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西安诺和达生物科技有限公司
For research, development and manufacturing use only. Not for human or veterinary use.

Growth Hormone & IGF · Modified GRF(1-29) research

CJC-1295 (without DAC)

Scientific Product Dossier

CJC-1295 without DAC is a research peptide related to growth-hormone-releasing hormone. Related short peptides can stimulate the pituitary, a small gland near the brain, to release growth hormone. However, the widely cited studies showing hormone elevation lasting days tested the DAC form, which can bind to blood albumin. Those longer-lasting results cannot be used to describe the without-DAC material. Research planning should first confirm the complete structure and distinguish pathway evidence from activity measured in the actual supplied material.

Research use only Lot documents on request
CJC-1295 (without DAC) research product family with 3 catalog variants
AI-generated packaging mockup for catalog navigation. It is not a photograph of an actual supplied lot; container, label and presentation may vary.

Product family

Compound overview

Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; request the applicable product specification and ask which lot records are available before ordering.

Product identity

Product type
Peptide research compound
Catalog family
CJC-1295 (without DAC)
Research category
Growth Hormone & IGF
Evidence status
Source-reviewed literature module available below
Intended use
Research, development and manufacturing use only

Literature reference parameters

Compound class
Commercial naming convention; exact sequence and terminal form unverifiedConfirm against current product specification and lot documentation
Evidence status
Direct matched human evidence gapSource-reviewed through 2026-08-28
Primary evidence anchor
GRF(1-29) background studies; DAC trial excluded from PK claimsSee linked references and study articles
Identity distinction: long-acting study
The 5.8–8.1-day half-life belongs to long-acting CJC-1295The linked paper is a comparison reference, not direct evidence for this non-DAC catalog family. Confirm sequence and conjugation before comparing compounds.

Identity safeguard Reference identifiers above describe the literature compound record. Confirm the supplied form, formula, molecular weight, purity and storage conditions against the applicable product specification and any available lot records.

Mechanism of action

How CJC-1295 (without DAC) is studied

A target-to-pathway view grounded in the linked research records.

Pituitary GHRH receptor activation

GRF(1-29)-type peptides act on the GHRH receptor on pituitary cells. Receptor activation raises cyclic AMP, which drives growth hormone release into the blood. An older study gave short GRF peptides (GRF1-29, GRF1-40, GRF1-44) to five healthy volunteers. All produced clear growth hormone peaks 15–30 minutes after injection. This supports the proposed mechanism but does not prove that any catalog without-DAC material works this way, because the study tested a different specified material.

Modifications aimed at stability

Natural GHRH-like peptides break down quickly in the body. Researchers alter the ends and some internal positions to slow this breakdown. In one comparison, a modified GRF1-29 analogue was more potent and lasted longer than a natural longer fragment. Such design work explains why modified GRF(1-29) types are studied, but it does not mean any supplied lot shares these properties. This comparison does not establish the activity of the supplied material.

The DAC difference is crucial

DAC stands for drug-affinity complex, a modification that lets the peptide bind to albumin in blood, keeping it in circulation for days. In a human study, the DAC form of CJC-1295 sustained growth hormone and IGF-I elevation, with an estimated half-life of about 6–8 days. Without DAC, that long-lasting behaviour is not expected. Results from the DAC molecule cannot be transferred to a without-DAC material. These are separate molecules with different behaviour.

Reported research findings

What published studies report about CJC-1295 (without DAC)

Reported outcomes are paired with their experimental model and evidence boundary.

Background human study

GRF1-29 stimulated an acute GH response

In five healthy volunteers, GRF1-29 and longer GRF fragments produced GH peaks 15–30 minutes after an intravenous bolus.

Older pathway context; not a matched trial of commercial “CJC-1295 without DAC.”

Read the primary study
Evidence safeguard

DAC pharmacokinetics do not transfer

The multi-day half-life reported for CJC-1295 depends on its albumin-binding drug-affinity-complex design.

Keep the two product families, schemas and evidence summaries separate.

Read the primary study
Translation boundary: findings are limited to the evidence level stated on each card. Experimental protocol quantities are research details, not usage instructions.

Catalog options

Variant specifications

Pack-level catalog data; lot-level controls remain document-specific.

Catalog no.CND2
Pack size2 mg × 10 vials
Specification & documents for CND2

Product specification

Single-component peptide · 2 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Catalog no.CND5
Pack size5 mg × 10 vials
Specification & documents for CND5

Product specification

Single-component peptide · 5 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Catalog no.CND10
Pack size10 mg × 10 vials
Specification & documents for CND10

Product specification

Single-component peptide · 10 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Quality system

Quality documentation

A listed document is not proof of availability for this lot. Ask the team to confirm the current COA status and the scope of any other records before ordering.

Lot-specific Certificate of AnalysisAvailability and scope must be confirmed for the selected catalog variant and lot
COA availability unconfirmed Ask about availability
Product Specification SheetAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Analytical Method SummaryAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request

Analytical interpretation

Interpret the documents, not just the headline number.

Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.

Open the Quality & Documentation Hub

HPLC area ≠ assayA dominant peak does not establish target mass fraction.

Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.

Counterions affect contentWater, salt form and solvents change the as-is composition.

Storage needs a data basisShipping practice is not the same as stability evidence.

Evidence map

Research context

Published studies and regulatory records, not customer testimonials or usage guidance.

Human study

GRF1-29 compared with longer human GRF fragments

Losa M, et al. Klinische Wochenschrift. 1984. PMID 6240568.

View primary record
Analog design

Potent long-acting GRF analogues

Rivier J, et al. Annals of the New York Academy of Sciences. 1988. PMID 3133968.

View primary record
Evidence boundary: each card states its evidence type. Human trials and regulatory records describe the studied or regulated intervention; preclinical records remain model-specific. None verifies the identity, quality, safety or efficacy of this catalog lot or provides usage instructions.

Literature basis

Curated references

Third-party publications selected for direct relevance.

  1. 01

    GRF1-29 compared with longer human GRF fragments

    Losa M, et al. Klin Wochenschr. 1984. PMID 6240568.

    Human study
  2. 02

    Potent long-acting GRF analogues

    Rivier J, et al. Ann N Y Acad Sci. 1988. PMID 3133968.

    Analogue design

Research FAQ

CJC-1295 (without DAC) questions

Concise answers for researchers comparing identity, evidence and catalog variants.

What effects are studied for CJC-1295 (without DAC)?

Short GRF peptides like GRF1-29 raised growth hormone in healthy volunteers in older studies. That is human evidence for the pathway, not for any catalog product. The long-lasting growth hormone and IGF-I increases came from the DAC form, which binds albumin. Those effects belong to that molecule, not to a without-DAC material. So we know the pathway, but not what any specific without-DAC batch does.

How should the CJC-1295 (without DAC) research findings be understood?

DAC stands for drug-affinity complex, a modification that lets the peptide bind to albumin in blood, keeping it in circulation for days. In a human study, the DAC form of CJC-1295 sustained growth hormone and IGF-I elevation, with an estimated half-life of about 6–8 days. Without DAC, that long-lasting behaviour is not expected. Results from the DAC molecule cannot be transferred to a without-DAC material. These are separate molecules with different behaviour.

Is CJC-1295 without DAC the same as CJC-1295 with DAC?

No. The DAC form has an albumin-reactive modification that changes persistence and evidence relevance.

What must a without-DAC specification state?

The complete sequence, substitutions, terminal form, molecular mass and lot-specific analytical results.

How is product identity verified?

Family-level identifiers organize the catalog. Confirm the supplied form, identity and release criteria using the applicable product specification and ask which lot records are available.

Which quality documents can be requested?

A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.

How should CJC-1295 (without DAC) be stored?

Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.

Knowledge center

Related insights

Owned educational content connected to this family.

Knowledge tools

Continue with structured evidence

Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.

Internal technical source review

Published-study results are tied to the linked records and kept separate from catalog-lot claims. Imported purity, storage and document-availability templates have been removed pending product- and lot-specific confirmation.

Editorial status: Source review complete · 2026-08-28 · Not independent medical review · Review policy

Technical procurement

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Selected: CND2 · 2 mg × 10 vials