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For research, development and manufacturing use only. Not for human or veterinary use.

Growth Hormone & IGF · Source-reviewed dossier

Sermorelin

Source-Reviewed Research Dossier

Sermorelin is a man-made 29-amino-acid piece of growth-hormone-releasing hormone (GHRH). GHRH is a natural signal from the brain that tells the pituitary, a small gland near the brain, to release growth hormone in pulses. Sermorelin has been studied as a way to encourage the body's own growth-hormone release, and historical articles discussed it for adult growth-hormone insufficiency. A separate analytical study looked at detecting it in urine for anti-doping. Neither record provides broad anti-aging, body-composition, or performance benefits. The research-catalog material is for laboratory investigation only, and its identity and lot quality depend on product-specific documents, not published clinical data.

Research use only Lot documents on request
Sermorelin research product family with 2 catalog variants
AI-generated packaging mockup for catalog navigation. It is not a photograph of an actual supplied lot; container, label and presentation may vary.

Product family

Compound overview

Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; request the applicable product specification and ask which lot records are available before ordering.

Product identity

Product type
Peptide research compound
Catalog family
Sermorelin
Research category
Growth Hormone & IGF
Catalog CAS RN
86168-78-7
Catalog molecular formula
C149H246N44O42S
Catalog molecular weight
3357.88 g/mol
Catalog sequence
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
Evidence status
Historical diagnostic/clinical use plus modern analytical literature; current catalog remains RUO
Intended use
Research, development and manufacturing use only

Literature reference parameters

Compound or material class
GHRH(1-29) analogueCatalog-family identity
Evidence scope
Historical diagnostic/clinical use plus modern analytical literature; current catalog remains RUODo not generalize beyond the cited model
Source review
Primary or authoritative records linked belowChecked 2026-09-01

Identity safeguard Reference identifiers above describe the literature compound record. Confirm the supplied form, formula, molecular weight, purity and storage conditions against the applicable product specification and any available lot records.

Mechanism of action

How Sermorelin is studied

A target-to-pathway view grounded in the linked research records.

Acts on the body's growth-hormone signal

Sermorelin copies the first 29 amino acids of natural GHRH, the part that binds the pituitary receptor. When it reaches the pituitary, it triggers growth-hormone release in pulses, not a steady flow. Researchers study this upstream step to understand how the body controls its own growth-hormone output. The evidence so far describes how the peptide behaves at the receptor; it does not show a health or performance benefit in people.

Clinical discussion and lab detection records

A 2006 narrative article discussed sermorelin as a possible approach for adult growth-hormone insufficiency, but such an article is not a controlled trial and cannot prove effectiveness. A later analytical study showed how to detect sermorelin and similar synthetic GHRH analogues in urine, which helps anti-doping monitoring. These two records answer different questions; neither validates a specific catalog lot or turns a growth-hormone response into a general health benefit.

Reported research findings

What published studies report about Sermorelin

Reported outcomes are paired with their experimental model and evidence boundary.

Clinical perspective

Adult GH-insufficiency management was discussed historically

A 2006 article reviewed sermorelin as an approach to adult-onset GH insufficiency.

The narrative perspective is not a modern controlled efficacy trial.

Read the primary study
Analytical review

Synthetic GHRH analogues require specific detection

A review described mass-spectrometric detection of GHRH analogues used in doping contexts.

Detection science informs identity and misuse monitoring, not therapeutic benefit.

Read the primary study
Translation boundary: findings are limited to the evidence level stated on each card. Experimental protocol quantities are research details, not usage instructions.

Catalog options

Variant specifications

Pack-level catalog data; lot-level controls remain document-specific.

Catalog no.SMO5
Pack size5 mg × 10 vials
Specification & documents for SMO5

Product specification

Single-component peptide · 5 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Catalog no.SMO10
Pack size10 mg × 10 vials
Specification & documents for SMO10

Product specification

Single-component peptide · 10 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Quality system

Quality documentation

A listed document is not proof of availability for this lot. Ask the team to confirm the current COA status and the scope of any other records before ordering.

Lot-specific Certificate of AnalysisAvailability and scope must be confirmed for the selected catalog variant and lot
COA availability unconfirmed Ask about availability
Product Specification SheetAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Analytical Method SummaryAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request

Analytical interpretation

Interpret the documents, not just the headline number.

Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.

Open the Quality & Documentation Hub

HPLC area ≠ assayA dominant peak does not establish target mass fraction.

Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.

Counterions affect contentWater, salt form and solvents change the as-is composition.

Storage needs a data basisShipping practice is not the same as stability evidence.

Evidence map

Research context

Published studies and regulatory records, not customer testimonials or usage guidance.

Clinical perspective

Adult GH-insufficiency management was discussed historically

The narrative perspective is not a modern controlled efficacy trial.

View primary record
Analytical review

Synthetic GHRH analogues require specific detection

Detection science informs identity and misuse monitoring, not therapeutic benefit.

View primary record
Evidence boundary: each card states its evidence type. Human trials and regulatory records describe the studied or regulated intervention; preclinical records remain model-specific. None verifies the identity, quality, safety or efficacy of this catalog lot or provides usage instructions.

Literature basis

Curated references

Third-party publications selected for direct relevance.

  1. 01 Clinical perspective
  2. 02

    Advances in detection of GHRH synthetic analogs

    Analytical review. 2021. PMID 34665524.

    Analytical review

Research FAQ

Sermorelin questions

Concise answers for researchers comparing identity, evidence and catalog variants.

What effects are studied for Sermorelin?

Two areas. A historical article discussed it for adult growth-hormone insufficiency, but that is a narrative view, not a controlled trial. A later analytical study used it to help develop urine detection methods for anti-doping. Neither shows anti-aging, fat loss, muscle building, or performance effects. So those wider claims are not supported by this evidence.

How should the Sermorelin research findings be understood?

A 2006 narrative article discussed sermorelin as a possible approach for adult growth-hormone insufficiency, but such an article is not a controlled trial and cannot prove effectiveness. A later analytical study showed how to detect sermorelin and similar synthetic GHRH analogues in urine, which helps anti-doping monitoring. These two records answer different questions; neither validates a specific catalog lot or turns a growth-hormone response into a general health benefit.

What evidence is available for Sermorelin?

The evidence base contains older clinical context and analytical identity/stability research rather than current broad-outcome trials.

Does the cited research validate this catalog material?

No. The cited records describe their own intervention, formulation, model and controls. They do not verify the identity, purity, sterility, safety or efficacy of a catalog lot.

Which quality documents can be requested?

A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.

How should Sermorelin be stored?

Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.

Knowledge center

Related insights

Owned educational content connected to this family.

Editorial comic illustration: Sermorelin Human Research. Conceptual cover, not experimental imagery.

Sermorelin Human Evidence: GH Response Tests and Historical Limits

Sermorelin is GHRH(1–29)-amide. Human research shows acute pituitary growth-hormone responses, while historical treatment data are limited and do not support modern anti-aging or performance…

Updated October 1, 2026
Editorial comic illustration: Sermorelin Identity Guide. Conceptual cover, not experimental imagery.

Sermorelin Identity Guide: GHRH(1–29)-Amide and LC-MS

Sermorelin is an amidated 29-residue peptide corresponding to the active N-terminal region of human GHRH. The C-terminal amide is identity-defining.

Updated October 1, 2026

Knowledge tools

Continue with structured evidence

Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.

Internal technical source review

Claims were checked against the linked primary publication, regulatory label or authoritative compound record. Published findings stay attached to their study model, formulation and route. Catalog identity and lot quality remain controlled by the applicable specification and lot-specific documents.

Editorial status: NHD evidence editorial workflow · 2026-09-01 · Not independent medical review · Review policy

Technical procurement

Ready to request a quote?

Selected: SMO5 · 5 mg × 10 vials