{"id":761,"date":"2026-09-01T16:45:45","date_gmt":"2026-09-01T16:45:45","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/semax-2024-2025-animal-model-evidence-stroke-spinal-cord\/"},"modified":"2026-09-01T16:45:45","modified_gmt":"2026-09-01T16:45:45","slug":"semax-2024-2025-%e5%8b%95%e7%89%a9%e3%83%a2%e3%83%87%e3%83%ab-%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9-%e8%84%b3%e5%8d%92%e4%b8%ad-%e8%84%8a%e9%ab%84","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ja\/semax-2024-2025-animal-model-evidence-stroke-spinal-cord\/","title":{"rendered":"Semax 2024\u20132025 \u306e\u8a3c\u62e0: \u30e9\u30c3\u30c8\u8133\u5352\u4e2d\u30e2\u30c7\u30eb\u3068\u30de\u30a6\u30b9\u810a\u9ac4\u30e2\u30c7\u30eb"},"content":{"rendered":"<p class=\"pim-standfirst wp-block-paragraph\">\u6700\u8fd1\u306e Semax \u8ad6\u6587\u3067\u306f\u3001\u30e9\u30c3\u30c8\u3001\u96cc\u30de\u30a6\u30b9\u3001\u7d30\u80de\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u5206\u5b50\u7684\u304a\u3088\u3073\u6a5f\u80fd\u7684\u767a\u898b\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4eee\u8aac\u3092\u62e1\u5f35\u3057\u307e\u3059\u304c\u3001\u5e83\u7bc4\u306a\u795e\u7d4c\u4fdd\u8b77\u306e\u4e3b\u5f35\u306b\u3088\u3063\u3066\u3057\u3070\u3057\u3070\u793a\u5506\u3055\u308c\u308b\u30d2\u30c8\u3068\u306e\u6bd4\u8f03\u8a3c\u62e0\u306f\u63d0\u4f9b\u3057\u307e\u305b\u3093\u3002<\/p><div class=\"wp-block-group pim-key-takeaways\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><h2 class=\"wp-block-heading\">\u4e00\u76ee\u3067\u308f\u304b\u308b\u8a3c\u62e0<\/h2><ul class=\"wp-block-list\"><li>2024\u30e9\u30c3\u30c8\u865a\u8840\u7814\u7a76\u3067\u306f\u30012\u3064\u306eACTH\u69d8\u30da\u30d7\u30c1\u30c9\u4e0b\u3067\u865a\u8840\u304a\u3088\u3073\u90e8\u5206\u7684\u6b63\u898f\u5316\u5f8c\u306b3,774\u907a\u4f1d\u5b50\u304c\u5dee\u6b21\u7684\u306b\u767a\u73fe\u3059\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u3002<\/li><li>Semax \u3068\u30b3\u30f3\u30d1\u30ec\u30fc\u30bf\u30fc\u6761\u4ef6\u306f\u3001\u305d\u308c\u305e\u308c 1,539 \u3068 2,066 \u306e\u5dee\u6b21\u7684\u306b\u767a\u73fe\u3055\u308c\u308b\u907a\u4f1d\u5b50\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002 1,171 \u865a\u8840\u306b\u3088\u3063\u3066\u6b6a\u3093\u3060\u907a\u4f1d\u5b50\u306f\u3001\u4e21\u65b9\u306b\u3088\u3063\u3066\u88dc\u511f\u3055\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/li><li>2025 \u7814\u7a76\u3067\u306f\u3001\u5b9f\u9a13\u7684\u306b\u810a\u9ac4\u640d\u50b7\u3092\u8ca0\u3063\u305f\u30e1\u30b9\u306e C57BL\/6 \u30de\u30a6\u30b9\u3092\u4f7f\u7528\u3057\u3001Oprm1\/USP18\/FTO \u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u63d0\u6848\u3057\u307e\u3057\u305f\u3002<\/li><\/ul><\/div><\/div><figure class=\"wp-block-image size-full pim-article-figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1672\" height=\"941\" src=\"http:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/semax-preclinical-evidence.webp\" alt=\"\u30de\u30a6\u30b9\u810a\u9ac4\u304a\u3088\u3073\u30e9\u30c3\u30c8\u8133\u865a\u8840\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u7814\u7a76\u306e\u30d3\u30b8\u30e5\u30a2\u30eb\" class=\"wp-image-745\" srcset=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/semax-preclinical-evidence.webp 1672w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/semax-preclinical-evidence-300x169.webp 300w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/semax-preclinical-evidence-1024x576.webp 1024w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/semax-preclinical-evidence-768x432.webp 768w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/semax-preclinical-evidence-1536x864.webp 1536w\" sizes=\"auto, (max-width: 1672px) 100vw, 1672px\" \/><figcaption class=\"wp-element-caption\">\u30aa\u30ea\u30b8\u30ca\u30eb\u306e\u7de8\u96c6\u8abf\u67fb\u30a4\u30e9\u30b9\u30c8\u3002\u3053\u308c\u306f\u3001\u7814\u7a76\u56f3\u3001\u60a3\u8005\u753b\u50cf\u3001\u88fd\u54c1\u5199\u771f\u3001\u63d0\u4f9b\u3055\u308c\u305f\u5206\u6790\u7d50\u679c\u3001\u307e\u305f\u306f\u30ab\u30bf\u30ed\u30b0\u30ed\u30c3\u30c8\u306e\u8868\u73fe\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/figcaption><\/figure><h2 class=\"wp-block-heading\">\u5b66\u7fd2\u8a18\u9332<\/h2><p class=\"wp-block-paragraph\">\u30e9\u30c3\u30c8\u306e\u8ad6\u6587\u3067\u306f\u3001\u4e00\u904e\u6027\u306e\u4e2d\u5927\u8133\u52d5\u8108\u9589\u585e\u304b\u3089\u6570\u6642\u9593\u5f8c\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb 24 \u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u6642\u70b9\u3067 2 \u3064\u306e\u30da\u30d7\u30c1\u30c9\u6761\u4ef6\u3092\u5206\u3051\u305f\u306e\u306f 32 \u5dee\u6b21\u7684\u306b\u767a\u73fe\u3057\u305f\u907a\u4f1d\u5b50\u3060\u3051\u3067\u3042\u3063\u305f\u305f\u3081\u3001\u8457\u8005\u3089\u306f\u76f4\u63a5\u306e\u5927\u304d\u306a\u9055\u3044\u3067\u306f\u306a\u304f\u5168\u4f53\u7684\u306a\u985e\u4f3c\u6027\u3092\u5f37\u8abf\u3057\u307e\u3057\u305f\u3002<\/p><div class=\"wp-block-group pim-evidence-table\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"pim-evidence-row\"><strong>2024\u30e2\u30c7\u30eb<\/strong><span>\u30e9\u30c3\u30c8\u306e\u4e00\u904e\u6027\u4e2d\u5927\u8133\u52d5\u8108\u9589\u585e\u3002 RNA-seq\u300124 \u6642\u9593<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u865a\u8840 DEG<\/strong><span>\u500d\u7387\u5909\u66f4\u6642\u306e 3,774 &gt;1.5 \u304a\u3088\u3073\u8abf\u6574\u6e08\u307f P&lt;0.05<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u88dc\u511f\u3055\u308c\u305f\u907a\u4f1d\u5b50\u306e\u5171\u6709<\/strong><span>1,171\u306f\u514d\u75ab\u304a\u3088\u3073\u795e\u7d4c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059<\/span><\/div><div class=\"pim-evidence-row\"><strong>2025\u30e2\u30c7\u30eb<\/strong><span>\u96cc\u30de\u30a6\u30b9 T9\u2013T10 \u810a\u9ac4\u640d\u50b7\u3068 PC12 \u7d30\u80de\u30e2\u30c7\u30eb<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u81e8\u5e8a\u5883\u754c<\/strong><span>\u30e9\u30f3\u30c0\u30e0\u5316\u3055\u308c\u305f\u30d2\u30c8\u3078\u306e\u6709\u52b9\u6027\u3084\u9577\u671f\u7684\u306a\u5b89\u5168\u6027\u306e\u7d50\u679c\u306f\u3042\u308a\u307e\u305b\u3093<\/span><\/div><\/div><\/div><h2 class=\"wp-block-heading\">\u30b3\u30f3\u30c6\u30ad\u30b9\u30c8\u5185\u306e\u7d50\u679c<\/h2><p class=\"wp-block-paragraph\">2025 \u810a\u9ac4\u8ad6\u6587\u3067\u306f\u3001\u904b\u52d5\u5668\u691c\u67fb\u3001\u7d44\u7e54\u67d3\u8272\u3001\u9855\u5fae\u93e1\u691c\u67fb\u3001RNA \u914d\u5217\u6c7a\u5b9a\u3001\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u5b9f\u9a13\u3001\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u85ac\u7406\u5b66\u3001\u5206\u5b50\u30c9\u30c3\u30ad\u30f3\u30b0\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u308c\u306f\u3001Semax \u95a2\u9023\u306e\u56de\u5fa9\u3068\u03bc-\u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3001USP18 \u304a\u3088\u3073 FTO \u8131\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3092\u7d50\u3073\u4ed8\u3051\u307e\u3057\u305f\u3002\u3053\u306e\u8907\u6570\u306e\u65b9\u6cd5\u306e\u9023\u9396\u306f\u3001\u4f9d\u7136\u3068\u3057\u3066\u524d\u81e8\u5e8a\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u63d0\u6848\u306b\u3068\u3069\u307e\u308a\u307e\u3059\u3002<\/p><p class=\"wp-block-paragraph\">\u52d5\u7269\u306e\u6a5f\u80fd\u56de\u5fa9\u3001\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u306e\u6b63\u898f\u5316\u3001\u7d30\u80de\u30e2\u30c7\u30eb\u30a2\u30c3\u30bb\u30a4\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u7591\u554f\u306b\u7b54\u3048\u307e\u3059\u3002\u3069\u308c\u3082\u4eba\u3005\u306e\u78ba\u7acb\u3055\u308c\u305f\u56de\u5fa9\u3068\u3057\u3066\u66f8\u304d\u63db\u3048\u3089\u308c\u308b\u3079\u304d\u3067\u306f\u306a\u304f\u3001\u5206\u5b50\u30c9\u30c3\u30ad\u30f3\u30b0\u3060\u3051\u3067\u306f\u30bf\u30fc\u30b2\u30c3\u30c8\u306e\u691c\u8a3c\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u3002<\/p><h2 class=\"wp-block-heading\">\u8a3c\u62e0\u304c\u8a3c\u660e\u3067\u304d\u306a\u3044\u3082\u306e<\/h2><p class=\"wp-block-paragraph\">\u7a2e\u3001\u50b7\u5bb3\u306e\u8a98\u767a\u3001\u30bf\u30a4\u30df\u30f3\u30b0\u3001\u5b9f\u9a13\u5ba4\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u4eba\u9593\u306e\u81e8\u5e8a\u30b1\u30a2\u3068\u306f\u7570\u306a\u308a\u307e\u3059\u3002<\/p><p class=\"wp-block-paragraph\">2025 \u306e\u7814\u7a76\u3067\u306f\u30e1\u30b9\u306e\u30de\u30a6\u30b9\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002\u6027\u5225\u3068\u7a2e\u306e\u4e00\u822c\u5316\u306b\u306f\u76f4\u63a5\u7684\u306a\u30c6\u30b9\u30c8\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p><p class=\"wp-block-paragraph\">\u3053\u308c\u3089\u306e\u7814\u7a76\u306f\u3001\u30d2\u30c8\u306b\u304a\u3051\u308b\u85ac\u7269\u52d5\u614b\u3001\u6709\u52b9\u6027\u306e\u6bd4\u8f03\u3001\u30ab\u30bf\u30ed\u30b0\u30ed\u30c3\u30c8\u306e\u540c\u7b49\u6027\u3092\u78ba\u7acb\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u6700\u8fd1\u306e Semax \u8ad6\u6587\u3067\u306f\u3001\u30e9\u30c3\u30c8\u3001\u96cc\u30de\u30a6\u30b9\u3001\u7d30\u80de\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u5206\u5b50\u7684\u304a\u3088\u3073\u6a5f\u80fd\u7684\u767a\u898b\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4eee\u8aac\u3092\u62e1\u5f35\u3057\u307e\u3059\u304c\u3001\u5e83\u7bc4\u306a\u795e\u7d4c\u4fdd\u8b77\u306e\u4e3b\u5f35\u306b\u3088\u3063\u3066\u3057\u3070\u3057\u3070\u793a\u5506\u3055\u308c\u308b\u30d2\u30c8\u3068\u306e\u6bd4\u8f03\u8a3c\u62e0\u306f\u63d0\u4f9b\u3057\u307e\u305b\u3093\u3002<\/p>","protected":false},"author":1,"featured_media":745,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"361","pim_article_type":"Published evidence review","pim_evidence_level":"Recent preclinical animal and cell-model evidence; no matched human efficacy trial","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, study size, model\/population limits and relevant conflicts are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary\/regulatory sources, factual claims, numerical results, limitations and product-evidence boundary checked for batch 3.","pim_creation_method":"The editorial workflow began with linked PubMed primary papers, systematic reviews, PubChem identity records and FDA\/DailyMed regulatory records. Population or model, denominators, endpoints, numerical results, null findings, limitations and conflicts were extracted before drafting. AI-assisted drafting and original image generation were used; the final facts and evidence boundaries were checked against the linked records on 2026-09-02. This is not independent peer review.","pim_sources":"[{\"title\":\"Semax and rat brain gene expression after ischemia\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39767736\/\",\"note\":\"Primary 2024 rat RNA-seq study; PMID 39767736.\"},{\"title\":\"Semax in a female-mouse spinal-cord-injury model\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40692165\/\",\"note\":\"Primary 2025 preclinical study; PMID 40692165.\"},{\"title\":\"Semax protein-expression study in rat cerebral ischemia\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34201112\/\",\"note\":\"Sequence and preclinical context; PMID 34201112.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-761","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Semax Evidence in 2024\u20132025: Rat Stroke and Mouse Spinal-Cord Models<\/title>\n<meta name=\"description\" content=\"Recent Semax papers report molecular and functional findings in rats, female mice and cell models. 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