{"id":825,"date":"2026-09-01T19:07:33","date_gmt":"2026-09-01T19:07:33","guid":{"rendered":"https:\/\/nhdbio.com\/resources\/foxo4-dri-senolytic-cell-and-mouse-evidence-review\/"},"modified":"2026-09-08T07:30:41","modified_gmt":"2026-09-08T07:30:41","slug":"foxo4-dri-senolytic-cell-and-mouse-evidence-review","status":"publish","type":"post","link":"https:\/\/nhdbio.com\/ja\/foxo4-dri-senolytic-cell-and-mouse-evidence-review\/","title":{"rendered":"FOXO4-DRI \u306e\u30a8\u30d3\u30c7\u30f3\u30b9\uff1a\u8001\u5316\u7d30\u80de\u3001\u30de\u30a6\u30b9\u3001\u30d2\u30c8\u306b\u95a2\u3059\u308b\u672a\u89e3\u660e\u70b9"},"content":{"rendered":"

FOXO4-DRI \u306f\u3001\u57f9\u990a\u7d30\u80de\u3068\u30de\u30a6\u30b9\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u30b5\u30dd\u30fc\u30c8\u3055\u308c\u305f\u5b9f\u9a13\u7684\u306a\u8001\u5316\u7d30\u80de\u7834\u58ca\u30c7\u30b6\u30a4\u30f3\u3067\u3059\u3002\u4f53\u529b\u3001\u814e\u6a5f\u80fd\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3001\u8840\u7ba1\u6a5f\u80fd\u304c\u56de\u5fa9\u3057\u305f\u3068\u3044\u3046\u5831\u544a\u306f\u307e\u3060\u524d\u81e8\u5e8a\u6bb5\u968e\u306b\u3042\u308a\u307e\u3059\u3002<\/p>

\u4e00\u76ee\u3067\u308f\u304b\u308b\u8a3c\u62e0<\/h2>
  • 2017 Cell \u8ad6\u6587\u306f\u3001FOXO4 \u3068 p53 \u306e\u76f8\u4e92\u4f5c\u7528\u3092\u7834\u58ca\u3057\u3001\u611f\u53d7\u6027\u306e\u3042\u308b\u8001\u5316\u7d30\u80de\u306b\u304a\u3051\u308b\u9078\u629e\u7684\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002<\/li>
  • \u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u5316\u5b66\u7642\u6cd5\u306b\u3055\u3089\u3055\u308c\u305f\u6025\u901f\u8001\u5316\u30de\u30a6\u30b9\u304a\u3088\u3073\u81ea\u7136\u8001\u5316\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u3001\u4f53\u529b\u3001\u6bdb\u76ae\u306e\u5bc6\u5ea6\u3001\u814e\u6a5f\u80fd\u306e\u6e2c\u5b9a\u5024\u306e\u5909\u5316\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>
  • 2020 \u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\u8ad6\u6587\u3068 2026 \u5185\u76ae\u8ad6\u6587\u306f\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306e\u6240\u898b\u3092\u8ffd\u52a0\u3057\u307e\u3057\u305f\u304c\u3001\u3044\u305a\u308c\u3082\u30d2\u30c8\u3078\u306e\u5229\u76ca\u3084\u9577\u671f\u7684\u306a\u5b89\u5168\u6027\u3092\u78ba\u7acb\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/li><\/ul><\/div><\/div>
    \"\u7d30\u80de\u7814\u7a76\u306e\u8a3c\u62e0\u3092\u30ec\u30d3\u30e5\u30fc\u3059\u308b\u8001\u5316\u751f\u7269\u5b66\u7814\u7a76\u5ba4\u306e\u30c9\u30ad\u30e5\u30e1\u30f3\u30bf\u30ea\u30fc\"
    AI \u304c\u4f5c\u6210\u3057\u305f\u30ea\u30b5\u30fc\u30c1 \u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3092\u793a\u3059\u7de8\u96c6\u7528\u30a4\u30e9\u30b9\u30c8\u3002\u7814\u7a76\u6570\u5024\u3001\u60a3\u8005\u753b\u50cf\u3001\u88fd\u54c1\u5199\u771f\u3001\u5206\u6790\u7d50\u679c\u3001\u30ab\u30bf\u30ed\u30b0\u30ed\u30c3\u30c8\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/figcaption><\/figure>

    \u5b66\u7fd2\u8a18\u9332<\/h2>

    2017 \u5b9f\u9a13\u306f\u3001FOXO4 \u95a2\u9023\u306e p53 \u4fdd\u6301\u3092\u7834\u58ca\u3059\u308b\u3068\u3001\u9078\u629e\u3055\u308c\u305f\u8001\u5316\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u4fc3\u9032\u3055\u308c\u308b\u3068\u3044\u3046\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7406\u8ad6\u7684\u6839\u62e0\u3092\u63d0\u4f9b\u3057\u307e\u3057\u305f\u3002 in vivo \u3067\u306e\u7d50\u679c\u306f\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u63a2\u7d22\u7684\u306a\u7d44\u7e54\u6052\u5e38\u6027\u6e2c\u5b9a\u3067\u3042\u308a\u3001\u30d2\u30c8\u306e\u9577\u5bff\u8a66\u9a13\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>

    2017\u30e2\u30c7\u30eb<\/strong>\u57f9\u990a\u8001\u5316\u7d30\u80de\u3002\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u640d\u50b7\u3002 XpdTTD\/TTD \u304a\u3088\u3073\u81ea\u7136\u8001\u5316\u30de\u30a6\u30b9<\/span><\/div>
    \u5831\u544a\u3055\u308c\u305f\u30de\u30a6\u30b9\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8<\/strong>\u30d5\u30a3\u30c3\u30c8\u30cd\u30b9\u3001\u6bdb\u76ae\u306e\u5bc6\u5ea6\u3001\u814e\u6a5f\u80fd\u306e\u6e2c\u5b9a<\/span><\/div>
    2020\u30e2\u30c7\u30eb<\/strong>H2O2\u8001\u5316TM3\u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\u3068\u81ea\u7136\u8001\u5316\u30de\u30a6\u30b9<\/span><\/div>
    2026\u30e2\u30c7\u30eb<\/strong>\u81ea\u7136\u8001\u5316\u30de\u30a6\u30b9\u3001\u8001\u5316\u8a98\u5c0e\u30de\u30a6\u30b9\u3001\u65e9\u8001\u75c7\u30de\u30a6\u30b9\u3068\u5185\u76ae\u7d30\u80de<\/span><\/div>
    \u4eba\u9593\u306e\u6210\u679c<\/strong>\u7ba1\u7406\u3055\u308c\u305f\u6709\u52b9\u6027\u3001\u7528\u91cf\u7bc4\u56f2\u3001\u307e\u305f\u306f\u9577\u671f\u7684\u306a\u5b89\u5168\u6027\u306e\u8a3c\u62e0\u306f\u78ba\u8a8d\u3055\u308c\u3066\u3044\u306a\u3044<\/span><\/div><\/div><\/div>

    \u30b3\u30f3\u30c6\u30ad\u30b9\u30c8\u5185\u306e\u7d50\u679c<\/h2>

    2020 \u7814\u7a76\u3067\u306f\u3001FOXO4-DRI \u3068\u9ad8\u9f62\u30de\u30a6\u30b9\u306e\u8001\u5316\u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\u306e\u751f\u5b58\u304a\u3088\u3073\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u95a2\u9023\u30de\u30fc\u30ab\u30fc\u306e\u5909\u5316\u304c\u95a2\u9023\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002 2026 \u5185\u76ae\u7814\u7a76\u3067\u306f\u3001\u8907\u6570\u306e\u30de\u30a6\u30b9\u8001\u5316\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u8840\u7ba1\u6a5f\u80fd\u3068\u8001\u5316\u7d4c\u8def\u306e\u6240\u898b\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>

    \u305d\u306e\u5f8c\u306e\u524d\u81e8\u5e8a\u51fa\u7248\u3067\u306f\u3001\u81ea\u52d5\u7684\u306b\u72ec\u7acb\u3057\u305f\u81e8\u5e8a\u78ba\u8a8d\u304c\u5f97\u3089\u308c\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7ffb\u8a33\u306b\u306f\u3001\u5b9a\u7fa9\u3055\u308c\u305f\u85ac\u7269\u52d5\u614b\u3001\u4f53\u5185\u5206\u5e03\u3001\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u52b9\u679c\u3001\u514d\u75ab\u539f\u6027\u3001\u7528\u91cf\u7bc4\u56f2\u3001\u304a\u3088\u3073\u30d2\u30c8\u3067\u306e\u8ee2\u5e30\u306e\u5236\u5fa1\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>

    \u8a3c\u62e0\u304c\u8a3c\u660e\u3067\u304d\u306a\u3044\u3082\u306e<\/h2>

    \u30de\u30a6\u30b9\u306e\u30d5\u30a3\u30c3\u30c8\u30cd\u30b9\u3001\u6bdb\u76ae\u3001\u814e\u81d3\u3001\u5185\u5206\u6ccc\u3001\u8840\u7ba1\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u306f\u3001\u30d2\u30c8\u306e\u82e5\u8fd4\u308a\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>

    \u7d30\u80de\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u9078\u629e\u6bd2\u6027\u306f\u3001\u751f\u7269\u5168\u4f53\u306e\u8001\u5316\u7d30\u80de\u306e\u9078\u629e\u6027\u3092\u8a3c\u660e\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>

    \u5206\u6790\u7684\u306a\u95a2\u9023\u6027\u304c\u5b9f\u8a3c\u3055\u308c\u306a\u3044\u9650\u308a\u3001\u30ab\u30bf\u30ed\u30b0 \u30ed\u30c3\u30c8\u306f\u7814\u7a76\u8ad6\u6587\u306b\u3088\u3063\u3066\u691c\u8a3c\u3055\u308c\u307e\u305b\u3093\u3002<\/p>","protected":false},"excerpt":{"rendered":"

    FOXO4-DRI \u306f\u3001\u57f9\u990a\u7d30\u80de\u3068\u30de\u30a6\u30b9\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u30b5\u30dd\u30fc\u30c8\u3055\u308c\u305f\u5b9f\u9a13\u7684\u306a\u8001\u5316\u7d30\u80de\u7834\u58ca\u30c7\u30b6\u30a4\u30f3\u3067\u3059\u3002\u4f53\u529b\u3001\u814e\u6a5f\u80fd\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3001\u8840\u7ba1\u6a5f\u80fd\u304c\u56de\u5fa9\u3057\u305f\u3068\u3044\u3046\u5831\u544a\u306f\u307e\u3060\u524d\u81e8\u5e8a\u6bb5\u968e\u306b\u3042\u308a\u307e\u3059\u3002<\/p>","protected":false},"author":1,"featured_media":809,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pim_family_ids":"328","pim_article_type":"Published evidence review","pim_evidence_level":"Cell and mouse evidence from 2017, 2020 and 2026; no controlled human efficacy study","pim_reviewer":"Site evidence editorial team","pim_reviewed_date":"2026-09-02","pim_editorial_note":"Source-checked on 2026-09-02. Null results, sample size, model\/population limits, finished-drug scope, regulatory status and product-evidence boundaries are retained. This is not medical advice, a customer case or validation of a catalog lot.","pim_review_status":"reviewed","pim_review_reason":"Primary and official sources, numerical results, null findings, limitations, product-evidence boundary and image disclosure checked for batch 5.","pim_creation_method":"This article discusses the source records listed below, with the study models and limitations stated alongside the findings. AI-assisted drafting and image generation were used. The reference list identifies the records behind this article; it is not an independent peer review or verification of a supplied catalog lot.","pim_sources":"[{\"title\":\"Targeted apoptosis of senescent cells\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28340339\/\",\"note\":\"Foundational 2017 cell and mouse study; PMID 28340339.\"},{\"title\":\"FOXO4-DRI and aged Leydig-cell function\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31959736\/\",\"note\":\"2020 cell and aged-mouse study; PMID 31959736.\"},{\"title\":\"FOXO4-DRI and endothelial-cell senescence\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41625068\/\",\"note\":\"2026 endothelial and mouse-aging-model study; PMID 41625068.\"}]","footnotes":""},"categories":[19],"tags":[],"class_list":["post-825","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-study-cases"],"yoast_head":"\nFOXO4-DRI Evidence: Senescent Cells, Mice and Human Unknowns<\/title>\n<meta name=\"description\" content=\"FOXO4-DRI is an experimental senolytic design supported by cultured-cell and mouse studies. 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