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西安诺和达生物科技有限公司
For research, development and manufacturing use only. Not for human or veterinary use.

Growth Hormone & IGF · Long-acting GHRH analogue research

CJC-1295 (with DAC)

Scientific Product Dossier

CJC-1295 with DAC is a lab-made peptide based on growth hormone-releasing hormone. The DAC group lets it stick to albumin, a common blood protein, which makes it last far longer in the body than natural GHRH. In short studies of healthy adults, one injection raised average growth hormone for at least six days and IGF-1 for about nine to eleven days. Growth hormone was still released in bursts, but levels between bursts were higher. These studies tracked hormones only. They tell us nothing about long-term health or body composition. This is a research material, not a medicine, and not the same as CJC-1295 without DAC.

Research use only Lot documents on request
CJC-1295 (with DAC) research product family with 3 catalog variants
AI-generated packaging mockup for catalog navigation. It is not a photograph of an actual supplied lot; container, label and presentation may vary.

Product family

Compound overview

Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; request the applicable product specification and ask which lot records are available before ordering.

Product identity

Product type
Peptide research compound
Catalog family
CJC-1295 (with DAC)
Research category
Growth Hormone & IGF
Evidence status
Source-reviewed literature module available below
Intended use
Research, development and manufacturing use only

Literature reference parameters

Compound class
Albumin-binding GHRH analogueCompound-level research classification
Evidence status
Small human PK/PD studies; not approvedSource-reviewed through 2026-08-28
Primary evidence anchor
Healthy-adult randomized studies · PMID 16352683See linked references and study articles
Reported pharmacokinetic window
Estimated half-life 5.8–8.1 daysLong-acting CJC-1295 in healthy-adult trials. Do not transfer this value to a non-DAC peptide.

Identity safeguard Reference identifiers above describe the literature compound record. Confirm the supplied form, formula, molecular weight, purity and storage conditions against the applicable product specification and any available lot records.

Mechanism of action

How CJC-1295 (with DAC) is studied

A target-to-pathway view grounded in the linked research records.

Sticking to blood albumin

The DAC group lets the peptide attach to albumin, a protein that carries substances through blood. This attachment keeps it in the body much longer than natural GHRH, which breaks down quickly. Human studies estimated a half-life of about a week, meaning half the dose left the blood in that time. This depends on the DAC group. CJC-1295 without DAC does not have this long-lasting behaviour.

Longer hormone signal

Once injected, CJC-1295 acts on cells in the pituitary, a small gland near the brain, just as natural GHRH would. In healthy adults, average growth hormone rose for at least six days and IGF-1 for about nine to eleven days. Repeated doses had a cumulative effect. These are blood hormone measurements in short studies. They do not show changes in muscle, fat, recovery or any health outcome.

Natural bursts kept

Growth hormone is normally released in bursts, and that pattern matters. In a small study of healthy men, CJC-1295 raised hormone levels between bursts but the bursts themselves stayed similar in size and frequency. This suggests the peptide boosts the existing signal rather than replacing it. This finding is for the DAC form given to healthy men. It does not apply to CJC-1295 without DAC or to catalog material.

Reported research findings

What published studies report about CJC-1295 (with DAC)

Reported outcomes are paired with their experimental model and evidence boundary.

Human PK/PD

Sustained endocrine response

Mean GH rose 2- to 10-fold for at least 6 days and mean IGF-1 rose 1.5- to 3-fold for 9–11 days; estimated half-life was 5.8–8.1 days.

Healthy adults, short ascending-dose studies, DAC form only.

Read the primary study
FDA review

Current safety concerns remain

FDA identifies limited clinical data, immunogenicity/impurity concerns and serious reports including increased heart rate and systemic vasodilation.

FDA lists CJC-1295 generically in this public summary and does not resolve the marketed DAC/without-DAC form. It is not a finding about a specific catalog lot.

Read the primary study
Healthy-adult randomized studies · 2006

Long-acting CJC-1295: measured endocrine response

Two placebo-controlled studies lasted 28 and 49 days. After a single administration, mean GH increased approximately 2–10-fold for at least 6 days and IGF-I approximately 1.5–3-fold for 9–11 days.

These were pharmacokinetic and endocrine endpoints in adults aged 21–61. They do not establish long-term outcomes, and they must not be assigned to CJC-1295 without DAC.

Read the primary study
Translation boundary: findings are limited to the evidence level stated on each card. Experimental protocol quantities are research details, not usage instructions.

Catalog options

Variant specifications

Pack-level catalog data; lot-level controls remain document-specific.

Catalog no.CD2
Pack size2 mg × 10 vials
Specification & documents for CD2

Product specification

Single-component peptide · 2 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Catalog no.CD5
Pack size5 mg × 10 vials
Specification & documents for CD5

Product specification

Single-component peptide · 5 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Catalog no.CD10
Pack size10 mg × 10 vials
Specification & documents for CD10

Product specification

Single-component peptide · 10 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Quality system

Quality documentation

A listed document is not proof of availability for this lot. Ask the team to confirm the current COA status and the scope of any other records before ordering.

Lot-specific Certificate of AnalysisAvailability and scope must be confirmed for the selected catalog variant and lot
COA availability unconfirmed Ask about availability
Product Specification SheetAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Analytical Method SummaryAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request

Analytical interpretation

Interpret the documents, not just the headline number.

Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.

Open the Quality & Documentation Hub

HPLC area ≠ assayA dominant peak does not establish target mass fraction.

Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.

Counterions affect contentWater, salt form and solvents change the as-is composition.

Storage needs a data basisShipping practice is not the same as stability evidence.

Evidence map

Research context

Published studies and regulatory records, not customer testimonials or usage guidance.

Human RCT

Prolonged GH and IGF-1 stimulation by CJC-1295

Teichman SL, et al. Journal of Clinical Endocrinology & Metabolism. 2006. PMID 16352683.

View primary record
Human study

Pulsatile GH secretion persists during CJC-1295 stimulation

Frohman LA, et al. Journal of Clinical Endocrinology & Metabolism. 2006. PMID 17018654.

View primary record
Evidence boundary: each card states its evidence type. Human trials and regulatory records describe the studied or regulated intervention; preclinical records remain model-specific. None verifies the identity, quality, safety or efficacy of this catalog lot or provides usage instructions.

Literature basis

Curated references

Third-party publications selected for direct relevance.

  1. 01

    Prolonged stimulation of GH and IGF-I secretion by CJC-1295

    Teichman SL, et al. J Clin Endocrinol Metab. 2006. PMID 16352683.

    Human randomized studies
  2. 02

    Pulsatile GH secretion persists during CJC-1295 stimulation

    Ionescu M, Frohman LA. J Clin Endocrinol Metab. 2006. PMID 17018654.

    Human study

Research FAQ

CJC-1295 (with DAC) questions

Concise answers for researchers comparing identity, evidence and catalog variants.

What effects are studied for CJC-1295 (with DAC)?

Two early randomized studies gave single injections to healthy adults. Average growth hormone rose 2- to 10-fold for at least six days, and IGF-1 rose 1.5- to 3-fold for nine to eleven days. A separate small study found hormone bursts were preserved while levels between them increased. These track hormone levels only. They do not show long-term benefits.

How should the CJC-1295 (with DAC) research findings be understood?

Growth hormone is normally released in bursts, and that pattern matters. In a small study of healthy men, CJC-1295 raised hormone levels between bursts but the bursts themselves stayed similar in size and frequency. This suggests the peptide boosts the existing signal rather than replacing it. This finding is for the DAC form given to healthy men. It does not apply to CJC-1295 without DAC or to catalog material.

What does DAC change?

The drug-affinity-complex group supports albumin binding and prolonged exposure; it is the defining feature behind the published multi-day pharmacokinetics.

Can the 5.8–8.1 day half-life be used for without-DAC material?

No. That estimate belongs to the albumin-binding form studied in the paper.

How is product identity verified?

Family-level identifiers organize the catalog. Confirm the supplied form, identity and release criteria using the applicable product specification and ask which lot records are available.

Which quality documents can be requested?

A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.

How should CJC-1295 (with DAC) be stored?

Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.

Knowledge center

Related insights

Owned educational content connected to this family.

CJC-1295 DAC editorial illustration

CJC-1295 With DAC in Healthy Adults: GH, IGF-1 and Half-Life Data

The classic CJC-1295 human paper evaluated a long-acting albumin-binding analog in healthy adults. Its sustained hormone profile is evidence for the DAC form studied—not…

Updated October 1, 2026

Source-traceable evidence

Public research cases

Structured readings of published studies, with the model, result and translation boundary stated explicitly.

Knowledge tools

Continue with structured evidence

Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.

Internal technical source review

Published-study results are tied to the linked records and kept separate from catalog-lot claims. Imported purity, storage and document-availability templates have been removed pending product- and lot-specific confirmation.

Editorial status: Source review complete · 2026-08-28 · Not independent medical review · Review policy

Technical procurement

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Selected: CD2 · 2 mg × 10 vials