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For research, development and manufacturing use only. Not for human or veterinary use.

Cosmetic & Skin · Copper tripeptide research

GHK-Cu

Product specifications & quotation

GHK-Cu is a small copper-binding peptide studied in skin and tissue-repair research. Cell experiments have examined collagen production; collagen is a protein that gives tissues structure. These laboratory findings help explain interest in the compound, but human evidence is limited and not uniformly positive. This page separates cell, animal and human findings, then lists catalog identity and research variants. Ask for the actual supplied form and available records before comparing quotations.

Research use only Lot documents on request
GHK-Cu research product family with 2 catalog variants
AI-generated packaging mockup for catalog navigation. It is not a photograph of an actual supplied lot; container, label and presentation may vary.

Product family

Compound overview

Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; request the applicable product specification and ask which lot records are available before ordering.

Product identity

Product type
Peptide research compound
Catalog family
GHK-Cu
Research category
Cosmetic & Skin
Evidence status
Source-reviewed literature module available below
Intended use
Research, development and manufacturing use only

Literature reference parameters

Compound class
Copper tripeptide complexCompound-level research classification
Evidence status
Topical human and preclinical evidence; route-specific gapsSource-reviewed through 2026-08-28
Primary evidence anchor
Randomized topical study with 13 completers · PMID 16847171Open the PMID link to read the original study.

Identity safeguard Reference identifiers above describe the literature compound record. Confirm the supplied form, formula, molecular weight, purity and storage conditions against the applicable product specification and any available lot records.

Mechanism of action

How GHK-Cu is studied

A target-to-pathway view grounded in the linked research records.

Collagen production in cell studies

Collagen is the supporting protein that keeps skin and other tissues intact. Fibroblasts are cells that make collagen. In laboratory fibroblast cultures, GHK-Cu increased collagen production at very low concentrations without changing cell numbers. This is a cell-level finding. It does not show that a supplied research material will produce the same effect in people.

Repair-related tissue changes in rats

In a rat wound-chamber experiment, GHK-Cu increased collagen and other connective-tissue material at the treated sites. The researchers also measured related gene activity and compared an unrelated peptide. These findings support further repair research. They do not establish faster wound healing in people or the activity of a supplied research batch.

Skin appearance after laser treatment

Thirteen people completed a randomized trial of topical GHK-Cu after CO2 laser resurfacing. Blinded and computer assessments found no significant difference between groups in redness, wrinkles, or overall skin quality, although all participants improved. A questionnaire favored perceived skin quality with GHK-Cu. The small sample, topical use, and specific formulation limit how far this result can be generalized.

Injectable safety questions remain open

The FDA has flagged potential concerns for injectable GHK-Cu used in compounding, including aggregation, peptide impurities, and immune reactions. These are route-specific issues. A topical study cannot resolve injectable safety questions, nor can laboratory collagen data. Route, formulation, and salt form all affect what evidence applies, so topical and injectable research should be evaluated separately.

Reported research findings

What published studies report about GHK-Cu

Reported outcomes are paired with their experimental model and evidence boundary.

Cultured cells

Collagen production: the main laboratory finding

Collagen helps support the structure of skin and other tissues. A published fibroblast-culture experiment found that GHK-Cu stimulated collagen synthesis. This explains the interest in skin research, while remaining a cell-level result. PMID 3169264.

An experimental finding, not a measured benefit of an NHD supplied lot.

Read the primary study
Small topical RCT

Objective group comparisons were null

Among 13 completers, blinded and computer assessments found no significant GHK-Cu advantage for erythema, wrinkles or overall skin quality.

The questionnaire favored perceived skin quality at p=0.04; exploratory given the small sample.

Read the primary study
FDA review

Injectable evidence remains limited

FDA flags potential aggregation, peptide-impurity and immunogenicity concerns for injectable GHK-Cu.

A topical study cannot close an injectable-route safety gap.

Read the primary study
Translation boundary: findings are limited to the evidence level stated on each card. Experimental protocol quantities are research details, not usage instructions.

Catalog options

Variant specifications

Pack-level catalog data; lot-level controls remain document-specific.

Catalog no.CU50
Pack size50 mg × 10 vials
Specification & documents for CU50

Product specification

50 mg nominal per vial · 10 vials per pack. Confirm supplied form, mass basis and lot release specifications before ordering.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Catalog no.CU100
Pack size100 mg × 10 vials
Specification & documents for CU100

Product specification

100 mg nominal per vial · 10 vials per pack. Confirm supplied form, mass basis and lot release specifications before ordering.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Quality system

Quality documentation

A listed document is not proof of availability for this lot. Ask the team to confirm the current COA status and the scope of any other records before ordering.

Lot-specific Certificate of AnalysisAvailability and scope must be confirmed for the selected catalog variant and lot
COA availability unconfirmed Ask about availability
Product Specification SheetAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Analytical Method SummaryAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request

Analytical interpretation

Interpret the documents, not just the headline number.

Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.

Open the Quality & Documentation Hub

HPLC area ≠ assayA dominant peak does not establish target mass fraction.

Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.

Counterions affect contentWater, salt form and solvents change the as-is composition.

Storage needs a data basisShipping practice is not the same as stability evidence.

Evidence map

Research context

Published studies and regulatory records, not customer testimonials or usage guidance.

Human RCT

Effects of topical copper tripeptide complex on laser-resurfaced skin

Miller TR, et al. Archives of Facial Plastic Surgery. 2006. PMID 16847171.

View primary record
FDA record

FDA bulk-substance safety concerns

U.S. FDA injectable GHK-Cu summary.

View primary record
Animal wound model

Connective-tissue accumulation in rat experimental wounds

Primary rat wound-chamber study; this is preclinical repair evidence. PMID 8227353.

View primary record
Evidence boundary: each card states its evidence type. Human trials and regulatory records describe the studied or regulated intervention; preclinical records remain model-specific. None verifies the identity, quality, safety or efficacy of this catalog lot or provides usage instructions.

Literature basis

Curated references

Third-party publications selected for direct relevance.

  1. 01

    Effects of topical copper tripeptide complex on laser-resurfaced skin

    Miller TR, et al. Archives of Facial Plastic Surgery. 2006. PMID 16847171.

    Human RCT
  2. 02

    Certain Bulk Drug Substances That May Present Significant Safety Risks

    U.S. FDA. Current compounding safety-information page.

Research FAQ

GHK-Cu questions

Concise answers for researchers comparing identity, evidence and catalog variants.

What effects are studied for GHK-Cu?

The clearest effect is increased collagen production in cultured fibroblasts. In rat wound chambers, more collagen and connective tissue accumulated. In people, a small trial of topical GHK-Cu after laser resurfacing found no objective skin differences; only a questionnaire favored perceived skin quality. These are model-specific findings, not proven benefits from a specific supplied lot.

How should the GHK-Cu research findings be understood?

The FDA has flagged potential concerns for injectable GHK-Cu used in compounding, including aggregation, peptide impurities, and immune reactions. These are route-specific issues. A topical study cannot resolve injectable safety questions, nor can laboratory collagen data. Route, formulation, and salt form all affect what evidence applies, so topical and injectable research should be evaluated separately.

Which GHK-Cu sizes can I enquire about?

CU50 lists 50 mg per vial and CU100 lists 100 mg per vial. Both are 10-vial packs. These are nominal catalogue sizes; confirm the supplied form, mass basis and release specifications before ordering.

Are these products in stock?

A catalogue listing is not a stock confirmation. Tell us the vial size, number of packs and destination so we can confirm availability and quotation details.

Can I request a COA before ordering?

Ask which documents are available for the selected variant and lot. A COA, specification sheet or method summary is not guaranteed by this listing; availability and scope must be confirmed before ordering.

What should I include in a quote request?

Include the product name, catalogue code, vial size, number of packs, research purpose, destination and required documents. Mention any requirements for supplied form, purity or peptide content so they can be assessed separately.

Does the labelled vial mass mean peptide content?

The listed mg per vial is a nominal catalogue size. It does not establish measured peptide content or purity. Confirm what the mass refers to and which measurements are available for the selected lot.

How should the material be stored?

Request the storage conditions for the exact supplied form and selected variant. A temperature stated for another supplier or a clinical drug preparation is not a verified storage specification for NHD catalog material.

What does the topical study tell us?

In the study with 13 completers, objective assessments found no significant group differences. One patient questionnaire favoured perceived skin quality at p=0.04. These topical findings do not validate injectable use.

Why should a GHK-Cu enquiry specify the supplied form?

GHK and the copper complex are different descriptions of material. A paper may also use a particular preparation or medium. State the intended research material clearly and ask which identity fields and documents apply to the selected variant.

What should I include in a research quotation request?

Send the exact product name, selected catalog variant, required quantity, destination and documents needed for the project. Specify whether the amount refers to powder mass or measured peptide content. Availability, price, lead time and document scope require confirmation.

Does a published study replace a lot-specific analytical report?

No. A paper describes the material and methods used in that study. It does not establish the identity, purity or content of a different supplied lot. Ask which records actually apply to the requested material; do not assume a COA is available.

Knowledge center

Related insights

Owned educational content connected to this family.

Peptide Synthesis Costs editorial illustration

Why Do Peptide Prices Vary? A Simple Guide

A simple introduction to peptide pricing: why sequence, purity, quantity, packaging and testing can change a quote, and what to ask before ordering.

Updated October 9, 2026

Knowledge tools

Continue with structured evidence

Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.

Internal technical source review

Published-study results are tied to the linked records and kept separate from catalog-lot claims. Imported purity, storage and document-availability templates have been removed pending product- and lot-specific confirmation.

Editorial status: Source review complete · 2026-10-09 · Not independent medical review · Review policy

Technical procurement

Ready to request a quote?

Selected: CU50 · 50 mg × 10 vials