MK-677, MK-0677 and ibutamoren are names found across the same development history. The existence of human trials does not mean the compound is an approved drug, nor does it erase trials that failed to show functional benefit or raised safety concerns.
What the record shows
- Ibutamoren is not an FDA-approved active ingredient.
- A 123-patient hip-fracture trial was stopped early after a congestive-heart-failure signal.
- Identity and assay must distinguish ibutamoren free form from ibutamoren mesylate.
The identity and evidence boundary
A certificate should state the exact molecular form, not use the parent name and mesylate interchangeably. Molecular mass, assay calculation and content per container depend on that choice.
What belongs in the material record
Marketing summaries frequently select the increase in IGF-1 or fat-free mass and omit the negative functional outcomes. A defensible page keeps the outcome hierarchy intact and cites the stopped hip-fracture trial as well as the longer healthy-older-adult study.
Editorial rule
Use the exact intervention name, model, population and endpoint from the cited record. Do not convert an association, mechanism, animal result, approved finished-drug record or analytical test into a claim about an unrelated catalog lot.
Sources & editorial method
The editorial workflow starts with linked peer-reviewed papers, trial registries or regulatory records; extracts the population or model, endpoints, numerical results and limitations; and separates the studied intervention from catalog material. AI-assisted drafting was used to structure the first version. Claims, figures, evidence labels and limitations were checked against the linked records in the site editorial workflow. This is not independent peer review.
3 linked records are listed in the references below. Read the editorial and AI-assistance policy.
How to interpret this article
Source-checked on 2026-08-28. Null findings and study limitations are retained. This is not independent peer review, medical advice, a customer case, or validation of a catalog lot.
Research-use boundary: Catalog materials discussed on this website are for laboratory research, development and manufacturing use only, not for human or veterinary use. This content is not medical advice and does not provide administration instructions.
Primary records and authoritative sources
- MK-677 in healthy older adultsNass R, et al. Annals of Internal Medicine. 2008. PMID 18981485.
- MK-0677 phase IIb hip-fracture studyAdunsky A, et al. Archives of Gerontology and Geriatrics. 2011. PMID 21067829.
- FDA Pharmacy Compounding Advisory Committee meeting materialsFDA assessment materials for ibutamoren and ipamorelin.
Continue with structured records
Move from this editorial analysis to the product identity, filtered evidence and controlled terminology behind it.
