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Healing & Tissue Repair · Source-reviewed dossier

TB-500 (Thymosin β4 Acetate)

Source-Reviewed Research Dossier

TB-500 is a trade-style research name associated in the literature with an N-terminal acetylated thymosin-β4 fragment, while some catalogs use it for full-length thymosin β4. The exact sequence must therefore be confirmed from the specification rather than inferred from the name.

Research use only Lot documents on request
TB-500 (Thymosin β4 Acetate) research product family with 3 catalog variants
AI-generated packaging mockup for catalog navigation. It is not a photograph of an actual supplied lot; container, label and presentation may vary.

Product family

Compound overview

Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; the current product specification and lot COA control.

Product identity

Product type
Peptide research compound
Catalog family
TB-500 (Thymosin β4 Acetate)
Research category
Healing & Tissue Repair
Catalog CAS RN
77591-33-4
Catalog molecular formula
C212H350N56O78S
Catalog molecular weight
4963.44 g/mol
Catalog sequence
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Identity boundary
TB-500 may denote a thymosin-β4 fragment or a differently defined catalog material; sequence and MS identity are controlling.
Evidence status
Identity ambiguity plus preclinical evidence; no controlled human efficacy
Intended use
Research, development and manufacturing use only

Literature reference parameters

Compound or material class
Thymosin-β4-related synthetic research materialCatalog-family identity
Evidence scope
Identity ambiguity plus preclinical evidence; no controlled human efficacyDo not generalize beyond the cited model
Source review
Primary or authoritative records linked belowChecked 2026-09-01

Identity safeguard Reference identifiers above describe the literature compound record. The supplied form, formula, molecular weight, purity and storage conditions must be verified against the product-specific specification and lot COA.

Mechanism of action

How TB-500 (Thymosin β4 Acetate) is studied

A target-to-pathway view grounded in the linked research records.

Thymosin-β4-related synthetic research material research basis

Thymosin-β4-related research examines actin binding, cell migration and tissue-repair pathways; fragment and full-length materials are not interchangeable.

Evidence and material boundary

Rat tendon and in-vitro findings do not establish human outcomes, and identity ambiguity must be resolved at the sequence and mass level for each lot.

Reported research findings

What published studies report about TB-500 (Thymosin β4 Acetate)

Reported outcomes are paired with their experimental model and evidence boundary.

Analytical identity study

A specific acetylated 17–23 fragment was identified as TB-500

A 2012 paper synthesized and characterized the N-terminal-acetylated thymosin β4 17–23 fragment found in a suspected doping product.

The record shows why “TB-500” cannot automatically be treated as full-length thymosin β4.

Read the primary study
Rat tendon study

TB-500 was evaluated in Achilles-tendon healing

A 2026 rat study reported histopathological and biomechanical outcomes for TB-500, BPC-157 and their combination.

Preclinical results do not establish human efficacy or catalog-lot identity.

Read the primary study
Translation boundary: findings are limited to the evidence level stated on each card. Experimental protocol quantities are research details, not usage instructions.

Catalog options

Variant specifications

Pack-level catalog data; lot-level controls remain document-specific.

Catalog no.BT2
Pack size2 mg × 10 vials
Specification & documents for BT2

Product specification

Single-component peptide · 2 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Catalog no.BT5
Pack size5 mg × 10 vials
Specification & documents for BT5

Product specification

Single-component peptide · 5 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Catalog no.BT10
Pack size10 mg × 10 vials
Specification & documents for BT10

Product specification

Single-component peptide · 10 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Quality system

Quality documentation

Document availability is stated honestly and can vary by catalog variant or lot.

Lot-specific Certificate of AnalysisAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Product Specification SheetAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Analytical Method SummaryAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request

Analytical interpretation

Interpret the documents, not just the headline number.

Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.

Open the Quality & Documentation Hub

HPLC area ≠ assayA dominant peak does not establish target mass fraction.

Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.

Counterions affect contentWater, salt form and solvents change the as-is composition.

Storage needs a data basisShipping practice is not the same as stability evidence.

Evidence map

Research context

Published studies and regulatory records, not customer testimonials or usage guidance.

Analytical identity study

A specific acetylated 17–23 fragment was identified as TB-500

The record shows why “TB-500” cannot automatically be treated as full-length thymosin β4.

View primary record
Rat tendon study

TB-500 was evaluated in Achilles-tendon healing

Preclinical results do not establish human efficacy or catalog-lot identity.

View primary record
Evidence boundary: each card states its evidence type. Human trials and regulatory records describe the studied or regulated intervention; preclinical records remain model-specific. None verifies the identity, quality, safety or efficacy of this catalog lot or provides usage instructions.

Literature basis

Curated references

Third-party publications selected for direct relevance.

  1. 01 Analytical identity
  2. 02

    Effects of BPC-157 and TB-500 on Achilles tendon healing in rats

    Biçer O, et al. Jt Dis Relat Surg. 2026;37:822–837. PMID 42542926.

    Randomized rat study

Research FAQ

TB-500 (Thymosin β4 Acetate) questions

Concise answers for researchers comparing identity, evidence and catalog variants.

What is TB-500 (Thymosin β4 Acetate)?

TB-500 is a trade-style research name associated in the literature with an N-terminal acetylated thymosin-β4 fragment, while some catalogs use it for full-length thymosin β4. The exact sequence must therefore be confirmed from the specification rather than inferred from the name.

What evidence is available for TB-500 (Thymosin β4 Acetate)?

The public evidence is preclinical and includes a direct analytical description of the 17–23 fragment sold under the TB-500 name.

Does the cited research validate this catalog material?

No. The cited records describe their own intervention, formulation, model and controls. They do not verify the identity, purity, sterility, safety or efficacy of a catalog lot.

Which quality documents can be requested?

A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.

How should TB-500 (Thymosin β4 Acetate) be stored?

Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.

Knowledge center

Related insights

Owned educational content connected to this family.

Source-traceable evidence

Public research cases

Structured readings of published studies, with the model, result and translation boundary stated explicitly.

Knowledge tools

Continue with structured evidence

Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.

Internal technical source review

Claims were checked against the linked primary publication, regulatory label or authoritative compound record. Published findings stay attached to their study model, formulation and route. Catalog identity and lot quality remain controlled by the applicable specification and lot-specific documents.

Editorial status: NHD evidence editorial workflow · 2026-09-01 · Not independent medical review · Review policy

Technical procurement

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Selected: BT2 · 2 mg × 10 vials