NHD Global
Metabolic & Weight Loss · Source-reviewed dossier
Source-Reviewed Research Dossier
AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) is converted intracellularly to ZMP, an AMP analogue used to study AMPK signaling and cellular energy sensing. Reviews emphasize that AICAR also produces important AMPK-independent effects.
Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; the current product specification and lot COA control.
Product identity
Literature reference parameters
Identity safeguard Reference identifiers above describe the literature compound record. The supplied form, formula, molecular weight, purity and storage conditions must be verified against the product-specific specification and lot COA.
A target-to-pathway view grounded in the linked research records.
Reported research findings
Reported outcomes are paired with their experimental model and evidence boundary.
A systematic review catalogued widely reported AMPK activation together with important AMPK-independent effects.
Experimental conclusions require controls that separate AMPK dependence from other AICAR/ZMP actions.
Read the primary studyA 2024 animal study reported prevention and reversal of diabetic-polyneuropathy measures alongside mitophagy-related changes.
Rodent disease-model findings do not establish clinical outcomes or catalog-lot performance.
Read the primary studyCatalog options
Pack-level catalog data; lot-level controls remain document-specific.
Small-molecule research compound · 50 mg/vial nominal · 10-vial pack · chemical form, identity and assay controlled by lot specification.
Request by lot: CoA, identity and assay summary
Document availability is stated honestly and can vary by catalog variant or lot.
Analytical interpretation
Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.
Open the Quality & Documentation HubHPLC area ≠ assayA dominant peak does not establish target mass fraction.
Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.
Counterions affect contentWater, salt form and solvents change the as-is composition.
Storage needs a data basisShipping practice is not the same as stability evidence.
Evidence map
Published studies and regulatory records, not customer testimonials or usage guidance.
Experimental conclusions require controls that separate AMPK dependence from other AICAR/ZMP actions.
View primary recordRodent disease-model findings do not establish clinical outcomes or catalog-lot performance.
View primary recordThird-party publications selected for direct relevance.
Višnjić D, et al. Cells. 2021. PMID 34064363.
Experimental study. 2024. PMID 39795939.
Concise answers for researchers comparing identity, evidence and catalog variants.
AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) is converted intracellularly to ZMP, an AMP analogue used to study AMPK signaling and cellular energy sensing. Reviews emphasize that AICAR also produces important AMPK-independent effects.
The evidence base is predominantly mechanistic and preclinical, with a systematic review documenting both AMPK-linked and independent actions.
No. The cited records describe their own intervention, formulation, model and controls. They do not verify the identity, purity, sterility, safety or efficacy of a catalog lot.
A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.
Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.
Knowledge center
Owned educational content connected to this family.
A 2024 study reported prevention and reversal of neuropathy measures after experimental AICAR exposure in mouse models of type 1 and type 2 diabetes.…
Updated September 1, 2026
AICAR naming often collapses acadesine, its intracellular phosphorylated metabolite ZMP and an entire AMPK pathway into one label. Reproducible research needs those three concepts…
Updated September 1, 2026Knowledge tools
Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.
Claims were checked against the linked primary publication, regulatory label or authoritative compound record. Published findings stay attached to their study model, formulation and route. Catalog identity and lot quality remain controlled by the applicable specification and lot-specific documents.
Technical procurement
Selected: AR50 · 50 mg × 10 vials
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