NHD Global
Mitochondrial-derived peptide research · MOTS-c
Product specifications & quotation
MOTS-c is a short peptide associated with mitochondria, the structures that help cells manage energy. Researchers study its links to metabolic signaling, cellular stress and exercise. Intervention findings largely come from laboratory and animal work. Measuring natural MOTS-c levels after exercise in people is a different experiment from administering the peptide. Here you can read those findings, check catalog identity and choose a research variant without confusing published studies with batch-specific evidence.
Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; request the applicable product specification and ask which lot records are available before ordering.
Product identity
Literature reference parameters
Identity safeguard Reference identifiers above describe the literature compound record. Confirm the supplied form, formula, molecular weight, purity and storage conditions against the applicable product specification and any available lot records.
A target-to-pathway view grounded in the linked research records.
Reported research findings
Reported outcomes are paired with their experimental model and evidence boundary.
Mouse experiments reported protection against diet- and age-associated insulin resistance. These experiments did not test treatment benefits in people.
Experimental metabolic findings; human treatment benefit has not been established by these studies.
Read the primary studyA 2021 study reported improved physical performance in mice given MOTS-c. A separate part of the study measured natural MOTS-c levels around exercise in 10 young men. The human participants were studied during exercise, rather than given MOTS-c to test a treatment benefit. PMID 33473109.
Human observation and administration experiments answer different questions.
Read the primary studyFDA states it has not identified human exposure data for drug products containing MOTS-c.
The “Human” catalog qualifier denotes a sequence reference, not permission for human use.
Read the primary studyCatalog options
Pack-level catalog data; lot-level controls remain document-specific.
10 mg nominal per vial · 10 vials per pack. Confirm supplied form, mass basis and lot release specifications before ordering.
Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.
20 mg nominal per vial · 10 vials per pack. Confirm supplied form, mass basis and lot release specifications before ordering.
Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.
40 mg nominal per vial · 10 vials per pack. Confirm supplied form, mass basis and lot release specifications before ordering.
Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.
A listed document is not proof of availability for this lot. Ask the team to confirm the current COA status and the scope of any other records before ordering.
Analytical interpretation
Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.
Open the Quality & Documentation HubHPLC area ≠ assayA dominant peak does not establish target mass fraction.
Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.
Counterions affect contentWater, salt form and solvents change the as-is composition.
Storage needs a data basisShipping practice is not the same as stability evidence.
Evidence map
Published studies and regulatory records, not customer testimonials or usage guidance.
Lee C, et al. Cell Metabolism. 2015. PMID 25738459.
View primary recordU.S. FDA current MOTS-c summary.
View primary recordThird-party publications selected for direct relevance.
Lee C, et al. Cell Metabolism. 2015. PMID 25738453.
U.S. FDA. Current compounding safety-information page.
Concise answers for researchers comparing identity, evidence and catalog variants.
The clearest effects come from mouse studies: protection against diet- and age-related insulin resistance, reduced diet-induced obesity, and better physical capacity, including when treatment started late in life. In humans, only natural MOTS-c changes after exercise have been measured, in a small observational setting. That is different from giving the peptide as a treatment, so human benefit from this research compound is not established. PMIDs 25738459, 33473109.
A 2021 study reported that MOTS-c improved physical performance in young, middle-aged and old mice, and late-life intermittent treatment increased capacity and healthspan. Separately, exercise raised natural MOTS-c in human muscle and circulation. The human part measured the body's own peptide response during exercise. It did not give MOTS-c to people to test a performance benefit. PMID 33473109.
It identifies the reference sequence. It does not mean the material is donor-derived, tested in people or intended for human use.
MS10 lists 10 mg per vial, MS20 lists 20 mg and MS40 lists 40 mg. Each pack contains 10 vials. Confirm availability, supplied form and lot specifications with your quote.
A catalogue listing is not a stock confirmation. Tell us the vial size, number of packs and destination so we can confirm availability and quotation details.
Ask which documents are available for the selected variant and lot. A COA, specification sheet or method summary is not guaranteed by this listing; availability and scope must be confirmed before ordering.
Include the product name, catalogue code, vial size, number of packs, research purpose, destination and required documents. Mention any requirements for supplied form, purity or peptide content so they can be assessed separately.
The listed mg per vial is a nominal catalogue size. It does not establish measured peptide content or purity. Confirm what the mass refers to and which measurements are available for the selected lot.
Request the storage conditions for the exact supplied form and selected variant. A temperature stated for another supplier or a clinical drug preparation is not a verified storage specification for NHD catalog material.
No. The foundational intervention results came from cell and mouse experiments. They do not establish treatment benefits in people.
No. The qualifier identifies the sequence reference. It does not describe approval or suitability for human administration. Confirm the sequence and supplied form needed for the laboratory project.
Send the exact product name, selected catalog variant, required quantity, destination and documents needed for the project. Specify whether the amount refers to powder mass or measured peptide content. Availability, price, lead time and document scope require confirmation.
No. A paper describes the material and methods used in that study. It does not establish the identity, purity or content of a different supplied lot. Ask which records actually apply to the requested material; do not assume a COA is available.
Knowledge center
Owned educational content connected to this family.
The paper that introduced MOTS-c combined cell experiments with mouse metabolic models. It is an important discovery record, but the intervention findings were preclinical.
Updated October 1, 2026
“Human” in a MOTS-c catalog title ordinarily describes the referenced peptide sequence; it does not mean the material was isolated from a human donor,…
Updated October 1, 2026
Find MOTS-c’s two methionines, then follow the mass change from one added oxygen.
Updated October 11, 2026
Researchers studying MOTS-c asked whether it changes location inside stressed cells and affects gene regulation. That is a mechanism experiment. This guide explains what…
Updated October 9, 2026Knowledge tools
Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.
Published-study results are tied to the linked records and kept separate from catalog-lot claims. Imported purity, storage and document-availability templates have been removed pending product- and lot-specific confirmation.
Technical procurement
Selected: MS10 · 10 mg × 10 vials
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