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Longevity & Bioregulators · Source-reviewed dossier

Thymosin Alpha-1

Source-Reviewed Research Dossier

Thymosin alpha-1 (thymalfasin) is a 28-amino-acid peptide studied as an immune modulator in infection, oncology and immune-response settings. Outcomes remain indication-, regimen- and product-specific and do not establish general immune enhancement.

Research use only Lot documents on request
Thymosin Alpha-1 research product family with 2 catalog variants
AI-generated packaging mockup for catalog navigation. It is not a photograph of an actual supplied lot; container, label and presentation may vary.

Product family

Compound overview

Shared values below are consolidated from the current catalog record. They are not independent verification or lot results; the current product specification and lot COA control.

Product identity

Product type
Peptide research compound
Catalog family
Thymosin Alpha-1
Research category
Longevity & Bioregulators
Catalog CAS RN
62304-98-7
Catalog molecular formula
C129H215N33O55
Catalog molecular weight
3108.28 g/mol
Catalog sequence
Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
Evidence status
Broad immunology and indication-specific clinical literature; regulatory status varies by jurisdiction
Intended use
Research, development and manufacturing use only

Literature reference parameters

Compound or material class
28-amino-acid thymic peptide / thymalfasinCatalog-family identity
Evidence scope
Broad immunology and indication-specific clinical literature; regulatory status varies by jurisdictionDo not generalize beyond the cited model
Source review
Primary or authoritative records linked belowChecked 2026-09-01

Identity safeguard Reference identifiers above describe the literature compound record. The supplied form, formula, molecular weight, purity and storage conditions must be verified against the product-specific specification and lot COA.

Mechanism of action

How Thymosin Alpha-1 is studied

A target-to-pathway view grounded in the linked research records.

28-amino-acid thymic peptide / thymalfasin research basis

Research describes modulation of innate and adaptive immune signaling, including dendritic-cell, T-cell and Toll-like-receptor-related pathways.

Evidence and material boundary

Reviewed clinical experience with named finished products cannot verify the identity, quality, approval or effectiveness of catalog research material.

Reported research findings

What published studies report about Thymosin Alpha-1

Reported outcomes are paired with their experimental model and evidence boundary.

Comprehensive review

Clinical and mechanistic literature spans multiple indications

A 2020 review summarized thymosin alpha-1 biology and reported uses across immune-compromised and infectious-disease settings.

The review does not support unrestricted use or interchangeability of materials.

Read the primary study
Clinical review

Sepsis evidence was evaluated across heterogeneous studies

A 2018 review assessed thymosin alpha-1 as an adjunct in sepsis and discussed the limits of the available clinical literature.

Adjunctive sepsis evidence is not a general immune-health claim.

Read the primary study
Translation boundary: findings are limited to the evidence level stated on each card. Experimental protocol quantities are research details, not usage instructions.

Catalog options

Variant specifications

Pack-level catalog data; lot-level controls remain document-specific.

Catalog no.TA5
Pack size5 mg × 10 vials
Specification & documents for TA5

Product specification

Single-component peptide · 5 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Catalog no.TA10
Pack size10 mg × 10 vials
Specification & documents for TA10

Product specification

Single-component peptide · 10 mg/vial nominal · 10-vial pack · supplied form and release limits controlled by lot specification.

Lot documentation

Request by lot: CoA, HPLC purity and MS identity

Quality system

Quality documentation

Document availability is stated honestly and can vary by catalog variant or lot.

Lot-specific Certificate of AnalysisAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Product Specification SheetAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request
Analytical Method SummaryAvailability and scope must be confirmed for the selected catalog variant and lot
Confirm before ordering Request

Analytical interpretation

Interpret the documents, not just the headline number.

Use the source-reviewed guide to separate chromatographic area purity, quantitative assay, LC-MS identity, composition and stability evidence before comparing variants or requesting a lot record.

Open the Quality & Documentation Hub

HPLC area ≠ assayA dominant peak does not establish target mass fraction.

Intact mass ≠ full sequenceIdentity strength depends on resolution and orthogonal evidence.

Counterions affect contentWater, salt form and solvents change the as-is composition.

Storage needs a data basisShipping practice is not the same as stability evidence.

Evidence map

Research context

Published studies and regulatory records, not customer testimonials or usage guidance.

Comprehensive review

Clinical and mechanistic literature spans multiple indications

The review does not support unrestricted use or interchangeability of materials.

View primary record
Clinical review

Sepsis evidence was evaluated across heterogeneous studies

Adjunctive sepsis evidence is not a general immune-health claim.

View primary record
Evidence boundary: each card states its evidence type. Human trials and regulatory records describe the studied or regulated intervention; preclinical records remain model-specific. None verifies the identity, quality, safety or efficacy of this catalog lot or provides usage instructions.

Literature basis

Curated references

Third-party publications selected for direct relevance.

  1. 01

    Thymosin alpha 1: a comprehensive review of the literature

    Dominari A, et al. World J Virol. 2020. PMID 33362999.

    Comprehensive review
  2. 02

    Thymosin alpha 1 treatment for patients with sepsis

    Clinical review. 2018. PMID 30063866.

    Clinical review

Research FAQ

Thymosin Alpha-1 questions

Concise answers for researchers comparing identity, evidence and catalog variants.

What is Thymosin Alpha-1?

Thymosin alpha-1 (thymalfasin) is a 28-amino-acid peptide studied as an immune modulator in infection, oncology and immune-response settings. Outcomes remain indication-, regimen- and product-specific and do not establish general immune enhancement.

What evidence is available for Thymosin Alpha-1?

Reviews cover both laboratory and clinical studies, with heterogeneous indications and study quality.

Does the cited research validate this catalog material?

No. The cited records describe their own intervention, formulation, model and controls. They do not verify the identity, purity, sterility, safety or efficacy of a catalog lot.

Which quality documents can be requested?

A lot-specific COA, product specification sheet and analytical method summary can be requested where applicable.

How should Thymosin Alpha-1 be stored?

Store at -20 °C, protected from light and moisture. After reconstitution, aliquot and avoid repeated freeze-thaw cycles. Confirm the applicable storage statement on the product-specific specification and lot documentation.

Knowledge center

Related insights

Owned educational content connected to this family.

AI-generated illustration: Multicenter two-arm sepsis trial data visualization with near-overlapping outcomes

Thymosin Alpha-1 in Sepsis: The 2025 TESTS Phase 3 Result

The 2025 TESTS trial is more informative than earlier small sepsis reports: 1,106 adults were randomized across 22 centers, and thymosin alpha-1 did not…

Updated September 1, 2026
AI-generated illustration: Analytical laboratory visualization of an acetylated 28-residue thymalfasin peptide

Thymalfasin Identity: Thymosin Alpha-1 Sequence and Acetylation

Thymalfasin is synthetic thymosin alpha-1: a defined 28-amino-acid peptide with an N-terminal acetyl group. Sequence and acetylation are part of identity, not optional catalog…

Updated September 1, 2026

Knowledge tools

Continue with structured evidence

Move from this dossier into canonical evidence maps, verified status records, analytical interpretation and laboratory calculations.

Internal technical source review

Claims were checked against the linked primary publication, regulatory label or authoritative compound record. Published findings stay attached to their study model, formulation and route. Catalog identity and lot quality remain controlled by the applicable specification and lot-specific documents.

Editorial status: NHD evidence editorial workflow · 2026-09-01 · Not independent medical review · Review policy

Technical procurement

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Selected: TA5 · 5 mg × 10 vials