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For research, development and manufacturing use only. Not for human or veterinary use.

Cosmetic & Skin · Copper tripeptide research

GHK-Cu

Scientific Product Dossier

GHK-Cu is the copper complex of glycyl-L-histidyl-L-lysine, studied in extracellular-matrix and wound models. In a randomized topical study with 13 completers after CO2 laser resurfacing, objective assessments found no significant group difference in erythema, wrinkles or skin quality; a patient questionnaire favored GHK-Cu for perceived skin quality (p=0.04). Topical evidence does not support injectable claims.

Research use only Lot documents on request
GHK-Cu research product family with 2 catalog variants
AI-generated packaging mockup for catalog navigation. It is not a photograph of an actual supplied lot; container, label and presentation may vary.

Product family

Compound overview

Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; the current product specification and lot COA control.

Product identity

Product type
Peptide research compound
Catalog family
GHK-Cu
Research category
Cosmetic & Skin
Evidence status
Source-reviewed literature module available below
Intended use
Research, development and manufacturing use only

Literature reference parameters

Compound class
Copper tripeptide complexCompound-level research classification
Evidence status
Topical human and preclinical evidence; route-specific gapsSource-reviewed through 2026-08-28
Primary evidence anchor
randomized topical study with 13 completers topical study · PMID 16847171See linked references and study articles

Identity safeguard Reference identifiers above describe the literature compound record. The supplied form, formula, molecular weight, purity and storage conditions must be verified against the product-specific specification and lot COA.

Mechanism of action

How GHK-Cu is studied

A target-to-pathway view grounded in the linked research records.

Copper-peptide complex

GHK-Cu research examines copper coordination, extracellular-matrix signaling and tissue-model responses.

Route-specific interpretation

Topical product findings cannot establish the safety or effect of injectable GHK-Cu.

Reported research findings

What published studies report about GHK-Cu

Reported outcomes are paired with their experimental model and evidence boundary.

Small topical RCT

Objective group comparisons were null

Among 13 completers, blinded and computer assessments found no significant GHK-Cu advantage for erythema, wrinkles or overall skin quality.

The questionnaire favored perceived skin quality at p=0.04; exploratory given the small sample.

Read the primary study
FDA review

Injectable evidence remains limited

FDA flags potential aggregation, peptide-impurity and immunogenicity concerns for injectable GHK-Cu.

A topical study cannot close an injectable-route safety gap.

Read the primary study
Translation boundary: findings are limited to the evidence level stated on each card. Experimental protocol quantities are research details, not usage instructions.

Catalog options

Variant specifications

Pack-level catalog data; lot-level controls remain document-specific.

Catalog no.CU50
Pack size50 mg × 10 vials
Specification & documents for CU50

Product specification

Single-component peptide · 50 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Catalog no.CU100
Pack size100 mg × 10 vials
Specification & documents for CU100

Product specification

Single-component peptide · 100 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Quality system

Quality documentation

Document availability is stated honestly and can vary by catalog variant or lot.

Lot-specific Certificate of AnalysisAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Product Specification SheetAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Analytical Method SummaryAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request

Analytical interpretation

Interpret the documents, not just the headline number.

Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.

Open the Quality & Documentation Hub

HPLC area ≠ assayA dominant peak does not establish target mass fraction.

Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.

Counterions affect contentWater, salt form and solvents change the as-is composition.

Storage needs a data basisShipping practice is not the same as stability evidence.

Evidence map

Research context

Published studies and regulatory records, not customer testimonials or usage guidance.

Human RCT

Effects of topical copper tripeptide complex on laser-resurfaced skin

Miller TR, et al. Archives of Facial Plastic Surgery. 2006. PMID 16847171.

View primary record
FDA record

FDA bulk-substance safety concerns

U.S. FDA injectable GHK-Cu summary.

View primary record
Evidence boundary: each card states its evidence type. Human trials and regulatory records describe the studied or regulated intervention; preclinical records remain model-specific. None verifies the identity, quality, safety or efficacy of this catalog lot or provides usage instructions.

Literature basis

Curated references

Third-party publications selected for direct relevance.

  1. 01

    Effects of topical copper tripeptide complex on laser-resurfaced skin

    Miller TR, et al. Archives of Facial Plastic Surgery. 2006. PMID 16847171.

    Human RCT
  2. 02

    Certain Bulk Drug Substances That May Present Significant Safety Risks

    U.S. FDA. Current compounding safety-information page.

Research FAQ

GHK-Cu questions

Concise answers for researchers comparing identity, evidence and catalog variants.

What did the randomized topical GHK-Cu study find?

Objective assessments found no significant group differences; one patient questionnaire favored perceived skin quality at p=0.04.

Does topical evidence validate injectable GHK-Cu?

No. Route, formulation, exposure and sterility requirements are different.

How is product identity verified?

Family-level identifiers organize the catalog, while the applicable product specification and lot-specific COA control the supplied form, identity and release results.

Which quality documents can be requested?

A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.

How should GHK-Cu be stored?

Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.

Knowledge center

Related insights

Owned educational content connected to this family.

Knowledge tools

Continue with structured evidence

Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.

Internal technical source review

Published-study results are tied to the linked records and kept separate from catalog-lot claims. Imported purity, storage and document-availability templates have been removed pending product- and lot-specific confirmation.

Editorial status: Source review complete · 2026-08-28 · Not independent medical review · Review policy

Technical procurement

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Selected: CU50 · 50 mg × 10 vials