{"id":821,"date":"2026-09-01T19:07:33","date_gmt":"2026-09-01T19:07:33","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/menotropins-hmg-randomized-trial-evidence-review\/"},"modified":"2026-09-08T07:30:41","modified_gmt":"2026-09-08T07:30:41","slug":"menotropins-hmg-randomized-trial-evidence-review","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ja\/menotropins-hmg-randomized-trial-evidence-review\/","title":{"rendered":"\u30e1\u30ce\u30c8\u30ed\u30d4\u30f3\u306e\u8a3c\u62e0: \u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u3001\u598a\u5a20\u3001OHSS"},"content":{"rendered":"<p class=\"pim-standfirst wp-block-paragraph\">\u30e1\u30ce\u30c8\u30ed\u30d4\u30f3\u306e\u8a66\u9a13\u3067\u306f\u3001\u76e3\u8996\u3055\u308c\u305f\u30d7\u30ed\u30c8\u30b3\u30eb\u5185\u3067\u6307\u5b9a\u3055\u308c\u305f\u6a19\u6e96\u5316\u3055\u308c\u305f\u4e0d\u598a\u6cbb\u7642\u85ac\u3092\u8a55\u4fa1\u3057\u307e\u3059\u3002\u305d\u308c\u3089\u306e\u7d50\u679c\u3092\u672a\u5b9a\u7fa9\u306e hMG \u6df7\u5408\u7269\u306b\u79fb\u3057\u305f\u308a\u3001\u4e00\u822c\u7684\u306a FSH \u30d7\u30e9\u30b9 LH \u306e\u4e3b\u5f35\u306b\u9084\u5143\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p><div class=\"wp-block-group pim-key-takeaways\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><h2 class=\"wp-block-heading\">\u4e00\u76ee\u3067\u308f\u304b\u308b\u8a3c\u62e0<\/h2><ul class=\"wp-block-list\"><li>620\u53c2\u52a0\u8005\u8a66\u9a13\u3067\u306f\u3001\u9ad8\u53cd\u5fdc\u6027\u3068\u4e88\u6e2c\u3055\u308c\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u9ad8\u5ea6\u306b\u7cbe\u88fd\u3055\u308c\u305fhMG\u3068\u7d44\u63db\u3048FSH\u3092\u6bd4\u8f03\u3057\u305f\u3002<\/li><li>\u7d99\u7d9a\u4e2d\u306e\u598a\u5a20\u306f 35.5% \u5bfe 30.7% \u3067\u3057\u305f\u3002\u5dee\u306f\u30012.7 \u304b\u3089 12.1 \u307e\u3067\u306e 95% CI \u306e 4.7 \u30d1\u30fc\u30bb\u30f3\u30c6\u30fc\u30b8 \u30dd\u30a4\u30f3\u30c8\u3067\u3057\u305f\u3002<\/li><li>OHSS \u306f 9.7% \u5bfe 21.4% \u3067\u767a\u751f\u3057\u307e\u3057\u305f\u304c\u3001\u7d2f\u7a4d\u51fa\u751f\u6570\u306f 50.6% \u5bfe 51.5% \u3067\u3057\u305f\u3002<\/li><\/ul><\/div><\/div><figure class=\"wp-block-image size-full pim-article-figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1672\" height=\"941\" src=\"http:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/hmg-evidence.webp\" alt=\"\u30e1\u30ce\u30c8\u30ed\u30d4\u30f3\u306b\u95a2\u3059\u308b\u30c9\u30ad\u30e5\u30e1\u30f3\u30bf\u30ea\u30fc\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u7d71\u8a08\u30ec\u30d3\u30e5\u30fc\" class=\"wp-image-805\" srcset=\"https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/hmg-evidence.webp 1672w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/hmg-evidence-300x169.webp 300w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/hmg-evidence-1024x576.webp 1024w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/hmg-evidence-768x432.webp 768w, https:\/\/nhdbio.com\/wp-content\/uploads\/2026\/09\/hmg-evidence-1536x864.webp 1536w\" sizes=\"auto, (max-width: 1672px) 100vw, 1672px\" \/><figcaption class=\"wp-element-caption\">AI \u304c\u4f5c\u6210\u3057\u305f\u30ea\u30b5\u30fc\u30c1 \u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3092\u793a\u3059\u7de8\u96c6\u7528\u30a4\u30e9\u30b9\u30c8\u3002\u7814\u7a76\u6570\u5024\u3001\u60a3\u8005\u753b\u50cf\u3001\u88fd\u54c1\u5199\u771f\u3001\u5206\u6790\u7d50\u679c\u3001\u30ab\u30bf\u30ed\u30b0\u30ed\u30c3\u30c8\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/figcaption><\/figure><h2 class=\"wp-block-heading\">\u5b66\u7fd2\u8a18\u9332<\/h2><p class=\"wp-block-paragraph\">\u9ad8\u53cd\u5fdc\u6027\u8a66\u9a13\u3067\u306f\u3001\u598a\u5a20\u306e\u307f\u3092\u5831\u544a\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u3044\u304f\u3064\u304b\u306e\u7d50\u679c\u304c\u7dad\u6301\u3055\u308c\u307e\u3057\u305f\u3002\u7570\u306a\u308bOHSS\u7387\u3068\u540c\u69d8\u306e\u7d2f\u7a4d\u51fa\u751f\u7387\u306f\u3001\u306a\u305c\u5229\u76ca\u3068\u5b89\u5168\u6027\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u4e21\u65b9\u304c\u8981\u7d04\u306b\u542b\u307e\u308c\u308b\u306e\u304b\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p><div class=\"wp-block-group pim-evidence-table\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"pim-evidence-row\"><strong>MEGASET-HR<\/strong><span>620 \u5973\u6027\u3002\u7121\u4f5c\u70ba\u5316\u3001\u975e\u76f2\u691c\u3001\u8a55\u4fa1\u8005\u76f2\u691c\u975e\u52a3\u6027<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u7d99\u7d9a\u4e2d\u306e\u598a\u5a20<\/strong><span>35.5% HP-hMG \u5bfe 30.7% rFSH<\/span><\/div><div class=\"pim-evidence-row\"><strong>OHSS<\/strong><span>9.7% \u5bfe 21.4%<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u7d2f\u7a4d\u51fa\u751f\u6570<\/strong><span>50.6% \u5bfe 51.5%<\/span><\/div><div class=\"pim-evidence-row\"><strong>\u53e4\u3044\u6392\u5375\u8a66\u9a13<\/strong><span>91 HP-hMG \u5bfe 93 rFSH;\u6392\u5375 85.7% \u3068 85.5%<\/span><\/div><\/div><\/div><h2 class=\"wp-block-heading\">\u30b3\u30f3\u30c6\u30ad\u30b9\u30c8\u5185\u306e\u7d50\u679c<\/h2><p class=\"wp-block-paragraph\">\u5225\u306eWHO\u30b0\u30eb\u30fc\u30d7II\u7121\u6392\u5375\u6027\u4e0d\u598a\u8a66\u9a13\u3067\u306f\u3001\u6392\u5375\u7387\u306f\u307b\u307c\u540c\u3058\u3067\u3057\u305f\u3002 OHSS \u307e\u305f\u306f\u904e\u5270\u5fdc\u7b54\u30ad\u30e3\u30f3\u30bb\u30eb\u306f\u3001p=0.058 \u306e 2.2% \u3068 9.8% \u3067\u3057\u305f\u3002 p \u5024\u306f\u6c7a\u5b9a\u7684\u306a\u5dee\u7570\u3068\u3057\u3066\u66f8\u304d\u63db\u3048\u3089\u308c\u308b\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p><p class=\"wp-block-paragraph\">DailyMed \u306f\u3001Menopur \u306b\u3064\u3044\u3066\u3001\u30d0\u30a4\u30a2\u30eb\u3042\u305f\u308a 75 IU FSH \u304a\u3088\u3073 75 IU LH \u6d3b\u6027\u3092\u542b\u307f\u3001hCG \u304c\u691c\u51fa\u53ef\u80fd\u306a\u9589\u7d4c\u5f8c\u306e\u5c3f\u7531\u6765\u7269\u8cea\u3067\u3042\u308b\u3068\u8aac\u660e\u3057\u3066\u3044\u307e\u3059\u3002\u30e9\u30d9\u30eb\u3068\u8a66\u9a13\u7d50\u679c\u306f\u3001\u898f\u5236\u3055\u308c\u305f\u8abf\u88fd\u7269\u3068\u76e3\u8996\u3055\u308c\u305f\u4f7f\u7528\u306b\u9069\u7528\u3055\u308c\u307e\u3059\u3002<\/p><h2 class=\"wp-block-heading\">\u8a3c\u62e0\u304c\u8a3c\u660e\u3067\u304d\u306a\u3044\u3082\u306e<\/h2><p class=\"wp-block-paragraph\">\u975e\u76f2\u691c\u8a2d\u8a08\u3068\u9078\u629e\u3055\u308c\u305f\u751f\u6b96\u80fd\u529b\u96c6\u56e3\u3067\u306f\u3001\u4e00\u822c\u5316\u304c\u5236\u9650\u3055\u308c\u307e\u3059\u3002<\/p><p class=\"wp-block-paragraph\">\u598a\u5a20\u3001\u51fa\u7523\u3001OHSS \u3092 1 \u3064\u306e\u6709\u52b9\u6027\u30b9\u30b3\u30a2\u306b\u307e\u3068\u3081\u308b\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p><p class=\"wp-block-paragraph\">Menopur \u307e\u305f\u306f\u5225\u306e\u540d\u524d\u306e\u88fd\u54c1\u306e\u8a66\u9a13\u8a3c\u62e0\u306f\u3001\u7814\u7a76 hMG \u3092\u691c\u8a3c\u3057\u307e\u305b\u3093\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u30e1\u30ce\u30c8\u30ed\u30d4\u30f3\u306e\u8a66\u9a13\u3067\u306f\u3001\u76e3\u8996\u3055\u308c\u305f\u30d7\u30ed\u30c8\u30b3\u30eb\u5185\u3067\u6307\u5b9a\u3055\u308c\u305f\u6a19\u6e96\u5316\u3055\u308c\u305f\u4e0d\u598a\u6cbb\u7642\u85ac\u3092\u8a55\u4fa1\u3057\u307e\u3059\u3002\u305d\u308c\u3089\u306e\u7d50\u679c\u3092\u672a\u5b9a\u7fa9\u306e hMG \u6df7\u5408\u7269\u306b\u79fb\u3057\u305f\u308a\u3001\u4e00\u822c\u7684\u306a FSH \u30d7\u30e9\u30b9 LH \u306e\u4e3b\u5f35\u306b\u9084\u5143\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>","protected":false},"author":1,"featured_media":805,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"339","pim_article_type":"Published evidence review","pim_evidence_level":"Large assessor-blinded noninferiority trial, smaller randomized trial and official product label","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, sample size, model\/population limits, finished-drug scope, regulatory status and product-evidence boundaries are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary and official sources, numerical results, null findings, limitations, product-evidence boundary and image disclosure checked for batch 5.","pim_creation_method":"This article discusses the source records listed below, with the study models and limitations stated alongside the findings. AI-assisted drafting and image generation were used. The reference list identifies the records behind this article; it is not an independent peer review or verification of a supplied catalog lot.","pim_sources":"[{\"title\":\"DailyMed Menopur label\",\"url\":\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=22c8db95-c3db-1770-8086-31356fbabe35\",\"note\":\"Official product description, potency, source and safety context.\"},{\"title\":\"Highly purified hMG versus recombinant FSH in high responders\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32416978\/\",\"note\":\"620-participant randomized noninferiority trial; PMID 32416978.\"},{\"title\":\"HP-hMG versus recombinant FSH in WHO group II infertility\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16571641\/\",\"note\":\"184-participant randomized trial; PMID 16571641.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-821","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Menotropins Evidence: Randomized Trials, Pregnancy and OHSS<\/title>\n<meta name=\"description\" content=\"Menotropins trials evaluate named, standardized fertility medicines within monitored protocols. 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