An in-vitro antimicrobial study shows why the salt form belongs in the material identity.
What the study actually tested
Researchers prepared acetate, chloride, and trifluoroacetate salts of five antimicrobial peptides and measured activity against Staphylococcus aureus alongside red-cell hemolysis and cell-based toxicity. For temporin A, Table 6 reports a selectivity index of 1.34 for the TFA salt, 0.22 for acetate, and 0.60 for chloride. Other tested peptides did not follow one universal ordering of salt performance.
Numbers worth reading in context
| Study measure | Reported result |
|---|---|
| Temporin A TFA | 1.34 (Table 6) |
| Temporin A acetate | 0.22 |
| Temporin A chloride | 0.60 |
The selectivity index is a ratio from the paper’s assays, not a clinical efficacy or safety score. The highest numerical value in this comparison does not make TFA a universally preferred salt: the same study described peptide-dependent differences and multiple assay endpoints. The tested lots, organisms, and cell systems define the evidence boundary.
Why the paper also contains 1.36
The discussion gives 1.36 for temporin A trifluoroacetate, whereas Table 6 gives 1.34. The tabulated IC50 of 7.91 µg/mL divided by the mean MIC of 5.9 µg/mL is approximately 1.34. We use the table value and flag the disagreement instead of treating both figures as interchangeable. This correction does not resolve uncertainties in the biological assays or establish a clinical safety margin.
What to put in the RFQ or experiment plan
When reproducing an antimicrobial-peptide experiment, specify the peptide sequence and counterion together. Record whether concentrations are expressed as total salt mass or peptide content, and ask for a measured counterion composition rather than a name inferred from purification solvent. Compare biological results only after aligning the material and assay conditions.
Evidence boundary
This article summarizes external in-vitro research. It makes no treatment recommendation, claims no human outcome, and does not report an NHD lot result.
Sources and next step
Primary research: Counter-ion effect on antistaphylococcal activity and cytotoxicity of selected antimicrobial peptides. These external figures are not test results for an NHD lot.
Related NHD guide: read the related article. For a material-specific question, request a written quotation with the sequence, amount, intended use, and required records.
Sources & editorial method
AI-assisted writing and source verification. Numerical claims were checked against the linked full-text records, with source inconsistencies identified in the article. This is not independent scientific peer review or verification of a supplied lot.
1 linked records are listed in the references below. Read the editorial and AI-assistance policy.
How to interpret this article
This article summarizes external in-vitro research. It makes no treatment recommendation, claims no human outcome, and does not report an NHD lot result.
Research-use boundary: Catalog materials discussed on this website are for laboratory research, development and manufacturing use only, not for human or veterinary use. This content is not medical advice and does not provide administration instructions.
