{"id":749,"date":"2026-09-01T16:45:45","date_gmt":"2026-09-01T16:45:45","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/ara-290-cibinetide-small-fiber-neuropathy-and-dme-trials\/"},"modified":"2026-09-01T16:45:45","modified_gmt":"2026-09-01T16:45:45","slug":"ara-290-cibinetide-small-fiber-neuropathy-and-dme-trials","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ja\/ara-290-cibinetide-small-fiber-neuropathy-and-dme-trials\/","title":{"rendered":"ARA-290\/\u30b7\u30d3\u30cd\u30c1\u30c9: \u5c0f\u7dda\u7dad\u6027\u795e\u7d4c\u969c\u5bb3\u304a\u3088\u3073 DME \u8a66\u9a13\u30c7\u30fc\u30bf"},"content":{"rendered":"<p class=\"pim-standfirst wp-block-paragraph\">\u30d2\u30c8\u306e\u30b7\u30d3\u30cd\u30c1\u30c9\u306e\u8a3c\u62e0\u306b\u306f\u3001\u975e\u5e38\u306b\u7570\u306a\u308b\u96c6\u56e3\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5c0f\u898f\u6a21\u306a\u63a2\u7d22\u7814\u7a76\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002 22 \u4eba\u306e\u30b5\u30eb\u30b3\u30a4\u30c9\u30fc\u30b7\u30b9\u795e\u7d4c\u969c\u5bb3\u306e\u30d1\u30a4\u30ed\u30c3\u30c8\u306f\u75c7\u72b6\u3068\u30b9\u30b3\u30a2\u306e\u9055\u3044\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u304c\u30019 \u4eba\u306e\u7cd6\u5c3f\u75c5\u9ec4\u6591\u6d6e\u816b\u306e\u7814\u7a76\u3067\u306f\u4e3b\u8981\u306a\u773c\u306e\u6e2c\u5b9a\u5024\u304c\u6b20\u843d\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p><div class=\"wp-block-group pim-key-takeaways\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><h2 class=\"wp-block-heading\">\u4e00\u76ee\u3067\u308f\u304b\u308b\u8a3c\u62e0<\/h2><ul class=\"wp-block-list\"><li>\u30e9\u30f3\u30c0\u30e0\u5316\u3055\u308c\u305f\u30b5\u30eb\u30b3\u30a4\u30c9\u30fc\u30b7\u30b9\u306e\u30d1\u30a4\u30ed\u30c3\u30c8\u3067\u306f\u300122 \u4eba\u306e\u53c2\u52a0\u8005\u304c\u767b\u9332\u3055\u308c\u307e\u3057\u305f\u300212 \u306b\u306f\u3001ARA-290 \u304a\u3088\u3073 10 \u306e\u30d7\u30e9\u30bb\u30dc\u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002<\/li><li>4 \u9031\u306e SFNSL \u306e\u5909\u5316\u306f\u3001\u221211.5 \u00b1 3.04 \u5bfe \u22122.9 \u00b1 3.34 \u3067\u3057\u305f\u304c\u3001\u75db\u307f\u306e\u5f37\u5ea6\u3068\u75b2\u52b4\u30b9\u30b3\u30a2\u306f\u4e21\u30b0\u30eb\u30fc\u30d7\u3067\u540c\u69d8\u306b\u6539\u5584\u3057\u307e\u3057\u305f\u3002<\/li><li>DME \u7814\u7a76\u3067\u306f\u30019 \u304c\u767b\u9332\u3055\u308c\u30018 \u304c\u5b8c\u4e86\u3057\u307e\u3057\u305f\u3002\u5e73\u5747\u8996\u529b\u3001\u7db2\u819c\u306e\u539a\u3055\u3001\u7db2\u819c\u306e\u611f\u5ea6\u3001\u6d99\u6db2\u91cf\u306f\u6539\u5584\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/li><\/ul><\/div><\/div><figure class=\"wp-block-image size-full pim-article-figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1672\" height=\"941\" src=\"http:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence.webp\" alt=\"\u30b7\u30d3\u30cd\u30c1\u30c9\u306e\u89d2\u819c\u304a\u3088\u3073\u672b\u68a2\u7d30\u795e\u7d4c\u7dda\u7dad\u7814\u7a76\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\" class=\"wp-image-733\" srcset=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence.webp 1672w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence-300x169.webp 300w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence-1024x576.webp 1024w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence-768x432.webp 768w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/cibinetide-small-fiber-evidence-1536x864.webp 1536w\" sizes=\"auto, (max-width: 1672px) 100vw, 1672px\" \/><figcaption class=\"wp-element-caption\">\u30aa\u30ea\u30b8\u30ca\u30eb\u306e\u7de8\u96c6\u8abf\u67fb\u30a4\u30e9\u30b9\u30c8\u3002\u3053\u308c\u306f\u3001\u7814\u7a76\u56f3\u3001\u60a3\u8005\u753b\u50cf\u3001\u88fd\u54c1\u5199\u771f\u3001\u63d0\u4f9b\u3055\u308c\u305f\u5206\u6790\u7d50\u679c\u3001\u307e\u305f\u306f\u30ab\u30bf\u30ed\u30b0\u30ed\u30c3\u30c8\u306e\u8868\u73fe\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/figcaption><\/figure><h2 class=\"wp-block-heading\">\u5b66\u7fd2\u8a18\u9332<\/h2><p class=\"wp-block-paragraph\">\u795e\u7d4c\u969c\u5bb3\u306e\u30d1\u30a4\u30ed\u30c3\u30c8\u306f\u3001\u5c0f\u7dda\u7dad\u795e\u7d4c\u969c\u5bb3\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30ea\u30b9\u30c8\u306e\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u5909\u5316\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u7c21\u5358\u306a\u75db\u307f\u306e\u30a4\u30f3\u30d9\u30f3\u30c8\u30ea\u3068\u75b2\u52b4\u30b9\u30b3\u30a2\u306f\u4e21\u30b0\u30eb\u30fc\u30d7\u3067\u5927\u5e45\u306b\u3001\u3057\u304b\u3057\u540c\u7b49\u306b\u6539\u5584\u3057\u307e\u3057\u305f\u304c\u3001\u3046\u3064\u75c5\u306e\u30a4\u30f3\u30d9\u30f3\u30c8\u30ea\u306f\u5909\u5316\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p><div class=\"wp-block-group pim-evidence-table\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"pim-evidence-row\"><strong>\u30b5\u30eb\u30b3\u30a4\u30c9\u30fc\u30b7\u30b9\u306e\u8a2d\u8a08<\/strong><span>\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u306e\u63a2\u7d22\u7684\u30d1\u30a4\u30ed\u30c3\u30c8\u3002 n=22<\/span><\/div><div class=\"pim-evidence-row\"><strong>SFNSL\u5909\u66f4<\/strong><span>\u221211.5 \u00b1 3.04 \u5bfe \u22122.9 \u00b1 3.34 (\u9031 4)<\/span><\/div><div class=\"pim-evidence-row\"><strong>DME\u30c7\u30b6\u30a4\u30f3<\/strong><span>\u30b7\u30f3\u30b0\u30eb\u30a2\u30fc\u30e0\u30d5\u30a7\u30fc\u30ba 2; 9 \u767b\u9332\u30018 \u5b8c\u4e86<\/span><\/div><div class=\"pim-evidence-row\"><strong>DME\u306e\u4e3b\u306a\u5bfe\u7b56<\/strong><span>BCVA\u3001CRT\u3001\u7db2\u819c\u904e\u654f\u75c7\u3001\u6d99\u6db2\u7523\u751f\u306e\u5e73\u5747\u7684\u306a\u6539\u5584\u306f\u307f\u3089\u308c\u306a\u3044<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u5168\u4f53\u7684\u306a\u89e3\u91c8<\/strong><span>\u30b7\u30b0\u30ca\u30eb\u306f\u4eee\u8aac\u3092\u751f\u6210\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u78ba\u8a8d\u7684\u306a\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/span><\/div><\/div><\/div><h2 class=\"wp-block-heading\">\u30b3\u30f3\u30c6\u30ad\u30b9\u30c8\u5185\u306e\u7d50\u679c<\/h2><p class=\"wp-block-paragraph\">2020 \u306e\u7cd6\u5c3f\u75c5\u9ec4\u6591\u6d6e\u816b\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u3055\u3089\u306b\u5c0f\u898f\u6a21\u3067\u3057\u305f\u3002 12 \u9031\u3067\u306f\u3001\u5e73\u5747 BCVA \u306f -2.9 \u00b1 5.0\u3001\u7db2\u819c\u4e2d\u5fc3\u539a\u306f 10 \u00b1 94.6 \u03bcm\u3001\u7db2\u819c\u4e2d\u5fc3\u611f\u5ea6\u306f -0.53 \u00b1 1.9 dB \u5909\u5316\u3057\u307e\u3059\u3002\u60a3\u8005\u304c\u5831\u544a\u3057\u305f\u8996\u899a\u6a5f\u80fd\u8907\u5408\u4f53\u306f\u30012.7 \u00b1 3.1 \u3060\u3051\u6539\u5584\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u8a2d\u8a08\u306f\u8a18\u8ff0\u7684\u3067\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p><p class=\"wp-block-paragraph\">DME \u8ad6\u6587\u306e\u8457\u8005\u306e\u4f55\u4eba\u304b\u306f\u3001\u958b\u767a\u8005\u306e\u5f79\u54e1\u3001\u6240\u6709\u8005\u3001\u307e\u305f\u306f\u30b3\u30f3\u30b5\u30eb\u30bf\u30f3\u30c8\u3067\u3057\u305f\u3002\u3053\u306e\u958b\u793a\u306f\u7d50\u679c\u3092\u7121\u52b9\u306b\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u8aad\u8005\u304c\u5c0f\u898f\u6a21\u306a\u63a2\u7d22\u7684\u8a66\u9a13\u3092\u5224\u65ad\u3059\u308b\u969b\u306b\u306f\u30c7\u30fc\u30bf\u306e\u5916\u306b\u5c5e\u3057\u307e\u3059\u3002<\/p><h2 class=\"wp-block-heading\">\u8a3c\u62e0\u304c\u8a3c\u660e\u3067\u304d\u306a\u3044\u3082\u306e<\/h2><p class=\"wp-block-paragraph\">\u30b5\u30f3\u30d7\u30eb\u304c\u5c11\u306a\u304f\u8ffd\u8de1\u8abf\u67fb\u304c\u77ed\u3044\u3068\u3001\u52b9\u679c\u306e\u63a8\u5b9a\u5024\u304c\u4e0d\u5b89\u5b9a\u306b\u306a\u308a\u307e\u3059\u3002<\/p><p class=\"wp-block-paragraph\">\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u3084\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3092 1 \u3064\u306e\u5e83\u7bc4\u306a\u300c\u795e\u7d4c\u4fee\u5fa9\u300d\u306e\u4e3b\u5f35\u306b\u7d44\u307f\u8fbc\u3080\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p><p class=\"wp-block-paragraph\">\u3069\u3061\u3089\u306e\u7814\u7a76\u3082\u3001\u30ab\u30bf\u30ed\u30b0\u8cc7\u6599\u3068\u306e\u540c\u7b49\u6027\u3092\u78ba\u7acb\u3057\u305f\u308a\u3001\u7814\u7a76\u5916\u3067\u306e\u4f7f\u7528\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u305f\u308a\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u30d2\u30c8\u306e\u30b7\u30d3\u30cd\u30c1\u30c9\u306e\u8a3c\u62e0\u306b\u306f\u3001\u975e\u5e38\u306b\u7570\u306a\u308b\u96c6\u56e3\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5c0f\u898f\u6a21\u306a\u63a2\u7d22\u7814\u7a76\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002 22 \u4eba\u306e\u30b5\u30eb\u30b3\u30a4\u30c9\u30fc\u30b7\u30b9\u795e\u7d4c\u969c\u5bb3\u306e\u30d1\u30a4\u30ed\u30c3\u30c8\u306f\u75c7\u72b6\u3068\u30b9\u30b3\u30a2\u306e\u9055\u3044\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u304c\u30019 \u4eba\u306e\u7cd6\u5c3f\u75c5\u9ec4\u6591\u6d6e\u816b\u306e\u7814\u7a76\u3067\u306f\u4e3b\u8981\u306a\u773c\u306e\u6e2c\u5b9a\u5024\u304c\u6b20\u843d\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>","protected":false},"author":1,"featured_media":733,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"315","pim_article_type":"Published evidence review","pim_evidence_level":"Small exploratory human trials; mixed endpoints and no confirmatory efficacy record","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, study size, model\/population limits and relevant conflicts are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary\/regulatory sources, factual claims, numerical results, limitations and product-evidence boundary checked for batch 3.","pim_creation_method":"The editorial workflow began with linked PubMed primary papers, systematic reviews, PubChem identity records and FDA\/DailyMed regulatory records. Population or model, denominators, endpoints, numerical results, null findings, limitations and conflicts were extracted before drafting. AI-assisted drafting and original image generation were used; the final facts and evidence boundaries were checked against the linked records on 2026-09-02. This is not independent peer review.","pim_sources":"[{\"title\":\"Randomized ARA-290 sarcoidosis-neuropathy pilot\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23168581\/\",\"note\":\"Primary exploratory trial; PMID 23168581.\"},{\"title\":\"Phase 2 cibinetide diabetic macular edema study\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32674280\/\",\"note\":\"Nine-person study with null principal ocular measures; PMID 32674280.\"},{\"title\":\"PubChem Cibinetide record\",\"url\":\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Cibinetide\",\"note\":\"Sequence, synonyms, formula and mass; CID 91810664.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-749","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>ARA-290\/Cibinetide: Small-Fiber Neuropathy and DME Trial Data<\/title>\n<meta name=\"description\" content=\"Human cibinetide evidence includes small exploratory studies with very different populations. 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