\u3055\u305b\u308b\u8981\u56e0\u3092\u7a81\u304d\u6b62\u3081\u3088\u3046\u3068\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7a2e\u306e\u7d30\u80de\u306f\u5f62\u8cea\u7d30\u80de\u69d8\u6a39\u72b6\u7d30\u80de\u3068\u547c\u3070\u308c\u3001\u672c\u6587\u4e2d\u3067\u306f\u3057\u3070\u3057\u3070pDC\u3068\u7565\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u306f\u30e1\u30ab\u30cb\u30ba\u30e0\u7814\u7a76\u3067\u3059\u3002\u7814\u7a76\u5bfe\u8c61\u3001\u7d30\u80de\u7cfb\u3001\u51e6\u7406\u6761\u4ef6\u306f\u3059\u3079\u3066\u7279\u5b9a\u306e\u7bc4\u56f2\u306b\u9650\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002LL-37\u306e\u81e8\u5e8a\u5229\u7528\u8a08\u753b\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h3>DNA\u3068LL-37\u304c\u4e00\u7dd2\u306b\u306a\u308b\u3068\u3001\u3069\u306e\u3088\u3046\u306a\u5909\u5316\u304c\u73fe\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/h3>\n<p>\u4e3b\u8981\u306a\u7814\u7a76\u306b\u3088\u308a\u3001LL-37\u306f\u81ea\u5df1DNA\u3068\u8907\u5408\u4f53\u69cb\u9020\u3092\u5f62\u6210\u3057\u3001\u305d\u308c\u304c\u95a2\u9023\u3059\u308b\u7d30\u80de\u5185\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u3078\u306e\u4fb5\u5165\u3068\u6ede\u7559\u3092\u52a9\u3051\u3001\u305d\u306e\u5f8cTLR9\u306b\u95a2\u9023\u3059\u308b\u904e\u7a0b\u3092\u901a\u3058\u3066\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u3053\u3067\u6ce8\u76ee\u3059\u3079\u304d\u306f\u3001\u30da\u30d7\u30c1\u30c9\u5358\u72ec\u3067\u306f\u306a\u304f\u3001DNA\u3068\u30da\u30d7\u30c1\u30c9\u304b\u3089\u306a\u308b\u8907\u5408\u4f53\u3067\u3059\u3002<\/p>\n<p>\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306f\u514d\u75ab\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\u306e\u4e00\u7a2e\u3067\u3059\u3002\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306e\u5909\u5316\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u306f\u3001\u7814\u7a76\u7cfb\u306b\u304a\u3051\u308b\u514d\u75ab\u5fdc\u7b54\u304c\u5909\u5316\u3057\u305f\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u305d\u308c\u306f\u6297\u83cc\u80fd\u3084\u6cbb\u7642\u52b9\u679c\u3068\u76f4\u63a5\u540c\u4e00\u8996\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<h3>\u5b9f\u9a13\u3092\u8aad\u3080\u3068\u304d\u3001\u5bfe\u7167\u7fa4\u306f\u3069\u306e\u3088\u3046\u306b\u898b\u308b\u3079\u304d\u3067\u3057\u3087\u3046\u304b\uff1f<\/h3>\n<p>DNA\u5358\u72ec\u3001LL-37\u5358\u72ec\u3001\u304a\u3088\u3073\u4e21\u65b9\u3092\u4e00\u7dd2\u306b\u3057\u305f\u3082\u306e\u3092\u9806\u306b\u6bd4\u8f03\u3057\u3001\u7814\u7a76\u8005\u304cDNA\u3084\u95a2\u9023\u7d4c\u8def\u306e\u5bc4\u4e0e\u3092\u3069\u306e\u3088\u3046\u306b\u691c\u8a3c\u3057\u305f\u304b\u3092\u78ba\u8a8d\u3067\u304d\u307e\u3059\u3002\u5bfe\u7167\u7fa4\u306e\u7d44\u307f\u65b9\u306f\u3001\u5909\u5316\u304c\u3069\u306e\u6bb5\u968e\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u304b\u3092\u7406\u89e3\u3059\u308b\u9375\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>The teaching diagram only shows the conceptual order of &quot;material composition &#8211; cell entry &#8211; measured readout&quot;; for specific cell compartments, controls, and observations, still refer to the original figures and methods.<\/p>\n<h3>Why does &quot;antimicrobial peptide&quot; not mean it only acts against microbes in all scenarios?<\/h3>\n<p>\u6750\u6599\u306f\u3001\u7570\u306a\u308b\u5b9f\u9a13\u5bfe\u8c61\u3001\u7d50\u5408\u30d1\u30fc\u30c8\u30ca\u30fc\u3001\u307e\u305f\u306f\u74b0\u5883\u306b\u304a\u3044\u3066\u3001\u7570\u306a\u308b\u554f\u984c\u3092\u542b\u3080\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u7814\u7a76\u540d\u306f\u4e3b\u306a\u30ab\u30c6\u30b4\u30ea\u30fc\u3092\u793a\u3059\u3060\u3051\u3067\u3042\u308a\u3001\u5b9f\u9a13\u306e\u6587\u8108\u5168\u4f53\u3092\u7f6e\u304d\u63db\u3048\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<p>\u3057\u305f\u304c\u3063\u3066\u3001LL-37 \u8cc7\u6599\u3092\u8aad\u3080\u969b\u306f\u3001\u6297\u83cc\u5b9f\u9a13\u3001\u7d30\u80de\u904a\u8d70\u3001\u6838\u9178\u76f8\u4e92\u4f5c\u7528\u3001\u304a\u3088\u3073\u30d2\u30c8\u5275\u50b7\u7814\u7a76\u3092\u5206\u3051\u3066\u304f\u3060\u3055\u3044\u3002\u305d\u308c\u305e\u308c\u304c\u7528\u3044\u308b\u30e2\u30c7\u30eb\u3001\u6307\u6a19\u3001\u6750\u6599\u6761\u4ef6\u306f\u7570\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h3>\u3053\u306e\u7814\u7a76\u3092\u30a8\u30d3\u30c7\u30f3\u30b9\u30d9\u30fc\u30b9\u306b\u8a18\u9332\u3059\u308b<\/h3>\n<p>\u539f\u8457\u306e\u767a\u8868\u5e74\u3001\u7814\u7a76\u30e2\u30c7\u30eb\u3001\u5171\u51e6\u7406\u6750\u6599\u3001\u4e3b\u306a\u8aad\u307f\u51fa\u3057\u3001\u304a\u3088\u3073\u6a5f\u5e8f\u306e\u7bc4\u56f2\u3092\u8a18\u9332\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u5b9f\u9a13\u3092\u518d\u73fe\u3059\u308b\u6e96\u5099\u3092\u3059\u308b\u5834\u5408\u306f\u3001\u4f7f\u7528\u3057\u305f\u914d\u5217\u3001\u6838\u9178\u6750\u6599\u3001\u304a\u3088\u3073\u691c\u51fa\u6761\u4ef6\u3082\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u8ad6\u6587\u306e\u6a5f\u5e8f\u7d50\u679c\u306f\u3001\u30ab\u30bf\u30ed\u30b0\u30ed\u30c3\u30c8\u306e\u8a3c\u660e\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n<figure class=\"nhd-cp-diagram\"><figcaption class=\"nhd-cp-flow-title\">\u7d50\u8ad6\u3092\u5b9f\u9a13\u4e0a\u306e\u554f\u3044\u306b\u623b\u3059<\/figcaption><div class=\"nhd-cp-steps\">\n<div class=\"nhd-cp-step\"><b>LL-37 \u3068 DNA \u306e\u76f8\u4e92\u4f5c\u7528<\/b><span>\u7814\u7a76\u30b7\u30b9\u30c6\u30e0\uff1a\u7279\u5b9a\u306e\u514d\u75ab\u7d30\u80de\u304a\u3088\u3073\u95a2\u9023\u5b9f\u9a13<\/span><span>\u6e2c\u5b9a\u3055\u308c\u305f\u8aad\u307f\u51fa\u3057\u9805\u76ee\uff1a\u7d30\u80de\u5185\u30d7\u30ed\u30bb\u30b9\u304a\u3088\u3073\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u5fdc\u7b54<\/span><\/div>\n<\/div><figcaption>\u6559\u80b2\u7528\u307e\u3068\u3081\u3002\u8aac\u660e\u3068\u539f\u5178\u3092\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u3053\u308c\u306f\u7e2e\u5c3a\u901a\u308a\u306e\u5206\u5b50\u30e2\u30c7\u30eb\u3067\u3082\u88fd\u54c1\u8a66\u9a13\u7d50\u679c\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002<\/figcaption><\/figure>\n<div class=\"nhd-cp-table\">\n<table>\n<caption>\u7d50\u8ad6\u3092\u5b9f\u9a13\u4e0a\u306e\u554f\u3044\u306b\u623b\u3059<\/caption>\n<thead>\n<tr>\n<th scope=\"col\">\u6750\u6599<\/th>\n<th scope=\"col\">\u7814\u7a76\u30b7\u30b9\u30c6\u30e0<\/th>\n<th scope=\"col\">\u6e2c\u5b9a\u3055\u308c\u305f\u8aad\u307f\u51fa\u3057\u9805\u76ee<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>LL-37 \u3068 DNA \u306e\u76f8\u4e92\u4f5c\u7528<\/td>\n<td>\u7279\u5b9a\u306e\u514d\u75ab\u7d30\u80de\u304a\u3088\u3073\u95a2\u9023\u5b9f\u9a13<\/td>\n<td>\u7d30\u80de\u5185\u30d7\u30ed\u30bb\u30b9\u304a\u3088\u3073\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u5fdc\u7b54<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<section class=\"nhd-cp-depth\">\n<h3>\u30d2\u30c8\u7531\u6765\u7d30\u80de\u3092\u4f7f\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u3053\u308c\u306f\u6cbb\u7642\u8a66\u9a13\u3067\u3059\u304b\uff1f<\/h3>\n<p>A separate 2020 study recruited 55 recently diagnosed type 1 diabetes subjects and 25 healthy controls, then stimulated their isolated cells with DNA-LL37 complexes in vitro. Its abstract reports IFN-\u03b1-related and immune-phenotype changes. This is a human-derived-cell mechanism study, not treatment of 80 people with LL-37. Check each figure for the actual assay sample size.<\/p>\n<h3>\u8a3c\u62e0\u306e\u9023\u9396\u30923\u3064\u306e\u30b9\u30c6\u30c3\u30d7\u3067\u8aad\u3080<\/h3>\n<p>\u307e\u305a\u95a2\u9023\u3059\u308b\u30b2\u30eb\u307e\u305f\u306f\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u8a3c\u62e0\u3092\u7528\u3044\u3066\u8907\u5408\u4f53\u5f62\u6210\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002\u6b21\u306b\u7814\u7a76\u5bfe\u8c61\u306e\u7d30\u80de\u3078\u306e\u53d6\u308a\u8fbc\u307f\u3092\u691c\u8a0e\u3057\u3001\u6700\u5f8c\u306b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u307e\u305f\u306f\u8868\u73fe\u578b\u306e\u8aad\u307f\u51fa\u3057\u3092\u8abf\u3079\u307e\u3059\u3002\u3042\u308b\u30b9\u30c6\u30c3\u30d7\u306e\u8a3c\u62e0\u306f\u81ea\u52d5\u7684\u306b\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u3092\u78ba\u7acb\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u8907\u5408\u4f53\u5f62\u6210\u3060\u3051\u3067\u306f\u30d2\u30c8\u3067\u306e\u7d50\u679c\u3092\u78ba\u7acb\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<h3>\u3053\u3053\u3067\u666e\u904d\u7684\u306a\u30d1\u30fc\u30bb\u30f3\u30c6\u30fc\u30b8\u6539\u5584\u304c\u5b58\u5728\u3057\u306a\u3044\u7406\u7531<\/h3>\n<p>Figures may report fluorescence intensity, positive-cell proportions or other measures in different units. They cannot be combined into a percentage \u201cimprovement in immunity.\u201d Start with Figure 1 of the 2020 paper for complex formation, then read the cell assays with their subjects, units and comparators.<\/p>\n<p class=\"nhd-cp-source\"><a href=\"https:\/\/www.nature.com\/articles\/s41598-020-65851-y\" target=\"_blank\" rel=\"noopener\">1\u578b\u7cd6\u5c3f\u75c5\u306e\u88ab\u9a13\u8005\u306b\u304a\u3051\u308b\u5f62\u8cea\u7d30\u80de\u69d8\u6a39\u72b6\u7d30\u80de\u304a\u3088\u3073\u5358\u7403\u306e\u6d3b\u6027\u5316\u306b\u304a\u3051\u308bDNA-LL37\u8907\u5408\u4f53\u306e\u5f79\u5272<\/a> \u00b7 2020<\/p>\n<\/section>\n<h3>\u539f\u5178\u3068\u53c2\u8003\u6587\u732e<\/h3>\n<ul class=\"nhd-cp-source\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/nature06116\" target=\"_blank\" rel=\"noopener\">LL-37\u3001\u81ea\u5df1DNA\u304a\u3088\u3073\u5f62\u8cea\u7d30\u80de\u69d8\u6a39\u72b6\u7d30\u80de<\/a> \u00b7 2007<\/li>\n<\/ul>\n<p class=\"nhd-cp-source\">\u60c5\u5831\u6e90\u306f 2026-10-13 \u306b\u78ba\u8a8d\u6e08\u307f\u3067\u3059\u3002\u77e5\u898b\u306f\u7814\u7a76\u3055\u308c\u305f\u30e2\u30c7\u30eb\u3068\u6750\u6599\u306b\u9069\u7528\u3055\u308c\u307e\u3059\u3002\u30d0\u30c3\u30c1\u306e\u54c1\u8cea\u306b\u306f\u5b9f\u969b\u306e\u30d0\u30c3\u30c1\u306e\u8a18\u9332\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<h3>\u95a2\u9023\u7814\u7a76\u8cc7\u6599<\/h3>\n<div class=\"nhd-cp-products\"><a class=\"nhd-cp-product\" href=\"https:\/\/nhdbio.com\/ja\/%e8%a3%bd%e5%93%81\/ll-37\/\"><strong>LL-37<\/strong><span>\u6750\u6599\u306e\u540c\u4e00\u6027\u3001\u4ed5\u69d8\u3001\u5305\u88c5\u3092\u78ba\u8a8d\u3067\u304d\u307e\u3059\u3002\u6587\u66f8\u306b\u95a2\u3059\u308b\u30cb\u30fc\u30ba\u306f\u304a\u554f\u3044\u5408\u308f\u305b\u3067\u3054\u76f8\u8ac7\u3044\u305f\u3060\u3051\u307e\u3059\u3002<\/span><\/a><\/div>\n<p><a href=\"https:\/\/nhdbio.com\/ja\/%e5%bc%95%e7%94%a8\/\">\u4ed5\u69d8\u3001\u6570\u91cf\u3001\u5fc5\u8981\u306a\u66f8\u985e\u306b\u3064\u3044\u3066\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044<\/a><\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>LL-37\u306f\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u3067\u3059\u304c\u3001\u305d\u306e\u7814\u7a76\u306f\u7d30\u83cc\u3060\u3051\u306b\u3068\u3069\u307e\u308a\u307e\u305b\u3093\u30022007\u306e\u4e3b\u8981\u7814\u7a76\u3067\u306f\u3001\u30d2\u30c8DNA\u3078\u306e\u7d50\u5408\u304c\u514d\u75ab\u7d30\u80de\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>","protected":false},"author":1,"featured_media":4595,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"348","pim_article_type":"Published research explained","pim_evidence_level":"Primary references and labeled teaching examples","pim_reviewer":"AI-assisted source and editorial check","pim_reviewed_date":"2026-10-13","pim_editorial_note":"Editorial illustrations are not experimental photographs. Teaching values are labeled.","pim_review_status":"reviewed","pim_review_reason":"Reviewed source scope, numerical examples, natural Chinese, product links and content layout.","pim_creation_method":"AI-assisted writing","pim_sources":"[{\"title\":\"LL-37, self-DNA and plasmacytoid dendritic cells\",\"note\":\"LL-37, self-DNA and plasmacytoid dendritic cells\",\"url\":\"https:\/\/www.nature.com\/articles\/nature06116\"},{\"title\":\"Role of DNA-LL37 complexes in the activation of plasmacytoid dendritic cells and monocytes in subjects with type 1 diabetes\",\"note\":\"Role of DNA-LL37 complexes in the activation of plasmacytoid dendritic cells and monocytes in subjects with type 1 diabetes\",\"url\":\"https:\/\/www.nature.com\/articles\/s41598-020-65851-y\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-4588","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>LL-37 and self-DNA: what happens when they reach immune cells? | NHD<\/title>\n<meta name=\"description\" content=\"LL-37 is an antimicrobial peptide, but its research is not only about bacteria. 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