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Healing & Tissue Repair · Source-reviewed dossier

ARA-290 (Cibinetide)

Source-Reviewed Research Dossier

ARA-290, also called cibinetide, is an erythropoietin helix-B-derived peptide designed to engage the innate repair receptor without stimulating erythropoiesis. Small clinical studies have examined neuropathy and macular-edema endpoints, while much of the mechanistic evidence remains preclinical.

Research use only Lot documents on request
ARA-290 (Cibinetide) research product family with 1 catalog variants
AI-generated packaging mockup for catalog navigation. It is not a photograph of an actual supplied lot; container, label and presentation may vary.

Product family

Compound overview

Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; the current product specification and lot COA control.

Product identity

Product type
Peptide research compound
Catalog family
ARA-290 (Cibinetide)
Research category
Healing & Tissue Repair
Catalog CAS RN
1208243-50-8
Catalog molecular formula
C50H83N17O21
Catalog molecular weight
1258.30 g/mol
Catalog sequence
pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
Evidence status
Small human studies plus preclinical innate-repair-receptor research
Intended use
Research, development and manufacturing use only

Literature reference parameters

Compound or material class
Non-erythropoietic EPO-derived peptideCatalog-family identity
Evidence scope
Small human studies plus preclinical innate-repair-receptor researchDo not generalize beyond the cited model
Source review
Primary or authoritative records linked belowChecked 2026-09-01

Identity safeguard Reference identifiers above describe the literature compound record. The supplied form, formula, molecular weight, purity and storage conditions must be verified against the product-specific specification and lot COA.

Mechanism of action

How ARA-290 (Cibinetide) is studied

A target-to-pathway view grounded in the linked research records.

Non-erythropoietic EPO-derived peptide research basis

Cibinetide is studied as a ligand of the EPOR–CD131 innate repair receptor complex, with downstream tissue-protective and inflammation-modulating hypotheses.

Evidence and material boundary

Disease-specific studies used defined formulations and protocols; they do not validate a third-party catalog material or support general treatment claims.

Reported research findings

What published studies report about ARA-290 (Cibinetide)

Reported outcomes are paired with their experimental model and evidence boundary.

Pilot human trial

Sarcoidosis small-fiber-neuropathy endpoints were explored

A pilot study evaluated ARA-290 in patients with sarcoidosis-associated small-fiber neuropathy and reported changes in selected symptoms and functional measures.

Small sample size and disease-specific design limit generalization.

Read the primary study
Phase 2 clinical study

Diabetic macular edema was studied separately

A phase 2 record evaluated cibinetide for diabetic macular edema.

Ophthalmic trial evidence is route-, formulation- and indication-specific.

Read the primary study
Translation boundary: findings are limited to the evidence level stated on each card. Experimental protocol quantities are research details, not usage instructions.

Catalog options

Variant specifications

Pack-level catalog data; lot-level controls remain document-specific.

Catalog no.ARA10
Pack size10 mg × 10 vials
Current variant
Specification & documents for ARA10

Product specification

Single-component peptide · 10 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Quality system

Quality documentation

Document availability is stated honestly and can vary by catalog variant or lot.

Lot-specific Certificate of AnalysisAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Product Specification SheetAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Analytical Method SummaryAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request

Analytical interpretation

Interpret the documents, not just the headline number.

Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.

Open the Quality & Documentation Hub

HPLC area ≠ assayA dominant peak does not establish target mass fraction.

Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.

Counterions affect contentWater, salt form and solvents change the as-is composition.

Storage needs a data basisShipping practice is not the same as stability evidence.

Evidence map

Research context

Published studies and regulatory records, not customer testimonials or usage guidance.

Pilot human trial

Sarcoidosis small-fiber-neuropathy endpoints were explored

Small sample size and disease-specific design limit generalization.

View primary record
Phase 2 clinical study

Diabetic macular edema was studied separately

Ophthalmic trial evidence is route-, formulation- and indication-specific.

View primary record
Evidence boundary: each card states its evidence type. Human trials and regulatory records describe the studied or regulated intervention; preclinical records remain model-specific. None verifies the identity, quality, safety or efficacy of this catalog lot or provides usage instructions.

Literature basis

Curated references

Third-party publications selected for direct relevance.

  1. 01

    ARA 290 for treatment of small fiber neuropathy in sarcoidosis

    Heij L, et al. Molecular Medicine. 2014. PMID 24555851.

    Pilot human trial
  2. 02

    Phase 2 clinical trial of cibinetide for diabetic macular edema

    Clinical Ophthalmology. 2020. PMID 32674280.

    Phase 2 clinical study

Research FAQ

ARA-290 (Cibinetide) questions

Concise answers for researchers comparing identity, evidence and catalog variants.

What is ARA-290 (Cibinetide)?

ARA-290, also called cibinetide, is an erythropoietin helix-B-derived peptide designed to engage the innate repair receptor without stimulating erythropoiesis. Small clinical studies have examined neuropathy and macular-edema endpoints, while much of the mechanistic evidence remains preclinical.

What evidence is available for ARA-290 (Cibinetide)?

The literature includes small human phase studies and multiple animal models, with limited scale and indication-specific endpoints.

Does the cited research validate this catalog material?

No. The cited records describe their own intervention, formulation, model and controls. They do not verify the identity, purity, sterility, safety or efficacy of a catalog lot.

Which quality documents can be requested?

A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.

How should ARA-290 (Cibinetide) be stored?

Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.

Knowledge center

Related insights

Owned educational content connected to this family.

AI-generated illustration: Corneal and peripheral small-nerve-fiber research imaging for cibinetide

ARA-290/Cibinetide: Small-Fiber Neuropathy and DME Trial Data

Human cibinetide evidence includes small exploratory studies with very different populations. A 22-person sarcoidosis-neuropathy pilot reported a symptom-score difference, while a 9-person diabetic-macular-edema study…

Updated September 1, 2026

Knowledge tools

Continue with structured evidence

Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.

Internal technical source review

Claims were checked against the linked primary publication, regulatory label or authoritative compound record. Published findings stay attached to their study model, formulation and route. Catalog identity and lot quality remain controlled by the applicable specification and lot-specific documents.

Editorial status: NHD evidence editorial workflow · 2026-09-01 · Not independent medical review · Review policy

Technical procurement

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Selected: ARA10 · 10 mg × 10 vials