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Reproductive & Hormone · Source-reviewed dossier

Kisspeptin-10

Source-Reviewed Research Dossier

Kisspeptin-10 is the active C-terminal decapeptide of KISS1-derived peptides and an agonist of KISS1R. Human experiments show acute reproductive-hormone responses, but they do not establish fertility, sexual-health or long-term treatment outcomes.

Research use only Lot documents on request
Kisspeptin-10 research product family with 2 catalog variants
AI-generated packaging mockup for catalog navigation. It is not a photograph of an actual supplied lot; container, label and presentation may vary.

Product family

Compound overview

Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; the current product specification and lot COA control.

Product identity

Product type
Peptide research compound
Catalog family
Kisspeptin-10
Research category
Reproductive & Hormone
Catalog CAS RN
374675-21-5
Catalog molecular formula
C63H83N17O14
Catalog molecular weight
1302.45 g/mol
Catalog sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Evidence status
Human endocrine-response studies plus extensive preclinical reproductive biology
Intended use
Research, development and manufacturing use only

Literature reference parameters

Compound or material class
C-terminal kisspeptin decapeptide / KISS1R agonistCatalog-family identity
Evidence scope
Human endocrine-response studies plus extensive preclinical reproductive biologyDo not generalize beyond the cited model
Source review
Primary or authoritative records linked belowChecked 2026-09-01

Identity safeguard Reference identifiers above describe the literature compound record. The supplied form, formula, molecular weight, purity and storage conditions must be verified against the product-specific specification and lot COA.

Mechanism of action

How Kisspeptin-10 is studied

A target-to-pathway view grounded in the linked research records.

C-terminal kisspeptin decapeptide / KISS1R agonist research basis

KISS1R activation stimulates hypothalamic GnRH neuronal signaling and downstream LH/FSH release; response varies by sex and reproductive state.

Evidence and material boundary

Acute endocrine changes in small controlled experiments are surrogate pharmacodynamic outcomes, not proof of a clinical benefit.

Reported research findings

What published studies report about Kisspeptin-10

Reported outcomes are paired with their experimental model and evidence boundary.

Human endocrine study

Acute LH responses were measured in healthy men

A controlled study characterized dose-related LH release after kisspeptin-10 administration.

A hormone-response curve does not establish fertility or sexual-health outcomes.

Read the primary study
Human physiology study

Responses differed by sex and endocrine context

A human study reported sexual dimorphism in gonadotropin responses to kisspeptin-10.

The result emphasizes context dependence and does not establish general efficacy.

Read the primary study
Translation boundary: findings are limited to the evidence level stated on each card. Experimental protocol quantities are research details, not usage instructions.

Catalog options

Variant specifications

Pack-level catalog data; lot-level controls remain document-specific.

Catalog no.KS5
Pack size5 mg × 10 vials
Specification & documents for KS5

Product specification

Single-component peptide · 5 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Catalog no.KS10
Pack size10 mg × 10 vials
Specification & documents for KS10

Product specification

Single-component peptide · 10 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Quality system

Quality documentation

Document availability is stated honestly and can vary by catalog variant or lot.

Lot-specific Certificate of AnalysisAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Product Specification SheetAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Analytical Method SummaryAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request

Analytical interpretation

Interpret the documents, not just the headline number.

Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.

Open the Quality & Documentation Hub

HPLC area ≠ assayA dominant peak does not establish target mass fraction.

Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.

Counterions affect contentWater, salt form and solvents change the as-is composition.

Storage needs a data basisShipping practice is not the same as stability evidence.

Evidence map

Research context

Published studies and regulatory records, not customer testimonials or usage guidance.

Human endocrine study

Acute LH responses were measured in healthy men

A hormone-response curve does not establish fertility or sexual-health outcomes.

View primary record
Human physiology study

Responses differed by sex and endocrine context

The result emphasizes context dependence and does not establish general efficacy.

View primary record
Evidence boundary: each card states its evidence type. Human trials and regulatory records describe the studied or regulated intervention; preclinical records remain model-specific. None verifies the identity, quality, safety or efficacy of this catalog lot or provides usage instructions.

Literature basis

Curated references

Third-party publications selected for direct relevance.

  1. 01 Human endocrine study
  2. 02

    Sexual dimorphism in response to kisspeptin-10

    Human physiology study. 2011. PMID 21976724.

    Human physiology study

Research FAQ

Kisspeptin-10 questions

Concise answers for researchers comparing identity, evidence and catalog variants.

What is Kisspeptin-10?

Kisspeptin-10 is the active C-terminal decapeptide of KISS1-derived peptides and an agonist of KISS1R. Human experiments show acute reproductive-hormone responses, but they do not establish fertility, sexual-health or long-term treatment outcomes.

What evidence is available for Kisspeptin-10?

Direct human endocrine-response data exist, alongside substantial preclinical physiology.

Does the cited research validate this catalog material?

No. The cited records describe their own intervention, formulation, model and controls. They do not verify the identity, purity, sterility, safety or efficacy of a catalog lot.

Which quality documents can be requested?

A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.

How should Kisspeptin-10 be stored?

Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.

Knowledge center

Related insights

Owned educational content connected to this family.

AI-generated illustration: Human neuroendocrine research visualization of kisspeptin-10 and LH pulses

Kisspeptin-10 and LH Pulses: The Small Human Physiology Study

A 2011 study established that kisspeptin-10 can acutely stimulate luteinizing-hormone secretion in healthy men. Its detailed pulse data are valuable physiology, but the very…

Updated September 1, 2026
AI-generated illustration: Analytical comparison of kisspeptin-10 and longer kisspeptin forms

Kisspeptin-10 vs Kisspeptin-54: Sequence and Amidation Guide

Kisspeptin-10 is the C-terminal decapeptide YNWNSFGLRF-amide. It shares an active C-terminal region with longer kisspeptins but is not the same material as kisspeptin-54.

Updated September 1, 2026

Knowledge tools

Continue with structured evidence

Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.

Internal technical source review

Claims were checked against the linked primary publication, regulatory label or authoritative compound record. Published findings stay attached to their study model, formulation and route. Catalog identity and lot quality remain controlled by the applicable specification and lot-specific documents.

Editorial status: NHD evidence editorial workflow · 2026-09-01 · Not independent medical review · Review policy

Technical procurement

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Selected: KS10 · 10 mg × 10 vials