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Growth Hormone & IGF · Source-reviewed dossier

IGF-1 LR3

Source-Reviewed Research Dossier

IGF-1 LR3 is an 83-amino-acid IGF-1 analogue with an Arg3 substitution and an N-terminal extension designed to reduce binding-protein affinity. Direct literature includes recombinant-expression work and animal metabolism studies, not controlled human efficacy trials.

Research use only Lot documents on request
IGF-1 LR3 research product family with 2 catalog variants
AI-generated packaging mockup for catalog navigation. It is not a photograph of an actual supplied lot; container, label and presentation may vary.

Product family

Compound overview

Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; the current product specification and lot COA control.

Product identity

Product type
Peptide research compound
Catalog family
IGF-1 LR3
Research category
Growth Hormone & IGF
Catalog CAS RN
946870-92-4
Catalog molecular formula
C400H625N111O115S9
Catalog molecular weight
9117.51 g/mol
Catalog sequence
83-amino-acid IGF-1 analog (Arg3 substitution, 13-aa N-terminal extension)
Evidence status
Cell, production and animal evidence; no established controlled human use
Intended use
Research, development and manufacturing use only

Literature reference parameters

Compound or material class
Long R3 insulin-like growth factor-1 analogueCatalog-family identity
Evidence scope
Cell, production and animal evidence; no established controlled human useDo not generalize beyond the cited model
Source review
Primary or authoritative records linked belowChecked 2026-09-01

Identity safeguard Reference identifiers above describe the literature compound record. The supplied form, formula, molecular weight, purity and storage conditions must be verified against the product-specific specification and lot COA.

Mechanism of action

How IGF-1 LR3 is studied

A target-to-pathway view grounded in the linked research records.

Long R3 insulin-like growth factor-1 analogue research basis

The analogue activates IGF-1 receptor signaling while altered binding-protein interactions can change exposure relative to native IGF-1.

Evidence and material boundary

Native IGF-1 findings cannot automatically be assigned to LR3 IGF-1, and animal production studies cannot establish human effects.

Reported research findings

What published studies report about IGF-1 LR3

Reported outcomes are paired with their experimental model and evidence boundary.

Recombinant production study

LR3 IGF-1 expression was characterized in yeast

A 2023 paper reported recombinant expression of IGF-1 and LR3 IGF-1 fusion constructs in Pichia pastoris.

Expression-system results do not verify this catalog manufacturing process.

Read the primary study
Livestock study

Protein-metabolism effects were measured in beef heifers

A 1999 study examined long(R3)-IGF-1 effects on protein metabolism in cattle.

Species, exposure and agricultural research context preclude human generalization.

Read the primary study
Translation boundary: findings are limited to the evidence level stated on each card. Experimental protocol quantities are research details, not usage instructions.

Catalog options

Variant specifications

Pack-level catalog data; lot-level controls remain document-specific.

Catalog no.IG01
Pack size0.1 mg × 10 vials
Specification & documents for IG01

Product specification

Single-component peptide · 0.1 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Catalog no.IG1
Pack size1 mg × 10 vials
Specification & documents for IG1

Product specification

Single-component peptide · 1 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Quality system

Quality documentation

Document availability is stated honestly and can vary by catalog variant or lot.

Lot-specific Certificate of AnalysisAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Product Specification SheetAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Analytical Method SummaryAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request

Analytical interpretation

Interpret the documents, not just the headline number.

Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.

Open the Quality & Documentation Hub

HPLC area ≠ assayA dominant peak does not establish target mass fraction.

Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.

Counterions affect contentWater, salt form and solvents change the as-is composition.

Storage needs a data basisShipping practice is not the same as stability evidence.

Evidence map

Research context

Published studies and regulatory records, not customer testimonials or usage guidance.

Recombinant production study

LR3 IGF-1 expression was characterized in yeast

Expression-system results do not verify this catalog manufacturing process.

View primary record
Livestock study

Protein-metabolism effects were measured in beef heifers

Species, exposure and agricultural research context preclude human generalization.

View primary record
Evidence boundary: each card states its evidence type. Human trials and regulatory records describe the studied or regulated intervention; preclinical records remain model-specific. None verifies the identity, quality, safety or efficacy of this catalog lot or provides usage instructions.

Literature basis

Curated references

Third-party publications selected for direct relevance.

  1. 01 Recombinant production study
  2. 02 Livestock study

Research FAQ

IGF-1 LR3 questions

Concise answers for researchers comparing identity, evidence and catalog variants.

What is IGF-1 LR3?

IGF-1 LR3 is an 83-amino-acid IGF-1 analogue with an Arg3 substitution and an N-terminal extension designed to reduce binding-protein affinity. Direct literature includes recombinant-expression work and animal metabolism studies, not controlled human efficacy trials.

What evidence is available for IGF-1 LR3?

Direct evidence is limited to laboratory production and non-human models.

Does the cited research validate this catalog material?

No. The cited records describe their own intervention, formulation, model and controls. They do not verify the identity, purity, sterility, safety or efficacy of a catalog lot.

Which quality documents can be requested?

A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.

How should IGF-1 LR3 be stored?

Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.

Knowledge center

Related insights

Owned educational content connected to this family.

AI-generated illustration: recombinant-protein bioreactor workflow

IGF-1 LR3 Evidence: Fermentation, Cattle and Null Results

Direct Long R3 IGF-1 literature is largely about recombinant production and animal biology. Some endpoints changed, while a 739-oocyte comparison found no difference in…

Updated September 8, 2026

Knowledge tools

Continue with structured evidence

Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.

Internal technical source review

Claims were checked against the linked primary publication, regulatory label or authoritative compound record. Published findings stay attached to their study model, formulation and route. Catalog identity and lot quality remain controlled by the applicable specification and lot-specific documents.

Editorial status: NHD evidence editorial workflow · 2026-09-01 · Not independent medical review · Review policy

Technical procurement

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Selected: IG1 · 1 mg × 10 vials