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Longevity & Bioregulators · Source-reviewed dossier

Epitalon

Source-Reviewed Research Dossier

Epitalon is a short synthetic peptide of four amino acids. Research has focused on how cells change with age and on egg cell quality after ovulation. In human cells grown in the lab, exposure to epitalon was followed by longer telomeres, the protective caps on chromosomes, and by signs of increased telomere‑maintaining activity. In a separate study, mouse egg cells aged in a dish showed less oxidative damage and better markers of cell quality when epitalon was added. These are early laboratory observations only. They do not show that epitalon slows aging or treats any disease in people. It is a research material, not a medicine.

Research use only Lot documents on request
Epitalon research product family with 2 catalog variants
AI-generated packaging mockup for catalog navigation. It is not a photograph of an actual supplied lot; container, label and presentation may vary.

Product family

Compound overview

Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; request the applicable product specification and ask which lot records are available before ordering.

Product identity

Product type
Peptide research compound
Catalog family
Epitalon
Research category
Longevity & Bioregulators
Catalog CAS RN
307297-39-8
Catalog molecular formula
C14H22N4O9
Catalog molecular weight
390.35 g/mol
Catalog sequence
Ala-Glu-Asp-Gly
Evidence status
Cell and animal evidence; no established controlled human outcome evidence
Intended use
Research, development and manufacturing use only

Literature reference parameters

Compound or material class
Synthetic tetrapeptide bioregulatorCatalog-family identity
Evidence scope
Cell and animal evidence; no established controlled human outcome evidenceDo not generalize beyond the cited model
Source review
Primary or authoritative records linked belowChecked 2026-09-01

Identity safeguard Reference identifiers above describe the literature compound record. Confirm the supplied form, formula, molecular weight, purity and storage conditions against the applicable product specification and any available lot records.

Mechanism of action

How Epitalon is studied

A target-to-pathway view grounded in the linked research records.

Telomeres and cell aging

Telomeres are protective caps on chromosome ends that shorten as cells divide. In human cell lines, epitalon exposure was followed by longer telomeres, more of the telomerase component hTERT, and higher telomerase activity in normal cells. Some cancer cell lines used a different lengthening route. These are dish observations in specific cell lines, not a proven mechanism in people.

Egg cell aging and oxidative stress

After ovulation, egg cells can deteriorate partly through reactive oxygen species. In mouse egg cells aged in a dish, adding epitalon lowered reactive oxygen species, reduced spindle and granule abnormalities, raised mitochondrial membrane potential and mitochondrial DNA copy number, and reduced apoptosis after extended in‑vitro aging. This was isolated mouse cells in culture, not living animals or humans.

Research material limits

The published findings apply only to the specific epitalon formulations, concentrations, cell lines and mouse‑oocyte models tested. Cell and mouse results cannot be transferred to human longevity, fertility or disease outcomes. Research materials are research and manufacturing materials, not finished medicines; identity and purity are controlled by lot‑specific documentation, not by the cited papers.

Reported research findings

What published studies report about Epitalon

Reported outcomes are paired with their experimental model and evidence boundary.

Cell study

Telomere-related measurements were made in cultured human cells

A 2025 study evaluated epitalon exposure and telomere length across human cell lines.

An in-vitro cell-line result is not a human longevity outcome.

Read the primary study
Mouse-oocyte study

Post-ovulatory aging outcomes were preclinical

A 2022 study reported changes in oxidative-stress and developmental markers in aged mouse oocytes.

The exposure, species and reproductive model do not establish human effects.

Read the primary study
Translation boundary: findings are limited to the evidence level stated on each card. Experimental protocol quantities are research details, not usage instructions.

Catalog options

Variant specifications

Pack-level catalog data; lot-level controls remain document-specific.

Catalog no.ET10
Pack size10 mg × 10 vials
Specification & documents for ET10

Product specification

Single-component peptide · 10 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Catalog no.ET50
Pack size50 mg × 10 vials
Specification & documents for ET50

Product specification

Single-component peptide · 50 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.

Quality system

Quality documentation

A listed document is not proof of availability for this lot. Ask the team to confirm the current COA status and the scope of any other records before ordering.

Lot-specific Certificate of AnalysisAvailability and scope must be confirmed for the selected catalog variant and lot
COA availability unconfirmed Ask about availability
Product Specification SheetAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Analytical Method SummaryAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request

Analytical interpretation

Interpret the documents, not just the headline number.

Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.

Open the Quality & Documentation Hub

HPLC area ≠ assayA dominant peak does not establish target mass fraction.

Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.

Counterions affect contentWater, salt form and solvents change the as-is composition.

Storage needs a data basisShipping practice is not the same as stability evidence.

Evidence map

Research context

Published studies and regulatory records, not customer testimonials or usage guidance.

Cell study

Telomere-related measurements were made in cultured human cells

An in-vitro cell-line result is not a human longevity outcome.

View primary record
Mouse-oocyte study

Post-ovulatory aging outcomes were preclinical

The exposure, species and reproductive model do not establish human effects.

View primary record
Evidence boundary: each card states its evidence type. Human trials and regulatory records describe the studied or regulated intervention; preclinical records remain model-specific. None verifies the identity, quality, safety or efficacy of this catalog lot or provides usage instructions.

Literature basis

Curated references

Third-party publications selected for direct relevance.

  1. 01

    Epitalon and telomere length in human cell lines

    Cell study. 2025. PMID 40908429.

    Cell study
  2. 02

    Epitalon delays postovulatory aging of mouse oocytes

    Preclinical study. 2022. PMID 35413689.

    Mouse-oocyte study

Research FAQ

Epitalon questions

Concise answers for researchers comparing identity, evidence and catalog variants.

What effects are studied for Epitalon?

Two main lines of lab work exist. In cultured human cell lines, epitalon was followed by telomere lengthening with telomerase upregulation in normal cells and a different lengthening route in some cancer lines. In a mouse‑oocyte study, it reduced oxidative and structural damage markers during in‑vitro aging. These are cell and animal observations, not established human benefits.

How should the Epitalon research findings be understood?

The published findings apply only to the specific epitalon formulations, concentrations, cell lines and mouse‑oocyte models tested. Cell and mouse results cannot be transferred to human longevity, fertility or disease outcomes. Research materials are research and manufacturing materials, not finished medicines; identity and purity are controlled by lot‑specific documentation, not by the cited papers.

What evidence is available for Epitalon?

Direct records are predominantly laboratory and animal studies, with no adequate controlled human trial supporting broad longevity claims.

Does the cited research validate this catalog material?

No. The cited records describe their own intervention, formulation, model and controls. They do not verify the identity, purity, sterility, safety or efficacy of a catalog lot.

Which quality documents can be requested?

A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.

How should Epitalon be stored?

Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.

Knowledge center

Related insights

Owned educational content connected to this family.

Epitalon editorial illustration

Epitalon Evidence Review: Telomere Cell Data and Mouse Oocytes

Recent Epitalon papers report telomere-related changes in cultured cells and oxidative-stress findings in post-ovulatory mouse oocytes. Neither experiment demonstrates longer life, slower aging or…

Updated October 1, 2026
Editorial comic illustration: Epitalon Identity Guide. Conceptual cover, not experimental imagery.

Epitalon Identity Guide: AEDG Sequence, Mass and Evidence Boundary

Epitalon is the tetrapeptide Ala-Glu-Asp-Gly, abbreviated AEDG. Identity, sequence confirmation, chromatographic purity and quantitative peptide content are related but separate measurements.

Updated October 1, 2026

Knowledge tools

Continue with structured evidence

Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.

Internal technical source review

Claims were checked against the linked primary publication, regulatory label or authoritative compound record. Published findings stay attached to their study model, formulation and route. Catalog identity and lot quality remain controlled by the applicable specification and lot-specific documents.

Editorial status: NHD evidence editorial workflow · 2026-09-01 · Not independent medical review · Review policy

Technical procurement

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Selected: ET10 · 10 mg × 10 vials