{"id":789,"date":"2026-09-01T17:35:05","date_gmt":"2026-09-01T17:35:05","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/igf-1-lr3-fermentation-and-animal-evidence-review\/"},"modified":"2026-09-08T07:30:41","modified_gmt":"2026-09-08T07:30:41","slug":"igf-1-lr3%e3%81%ae%e7%99%ba%e9%85%b5%e3%81%8a%e3%82%88%e3%81%b3%e5%8b%95%e7%89%a9%e5%ae%9f%e9%a8%93%e3%81%ab%e3%82%88%e3%82%8b%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ae%e3%83%ac%e3%83%93","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ja\/igf-1-lr3-fermentation-and-animal-evidence-review\/","title":{"rendered":"IGF-1 LR3 \u8a3c\u62e0: \u767a\u9175\u3001\u725b\u3001\u30cc\u30eb\u306e\u7d50\u679c"},"content":{"rendered":"<p class=\"pim-standfirst wp-block-paragraph\">Direct Long R3 IGF-1 \u306e\u6587\u732e\u306f\u3001\u4e3b\u306b\u7d44\u63db\u3048\u751f\u7523\u3068\u52d5\u7269\u751f\u7269\u5b66\u306b\u95a2\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u4e00\u90e8\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u5909\u66f4\u3055\u308c\u307e\u3057\u305f\u304c\u3001739 \u3068\u5375\u6bcd\u7d30\u80de\u306e\u6bd4\u8f03\u3067\u306f\u3001\u6e1b\u6570\u5206\u88c2\u306e\u9032\u884c\u3084\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u9055\u3044\u306f\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p><div class=\"wp-block-group pim-key-takeaways\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><h2 class=\"wp-block-heading\">\u4e00\u76ee\u3067\u308f\u304b\u308b\u8a3c\u62e0<\/h2><ul class=\"wp-block-list\"><li>2023 Pichia \u7814\u7a76\u3067\u306f\u300115 L \u30d0\u30a4\u30aa\u30ea\u30a2\u30af\u30bf\u30fc\u306b\u304a\u3051\u308b\u30ad\u30b7\u30e9\u30ca\u30fc\u30bc-TEV-LR3 IGF-1 \u878d\u5408\u4f53\u306e 1 g\/L \u306b\u3064\u3044\u3066\u5831\u544a\u3057\u307e\u3057\u305f\u3002<\/li><li>2020 \u7814\u7a76\u3067\u306f\u300110 \u30d7\u30fc\u30eb\u5185\u306e 739 \u30a6\u30b7\u5375\u4e18 - \u5375\u6bcd\u7d30\u80de\u8907\u5408\u4f53\u3092\u5206\u6790\u3057\u3001\u6e1b\u6570\u5206\u88c2\u306e\u9032\u884c\u3084\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u30b0\u30eb\u30fc\u30d7\u306e\u9055\u3044\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/li><li>1999\u306e\u672a\u7d4c\u7523\u725b\u306e\u7814\u7a76\u3067\u306f\u3001\u30d2\u30c8\u306e\u540c\u5316\u52b9\u679c\u3067\u306f\u306a\u304f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4fdd\u5b58\u3068\u8840\u6f3f\u30a2\u30df\u30ce\u9178\u3068\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u9855\u8457\u306a\u6e1b\u5c11\u306e\u50be\u5411\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/li><\/ul><\/div><\/div><figure class=\"wp-block-image size-full pim-article-figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1672\" height=\"941\" src=\"http:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/igf1-lr3-evidence.webp\" alt=\"\u30c9\u30ad\u30e5\u30e1\u30f3\u30bf\u30ea\u30fc\u306e\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\u30d0\u30a4\u30aa\u30ea\u30a2\u30af\u30bf\u30fc\u306e\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\" class=\"wp-image-773\" srcset=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/igf1-lr3-evidence.webp 1672w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/igf1-lr3-evidence-300x169.webp 300w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/igf1-lr3-evidence-1024x576.webp 1024w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/igf1-lr3-evidence-768x432.webp 768w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/igf1-lr3-evidence-1536x864.webp 1536w\" sizes=\"auto, (max-width: 1672px) 100vw, 1672px\" \/><figcaption class=\"wp-element-caption\">AI \u304c\u4f5c\u6210\u3057\u305f\u30ea\u30b5\u30fc\u30c1 \u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3092\u793a\u3059\u7de8\u96c6\u7528\u30a4\u30e9\u30b9\u30c8\u3002\u7814\u7a76\u6570\u5024\u3001\u60a3\u8005\u753b\u50cf\u3001\u88fd\u54c1\u5199\u771f\u3001\u5206\u6790\u7d50\u679c\u3001\u30ab\u30bf\u30ed\u30b0\u30ed\u30c3\u30c8\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/figcaption><\/figure><h2 class=\"wp-block-heading\">\u5b66\u7fd2\u8a18\u9332<\/h2><p class=\"wp-block-paragraph\">2023 \u306e\u8ad6\u6587\u3067\u306f\u3001\u30d4\u30ad\u30a2 \u30d1\u30b9\u30c8\u30ea\u30b9\u3067\u306e\u7570\u7a2e\u767a\u73fe\u3092\u9ad8\u3081\u308b\u305f\u3081\u306e\u878d\u5408\u30d1\u30fc\u30c8\u30ca\u30fc\u3068\u3057\u3066\u30ad\u30b7\u30e9\u30ca\u30fc\u30bc\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7cbe\u88fd\u3055\u308c\u305f IGF-1 \u304a\u3088\u3073 LR3 IGF-1 \u306f\u6a19\u6e96\u3068\u540c\u7b49\u306e\u7d30\u80de\u5897\u6b96\u6d3b\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u304c\u3001\u751f\u7523\u53ce\u91cf\u3068 in vitro \u30d0\u30a4\u30aa\u30a2\u30c3\u30bb\u30a4\u3067\u306f\u81e8\u5e8a\u52b9\u679c\u304c\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p><div class=\"wp-block-group pim-evidence-table\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"pim-evidence-row\"><strong>2023\u5236\u4f5c<\/strong><span>Pichia pastoris\u300115 L \u30d0\u30a4\u30aa\u30ea\u30a2\u30af\u30bf\u30fc\u3001\u7d04 1 g\/L \u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea<\/span><\/div><div class=\"pim-evidence-row\"><strong>2020 \u5375\u6bcd\u7d30\u80de\u306e\u7814\u7a76<\/strong><span>739 \u30a6\u30b7 COC; 10 \u30d7\u30fc\u30eb\u3002 100 ng\/mL; 22\u201324 \u6642\u9593<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u30cc\u30eb\u7d50\u679c<\/strong><span>\u6e1b\u6570\u5206\u88c2\u306e\u9032\u884c\u307e\u305f\u306f\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u9055\u3044\u306f\u3042\u308a\u307e\u305b\u3093 (P&gt;0.05)<\/span><\/div><div class=\"pim-evidence-row\"><strong>1999\u30e2\u30c7\u30eb<\/strong><span>8\u6642\u9593\u306eIV\u70b9\u6ef4\u4e2d\u306e\u5236\u9650\u7d66\u990c\u725b\u672a\u7d4c\u7523\u725b<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u4eba\u9593\u306e\u5883\u754c\u7dda<\/strong><span>\u3053\u308c\u3089\u306e\u60c5\u5831\u6e90\u3067\u306f\u30d2\u30c8\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u3084\u5b89\u5168\u6027\u3092\u7ba1\u7406\u3059\u308b\u8a66\u9a13\u306f\u884c\u308f\u308c\u3066\u3044\u307e\u305b\u3093<\/span><\/div><\/div><\/div><h2 class=\"wp-block-heading\">\u30b3\u30f3\u30c6\u30ad\u30b9\u30c8\u5185\u306e\u7d50\u679c<\/h2><p class=\"wp-block-paragraph\">\u30a6\u30b7\u5375\u6bcd\u7d30\u80de\u6210\u719f\u306b\u304a\u3044\u3066\u3001100 ng\/mL IGF-1 \u307e\u305f\u306f Long R3 IGF-1 \u3092 PVA \u304a\u3088\u3073\u30a6\u30b7\u80ce\u5150\u8840\u6e05\u5bfe\u7167\u3068\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u3044\u304f\u3064\u304b\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u9055\u3044\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u6e1b\u6570\u5206\u88c2\u306e\u9032\u884c\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u306f\u9055\u3044\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u306e null \u7d50\u679c\u3092\u4fdd\u6301\u3059\u308b\u3068\u3001\u9078\u629e\u7684\u306a\u30ec\u30dd\u30fc\u30c8\u304c\u751f\u6210\u3055\u308c\u306a\u304f\u306a\u308a\u307e\u3059\u3002<\/p><p class=\"wp-block-paragraph\">\u5236\u9650\u7d66\u990c\u725b\u306e\u672a\u7d4c\u7523\u725b\u3067\u306f\u30018\u6642\u9593\u306e\u6ce8\u5165\u306b\u3088\u308a\u5168\u8eab\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7b4b\u8089\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7dad\u6301\u3055\u308c\u3001\u5faa\u74b0\u4ee3\u8b1d\u7523\u7269\u3068\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5909\u5316\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u7a2e\u3001\u6804\u990a\u72b6\u614b\u3001\u304a\u3088\u3073\u6ce8\u5165\u30c7\u30b6\u30a4\u30f3\u306b\u3088\u308a\u3001\u3053\u306e\u7d50\u679c\u306f\u4eba\u9593\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u76f4\u63a5\u4e3b\u5f35\u3059\u308b\u306e\u306b\u306f\u4e0d\u9069\u5207\u3067\u3059\u3002<\/p><h2 class=\"wp-block-heading\">\u8a3c\u62e0\u304c\u8a3c\u660e\u3067\u304d\u306a\u3044\u3082\u306e<\/h2><p class=\"wp-block-paragraph\">\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u53ce\u91cf\u306f\u88fd\u9020\u7d50\u679c\u3067\u3042\u308a\u3001\u6709\u52b9\u6027\u306e\u7d50\u679c\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p><p class=\"wp-block-paragraph\">\u725b\u306e\u7d30\u80de\u304a\u3088\u3073\u52d5\u7269\u5168\u4f53\u306e\u6240\u898b\u306f\u3001\u7ffb\u8a33\u524d\u306b\u4eba\u4f53\u3067\u306e\u85ac\u7406\u5b66\u304a\u3088\u3073\u5b89\u5168\u6027\u306e\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p><p class=\"wp-block-paragraph\">\u76f4\u63a5\u7684\u306a\u6587\u732e\u306f\u3042\u307e\u308a\u306b\u3082\u591a\u69d8\u3067\u3042\u308b\u305f\u3081\u3001\u5358\u4e00\u306e\u666e\u904d\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3084\u5229\u76ca\u306e\u4e3b\u5f35\u3092\u88cf\u4ed8\u3051\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>Direct Long R3 IGF-1 \u306e\u6587\u732e\u306f\u3001\u4e3b\u306b\u7d44\u63db\u3048\u751f\u7523\u3068\u52d5\u7269\u751f\u7269\u5b66\u306b\u95a2\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u4e00\u90e8\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u5909\u66f4\u3055\u308c\u307e\u3057\u305f\u304c\u3001739 \u3068\u5375\u6bcd\u7d30\u80de\u306e\u6bd4\u8f03\u3067\u306f\u3001\u6e1b\u6570\u5206\u88c2\u306e\u9032\u884c\u3084\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u9055\u3044\u306f\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>","protected":false},"author":1,"featured_media":773,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"340","pim_article_type":"Published evidence review","pim_evidence_level":"Recombinant-production, cell and cattle studies; no controlled human efficacy trial","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, sample size, model\/population limits and regulatory scope are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary and official sources, numerical results, null findings, limitations, product-evidence boundary and image disclosure checked for batch 4.","pim_creation_method":"This article discusses the source records listed below, with the study models and limitations stated alongside the findings. AI-assisted drafting and image generation were used. The reference list identifies the records behind this article; it is not an independent peer review or verification of a supplied catalog lot.","pim_sources":"[{\"title\":\"Recombinant IGF-1 and LR3 IGF-1 expression in Pichia\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37261455\/\",\"note\":\"Primary 2023 expression and bioactivity study; PMID 37261455.\"},{\"title\":\"IGF-1 and LongR3 IGF-1 in bovine oocyte maturation\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33038561\/\",\"note\":\"Comparative 739-COC study with null meiotic\/apoptosis results; PMID 33038561.\"},{\"title\":\"Long R3 IGF-1 and protein metabolism in beef heifers\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10370861\/\",\"note\":\"Primary 1999 cattle metabolism study; PMID 10370861.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-789","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>IGF-1 LR3 Evidence: Fermentation, Cattle and Null Results<\/title>\n<meta name=\"description\" content=\"Direct Long R3 IGF-1 literature is largely about recombinant production and animal biology. 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