NHD Global
Longevity & Bioregulators · Source-reviewed dossier
Source-Reviewed Research Dossier
FOXO4-DRI is a research peptide designed to make certain aged or stressed cells self-destruct while leaving ordinary cells mostly alone. These cells, called senescent cells, stop dividing but resist dying, and build up with age and after chemotherapy. Researchers study them because they may contribute to tissue decline. The main experiments used cultured senescent cells and live mice. In mice, the peptide improved measures such as physical fitness, fur density, kidney function in one report, and testosterone-related measures in another. These are early animal findings, not proven human treatments. Material sold as a research peptide is a laboratory item. Its identity and quality are covered by its own documents, not by published experiments.
Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; request the applicable product specification and ask which lot records are available before ordering.
Product identity
Literature reference parameters
Identity safeguard Reference identifiers above describe the literature compound record. Confirm the supplied form, formula, molecular weight, purity and storage conditions against the applicable product specification and any available lot records.
A target-to-pathway view grounded in the linked research records.
Reported research findings
Reported outcomes are paired with their experimental model and evidence boundary.
The foundational report tested FOXO4-DRI in senescent cells and naturally aged or chemotherapy-exposed mice.
The study is preclinical and does not define human benefit, dose or long-term safety.
Read the primary studyA later study examined senescent-cell clearance and testosterone-related measures in naturally aged male mice.
A murine endocrine model cannot establish a human hormonal outcome.
Read the primary studyCatalog options
Pack-level catalog data; lot-level controls remain document-specific.
Single-component peptide · 10 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.
Document availability and scope must be confirmed for this variant and lot in the written quotation. A catalog description is not a lot-specific test result.
A listed document is not proof of availability for this lot. Ask the team to confirm the current COA status and the scope of any other records before ordering.
Analytical interpretation
Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.
Open the Quality & Documentation HubHPLC area ≠ assayA dominant peak does not establish target mass fraction.
Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.
Counterions affect contentWater, salt form and solvents change the as-is composition.
Storage needs a data basisShipping practice is not the same as stability evidence.
Evidence map
Published studies and regulatory records, not customer testimonials or usage guidance.
The study is preclinical and does not define human benefit, dose or long-term safety.
View primary recordA murine endocrine model cannot establish a human hormonal outcome.
View primary recordThird-party publications selected for direct relevance.
Baar MP, et al. Cell. 2017. PMID 28340339.
Preclinical study. 2020. PMID 31959736.
Concise answers for researchers comparing identity, evidence and catalog variants.
In cultured senescent cells, it caused those cells to die while ordinary cells were largely spared. In mice, the foundational study reported better fitness, fur density and kidney function in some aging models. A later study in aged male mice reported changes in the testicular environment and testosterone-related measures. These are animal and cell results only. They do not establish human benefit, dosing or long-term safety.
Mouse studies describe specific preparations, routes and doses. They cannot guarantee that any independently supplied research product matches those preparations or behaves the same way. A catalog item's identity comes from its own specification and lot records. Those records cover composition and handling; they say nothing about clinical benefit. Published biological findings and catalog identity are separate questions and should be treated as such.
Foundational cell and aged-mouse studies exist, but controlled human clinical evidence was not identified.
No. The cited records describe their own intervention, formulation, model and controls. They do not verify the identity, purity, sterility, safety or efficacy of a catalog lot.
A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.
Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.
Knowledge center
Owned educational content connected to this family.
FOXO4-DRI is an experimental senolytic design supported by cultured-cell and mouse studies. Reports of restored fitness, renal function, testosterone or vascular function remain preclinical.
Updated October 1, 2026
FOXO4-DRI describes a D-retro-inverso peptide design intended to mimic the side-chain topology of a FOXO4 interaction segment while reversing backbone direction. It is not…
Updated October 1, 2026Knowledge tools
Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.
Claims were checked against the linked primary publication, regulatory label or authoritative compound record. Published findings stay attached to their study model, formulation and route. Catalog identity and lot quality remain controlled by the applicable specification and lot-specific documents.
Technical procurement
Selected: F410 · 10 mg × 10 vials
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