Longevity & Bioregulators · Source-reviewed dossier
Pinealon
Source-Reviewed Research Dossier
Pinealon is a short laboratory-made peptide with the sequence Glu-Asp-Arg. Research interest centres on oxidative stress and early brain development. In isolated cells under stress, it lowered harmful free-radical buildup and reduced one type of cell death. In a rat study, pregnant animals fed a methionine-rich diet produced offspring that learned a spatial task better, and their cerebellum neurons resisted oxidative stress more. These are early cell and animal findings only; no controlled human outcomes have been shown for memory, nerve protection or ageing. This is a research material, not a medicine or supplement.
Compound overview
Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; request the applicable product specification and ask which lot records are available before ordering.
Product identity
- Product type
- Peptide research compound
- Catalog family
- Pinealon
- Research category
- Longevity & Bioregulators
- Catalog molecular formula
- C15H26N6O8
- Catalog molecular weight
- 418.40 g/mol
- Catalog sequence
- Glu-Asp-Arg
- Evidence status
- Cell and rodent evidence; no established controlled human outcome evidence
- Intended use
- Research, development and manufacturing use only
Literature reference parameters
- Compound or material class
- Short synthetic peptide bioregulatorCatalog-family identity
- Evidence scope
- Cell and rodent evidence; no established controlled human outcome evidenceDo not generalize beyond the cited model
- Source review
- Primary or authoritative records linked belowChecked 2026-09-01
Identity safeguard Reference identifiers above describe the literature compound record. Confirm the supplied form, formula, molecular weight, purity and storage conditions against the applicable product specification and any available lot records.
How Pinealon is studied
A target-to-pathway view grounded in the linked research records.
Reported research findings
What published studies report about Pinealon
Reported outcomes are paired with their experimental model and evidence boundary.
Cell viability and free-radical processes were measured
A 2011 study evaluated Pinealon in cultured cells under experimental stress conditions.
In-vitro endpoints do not establish a clinical neuroprotective effect.
Read the primary studyPrenatal hyperhomocysteinemia outcomes were preclinical
A 2012 report studied Pinealon in offspring from a rat prenatal hyperhomocysteinemia model.
Developmental findings in rats cannot be generalized to humans.
Read the primary studyCatalog options
Variant specifications
Pack-level catalog data; lot-level controls remain document-specific.
Specification & documents for PIN5
Product specification
Single-component peptide · 5 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.
Lot documentation
Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.
Specification & documents for PIN10
Product specification
Single-component peptide · 10 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.
Lot documentation
Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.
Quality documentation
A listed document is not proof of availability for this lot. Ask the team to confirm the current COA status and the scope of any other records before ordering.
Analytical interpretation
Interpret the documents, not just the headline number.
Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.
Open the Quality & Documentation HubHPLC area ≠ assayA dominant peak does not establish target mass fraction.
Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.
Counterions affect contentWater, salt form and solvents change the as-is composition.
Storage needs a data basisShipping practice is not the same as stability evidence.
Evidence map
Research context
Published studies and regulatory records, not customer testimonials or usage guidance.
Cell viability and free-radical processes were measured
In-vitro endpoints do not establish a clinical neuroprotective effect.
View primary recordPrenatal hyperhomocysteinemia outcomes were preclinical
Developmental findings in rats cannot be generalized to humans.
View primary recordCurated references
Third-party publications selected for direct relevance.
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01
Cell study
Pinealon effects on cell viability and proliferative processes
Cell study. 2011. PMID 21978084.
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02
Rat developmental study
Pinealon in a prenatal hyperhomocysteinemia model
Preclinical study. 2012. PMID 22567179.
Pinealon questions
Concise answers for researchers comparing identity, evidence and catalog variants.
What effects are studied for Pinealon?
Two main laboratory observations. In isolated cells, Pinealon reduced free-radical buildup and necrotic cell death and altered cell-division signalling. In a rat model of high homocysteine during pregnancy, offspring of treated mothers learned a spatial task better and their cerebellum neurons were more stress-resistant. No controlled human trials have tested memory, nerve protection or longevity.
How should the Pinealon research findings be understood?
In pregnant rats with diet-induced high homocysteine, a condition linked to oxidative stress, Pinealon improved the offspring's spatial orientation and learning. Neurons from the offspring's cerebellum showed less free-radical accumulation and fewer necrotic cells. The authors called this neuroprotective. It is one animal model with a specific dietary trigger, so it cannot be generalised to human pregnancy, development or cognition.
What evidence is available for Pinealon?
The accessible literature is small and predominantly preclinical.
Does the cited research validate this catalog material?
No. The cited records describe their own intervention, formulation, model and controls. They do not verify the identity, purity, sterility, safety or efficacy of a catalog lot.
Which quality documents can be requested?
A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.
How should Pinealon be stored?
Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.
Knowledge tools
Continue with structured evidence
Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.
Claims were checked against the linked primary publication, regulatory label or authoritative compound record. Published findings stay attached to their study model, formulation and route. Catalog identity and lot quality remain controlled by the applicable specification and lot-specific documents.
Technical procurement
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Selected: PIN5 · 5 mg × 10 vials